5TTFA

Crystal structure of catalytic domain of g9a with ms012
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
269
structure length
265
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 73
structure length 265
sequence length 269
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-11-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5ttfA00
3QWPA 2IGQA 4NJ5A 4BUPA 1ZKKA 5CPRB 1XQHA 5KJNA 5EX3A 4J83A 4JLGA 5EX0A 3VUZA 4LDGA 3VV0A 3BO5A 1MUFA 3DALA 3M59A 4QEPA 1ML9A 2G46A 3TG4A 5T0MA 5JHNA 4QEOA 3OOIA 4RZ0A 5TTFA 3CBOA 3K5KA 2F69A 3OXFA 4J8OA 2W5YA 5TH7A 2O8JA 5F59A 3M5AA 3M54A 3S8PA 3F9XA 5KJLA 1N3JA 4O6FA 3OXLA 1O9SA 5TEGA 3F9YA 3HNAA 4FMUA 3M57A 3S7BA 3IHXA 3MO0A 5CCMA 3TG5A 5F5EA 1N6AA 3S7DA 4IJDA 4E47A 3QWWA 5HI7A 4WUYA 3RQ4A 3MEKA 3MO2A 5T0KA 4YNDA 4I51A 4YNPA 1H3IA 2W5ZA 3F9WA 3M53A 4YPEA 2JV0A 4YNMA 5KJMA 3EP0A 5T5GA 5KJKA 2BQZA 5ARGA 1MVXA 5F6KC 3OS5A 3RJWA 3N71A 3RIBA 3M55A 3RAYA 2R3AA 4O30A 3OPEA 5EG2A 5LSXA 3KMTA 5AYFA 3FPDA 2QPWA 1PEGA 3CBMA 3CBPA 4IJ8A 3M56A 5ARFA 4AU7A 5JJ0A 5HQ8A 3RU0A 3SWCA 3S7FA 2RFIA 3DB5A 4NVQA 4C1QA 5LSZA 4JDSA 1MT6A 5F6LA 3KMJA 3S7JA 3M58A 4MI5A 4H12A 3MO5A 5JIYA 4Z4PA 5CCLA 4QENA 4J7FA 4YPAA 3SW9A 4MI0A 5JINA 4YPUA 1MVHA 4J7IA 3QWVA 3F9ZA 3KMAA 3PDNA 3OXGA 1N6CA
chains in the Genus database with same CATH superfamily
3QWPA 2IGQA 4NJ5A 4BUPA 1ZKKA 5CPRB 1XQHA 5KJNA 5EX3A 4J83A 4JLGA 5EX0A 3VUZA 4LDGA 3VV0A 3BO5A 1MUFA 3DALA 3M59A 4QEPA 1ML9A 2G46A 3TG4A 5T0MA 5JHNA 4QEOA 3OOIA 4RZ0A 5TTFA 3CBOA 3K5KA 2F69A 3OXFA 4J8OA 2W5YA 5TH7A 2O8JA 5F59A 3M5AA 3M54A 3S8PA 3F9XA 5KJLA 1N3JA 4O6FA 3OXLA 1O9SA 5TEGA 3F9YA 3HNAA 4FMUA 3M57A 3S7BA 3IHXA 3MO0A 5CCMA 3TG5A 5F5EA 1N6AA 3S7DA 4IJDA 4E47A 3QWWA 5HI7A 4WUYA 3RQ4A 3MEKA 3MO2A 5T0KA 4YNDA 4I51A 4YNPA 1H3IA 2W5ZA 3F9WA 3M53A 4YPEA 2JV0A 4YNMA 5KJMA 3EP0A 5T5GA 5KJKA 2BQZA 5ARGA 1MVXA 5F6KC 3OS5A 3RJWA 3N71A 3RIBA 3M55A 3RAYA 2R3AA 4O30A 3OPEA 5EG2A 5LSXA 3KMTA 5AYFA 3FPDA 2QPWA 1PEGA 3CBMA 3CBPA 4IJ8A 3M56A 5ARFA 4AU7A 5JJ0A 5HQ8A 3RU0A 3SWCA 3S7FA 2RFIA 3DB5A 4NVQA 4C1QA 5LSZA 4JDSA 1MT6A 5F6LA 3KMJA 3S7JA 3M58A 4MI5A 4H12A 3MO5A 5JIYA 4Z4PA 5CCLA 4QENA 4J7FA 4YPAA 3SW9A 4MI0A 5JINA 4YPUA 1MVHA 4J7IA 3QWVA 3F9ZA 3KMAA 3PDNA 3OXGA 1N6CA
chains in the Genus database with same CATH topology
3QWPA 2IGQA 4NJ5A 4BUPA 1ZKKA 5CPRB 1XQHA 5KJNA 5EX3A 4J83A 4JLGA 5EX0A 3VUZA 4LDGA 3VV0A 3BO5A 1MUFA 3DALA 3M59A 4QEPA 1ML9A 2G46A 3TG4A 5T0MA 5JHNA 4QEOA 3OOIA 4RZ0A 5TTFA 3CBOA 3K5KA 2F69A 3OXFA 4J8OA 2W5YA 5TH7A 2O8JA 5F59A 3M5AA 3M54A 3S8PA 3F9XA 5KJLA 1N3JA 4O6FA 3OXLA 1O9SA 5TEGA 3F9YA 3HNAA 4FMUA 3M57A 3S7BA 3IHXA 3MO0A 5CCMA 3TG5A 5F5EA 1N6AA 3S7DA 4IJDA 4E47A 3QWWA 5HI7A 4WUYA 3RQ4A 3MEKA 3MO2A 5T0KA 4YNDA 4I51A 4YNPA 1H3IA 2W5ZA 3F9WA 3M53A 4YPEA 2JV0A 4YNMA 5KJMA 3EP0A 5T5GA 5KJKA 2BQZA 5ARGA 1MVXA 5F6KC 3OS5A 3RJWA 3N71A 3RIBA 3M55A 3RAYA 2R3AA 4O30A 3OPEA 5EG2A 5LSXA 3KMTA 5AYFA 3FPDA 2QPWA 1PEGA 3CBMA 3CBPA 4IJ8A 3M56A 5ARFA 4AU7A 5JJ0A 5HQ8A 3RU0A 3SWCA 3S7FA 2RFIA 3DB5A 4NVQA 4C1QA 5LSZA 4JDSA 1MT6A 5F6LA 3KMJA 3S7JA 3M58A 4MI5A 4H12A 3MO5A 5JIYA 4Z4PA 5CCLA 4QENA 4J7FA 4YPAA 3SW9A 4MI0A 5JINA 4YPUA 1MVHA 4J7IA 3QWVA 3F9ZA 3KMAA 3PDNA 3OXGA 1N6CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QWP A;  2IGQ A;  4NJ5 A;  4BUP A;  1ZKK A;  5CPR B;  1XQH A;  5KJN A;  5EX3 A;  4J83 A;  4JLG A;  5EX0 A;  3VUZ A;  4LDG A;  3VV0 A;  3BO5 A;  1MUF A;  3DAL A;  3M59 A;  4QEP A;  1ML9 A;  2G46 A;  3TG4 A;  5T0M A;  5JHN A;  4QEO A;  3OOI A;  4RZ0 A;  5TTF A;  3CBO A;  3K5K A;  2F69 A;  3OXF A;  4J8O A;  2W5Y A;  5TH7 A;  2O8J A;  5F59 A;  3M5A A;  3M54 A;  3S8P A;  3F9X A;  5KJL A;  1N3J A;  4O6F A;  3OXL A;  1O9S A;  5TEG A;  3F9Y A;  3HNA A;  4FMU A;  3M57 A;  3S7B A;  3IHX A;  3MO0 A;  5CCM A;  3TG5 A;  5F5E A;  1N6A A;  3S7D A;  4IJD A;  4E47 A;  3QWW A;  5HI7 A;  4WUY A;  3RQ4 A;  3MEK A;  3MO2 A;  5T0K A;  4YND A;  4I51 A;  4YNP A;  1H3I A;  2W5Z A;  3F9W A;  3M53 A;  4YPE A;  2JV0 A;  4YNM A;  5KJM A;  3EP0 A;  5T5G A;  5KJK A;  2BQZ A;  5ARG A;  1MVX A;  5F6K C;  3OS5 A;  3RJW A;  3N71 A;  3RIB A;  3M55 A;  3RAY A;  2R3A A;  4O30 A;  3OPE A;  5EG2 A;  5LSX A;  3KMT A;  5AYF A;  3FPD A;  2QPW A;  1PEG A;  3CBM A;  3CBP A;  4IJ8 A;  3M56 A;  5ARF A;  4AU7 A;  5JJ0 A;  5HQ8 A;  3RU0 A;  3SWC A;  3S7F A;  2RFI A;  3DB5 A;  4NVQ A;  4C1Q A;  5LSZ A;  4JDS A;  1MT6 A;  5F6L A;  3KMJ A;  3S7J A;  3M58 A;  4MI5 A;  4H12 A;  3MO5 A;  5JIY A;  4Z4P A;  5CCL A;  4QEN A;  4J7F A;  4YPA A;  3SW9 A;  4MI0 A;  5JIN A;  4YPU A;  1MVH A;  4J7I A;  3QWV A;  3F9Z A;  3KMA A;  3PDN A;  3OXG A;  1N6C A; 
#chains in the Genus database with same CATH topology
 3QWP A;  2IGQ A;  4NJ5 A;  4BUP A;  1ZKK A;  5CPR B;  1XQH A;  5KJN A;  5EX3 A;  4J83 A;  4JLG A;  5EX0 A;  3VUZ A;  4LDG A;  3VV0 A;  3BO5 A;  1MUF A;  3DAL A;  3M59 A;  4QEP A;  1ML9 A;  2G46 A;  3TG4 A;  5T0M A;  5JHN A;  4QEO A;  3OOI A;  4RZ0 A;  5TTF A;  3CBO A;  3K5K A;  2F69 A;  3OXF A;  4J8O A;  2W5Y A;  5TH7 A;  2O8J A;  5F59 A;  3M5A A;  3M54 A;  3S8P A;  3F9X A;  5KJL A;  1N3J A;  4O6F A;  3OXL A;  1O9S A;  5TEG A;  3F9Y A;  3HNA A;  4FMU A;  3M57 A;  3S7B A;  3IHX A;  3MO0 A;  5CCM A;  3TG5 A;  5F5E A;  1N6A A;  3S7D A;  4IJD A;  4E47 A;  3QWW A;  5HI7 A;  4WUY A;  3RQ4 A;  3MEK A;  3MO2 A;  5T0K A;  4YND A;  4I51 A;  4YNP A;  1H3I A;  2W5Z A;  3F9W A;  3M53 A;  4YPE A;  2JV0 A;  4YNM A;  5KJM A;  3EP0 A;  5T5G A;  5KJK A;  2BQZ A;  5ARG A;  1MVX A;  5F6K C;  3OS5 A;  3RJW A;  3N71 A;  3RIB A;  3M55 A;  3RAY A;  2R3A A;  4O30 A;  3OPE A;  5EG2 A;  5LSX A;  3KMT A;  5AYF A;  3FPD A;  2QPW A;  1PEG A;  3CBM A;  3CBP A;  4IJ8 A;  3M56 A;  5ARF A;  4AU7 A;  5JJ0 A;  5HQ8 A;  3RU0 A;  3SWC A;  3S7F A;  2RFI A;  3DB5 A;  4NVQ A;  4C1Q A;  5LSZ A;  4JDS A;  1MT6 A;  5F6L A;  3KMJ A;  3S7J A;  3M58 A;  4MI5 A;  4H12 A;  3MO5 A;  5JIY A;  4Z4P A;  5CCL A;  4QEN A;  4J7F A;  4YPA A;  3SW9 A;  4MI0 A;  5JIN A;  4YPU A;  1MVH A;  4J7I A;  3QWV A;  3F9Z A;  3KMA A;  3PDN A;  3OXG A;  1N6C A; 
#chains in the Genus database with same CATH homology
 3QWP A;  2IGQ A;  4NJ5 A;  4BUP A;  1ZKK A;  5CPR B;  1XQH A;  5KJN A;  5EX3 A;  4J83 A;  4JLG A;  5EX0 A;  3VUZ A;  4LDG A;  3VV0 A;  3BO5 A;  1MUF A;  3DAL A;  3M59 A;  4QEP A;  1ML9 A;  2G46 A;  3TG4 A;  5T0M A;  5JHN A;  4QEO A;  3OOI A;  4RZ0 A;  5TTF A;  3CBO A;  3K5K A;  2F69 A;  3OXF A;  4J8O A;  2W5Y A;  5TH7 A;  2O8J A;  5F59 A;  3M5A A;  3M54 A;  3S8P A;  3F9X A;  5KJL A;  1N3J A;  4O6F A;  3OXL A;  1O9S A;  5TEG A;  3F9Y A;  3HNA A;  4FMU A;  3M57 A;  3S7B A;  3IHX A;  3MO0 A;  5CCM A;  3TG5 A;  5F5E A;  1N6A A;  3S7D A;  4IJD A;  4E47 A;  3QWW A;  5HI7 A;  4WUY A;  3RQ4 A;  3MEK A;  3MO2 A;  5T0K A;  4YND A;  4I51 A;  4YNP A;  1H3I A;  2W5Z A;  3F9W A;  3M53 A;  4YPE A;  2JV0 A;  4YNM A;  5KJM A;  3EP0 A;  5T5G A;  5KJK A;  2BQZ A;  5ARG A;  1MVX A;  5F6K C;  3OS5 A;  3RJW A;  3N71 A;  3RIB A;  3M55 A;  3RAY A;  2R3A A;  4O30 A;  3OPE A;  5EG2 A;  5LSX A;  3KMT A;  5AYF A;  3FPD A;  2QPW A;  1PEG A;  3CBM A;  3CBP A;  4IJ8 A;  3M56 A;  5ARF A;  4AU7 A;  5JJ0 A;  5HQ8 A;  3RU0 A;  3SWC A;  3S7F A;  2RFI A;  3DB5 A;  4NVQ A;  4C1Q A;  5LSZ A;  4JDS A;  1MT6 A;  5F6L A;  3KMJ A;  3S7J A;  3M58 A;  4MI5 A;  4H12 A;  3MO5 A;  5JIY A;  4Z4P A;  5CCL A;  4QEN A;  4J7F A;  4YPA A;  3SW9 A;  4MI0 A;  5JIN A;  4YPU A;  1MVH A;  4J7I A;  3QWV A;  3F9Z A;  3KMA A;  3PDN A;  3OXG A;  1N6C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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