5TTFA

Crystal structure of catalytic domain of g9a with ms012
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
269
structure length
265
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 73
structure length 265
sequence length 269
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-11-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5ttfA00
5KJMA 5ARFA 4J8OA 4YPUA 5LSXA 5CCLA 3OPEA 3S7DA 1ML9A 3K5KA 3KMAA 5TEGA 5TTFA 5CPRB 3M55A 3DB5A 3F9YA 1ZKKA 3RQ4A 3MO2A 3QWWA 4NVQA 4Z4PA 3RIBA 3M57A 5F59A 2JV0A 4I51A 5F6KC 3KMJA 3TG4A 1MVXA 1PEGA 4IJDA 4O6FA 4YNDA 5JHNA 4JLGA 4J7FA 1MVHA 3N71A 3S7BA 3PDNA 3TG5A 2G46A 5KJLA 4LDGA 3F9XA 3VUZA 5F6LA 4O30A 5KJNA 1H3IA 4QEPA 2RFIA 4NJ5A 4RZ0A 3RJWA 4QEOA 5CCMA 4JDSA 1MUFA 3M54A 3BO5A 3OS5A 3QWVA 3S8PA 3OXFA 3EP0A 3RU0A 3M5AA 5LSZA 4FMUA 3OXGA 3KMTA 4J7IA 3IHXA 4YPAA 2BQZA 1N6CA 5F5EA 3VV0A 4QENA 3MEKA 3M59A 2R3AA 2QPWA 5ARGA 5EX0A 4E47A 4YNMA 5EG2A 3CBPA 2O8JA 3RAYA 3MO5A 4IJ8A 3M56A 3FPDA 5KJKA 3OOIA 1N3JA 3F9WA 4J83A 3M58A 5TH7A 5HQ8A 3F9ZA 3SW9A 4BUPA 4YPEA 4AU7A 1N6AA 3MO0A 5T0KA 5JIYA 4MI5A 5JINA 4WUYA 3SWCA 4YNPA 2W5ZA 4C1QA 5JJ0A 2W5YA 1MT6A 5AYFA 5HI7A 3CBMA 4MI0A 3DALA 2IGQA 3HNAA 3M53A 3CBOA 3S7FA 1O9SA 3QWPA 2F69A 1XQHA 3S7JA 4H12A 3OXLA 5T5GA 5EX3A 5T0MA
chains in the Genus database with same CATH superfamily
5KJMA 5ARFA 4J8OA 4YPUA 5LSXA 5CCLA 3OPEA 3S7DA 1ML9A 3K5KA 3KMAA 5TEGA 5TTFA 5CPRB 3M55A 3DB5A 3F9YA 1ZKKA 3RQ4A 3MO2A 3QWWA 4NVQA 4Z4PA 3RIBA 3M57A 5F59A 2JV0A 4I51A 5F6KC 3KMJA 3TG4A 1MVXA 1PEGA 4IJDA 4O6FA 4YNDA 5JHNA 4JLGA 4J7FA 1MVHA 3N71A 3S7BA 3PDNA 3TG5A 2G46A 5KJLA 4LDGA 3F9XA 3VUZA 5F6LA 4O30A 5KJNA 1H3IA 4QEPA 2RFIA 4NJ5A 4RZ0A 3RJWA 4QEOA 5CCMA 4JDSA 1MUFA 3M54A 3BO5A 3OS5A 3QWVA 3S8PA 3OXFA 3EP0A 3RU0A 3M5AA 5LSZA 4FMUA 3OXGA 3KMTA 4J7IA 3IHXA 4YPAA 2BQZA 1N6CA 5F5EA 3VV0A 4QENA 3MEKA 3M59A 2R3AA 2QPWA 5ARGA 5EX0A 4E47A 4YNMA 5EG2A 3CBPA 2O8JA 3RAYA 3MO5A 4IJ8A 3M56A 3FPDA 5KJKA 3OOIA 1N3JA 3F9WA 4J83A 3M58A 5TH7A 5HQ8A 3F9ZA 3SW9A 4BUPA 4YPEA 4AU7A 1N6AA 3MO0A 5T0KA 5JIYA 4MI5A 5JINA 4WUYA 3SWCA 4YNPA 2W5ZA 4C1QA 5JJ0A 2W5YA 1MT6A 5AYFA 5HI7A 3CBMA 4MI0A 3DALA 2IGQA 3HNAA 3M53A 3CBOA 3S7FA 1O9SA 3QWPA 2F69A 1XQHA 3S7JA 4H12A 3OXLA 5T5GA 5EX3A 5T0MA
chains in the Genus database with same CATH topology
5KJMA 5ARFA 4J8OA 4YPUA 5LSXA 5CCLA 3OPEA 3S7DA 1ML9A 3K5KA 3KMAA 5TEGA 5TTFA 5CPRB 3M55A 3DB5A 3F9YA 1ZKKA 3RQ4A 3MO2A 3QWWA 4NVQA 4Z4PA 3RIBA 3M57A 5F59A 2JV0A 4I51A 5F6KC 3KMJA 3TG4A 1MVXA 1PEGA 4IJDA 4O6FA 4YNDA 5JHNA 4JLGA 4J7FA 1MVHA 3N71A 3S7BA 3PDNA 3TG5A 2G46A 5KJLA 4LDGA 3F9XA 3VUZA 5F6LA 4O30A 5KJNA 1H3IA 4QEPA 2RFIA 4NJ5A 4RZ0A 3RJWA 4QEOA 5CCMA 4JDSA 1MUFA 3M54A 3BO5A 3OS5A 3QWVA 3S8PA 3OXFA 3EP0A 3RU0A 3M5AA 5LSZA 4FMUA 3OXGA 3KMTA 4J7IA 3IHXA 4YPAA 2BQZA 1N6CA 5F5EA 3VV0A 4QENA 3MEKA 3M59A 2R3AA 2QPWA 5ARGA 5EX0A 4E47A 4YNMA 5EG2A 3CBPA 2O8JA 3RAYA 3MO5A 4IJ8A 3M56A 3FPDA 5KJKA 3OOIA 1N3JA 3F9WA 4J83A 3M58A 5TH7A 5HQ8A 3F9ZA 3SW9A 4BUPA 4YPEA 4AU7A 1N6AA 3MO0A 5T0KA 5JIYA 4MI5A 5JINA 4WUYA 3SWCA 4YNPA 2W5ZA 4C1QA 5JJ0A 2W5YA 1MT6A 5AYFA 5HI7A 3CBMA 4MI0A 3DALA 2IGQA 3HNAA 3M53A 3CBOA 3S7FA 1O9SA 3QWPA 2F69A 1XQHA 3S7JA 4H12A 3OXLA 5T5GA 5EX3A 5T0MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KJM A;  5ARF A;  4J8O A;  4YPU A;  5LSX A;  5CCL A;  3OPE A;  3S7D A;  1ML9 A;  3K5K A;  3KMA A;  5TEG A;  5TTF A;  5CPR B;  3M55 A;  3DB5 A;  3F9Y A;  1ZKK A;  3RQ4 A;  3MO2 A;  3QWW A;  4NVQ A;  4Z4P A;  3RIB A;  3M57 A;  5F59 A;  2JV0 A;  4I51 A;  5F6K C;  3KMJ A;  3TG4 A;  1MVX A;  1PEG A;  4IJD A;  4O6F A;  4YND A;  5JHN A;  4JLG A;  4J7F A;  1MVH A;  3N71 A;  3S7B A;  3PDN A;  3TG5 A;  2G46 A;  5KJL A;  4LDG A;  3F9X A;  3VUZ A;  5F6L A;  4O30 A;  5KJN A;  1H3I A;  4QEP A;  2RFI A;  4NJ5 A;  4RZ0 A;  3RJW A;  4QEO A;  5CCM A;  4JDS A;  1MUF A;  3M54 A;  3BO5 A;  3OS5 A;  3QWV A;  3S8P A;  3OXF A;  3EP0 A;  3RU0 A;  3M5A A;  5LSZ A;  4FMU A;  3OXG A;  3KMT A;  4J7I A;  3IHX A;  4YPA A;  2BQZ A;  1N6C A;  5F5E A;  3VV0 A;  4QEN A;  3MEK A;  3M59 A;  2R3A A;  2QPW A;  5ARG A;  5EX0 A;  4E47 A;  4YNM A;  5EG2 A;  3CBP A;  2O8J A;  3RAY A;  3MO5 A;  4IJ8 A;  3M56 A;  3FPD A;  5KJK A;  3OOI A;  1N3J A;  3F9W A;  4J83 A;  3M58 A;  5TH7 A;  5HQ8 A;  3F9Z A;  3SW9 A;  4BUP A;  4YPE A;  4AU7 A;  1N6A A;  3MO0 A;  5T0K A;  5JIY A;  4MI5 A;  5JIN A;  4WUY A;  3SWC A;  4YNP A;  2W5Z A;  4C1Q A;  5JJ0 A;  2W5Y A;  1MT6 A;  5AYF A;  5HI7 A;  3CBM A;  4MI0 A;  3DAL A;  2IGQ A;  3HNA A;  3M53 A;  3CBO A;  3S7F A;  1O9S A;  3QWP A;  2F69 A;  1XQH A;  3S7J A;  4H12 A;  3OXL A;  5T5G A;  5EX3 A;  5T0M A; 
#chains in the Genus database with same CATH topology
 5KJM A;  5ARF A;  4J8O A;  4YPU A;  5LSX A;  5CCL A;  3OPE A;  3S7D A;  1ML9 A;  3K5K A;  3KMA A;  5TEG A;  5TTF A;  5CPR B;  3M55 A;  3DB5 A;  3F9Y A;  1ZKK A;  3RQ4 A;  3MO2 A;  3QWW A;  4NVQ A;  4Z4P A;  3RIB A;  3M57 A;  5F59 A;  2JV0 A;  4I51 A;  5F6K C;  3KMJ A;  3TG4 A;  1MVX A;  1PEG A;  4IJD A;  4O6F A;  4YND A;  5JHN A;  4JLG A;  4J7F A;  1MVH A;  3N71 A;  3S7B A;  3PDN A;  3TG5 A;  2G46 A;  5KJL A;  4LDG A;  3F9X A;  3VUZ A;  5F6L A;  4O30 A;  5KJN A;  1H3I A;  4QEP A;  2RFI A;  4NJ5 A;  4RZ0 A;  3RJW A;  4QEO A;  5CCM A;  4JDS A;  1MUF A;  3M54 A;  3BO5 A;  3OS5 A;  3QWV A;  3S8P A;  3OXF A;  3EP0 A;  3RU0 A;  3M5A A;  5LSZ A;  4FMU A;  3OXG A;  3KMT A;  4J7I A;  3IHX A;  4YPA A;  2BQZ A;  1N6C A;  5F5E A;  3VV0 A;  4QEN A;  3MEK A;  3M59 A;  2R3A A;  2QPW A;  5ARG A;  5EX0 A;  4E47 A;  4YNM A;  5EG2 A;  3CBP A;  2O8J A;  3RAY A;  3MO5 A;  4IJ8 A;  3M56 A;  3FPD A;  5KJK A;  3OOI A;  1N3J A;  3F9W A;  4J83 A;  3M58 A;  5TH7 A;  5HQ8 A;  3F9Z A;  3SW9 A;  4BUP A;  4YPE A;  4AU7 A;  1N6A A;  3MO0 A;  5T0K A;  5JIY A;  4MI5 A;  5JIN A;  4WUY A;  3SWC A;  4YNP A;  2W5Z A;  4C1Q A;  5JJ0 A;  2W5Y A;  1MT6 A;  5AYF A;  5HI7 A;  3CBM A;  4MI0 A;  3DAL A;  2IGQ A;  3HNA A;  3M53 A;  3CBO A;  3S7F A;  1O9S A;  3QWP A;  2F69 A;  1XQH A;  3S7J A;  4H12 A;  3OXL A;  5T5G A;  5EX3 A;  5T0M A; 
#chains in the Genus database with same CATH homology
 5KJM A;  5ARF A;  4J8O A;  4YPU A;  5LSX A;  5CCL A;  3OPE A;  3S7D A;  1ML9 A;  3K5K A;  3KMA A;  5TEG A;  5TTF A;  5CPR B;  3M55 A;  3DB5 A;  3F9Y A;  1ZKK A;  3RQ4 A;  3MO2 A;  3QWW A;  4NVQ A;  4Z4P A;  3RIB A;  3M57 A;  5F59 A;  2JV0 A;  4I51 A;  5F6K C;  3KMJ A;  3TG4 A;  1MVX A;  1PEG A;  4IJD A;  4O6F A;  4YND A;  5JHN A;  4JLG A;  4J7F A;  1MVH A;  3N71 A;  3S7B A;  3PDN A;  3TG5 A;  2G46 A;  5KJL A;  4LDG A;  3F9X A;  3VUZ A;  5F6L A;  4O30 A;  5KJN A;  1H3I A;  4QEP A;  2RFI A;  4NJ5 A;  4RZ0 A;  3RJW A;  4QEO A;  5CCM A;  4JDS A;  1MUF A;  3M54 A;  3BO5 A;  3OS5 A;  3QWV A;  3S8P A;  3OXF A;  3EP0 A;  3RU0 A;  3M5A A;  5LSZ A;  4FMU A;  3OXG A;  3KMT A;  4J7I A;  3IHX A;  4YPA A;  2BQZ A;  1N6C A;  5F5E A;  3VV0 A;  4QEN A;  3MEK A;  3M59 A;  2R3A A;  2QPW A;  5ARG A;  5EX0 A;  4E47 A;  4YNM A;  5EG2 A;  3CBP A;  2O8J A;  3RAY A;  3MO5 A;  4IJ8 A;  3M56 A;  3FPD A;  5KJK A;  3OOI A;  1N3J A;  3F9W A;  4J83 A;  3M58 A;  5TH7 A;  5HQ8 A;  3F9Z A;  3SW9 A;  4BUP A;  4YPE A;  4AU7 A;  1N6A A;  3MO0 A;  5T0K A;  5JIY A;  4MI5 A;  5JIN A;  4WUY A;  3SWC A;  4YNP A;  2W5Z A;  4C1Q A;  5JJ0 A;  2W5Y A;  1MT6 A;  5AYF A;  5HI7 A;  3CBM A;  4MI0 A;  3DAL A;  2IGQ A;  3HNA A;  3M53 A;  3CBO A;  3S7F A;  1O9S A;  3QWP A;  2F69 A;  1XQH A;  3S7J A;  4H12 A;  3OXL A;  5T5G A;  5EX3 A;  5T0M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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