5TTFA

Crystal structure of catalytic domain of g9a with ms012
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
269
structure length
265
Chain Sequence
b'TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
molecule tags Transferase
source organism Homo sapiens
publication title Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
pubmed doi rcsb
total genus 73
structure length 265
sequence length 269
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-11-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5ttfA00
1H3IA 2W5YA 2R3AA 4O30A 5JHNA 3M58A 3KMTA 5KJMA 1PEGA 3CBPA 3OXFA 3M55A 3M54A 3OPEA 5ARFA 3S7JA 1N6CA 1N6AA 3MO5A 4H12A 4RZ0A 3F9WA 3S8PA 5T5GA 3EP0A 4J83A 4QEPA 4QEOA 5AYFA 3S7DA 4E47A 3SW9A 3F9YA 3CBMA 3M57A 2W5ZA 4FMUA 3OOIA 3MEKA 5T0KA 4QENA 4JLGA 3HNAA 3RU0A 3FPDA 4WUYA 5TTFA 1MVHA 3F9ZA 4YPEA 3VV0A 4YNPA 5F6LA 3KMJA 5F59A 4MI5A 2IGQA 3QWWA 5KJKA 3OS5A 3DB5A 3S7FA 3IHXA 3RIBA 5JJ0A 4I51A 2G46A 3OXGA 5TEGA 5JIYA 1N3JA 3CBOA 1MUFA 3RAYA 4BUPA 5CCMA 1ZKKA 2JV0A 4J7IA 5KJLA 4JDSA 4Z4PA 5LSXA 3VUZA 5HQ8A 1O9SA 4YNDA 3F9XA 4NVQA 1XQHA 3TG4A 3QWPA 3K5KA 3M5AA 1ML9A 4AU7A 5CCLA 3RJWA 5CPRB 3N71A 3OXLA 3PDNA 5EX0A 1MT6A 3BO5A 5ARGA 4J7FA 3RQ4A 5F6KC 4NJ5A 2F69A 3M53A 4J8OA 5EG2A 4O6FA 3KMAA 5KJNA 2QPWA 3M56A 1MVXA 4IJDA 5F5EA 5TH7A 4C1QA 4IJ8A 5T0MA 4LDGA 3TG5A 4YPUA 5HI7A 4YPAA 3SWCA 3M59A 3MO0A 4MI0A 2O8JA 3MO2A 5JINA 3DALA 3S7BA 5EX3A 2RFIA 2BQZA 5LSZA 3QWVA 4YNMA
chains in the Genus database with same CATH superfamily
1H3IA 2W5YA 2R3AA 4O30A 5JHNA 3M58A 3KMTA 5KJMA 1PEGA 3CBPA 3OXFA 3M55A 3M54A 3OPEA 5ARFA 3S7JA 1N6CA 1N6AA 3MO5A 4H12A 4RZ0A 3F9WA 3S8PA 5T5GA 3EP0A 4J83A 4QEPA 4QEOA 5AYFA 3S7DA 4E47A 3SW9A 3F9YA 3CBMA 3M57A 2W5ZA 4FMUA 3OOIA 3MEKA 5T0KA 4QENA 4JLGA 3HNAA 3RU0A 3FPDA 4WUYA 5TTFA 1MVHA 3F9ZA 4YPEA 3VV0A 4YNPA 5F6LA 3KMJA 5F59A 4MI5A 2IGQA 3QWWA 5KJKA 3OS5A 3DB5A 3S7FA 3IHXA 3RIBA 5JJ0A 4I51A 2G46A 3OXGA 5TEGA 5JIYA 1N3JA 3CBOA 1MUFA 3RAYA 4BUPA 5CCMA 1ZKKA 2JV0A 4J7IA 5KJLA 4JDSA 4Z4PA 5LSXA 3VUZA 5HQ8A 1O9SA 4YNDA 3F9XA 4NVQA 1XQHA 3TG4A 3QWPA 3K5KA 3M5AA 1ML9A 4AU7A 5CCLA 3RJWA 5CPRB 3N71A 3OXLA 3PDNA 5EX0A 1MT6A 3BO5A 5ARGA 4J7FA 3RQ4A 5F6KC 4NJ5A 2F69A 3M53A 4J8OA 5EG2A 4O6FA 3KMAA 5KJNA 2QPWA 3M56A 1MVXA 4IJDA 5F5EA 5TH7A 4C1QA 4IJ8A 5T0MA 4LDGA 3TG5A 4YPUA 5HI7A 4YPAA 3SWCA 3M59A 3MO0A 4MI0A 2O8JA 3MO2A 5JINA 3DALA 3S7BA 5EX3A 2RFIA 2BQZA 5LSZA 3QWVA 4YNMA
chains in the Genus database with same CATH topology
1H3IA 2W5YA 2R3AA 4O30A 5JHNA 3M58A 3KMTA 5KJMA 1PEGA 3CBPA 3OXFA 3M55A 3M54A 3OPEA 5ARFA 3S7JA 1N6CA 1N6AA 3MO5A 4H12A 4RZ0A 3F9WA 3S8PA 5T5GA 3EP0A 4J83A 4QEPA 4QEOA 5AYFA 3S7DA 4E47A 3SW9A 3F9YA 3CBMA 3M57A 2W5ZA 4FMUA 3OOIA 3MEKA 5T0KA 4QENA 4JLGA 3HNAA 3RU0A 3FPDA 4WUYA 5TTFA 1MVHA 3F9ZA 4YPEA 3VV0A 4YNPA 5F6LA 3KMJA 5F59A 4MI5A 2IGQA 3QWWA 5KJKA 3OS5A 3DB5A 3S7FA 3IHXA 3RIBA 5JJ0A 4I51A 2G46A 3OXGA 5TEGA 5JIYA 1N3JA 3CBOA 1MUFA 3RAYA 4BUPA 5CCMA 1ZKKA 2JV0A 4J7IA 5KJLA 4JDSA 4Z4PA 5LSXA 3VUZA 5HQ8A 1O9SA 4YNDA 3F9XA 4NVQA 1XQHA 3TG4A 3QWPA 3K5KA 3M5AA 1ML9A 4AU7A 5CCLA 3RJWA 5CPRB 3N71A 3OXLA 3PDNA 5EX0A 1MT6A 3BO5A 5ARGA 4J7FA 3RQ4A 5F6KC 4NJ5A 2F69A 3M53A 4J8OA 5EG2A 4O6FA 3KMAA 5KJNA 2QPWA 3M56A 1MVXA 4IJDA 5F5EA 5TH7A 4C1QA 4IJ8A 5T0MA 4LDGA 3TG5A 4YPUA 5HI7A 4YPAA 3SWCA 3M59A 3MO0A 4MI0A 2O8JA 3MO2A 5JINA 3DALA 3S7BA 5EX3A 2RFIA 2BQZA 5LSZA 3QWVA 4YNMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H3I A;  2W5Y A;  2R3A A;  4O30 A;  5JHN A;  3M58 A;  3KMT A;  5KJM A;  1PEG A;  3CBP A;  3OXF A;  3M55 A;  3M54 A;  3OPE A;  5ARF A;  3S7J A;  1N6C A;  1N6A A;  3MO5 A;  4H12 A;  4RZ0 A;  3F9W A;  3S8P A;  5T5G A;  3EP0 A;  4J83 A;  4QEP A;  4QEO A;  5AYF A;  3S7D A;  4E47 A;  3SW9 A;  3F9Y A;  3CBM A;  3M57 A;  2W5Z A;  4FMU A;  3OOI A;  3MEK A;  5T0K A;  4QEN A;  4JLG A;  3HNA A;  3RU0 A;  3FPD A;  4WUY A;  5TTF A;  1MVH A;  3F9Z A;  4YPE A;  3VV0 A;  4YNP A;  5F6L A;  3KMJ A;  5F59 A;  4MI5 A;  2IGQ A;  3QWW A;  5KJK A;  3OS5 A;  3DB5 A;  3S7F A;  3IHX A;  3RIB A;  5JJ0 A;  4I51 A;  2G46 A;  3OXG A;  5TEG A;  5JIY A;  1N3J A;  3CBO A;  1MUF A;  3RAY A;  4BUP A;  5CCM A;  1ZKK A;  2JV0 A;  4J7I A;  5KJL A;  4JDS A;  4Z4P A;  5LSX A;  3VUZ A;  5HQ8 A;  1O9S A;  4YND A;  3F9X A;  4NVQ A;  1XQH A;  3TG4 A;  3QWP A;  3K5K A;  3M5A A;  1ML9 A;  4AU7 A;  5CCL A;  3RJW A;  5CPR B;  3N71 A;  3OXL A;  3PDN A;  5EX0 A;  1MT6 A;  3BO5 A;  5ARG A;  4J7F A;  3RQ4 A;  5F6K C;  4NJ5 A;  2F69 A;  3M53 A;  4J8O A;  5EG2 A;  4O6F A;  3KMA A;  5KJN A;  2QPW A;  3M56 A;  1MVX A;  4IJD A;  5F5E A;  5TH7 A;  4C1Q A;  4IJ8 A;  5T0M A;  4LDG A;  3TG5 A;  4YPU A;  5HI7 A;  4YPA A;  3SWC A;  3M59 A;  3MO0 A;  4MI0 A;  2O8J A;  3MO2 A;  5JIN A;  3DAL A;  3S7B A;  5EX3 A;  2RFI A;  2BQZ A;  5LSZ A;  3QWV A;  4YNM A; 
#chains in the Genus database with same CATH topology
 1H3I A;  2W5Y A;  2R3A A;  4O30 A;  5JHN A;  3M58 A;  3KMT A;  5KJM A;  1PEG A;  3CBP A;  3OXF A;  3M55 A;  3M54 A;  3OPE A;  5ARF A;  3S7J A;  1N6C A;  1N6A A;  3MO5 A;  4H12 A;  4RZ0 A;  3F9W A;  3S8P A;  5T5G A;  3EP0 A;  4J83 A;  4QEP A;  4QEO A;  5AYF A;  3S7D A;  4E47 A;  3SW9 A;  3F9Y A;  3CBM A;  3M57 A;  2W5Z A;  4FMU A;  3OOI A;  3MEK A;  5T0K A;  4QEN A;  4JLG A;  3HNA A;  3RU0 A;  3FPD A;  4WUY A;  5TTF A;  1MVH A;  3F9Z A;  4YPE A;  3VV0 A;  4YNP A;  5F6L A;  3KMJ A;  5F59 A;  4MI5 A;  2IGQ A;  3QWW A;  5KJK A;  3OS5 A;  3DB5 A;  3S7F A;  3IHX A;  3RIB A;  5JJ0 A;  4I51 A;  2G46 A;  3OXG A;  5TEG A;  5JIY A;  1N3J A;  3CBO A;  1MUF A;  3RAY A;  4BUP A;  5CCM A;  1ZKK A;  2JV0 A;  4J7I A;  5KJL A;  4JDS A;  4Z4P A;  5LSX A;  3VUZ A;  5HQ8 A;  1O9S A;  4YND A;  3F9X A;  4NVQ A;  1XQH A;  3TG4 A;  3QWP A;  3K5K A;  3M5A A;  1ML9 A;  4AU7 A;  5CCL A;  3RJW A;  5CPR B;  3N71 A;  3OXL A;  3PDN A;  5EX0 A;  1MT6 A;  3BO5 A;  5ARG A;  4J7F A;  3RQ4 A;  5F6K C;  4NJ5 A;  2F69 A;  3M53 A;  4J8O A;  5EG2 A;  4O6F A;  3KMA A;  5KJN A;  2QPW A;  3M56 A;  1MVX A;  4IJD A;  5F5E A;  5TH7 A;  4C1Q A;  4IJ8 A;  5T0M A;  4LDG A;  3TG5 A;  4YPU A;  5HI7 A;  4YPA A;  3SWC A;  3M59 A;  3MO0 A;  4MI0 A;  2O8J A;  3MO2 A;  5JIN A;  3DAL A;  3S7B A;  5EX3 A;  2RFI A;  2BQZ A;  5LSZ A;  3QWV A;  4YNM A; 
#chains in the Genus database with same CATH homology
 1H3I A;  2W5Y A;  2R3A A;  4O30 A;  5JHN A;  3M58 A;  3KMT A;  5KJM A;  1PEG A;  3CBP A;  3OXF A;  3M55 A;  3M54 A;  3OPE A;  5ARF A;  3S7J A;  1N6C A;  1N6A A;  3MO5 A;  4H12 A;  4RZ0 A;  3F9W A;  3S8P A;  5T5G A;  3EP0 A;  4J83 A;  4QEP A;  4QEO A;  5AYF A;  3S7D A;  4E47 A;  3SW9 A;  3F9Y A;  3CBM A;  3M57 A;  2W5Z A;  4FMU A;  3OOI A;  3MEK A;  5T0K A;  4QEN A;  4JLG A;  3HNA A;  3RU0 A;  3FPD A;  4WUY A;  5TTF A;  1MVH A;  3F9Z A;  4YPE A;  3VV0 A;  4YNP A;  5F6L A;  3KMJ A;  5F59 A;  4MI5 A;  2IGQ A;  3QWW A;  5KJK A;  3OS5 A;  3DB5 A;  3S7F A;  3IHX A;  3RIB A;  5JJ0 A;  4I51 A;  2G46 A;  3OXG A;  5TEG A;  5JIY A;  1N3J A;  3CBO A;  1MUF A;  3RAY A;  4BUP A;  5CCM A;  1ZKK A;  2JV0 A;  4J7I A;  5KJL A;  4JDS A;  4Z4P A;  5LSX A;  3VUZ A;  5HQ8 A;  1O9S A;  4YND A;  3F9X A;  4NVQ A;  1XQH A;  3TG4 A;  3QWP A;  3K5K A;  3M5A A;  1ML9 A;  4AU7 A;  5CCL A;  3RJW A;  5CPR B;  3N71 A;  3OXL A;  3PDN A;  5EX0 A;  1MT6 A;  3BO5 A;  5ARG A;  4J7F A;  3RQ4 A;  5F6K C;  4NJ5 A;  2F69 A;  3M53 A;  4J8O A;  5EG2 A;  4O6F A;  3KMA A;  5KJN A;  2QPW A;  3M56 A;  1MVX A;  4IJD A;  5F5E A;  5TH7 A;  4C1Q A;  4IJ8 A;  5T0M A;  4LDG A;  3TG5 A;  4YPU A;  5HI7 A;  4YPA A;  3SWC A;  3M59 A;  3MO0 A;  4MI0 A;  2O8J A;  3MO2 A;  5JIN A;  3DAL A;  3S7B A;  5EX3 A;  2RFI A;  2BQZ A;  5LSZ A;  3QWV A;  4YNM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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