5BQEA

Crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
101
structure length
101
Chain Sequence
DSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Norrin
publication title Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
pubmed doi rcsb
source organism Homo sapiens
total genus 8
structure length 101
sequence length 101
ec nomenclature
pdb deposition date 2015-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00007 Cys_knot Cystine-knot domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 5bqeA00
1S4YB 1TZHV 3BMPA 1NYUB 1KATW 3V6BA 1CZ8V 2VPFA 1QFWA 4N1DA 2FJHV 1FL7A 1WWWV 4UI1A 1B98A 4EAXA 4AY9A 1REWA 3IJ2A 3MJGA 4BV4L 2GYRA 4EC7A 4UHZA 5HHDA 2QJ9A 1HCNA 1ES7A 2B0UA 4EDXV 4UI2B 2X1XE 5BQBA 4QAFC 1TZIV 1WQ9A 1VPPV 5AEJA 5BQEB 3BUKA 1M4UA 1BMPA 4QCIC 2P6AA 1ZKZA 4KXZA 3S1KV 5HHCA 1MKKA 1AOCA 2PJYA 1WQ8A 4HR9A 4FAOA 2QJAA 4MPLA 1KTZA 1TGJA 5BQ8B 1LX5A 1KLAA 3EVSB 4ZFFC 1M4UL 1XWDA 2BHKA 5HK5E 2GH0C 2QCWA 3P9WA 1E9JA 2R53A 5JZ7A 1SGFB 4X1JA 3V2AA 2ASKA 2ARVA 3SEKB 3EO1C 2QR0C 1BETA 3FUBB 4LXRJ 5HHVA 5BQ8D 2VWEA 1VPFA 1TFGA 1HRPB 5BQ8A 5FV2V 3E07A 3RJRA 3MJKA 2QCQA 4MIDA 5HHXA 1AGQA 4MQWB 1LXIA 5E4GA 4LXSJ 4YCIC 1BNDB 5F3BC 4YCGC 4HQUA 4EFVA 4XPJA 5BQCA 4UI0A 2VXSA 5HI3A 2QJBA 3B4VA 1PDGA 4GLNE 2IFGE 2H62A 3BK3A 1QFWB 1FLTV 1HRPA 1JPYA 1FL7B 2XACA 3QB4A 5HI4A 5BQEA 5F3HI 4GLSE 5FV1V 4HQXA 2XV7A 4KZNA 1BTGA 4AY9B 2X1WA 2ARPA 1KLCA 1REUA 5HI5A 1HCNB 3QTKA 1HD4A 2FJGV 3S1BV 5BPUA 2C7WA 1NYSB 4QHUC 1B8MB 1B8KA 3HH2A 4EDWV 2R52A 2TGIA 2V5EB 1WQ9B 1QTYR 1SG1A 4HSAA 4KV5A 1FZVA 1RV6V 1MJVA 1WAQA 3BDYV 1NT3A 4ZBNA 2H64A 5HK5A 1TGKA 1B8MA 1MKGA 2KD3A 1HCFA 3KFDA 2GYZA 4MQWA 2GNNA 4WPBA 1XWDB 3JVFA 1DZ7A 1BJ1V 4UHYA 2GOOA 1BNDA
chains in the Genus database with same CATH superfamily
1S4YB 1TZHV 3BMPA 1NYUB 1KATW 3V6BA 1CZ8V 2VPFA 1QFWA 4N1DA 2FJHV 1FL7A 1WWWV 4UI1A 1B98A 4EAXA 4AY9A 1REWA 3IJ2A 3MJGA 4BV4L 2GYRA 4EC7A 4UHZA 5HHDA 2QJ9A 1HCNA 1ES7A 2B0UA 4EDXV 4UI2B 2X1XE 5BQBA 4QAFC 1TZIV 1WQ9A 1VPPV 5AEJA 5BQEB 3BUKA 1M4UA 1BMPA 4QCIC 2P6AA 1ZKZA 4KXZA 3S1KV 5HHCA 1MKKA 1AOCA 2PJYA 1WQ8A 4HR9A 4FAOA 2QJAA 4MPLA 1KTZA 1TGJA 5BQ8B 1LX5A 1KLAA 3EVSB 4ZFFC 1M4UL 1XWDA 2BHKA 5HK5E 2GH0C 2QCWA 3P9WA 1E9JA 2R53A 5JZ7A 1SGFB 4X1JA 3V2AA 2ASKA 2ARVA 3SEKB 3EO1C 2QR0C 1BETA 3FUBB 4LXRJ 5HHVA 5BQ8D 2VWEA 1VPFA 1TFGA 1HRPB 5BQ8A 5FV2V 3E07A 3RJRA 3MJKA 2QCQA 4MIDA 5HHXA 1AGQA 4MQWB 1LXIA 5E4GA 4LXSJ 4YCIC 1BNDB 5F3BC 4YCGC 4HQUA 4EFVA 4XPJA 5BQCA 4UI0A 2VXSA 5HI3A 2QJBA 3B4VA 1PDGA 4GLNE 2IFGE 2H62A 3BK3A 1QFWB 1FLTV 1HRPA 1JPYA 1FL7B 2XACA 3QB4A 5HI4A 5BQEA 5F3HI 4GLSE 5FV1V 4HQXA 2XV7A 4KZNA 1BTGA 4AY9B 2X1WA 2ARPA 1KLCA 1REUA 5HI5A 1HCNB 3QTKA 1HD4A 2FJGV 3S1BV 5BPUA 2C7WA 1NYSB 4QHUC 1B8MB 1B8KA 3HH2A 4EDWV 2R52A 2TGIA 2V5EB 1WQ9B 1QTYR 1SG1A 4HSAA 4KV5A 1FZVA 1RV6V 1MJVA 1WAQA 3BDYV 1NT3A 4ZBNA 2H64A 5HK5A 1TGKA 1B8MA 1MKGA 2KD3A 1HCFA 3KFDA 2GYZA 4MQWA 2GNNA 4WPBA 1XWDB 3JVFA 1DZ7A 1BJ1V 4UHYA 2GOOA 1BNDA
chains in the Genus database with same CATH topology
1S4YB 1TZHV 3BMPA 1NYUB 1KATW 3V6BA 1CZ8V 2VPFA 1QFWA 4N1DA 2FJHV 1FL7A 1WWWV 4UI1A 1B98A 4EAXA 4AY9A 1REWA 3IJ2A 3MJGA 4BV4L 2GYRA 4EC7A 4UHZA 5HHDA 2QJ9A 1HCNA 1ES7A 2B0UA 4EDXV 4UI2B 2X1XE 5BQBA 4QAFC 1TZIV 1WQ9A 1VPPV 5AEJA 5BQEB 3BUKA 1M4UA 1BMPA 4QCIC 2P6AA 1ZKZA 4KXZA 3S1KV 5HHCA 1MKKA 1AOCA 2PJYA 1WQ8A 4HR9A 4FAOA 2QJAA 4MPLA 1KTZA 1TGJA 5BQ8B 1LX5A 1KLAA 3EVSB 4ZFFC 1M4UL 1XWDA 2BHKA 5HK5E 2GH0C 2QCWA 3P9WA 1E9JA 2R53A 5JZ7A 1SGFB 4X1JA 3V2AA 2ASKA 2ARVA 3SEKB 3EO1C 2QR0C 1BETA 3FUBB 4LXRJ 5HHVA 5BQ8D 2VWEA 1VPFA 1TFGA 1HRPB 5BQ8A 5FV2V 3E07A 3RJRA 3MJKA 2QCQA 4MIDA 5HHXA 1AGQA 4MQWB 1LXIA 5E4GA 4LXSJ 4YCIC 1BNDB 5F3BC 4YCGC 4HQUA 4EFVA 4XPJA 5BQCA 4UI0A 2VXSA 5HI3A 2QJBA 3B4VA 1PDGA 4GLNE 2IFGE 2H62A 3BK3A 1QFWB 1FLTV 1HRPA 1JPYA 1FL7B 2XACA 3QB4A 5HI4A 5BQEA 5F3HI 4GLSE 5FV1V 4HQXA 2XV7A 4KZNA 1BTGA 4AY9B 2X1WA 2ARPA 1KLCA 1REUA 5HI5A 1HCNB 3QTKA 1HD4A 2FJGV 3S1BV 5BPUA 2C7WA 1NYSB 4QHUC 1B8MB 1B8KA 3HH2A 4EDWV 2R52A 2TGIA 2V5EB 1WQ9B 1QTYR 1SG1A 4HSAA 4KV5A 1FZVA 1RV6V 1MJVA 1WAQA 3BDYV 1NT3A 4ZBNA 2H64A 5HK5A 1TGKA 1B8MA 1MKGA 2KD3A 1HCFA 3KFDA 2GYZA 4MQWA 2GNNA 4WPBA 1XWDB 3JVFA 1DZ7A 1BJ1V 4UHYA 2GOOA 1BNDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S4Y B;  1TZH V;  3BMP A;  1NYU B;  1KAT W;  3V6B A;  1CZ8 V;  2VPF A;  1QFW A;  4N1D A;  2FJH V;  1FL7 A;  1WWW V;  4UI1 A;  1B98 A;  4EAX A;  4AY9 A;  1REW A;  3IJ2 A;  3MJG A;  4BV4 L;  2GYR A;  4EC7 A;  4UHZ A;  5HHD A;  2QJ9 A;  1HCN A;  1ES7 A;  2B0U A;  4EDX V;  4UI2 B;  2X1X E;  5BQB A;  4QAF C;  1TZI V;  1WQ9 A;  1VPP V;  5AEJ A;  5BQE B;  3BUK A;  1M4U A;  1BMP A;  4QCI C;  2P6A A;  1ZKZ A;  4KXZ A;  3S1K V;  5HHC A;  1MKK A;  1AOC A;  2PJY A;  1WQ8 A;  4HR9 A;  4FAO A;  2QJA A;  4MPL A;  1KTZ A;  1TGJ A;  5BQ8 B;  1LX5 A;  1KLA A;  3EVS B;  4ZFF C;  1M4U L;  1XWD A;  2BHK A;  5HK5 E;  2GH0 C;  2QCW A;  3P9W A;  1E9J A;  2R53 A;  5JZ7 A;  1SGF B;  4X1J A;  3V2A A;  2ASK A;  2ARV A;  3SEK B;  3EO1 C;  2QR0 C;  1BET A;  3FUB B;  4LXR J;  5HHV A;  5BQ8 D;  2VWE A;  1VPF A;  1TFG A;  1HRP B;  5BQ8 A;  5FV2 V;  3E07 A;  3RJR A;  3MJK A;  2QCQ A;  4MID A;  5HHX A;  1AGQ A;  4MQW B;  1LXI A;  5E4G A;  4LXS J;  4YCI C;  1BND B;  5F3B C;  4YCG C;  4HQU A;  4EFV A;  4XPJ A;  5BQC A;  4UI0 A;  2VXS A;  5HI3 A;  2QJB A;  3B4V A;  1PDG A;  4GLN E;  2IFG E;  2H62 A;  3BK3 A;  1QFW B;  1FLT V;  1HRP A;  1JPY A;  1FL7 B;  2XAC A;  3QB4 A;  5HI4 A;  5BQE A;  5F3H I;  4GLS E;  5FV1 V;  4HQX A;  2XV7 A;  4KZN A;  1BTG A;  4AY9 B;  2X1W A;  2ARP A;  1KLC A;  1REU A;  5HI5 A;  1HCN B;  3QTK A;  1HD4 A;  2FJG V;  3S1B V;  5BPU A;  2C7W A;  1NYS B;  4QHU C;  1B8M B;  1B8K A;  3HH2 A;  4EDW V;  2R52 A;  2TGI A;  2V5E B;  1WQ9 B;  1QTY R;  1SG1 A;  4HSA A;  4KV5 A;  1FZV A;  1RV6 V;  1MJV A;  1WAQ A;  3BDY V;  1NT3 A;  4ZBN A;  2H64 A;  5HK5 A;  1TGK A;  1B8M A;  1MKG A;  2KD3 A;  1HCF A;  3KFD A;  2GYZ A;  4MQW A;  2GNN A;  4WPB A;  1XWD B;  3JVF A;  1DZ7 A;  1BJ1 V;  4UHY A;  2GOO A;  1BND A; 
#chains in the Genus database with same CATH topology
 1S4Y B;  1TZH V;  3BMP A;  1NYU B;  1KAT W;  3V6B A;  1CZ8 V;  2VPF A;  1QFW A;  4N1D A;  2FJH V;  1FL7 A;  1WWW V;  4UI1 A;  1B98 A;  4EAX A;  4AY9 A;  1REW A;  3IJ2 A;  3MJG A;  4BV4 L;  2GYR A;  4EC7 A;  4UHZ A;  5HHD A;  2QJ9 A;  1HCN A;  1ES7 A;  2B0U A;  4EDX V;  4UI2 B;  2X1X E;  5BQB A;  4QAF C;  1TZI V;  1WQ9 A;  1VPP V;  5AEJ A;  5BQE B;  3BUK A;  1M4U A;  1BMP A;  4QCI C;  2P6A A;  1ZKZ A;  4KXZ A;  3S1K V;  5HHC A;  1MKK A;  1AOC A;  2PJY A;  1WQ8 A;  4HR9 A;  4FAO A;  2QJA A;  4MPL A;  1KTZ A;  1TGJ A;  5BQ8 B;  1LX5 A;  1KLA A;  3EVS B;  4ZFF C;  1M4U L;  1XWD A;  2BHK A;  5HK5 E;  2GH0 C;  2QCW A;  3P9W A;  1E9J A;  2R53 A;  5JZ7 A;  1SGF B;  4X1J A;  3V2A A;  2ASK A;  2ARV A;  3SEK B;  3EO1 C;  2QR0 C;  1BET A;  3FUB B;  4LXR J;  5HHV A;  5BQ8 D;  2VWE A;  1VPF A;  1TFG A;  1HRP B;  5BQ8 A;  5FV2 V;  3E07 A;  3RJR A;  3MJK A;  2QCQ A;  4MID A;  5HHX A;  1AGQ A;  4MQW B;  1LXI A;  5E4G A;  4LXS J;  4YCI C;  1BND B;  5F3B C;  4YCG C;  4HQU A;  4EFV A;  4XPJ A;  5BQC A;  4UI0 A;  2VXS A;  5HI3 A;  2QJB A;  3B4V A;  1PDG A;  4GLN E;  2IFG E;  2H62 A;  3BK3 A;  1QFW B;  1FLT V;  1HRP A;  1JPY A;  1FL7 B;  2XAC A;  3QB4 A;  5HI4 A;  5BQE A;  5F3H I;  4GLS E;  5FV1 V;  4HQX A;  2XV7 A;  4KZN A;  1BTG A;  4AY9 B;  2X1W A;  2ARP A;  1KLC A;  1REU A;  5HI5 A;  1HCN B;  3QTK A;  1HD4 A;  2FJG V;  3S1B V;  5BPU A;  2C7W A;  1NYS B;  4QHU C;  1B8M B;  1B8K A;  3HH2 A;  4EDW V;  2R52 A;  2TGI A;  2V5E B;  1WQ9 B;  1QTY R;  1SG1 A;  4HSA A;  4KV5 A;  1FZV A;  1RV6 V;  1MJV A;  1WAQ A;  3BDY V;  1NT3 A;  4ZBN A;  2H64 A;  5HK5 A;  1TGK A;  1B8M A;  1MKG A;  2KD3 A;  1HCF A;  3KFD A;  2GYZ A;  4MQW A;  2GNN A;  4WPB A;  1XWD B;  3JVF A;  1DZ7 A;  1BJ1 V;  4UHY A;  2GOO A;  1BND A; 
#chains in the Genus database with same CATH homology
 1S4Y B;  1TZH V;  3BMP A;  1NYU B;  1KAT W;  3V6B A;  1CZ8 V;  2VPF A;  1QFW A;  4N1D A;  2FJH V;  1FL7 A;  1WWW V;  4UI1 A;  1B98 A;  4EAX A;  4AY9 A;  1REW A;  3IJ2 A;  3MJG A;  4BV4 L;  2GYR A;  4EC7 A;  4UHZ A;  5HHD A;  2QJ9 A;  1HCN A;  1ES7 A;  2B0U A;  4EDX V;  4UI2 B;  2X1X E;  5BQB A;  4QAF C;  1TZI V;  1WQ9 A;  1VPP V;  5AEJ A;  5BQE B;  3BUK A;  1M4U A;  1BMP A;  4QCI C;  2P6A A;  1ZKZ A;  4KXZ A;  3S1K V;  5HHC A;  1MKK A;  1AOC A;  2PJY A;  1WQ8 A;  4HR9 A;  4FAO A;  2QJA A;  4MPL A;  1KTZ A;  1TGJ A;  5BQ8 B;  1LX5 A;  1KLA A;  3EVS B;  4ZFF C;  1M4U L;  1XWD A;  2BHK A;  5HK5 E;  2GH0 C;  2QCW A;  3P9W A;  1E9J A;  2R53 A;  5JZ7 A;  1SGF B;  4X1J A;  3V2A A;  2ASK A;  2ARV A;  3SEK B;  3EO1 C;  2QR0 C;  1BET A;  3FUB B;  4LXR J;  5HHV A;  5BQ8 D;  2VWE A;  1VPF A;  1TFG A;  1HRP B;  5BQ8 A;  5FV2 V;  3E07 A;  3RJR A;  3MJK A;  2QCQ A;  4MID A;  5HHX A;  1AGQ A;  4MQW B;  1LXI A;  5E4G A;  4LXS J;  4YCI C;  1BND B;  5F3B C;  4YCG C;  4HQU A;  4EFV A;  4XPJ A;  5BQC A;  4UI0 A;  2VXS A;  5HI3 A;  2QJB A;  3B4V A;  1PDG A;  4GLN E;  2IFG E;  2H62 A;  3BK3 A;  1QFW B;  1FLT V;  1HRP A;  1JPY A;  1FL7 B;  2XAC A;  3QB4 A;  5HI4 A;  5BQE A;  5F3H I;  4GLS E;  5FV1 V;  4HQX A;  2XV7 A;  4KZN A;  1BTG A;  4AY9 B;  2X1W A;  2ARP A;  1KLC A;  1REU A;  5HI5 A;  1HCN B;  3QTK A;  1HD4 A;  2FJG V;  3S1B V;  5BPU A;  2C7W A;  1NYS B;  4QHU C;  1B8M B;  1B8K A;  3HH2 A;  4EDW V;  2R52 A;  2TGI A;  2V5E B;  1WQ9 B;  1QTY R;  1SG1 A;  4HSA A;  4KV5 A;  1FZV A;  1RV6 V;  1MJV A;  1WAQ A;  3BDY V;  1NT3 A;  4ZBN A;  2H64 A;  5HK5 A;  1TGK A;  1B8M A;  1MKG A;  2KD3 A;  1HCF A;  3KFD A;  2GYZ A;  4MQW A;  2GNN A;  4WPB A;  1XWD B;  3JVF A;  1DZ7 A;  1BJ1 V;  4UHY A;  2GOO A;  1BND A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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