5BQ8B

Crystal structure of norrin, a wnt signalling activator, crystal form ii
Total Genus 6
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
97
structure length
94
Chain Sequence
PRRCMRHHYVDSISHPLYCSSKMVLLARCEGHCSQASRSEPLVSFSTVLQPFRSSCHCCRPQTSKLALRLRCSGGMRLTATYRYILSCHCEECN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Signaling protein
molecule keywords Norrin
publication title Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
pubmed doi rcsb
source organism Homo sapiens
total genus 6
structure length 94
sequence length 97
ec nomenclature
pdb deposition date 2015-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00007 Cys_knot Cystine-knot domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 5bq8B00
1BNDA 1BTGA 5BQ8B 1FLTV 2ARVA 1HRPA 1HCNA 2GYZA 2ARPA 4AY9B 5F3BC 1MJVA 1NYUB 1WWWV 2QCWA 2X1WA 3S1BV 1AGQA 2QJAA 4UHYA 2R52A 5HHVA 1LX5A 5HI4A 1TZHV 5HHXA 4QHUC 1XWDA 4EDWV 1MKKA 2XACA 3BK3A 5E4GA 4HQUA 1ES7A 1QTYR 2BHKA 5HK5E 4EAXA 3MJKA 5BQEB 2VXSA 1WQ9A 1ZKZA 4FAOA 1KLAA 1NT3A 1BMPA 1M4UA 5HI5A 4MQWB 5HK5A 3JVFA 4KZNA 5BQ8A 4QCIC 2V5EB 1TGJA 2FJGV 1FL7B 1TZIV 4AY9A 2H64A 2KD3A 4UI2B 1RV6V 1B8MB 3B4VA 1HCFA 4KV5A 1SG1A 3SEKB 4YCIC 4EC7A 3RJRA 2FJHV 1VPPV 4EDXV 2XV7A 5FV1V 4BV4L 3E07A 2QJBA 1KTZA 2VWEA 4X1JA 1M4UL 1QFWB 2R53A 3BMPA 4EFVA 3V2AA 5BQEA 1KLCA 2TGIA 5BPUA 1WAQA 4HSAA 3EVSB 4MQWA 5BQCA 3HH2A 2P6AA 1SGFB 1REWA 5BQ8D 3P9WA 1S4YB 1FL7A 3IJ2A 2QJ9A 3BUKA 1BETA 3BDYV 1B8MA 1NYSB 2QR0C 1KATW 2GNNA 1TFGA 4YCGC 4MPLA 4GLNE 1REUA 4N1DA 3EO1C 5HHDA 2ASKA 2GYRA 4HQXA 5AEJA 4UI0A 1VPFA 2GH0C 1QFWA 5F3HI 4XPJA 1DZ7A 1BNDB 4KXZA 4WPBA 4UHZA 5HI3A 1HRPB 2X1XE 1HCNB 3QB4A 4LXSJ 1E9JA 4UI1A 5HHCA 1PDGA 1LXIA 3KFDA 1JPYA 1HD4A 4HR9A 5FV2V 1CZ8V 1AOCA 2B0UA 2GOOA 2H62A 3V6BA 1XWDB 1B98A 4ZFFC 4MIDA 4QAFC 4ZBNA 1B8KA 1MKGA 3QTKA 1FZVA 1TGKA 5JZ7A 3FUBB 1WQ8A 4GLSE 1BJ1V 2VPFA 2PJYA 2QCQA 1WQ9B 4LXRJ 2IFGE 2C7WA 3S1KV 5BQBA 3MJGA
chains in the Genus database with same CATH superfamily
1BNDA 1BTGA 5BQ8B 1FLTV 2ARVA 1HRPA 1HCNA 2GYZA 2ARPA 4AY9B 5F3BC 1MJVA 1NYUB 1WWWV 2QCWA 2X1WA 3S1BV 1AGQA 2QJAA 4UHYA 2R52A 5HHVA 1LX5A 5HI4A 1TZHV 5HHXA 4QHUC 1XWDA 4EDWV 1MKKA 2XACA 3BK3A 5E4GA 4HQUA 1ES7A 1QTYR 2BHKA 5HK5E 4EAXA 3MJKA 5BQEB 2VXSA 1WQ9A 1ZKZA 4FAOA 1KLAA 1NT3A 1BMPA 1M4UA 5HI5A 4MQWB 5HK5A 3JVFA 4KZNA 5BQ8A 4QCIC 2V5EB 1TGJA 2FJGV 1FL7B 1TZIV 4AY9A 2H64A 2KD3A 4UI2B 1RV6V 1B8MB 3B4VA 1HCFA 4KV5A 1SG1A 3SEKB 4YCIC 4EC7A 3RJRA 2FJHV 1VPPV 4EDXV 2XV7A 5FV1V 4BV4L 3E07A 2QJBA 1KTZA 2VWEA 4X1JA 1M4UL 1QFWB 2R53A 3BMPA 4EFVA 3V2AA 5BQEA 1KLCA 2TGIA 5BPUA 1WAQA 4HSAA 3EVSB 4MQWA 5BQCA 3HH2A 2P6AA 1SGFB 1REWA 5BQ8D 3P9WA 1S4YB 1FL7A 3IJ2A 2QJ9A 3BUKA 1BETA 3BDYV 1B8MA 1NYSB 2QR0C 1KATW 2GNNA 1TFGA 4YCGC 4MPLA 4GLNE 1REUA 4N1DA 3EO1C 5HHDA 2ASKA 2GYRA 4HQXA 5AEJA 4UI0A 1VPFA 2GH0C 1QFWA 5F3HI 4XPJA 1DZ7A 1BNDB 4KXZA 4WPBA 4UHZA 5HI3A 1HRPB 2X1XE 1HCNB 3QB4A 4LXSJ 1E9JA 4UI1A 5HHCA 1PDGA 1LXIA 3KFDA 1JPYA 1HD4A 4HR9A 5FV2V 1CZ8V 1AOCA 2B0UA 2GOOA 2H62A 3V6BA 1XWDB 1B98A 4ZFFC 4MIDA 4QAFC 4ZBNA 1B8KA 1MKGA 3QTKA 1FZVA 1TGKA 5JZ7A 3FUBB 1WQ8A 4GLSE 1BJ1V 2VPFA 2PJYA 2QCQA 1WQ9B 4LXRJ 2IFGE 2C7WA 3S1KV 5BQBA 3MJGA
chains in the Genus database with same CATH topology
1BNDA 1BTGA 5BQ8B 1FLTV 2ARVA 1HRPA 1HCNA 2GYZA 2ARPA 4AY9B 5F3BC 1MJVA 1NYUB 1WWWV 2QCWA 2X1WA 3S1BV 1AGQA 2QJAA 4UHYA 2R52A 5HHVA 1LX5A 5HI4A 1TZHV 5HHXA 4QHUC 1XWDA 4EDWV 1MKKA 2XACA 3BK3A 5E4GA 4HQUA 1ES7A 1QTYR 2BHKA 5HK5E 4EAXA 3MJKA 5BQEB 2VXSA 1WQ9A 1ZKZA 4FAOA 1KLAA 1NT3A 1BMPA 1M4UA 5HI5A 4MQWB 5HK5A 3JVFA 4KZNA 5BQ8A 4QCIC 2V5EB 1TGJA 2FJGV 1FL7B 1TZIV 4AY9A 2H64A 2KD3A 4UI2B 1RV6V 1B8MB 3B4VA 1HCFA 4KV5A 1SG1A 3SEKB 4YCIC 4EC7A 3RJRA 2FJHV 1VPPV 4EDXV 2XV7A 5FV1V 4BV4L 3E07A 2QJBA 1KTZA 2VWEA 4X1JA 1M4UL 1QFWB 2R53A 3BMPA 4EFVA 3V2AA 5BQEA 1KLCA 2TGIA 5BPUA 1WAQA 4HSAA 3EVSB 4MQWA 5BQCA 3HH2A 2P6AA 1SGFB 1REWA 5BQ8D 3P9WA 1S4YB 1FL7A 3IJ2A 2QJ9A 3BUKA 1BETA 3BDYV 1B8MA 1NYSB 2QR0C 1KATW 2GNNA 1TFGA 4YCGC 4MPLA 4GLNE 1REUA 4N1DA 3EO1C 5HHDA 2ASKA 2GYRA 4HQXA 5AEJA 4UI0A 1VPFA 2GH0C 1QFWA 5F3HI 4XPJA 1DZ7A 1BNDB 4KXZA 4WPBA 4UHZA 5HI3A 1HRPB 2X1XE 1HCNB 3QB4A 4LXSJ 1E9JA 4UI1A 5HHCA 1PDGA 1LXIA 3KFDA 1JPYA 1HD4A 4HR9A 5FV2V 1CZ8V 1AOCA 2B0UA 2GOOA 2H62A 3V6BA 1XWDB 1B98A 4ZFFC 4MIDA 4QAFC 4ZBNA 1B8KA 1MKGA 3QTKA 1FZVA 1TGKA 5JZ7A 3FUBB 1WQ8A 4GLSE 1BJ1V 2VPFA 2PJYA 2QCQA 1WQ9B 4LXRJ 2IFGE 2C7WA 3S1KV 5BQBA 3MJGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BND A;  1BTG A;  5BQ8 B;  1FLT V;  2ARV A;  1HRP A;  1HCN A;  2GYZ A;  2ARP A;  4AY9 B;  5F3B C;  1MJV A;  1NYU B;  1WWW V;  2QCW A;  2X1W A;  3S1B V;  1AGQ A;  2QJA A;  4UHY A;  2R52 A;  5HHV A;  1LX5 A;  5HI4 A;  1TZH V;  5HHX A;  4QHU C;  1XWD A;  4EDW V;  1MKK A;  2XAC A;  3BK3 A;  5E4G A;  4HQU A;  1ES7 A;  1QTY R;  2BHK A;  5HK5 E;  4EAX A;  3MJK A;  5BQE B;  2VXS A;  1WQ9 A;  1ZKZ A;  4FAO A;  1KLA A;  1NT3 A;  1BMP A;  1M4U A;  5HI5 A;  4MQW B;  5HK5 A;  3JVF A;  4KZN A;  5BQ8 A;  4QCI C;  2V5E B;  1TGJ A;  2FJG V;  1FL7 B;  1TZI V;  4AY9 A;  2H64 A;  2KD3 A;  4UI2 B;  1RV6 V;  1B8M B;  3B4V A;  1HCF A;  4KV5 A;  1SG1 A;  3SEK B;  4YCI C;  4EC7 A;  3RJR A;  2FJH V;  1VPP V;  4EDX V;  2XV7 A;  5FV1 V;  4BV4 L;  3E07 A;  2QJB A;  1KTZ A;  2VWE A;  4X1J A;  1M4U L;  1QFW B;  2R53 A;  3BMP A;  4EFV A;  3V2A A;  5BQE A;  1KLC A;  2TGI A;  5BPU A;  1WAQ A;  4HSA A;  3EVS B;  4MQW A;  5BQC A;  3HH2 A;  2P6A A;  1SGF B;  1REW A;  5BQ8 D;  3P9W A;  1S4Y B;  1FL7 A;  3IJ2 A;  2QJ9 A;  3BUK A;  1BET A;  3BDY V;  1B8M A;  1NYS B;  2QR0 C;  1KAT W;  2GNN A;  1TFG A;  4YCG C;  4MPL A;  4GLN E;  1REU A;  4N1D A;  3EO1 C;  5HHD A;  2ASK A;  2GYR A;  4HQX A;  5AEJ A;  4UI0 A;  1VPF A;  2GH0 C;  1QFW A;  5F3H I;  4XPJ A;  1DZ7 A;  1BND B;  4KXZ A;  4WPB A;  4UHZ A;  5HI3 A;  1HRP B;  2X1X E;  1HCN B;  3QB4 A;  4LXS J;  1E9J A;  4UI1 A;  5HHC A;  1PDG A;  1LXI A;  3KFD A;  1JPY A;  1HD4 A;  4HR9 A;  5FV2 V;  1CZ8 V;  1AOC A;  2B0U A;  2GOO A;  2H62 A;  3V6B A;  1XWD B;  1B98 A;  4ZFF C;  4MID A;  4QAF C;  4ZBN A;  1B8K A;  1MKG A;  3QTK A;  1FZV A;  1TGK A;  5JZ7 A;  3FUB B;  1WQ8 A;  4GLS E;  1BJ1 V;  2VPF A;  2PJY A;  2QCQ A;  1WQ9 B;  4LXR J;  2IFG E;  2C7W A;  3S1K V;  5BQB A;  3MJG A; 
#chains in the Genus database with same CATH topology
 1BND A;  1BTG A;  5BQ8 B;  1FLT V;  2ARV A;  1HRP A;  1HCN A;  2GYZ A;  2ARP A;  4AY9 B;  5F3B C;  1MJV A;  1NYU B;  1WWW V;  2QCW A;  2X1W A;  3S1B V;  1AGQ A;  2QJA A;  4UHY A;  2R52 A;  5HHV A;  1LX5 A;  5HI4 A;  1TZH V;  5HHX A;  4QHU C;  1XWD A;  4EDW V;  1MKK A;  2XAC A;  3BK3 A;  5E4G A;  4HQU A;  1ES7 A;  1QTY R;  2BHK A;  5HK5 E;  4EAX A;  3MJK A;  5BQE B;  2VXS A;  1WQ9 A;  1ZKZ A;  4FAO A;  1KLA A;  1NT3 A;  1BMP A;  1M4U A;  5HI5 A;  4MQW B;  5HK5 A;  3JVF A;  4KZN A;  5BQ8 A;  4QCI C;  2V5E B;  1TGJ A;  2FJG V;  1FL7 B;  1TZI V;  4AY9 A;  2H64 A;  2KD3 A;  4UI2 B;  1RV6 V;  1B8M B;  3B4V A;  1HCF A;  4KV5 A;  1SG1 A;  3SEK B;  4YCI C;  4EC7 A;  3RJR A;  2FJH V;  1VPP V;  4EDX V;  2XV7 A;  5FV1 V;  4BV4 L;  3E07 A;  2QJB A;  1KTZ A;  2VWE A;  4X1J A;  1M4U L;  1QFW B;  2R53 A;  3BMP A;  4EFV A;  3V2A A;  5BQE A;  1KLC A;  2TGI A;  5BPU A;  1WAQ A;  4HSA A;  3EVS B;  4MQW A;  5BQC A;  3HH2 A;  2P6A A;  1SGF B;  1REW A;  5BQ8 D;  3P9W A;  1S4Y B;  1FL7 A;  3IJ2 A;  2QJ9 A;  3BUK A;  1BET A;  3BDY V;  1B8M A;  1NYS B;  2QR0 C;  1KAT W;  2GNN A;  1TFG A;  4YCG C;  4MPL A;  4GLN E;  1REU A;  4N1D A;  3EO1 C;  5HHD A;  2ASK A;  2GYR A;  4HQX A;  5AEJ A;  4UI0 A;  1VPF A;  2GH0 C;  1QFW A;  5F3H I;  4XPJ A;  1DZ7 A;  1BND B;  4KXZ A;  4WPB A;  4UHZ A;  5HI3 A;  1HRP B;  2X1X E;  1HCN B;  3QB4 A;  4LXS J;  1E9J A;  4UI1 A;  5HHC A;  1PDG A;  1LXI A;  3KFD A;  1JPY A;  1HD4 A;  4HR9 A;  5FV2 V;  1CZ8 V;  1AOC A;  2B0U A;  2GOO A;  2H62 A;  3V6B A;  1XWD B;  1B98 A;  4ZFF C;  4MID A;  4QAF C;  4ZBN A;  1B8K A;  1MKG A;  3QTK A;  1FZV A;  1TGK A;  5JZ7 A;  3FUB B;  1WQ8 A;  4GLS E;  1BJ1 V;  2VPF A;  2PJY A;  2QCQ A;  1WQ9 B;  4LXR J;  2IFG E;  2C7W A;  3S1K V;  5BQB A;  3MJG A; 
#chains in the Genus database with same CATH homology
 1BND A;  1BTG A;  5BQ8 B;  1FLT V;  2ARV A;  1HRP A;  1HCN A;  2GYZ A;  2ARP A;  4AY9 B;  5F3B C;  1MJV A;  1NYU B;  1WWW V;  2QCW A;  2X1W A;  3S1B V;  1AGQ A;  2QJA A;  4UHY A;  2R52 A;  5HHV A;  1LX5 A;  5HI4 A;  1TZH V;  5HHX A;  4QHU C;  1XWD A;  4EDW V;  1MKK A;  2XAC A;  3BK3 A;  5E4G A;  4HQU A;  1ES7 A;  1QTY R;  2BHK A;  5HK5 E;  4EAX A;  3MJK A;  5BQE B;  2VXS A;  1WQ9 A;  1ZKZ A;  4FAO A;  1KLA A;  1NT3 A;  1BMP A;  1M4U A;  5HI5 A;  4MQW B;  5HK5 A;  3JVF A;  4KZN A;  5BQ8 A;  4QCI C;  2V5E B;  1TGJ A;  2FJG V;  1FL7 B;  1TZI V;  4AY9 A;  2H64 A;  2KD3 A;  4UI2 B;  1RV6 V;  1B8M B;  3B4V A;  1HCF A;  4KV5 A;  1SG1 A;  3SEK B;  4YCI C;  4EC7 A;  3RJR A;  2FJH V;  1VPP V;  4EDX V;  2XV7 A;  5FV1 V;  4BV4 L;  3E07 A;  2QJB A;  1KTZ A;  2VWE A;  4X1J A;  1M4U L;  1QFW B;  2R53 A;  3BMP A;  4EFV A;  3V2A A;  5BQE A;  1KLC A;  2TGI A;  5BPU A;  1WAQ A;  4HSA A;  3EVS B;  4MQW A;  5BQC A;  3HH2 A;  2P6A A;  1SGF B;  1REW A;  5BQ8 D;  3P9W A;  1S4Y B;  1FL7 A;  3IJ2 A;  2QJ9 A;  3BUK A;  1BET A;  3BDY V;  1B8M A;  1NYS B;  2QR0 C;  1KAT W;  2GNN A;  1TFG A;  4YCG C;  4MPL A;  4GLN E;  1REU A;  4N1D A;  3EO1 C;  5HHD A;  2ASK A;  2GYR A;  4HQX A;  5AEJ A;  4UI0 A;  1VPF A;  2GH0 C;  1QFW A;  5F3H I;  4XPJ A;  1DZ7 A;  1BND B;  4KXZ A;  4WPB A;  4UHZ A;  5HI3 A;  1HRP B;  2X1X E;  1HCN B;  3QB4 A;  4LXS J;  1E9J A;  4UI1 A;  5HHC A;  1PDG A;  1LXI A;  3KFD A;  1JPY A;  1HD4 A;  4HR9 A;  5FV2 V;  1CZ8 V;  1AOC A;  2B0U A;  2GOO A;  2H62 A;  3V6B A;  1XWD B;  1B98 A;  4ZFF C;  4MID A;  4QAF C;  4ZBN A;  1B8K A;  1MKG A;  3QTK A;  1FZV A;  1TGK A;  5JZ7 A;  3FUB B;  1WQ8 A;  4GLS E;  1BJ1 V;  2VPF A;  2PJY A;  2QCQ A;  1WQ9 B;  4LXR J;  2IFG E;  2C7W A;  3S1K V;  5BQB A;  3MJG A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...