5TTFA

Crystal structure of catalytic domain of g9a with ms012
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
269
structure length
265
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 73
structure length 265
sequence length 269
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-11-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5ttfA00
2R3AA 3K5KA 3M58A 2JV0A 4WUYA 3OOIA 5JINA 3F9WA 2IGQA 3OXFA 3M53A 3QWWA 5TH7A 4AU7A 3PDNA 5CCMA 5JHNA 4RZ0A 3S8PA 3RIBA 3MO0A 3OS5A 3QWPA 5TTFA 5TEGA 5AYFA 3RQ4A 3DB5A 5F6LA 4J8OA 5F5EA 5JIYA 4C1QA 3M56A 3QWVA 3OXGA 5KJMA 1MVHA 3CBOA 4JLGA 3RJWA 4QENA 5EG2A 5T0KA 2O8JA 3RAYA 1XQHA 4FMUA 4YNPA 5T0MA 5ARGA 3SW9A 3M59A 4IJ8A 2F69A 3IHXA 4YPAA 3VV0A 4O30A 5EX0A 1MT6A 3N71A 3F9ZA 3SWCA 3HNAA 1O9SA 3VUZA 2G46A 3M54A 5HQ8A 1N3JA 3KMTA 2QPWA 5T5GA 2W5YA 2BQZA 1H3IA 4NJ5A 4QEOA 3OPEA 3M55A 5F59A 1N6AA 3F9XA 3KMJA 5KJKA 5CPRB 3S7FA 4JDSA 4BUPA 5CCLA 3DALA 3CBPA 4J83A 5LSZA 3S7DA 4YPUA 3S7JA 3TG4A 4E47A 1MVXA 4Z4PA 1MUFA 4J7IA 4YPEA 1ML9A 3EP0A 1ZKKA 4YNMA 1N6CA 3MEKA 4J7FA 4O6FA 5KJNA 3BO5A 4H12A 3FPDA 4MI0A 1PEGA 2RFIA 3MO2A 4IJDA 3OXLA 5JJ0A 5KJLA 5EX3A 2W5ZA 4NVQA 3CBMA 4I51A 3M57A 5F6KC 4LDGA 4YNDA 5LSXA 3F9YA 4MI5A 3S7BA 3M5AA 3KMAA 5ARFA 3MO5A 3RU0A 3TG5A 4QEPA 5HI7A
chains in the Genus database with same CATH superfamily
2R3AA 3K5KA 3M58A 2JV0A 4WUYA 3OOIA 5JINA 3F9WA 2IGQA 3OXFA 3M53A 3QWWA 5TH7A 4AU7A 3PDNA 5CCMA 5JHNA 4RZ0A 3S8PA 3RIBA 3MO0A 3OS5A 3QWPA 5TTFA 5TEGA 5AYFA 3RQ4A 3DB5A 5F6LA 4J8OA 5F5EA 5JIYA 4C1QA 3M56A 3QWVA 3OXGA 5KJMA 1MVHA 3CBOA 4JLGA 3RJWA 4QENA 5EG2A 5T0KA 2O8JA 3RAYA 1XQHA 4FMUA 4YNPA 5T0MA 5ARGA 3SW9A 3M59A 4IJ8A 2F69A 3IHXA 4YPAA 3VV0A 4O30A 5EX0A 1MT6A 3N71A 3F9ZA 3SWCA 3HNAA 1O9SA 3VUZA 2G46A 3M54A 5HQ8A 1N3JA 3KMTA 2QPWA 5T5GA 2W5YA 2BQZA 1H3IA 4NJ5A 4QEOA 3OPEA 3M55A 5F59A 1N6AA 3F9XA 3KMJA 5KJKA 5CPRB 3S7FA 4JDSA 4BUPA 5CCLA 3DALA 3CBPA 4J83A 5LSZA 3S7DA 4YPUA 3S7JA 3TG4A 4E47A 1MVXA 4Z4PA 1MUFA 4J7IA 4YPEA 1ML9A 3EP0A 1ZKKA 4YNMA 1N6CA 3MEKA 4J7FA 4O6FA 5KJNA 3BO5A 4H12A 3FPDA 4MI0A 1PEGA 2RFIA 3MO2A 4IJDA 3OXLA 5JJ0A 5KJLA 5EX3A 2W5ZA 4NVQA 3CBMA 4I51A 3M57A 5F6KC 4LDGA 4YNDA 5LSXA 3F9YA 4MI5A 3S7BA 3M5AA 3KMAA 5ARFA 3MO5A 3RU0A 3TG5A 4QEPA 5HI7A
chains in the Genus database with same CATH topology
2R3AA 3K5KA 3M58A 2JV0A 4WUYA 3OOIA 5JINA 3F9WA 2IGQA 3OXFA 3M53A 3QWWA 5TH7A 4AU7A 3PDNA 5CCMA 5JHNA 4RZ0A 3S8PA 3RIBA 3MO0A 3OS5A 3QWPA 5TTFA 5TEGA 5AYFA 3RQ4A 3DB5A 5F6LA 4J8OA 5F5EA 5JIYA 4C1QA 3M56A 3QWVA 3OXGA 5KJMA 1MVHA 3CBOA 4JLGA 3RJWA 4QENA 5EG2A 5T0KA 2O8JA 3RAYA 1XQHA 4FMUA 4YNPA 5T0MA 5ARGA 3SW9A 3M59A 4IJ8A 2F69A 3IHXA 4YPAA 3VV0A 4O30A 5EX0A 1MT6A 3N71A 3F9ZA 3SWCA 3HNAA 1O9SA 3VUZA 2G46A 3M54A 5HQ8A 1N3JA 3KMTA 2QPWA 5T5GA 2W5YA 2BQZA 1H3IA 4NJ5A 4QEOA 3OPEA 3M55A 5F59A 1N6AA 3F9XA 3KMJA 5KJKA 5CPRB 3S7FA 4JDSA 4BUPA 5CCLA 3DALA 3CBPA 4J83A 5LSZA 3S7DA 4YPUA 3S7JA 3TG4A 4E47A 1MVXA 4Z4PA 1MUFA 4J7IA 4YPEA 1ML9A 3EP0A 1ZKKA 4YNMA 1N6CA 3MEKA 4J7FA 4O6FA 5KJNA 3BO5A 4H12A 3FPDA 4MI0A 1PEGA 2RFIA 3MO2A 4IJDA 3OXLA 5JJ0A 5KJLA 5EX3A 2W5ZA 4NVQA 3CBMA 4I51A 3M57A 5F6KC 4LDGA 4YNDA 5LSXA 3F9YA 4MI5A 3S7BA 3M5AA 3KMAA 5ARFA 3MO5A 3RU0A 3TG5A 4QEPA 5HI7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R3A A;  3K5K A;  3M58 A;  2JV0 A;  4WUY A;  3OOI A;  5JIN A;  3F9W A;  2IGQ A;  3OXF A;  3M53 A;  3QWW A;  5TH7 A;  4AU7 A;  3PDN A;  5CCM A;  5JHN A;  4RZ0 A;  3S8P A;  3RIB A;  3MO0 A;  3OS5 A;  3QWP A;  5TTF A;  5TEG A;  5AYF A;  3RQ4 A;  3DB5 A;  5F6L A;  4J8O A;  5F5E A;  5JIY A;  4C1Q A;  3M56 A;  3QWV A;  3OXG A;  5KJM A;  1MVH A;  3CBO A;  4JLG A;  3RJW A;  4QEN A;  5EG2 A;  5T0K A;  2O8J A;  3RAY A;  1XQH A;  4FMU A;  4YNP A;  5T0M A;  5ARG A;  3SW9 A;  3M59 A;  4IJ8 A;  2F69 A;  3IHX A;  4YPA A;  3VV0 A;  4O30 A;  5EX0 A;  1MT6 A;  3N71 A;  3F9Z A;  3SWC A;  3HNA A;  1O9S A;  3VUZ A;  2G46 A;  3M54 A;  5HQ8 A;  1N3J A;  3KMT A;  2QPW A;  5T5G A;  2W5Y A;  2BQZ A;  1H3I A;  4NJ5 A;  4QEO A;  3OPE A;  3M55 A;  5F59 A;  1N6A A;  3F9X A;  3KMJ A;  5KJK A;  5CPR B;  3S7F A;  4JDS A;  4BUP A;  5CCL A;  3DAL A;  3CBP A;  4J83 A;  5LSZ A;  3S7D A;  4YPU A;  3S7J A;  3TG4 A;  4E47 A;  1MVX A;  4Z4P A;  1MUF A;  4J7I A;  4YPE A;  1ML9 A;  3EP0 A;  1ZKK A;  4YNM A;  1N6C A;  3MEK A;  4J7F A;  4O6F A;  5KJN A;  3BO5 A;  4H12 A;  3FPD A;  4MI0 A;  1PEG A;  2RFI A;  3MO2 A;  4IJD A;  3OXL A;  5JJ0 A;  5KJL A;  5EX3 A;  2W5Z A;  4NVQ A;  3CBM A;  4I51 A;  3M57 A;  5F6K C;  4LDG A;  4YND A;  5LSX A;  3F9Y A;  4MI5 A;  3S7B A;  3M5A A;  3KMA A;  5ARF A;  3MO5 A;  3RU0 A;  3TG5 A;  4QEP A;  5HI7 A; 
#chains in the Genus database with same CATH topology
 2R3A A;  3K5K A;  3M58 A;  2JV0 A;  4WUY A;  3OOI A;  5JIN A;  3F9W A;  2IGQ A;  3OXF A;  3M53 A;  3QWW A;  5TH7 A;  4AU7 A;  3PDN A;  5CCM A;  5JHN A;  4RZ0 A;  3S8P A;  3RIB A;  3MO0 A;  3OS5 A;  3QWP A;  5TTF A;  5TEG A;  5AYF A;  3RQ4 A;  3DB5 A;  5F6L A;  4J8O A;  5F5E A;  5JIY A;  4C1Q A;  3M56 A;  3QWV A;  3OXG A;  5KJM A;  1MVH A;  3CBO A;  4JLG A;  3RJW A;  4QEN A;  5EG2 A;  5T0K A;  2O8J A;  3RAY A;  1XQH A;  4FMU A;  4YNP A;  5T0M A;  5ARG A;  3SW9 A;  3M59 A;  4IJ8 A;  2F69 A;  3IHX A;  4YPA A;  3VV0 A;  4O30 A;  5EX0 A;  1MT6 A;  3N71 A;  3F9Z A;  3SWC A;  3HNA A;  1O9S A;  3VUZ A;  2G46 A;  3M54 A;  5HQ8 A;  1N3J A;  3KMT A;  2QPW A;  5T5G A;  2W5Y A;  2BQZ A;  1H3I A;  4NJ5 A;  4QEO A;  3OPE A;  3M55 A;  5F59 A;  1N6A A;  3F9X A;  3KMJ A;  5KJK A;  5CPR B;  3S7F A;  4JDS A;  4BUP A;  5CCL A;  3DAL A;  3CBP A;  4J83 A;  5LSZ A;  3S7D A;  4YPU A;  3S7J A;  3TG4 A;  4E47 A;  1MVX A;  4Z4P A;  1MUF A;  4J7I A;  4YPE A;  1ML9 A;  3EP0 A;  1ZKK A;  4YNM A;  1N6C A;  3MEK A;  4J7F A;  4O6F A;  5KJN A;  3BO5 A;  4H12 A;  3FPD A;  4MI0 A;  1PEG A;  2RFI A;  3MO2 A;  4IJD A;  3OXL A;  5JJ0 A;  5KJL A;  5EX3 A;  2W5Z A;  4NVQ A;  3CBM A;  4I51 A;  3M57 A;  5F6K C;  4LDG A;  4YND A;  5LSX A;  3F9Y A;  4MI5 A;  3S7B A;  3M5A A;  3KMA A;  5ARF A;  3MO5 A;  3RU0 A;  3TG5 A;  4QEP A;  5HI7 A; 
#chains in the Genus database with same CATH homology
 2R3A A;  3K5K A;  3M58 A;  2JV0 A;  4WUY A;  3OOI A;  5JIN A;  3F9W A;  2IGQ A;  3OXF A;  3M53 A;  3QWW A;  5TH7 A;  4AU7 A;  3PDN A;  5CCM A;  5JHN A;  4RZ0 A;  3S8P A;  3RIB A;  3MO0 A;  3OS5 A;  3QWP A;  5TTF A;  5TEG A;  5AYF A;  3RQ4 A;  3DB5 A;  5F6L A;  4J8O A;  5F5E A;  5JIY A;  4C1Q A;  3M56 A;  3QWV A;  3OXG A;  5KJM A;  1MVH A;  3CBO A;  4JLG A;  3RJW A;  4QEN A;  5EG2 A;  5T0K A;  2O8J A;  3RAY A;  1XQH A;  4FMU A;  4YNP A;  5T0M A;  5ARG A;  3SW9 A;  3M59 A;  4IJ8 A;  2F69 A;  3IHX A;  4YPA A;  3VV0 A;  4O30 A;  5EX0 A;  1MT6 A;  3N71 A;  3F9Z A;  3SWC A;  3HNA A;  1O9S A;  3VUZ A;  2G46 A;  3M54 A;  5HQ8 A;  1N3J A;  3KMT A;  2QPW A;  5T5G A;  2W5Y A;  2BQZ A;  1H3I A;  4NJ5 A;  4QEO A;  3OPE A;  3M55 A;  5F59 A;  1N6A A;  3F9X A;  3KMJ A;  5KJK A;  5CPR B;  3S7F A;  4JDS A;  4BUP A;  5CCL A;  3DAL A;  3CBP A;  4J83 A;  5LSZ A;  3S7D A;  4YPU A;  3S7J A;  3TG4 A;  4E47 A;  1MVX A;  4Z4P A;  1MUF A;  4J7I A;  4YPE A;  1ML9 A;  3EP0 A;  1ZKK A;  4YNM A;  1N6C A;  3MEK A;  4J7F A;  4O6F A;  5KJN A;  3BO5 A;  4H12 A;  3FPD A;  4MI0 A;  1PEG A;  2RFI A;  3MO2 A;  4IJD A;  3OXL A;  5JJ0 A;  5KJL A;  5EX3 A;  2W5Z A;  4NVQ A;  3CBM A;  4I51 A;  3M57 A;  5F6K C;  4LDG A;  4YND A;  5LSX A;  3F9Y A;  4MI5 A;  3S7B A;  3M5A A;  3KMA A;  5ARF A;  3MO5 A;  3RU0 A;  3TG5 A;  4QEP A;  5HI7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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