5BQEB

Crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Total Genus 5
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
5
sequence length
101
structure length
97
Chain Sequence
DSDPRRCMRHHYVDSISHPLYKCSSMVLLARCEGHCSQASRSEPLVSFSTVLQPFRSSCHCCRPQTSLALRLRCSGGMRLTATYRYILSCHCEECNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Norrin
publication title Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
pubmed doi rcsb
source organism Homo sapiens
total genus 5
structure length 97
sequence length 101
ec nomenclature
pdb deposition date 2015-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00007 Cys_knot Cystine-knot domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 5bqeB00
1BJ1V 1ZKZA 4QAFC 4GLSE 2X1XE 2KD3A 4YCIC 3QB4A 1BNDB 1KLAA 1M4UL 1HD4A 4KXZA 1NYSB 2C7WA 1CZ8V 2ARVA 5BQCA 1RV6V 1WWWV 2VPFA 1VPPV 1NT3A 1MKGA 1BMPA 2TGIA 3BK3A 1NYUB 5F3BC 4EDWV 1WQ9B 1KLCA 1FL7A 3IJ2A 4MQWB 1HCNA 1TGJA 2QR0C 1B98A 1TZIV 1PDGA 1BETA 2P6AA 3MJGA 4GLNE 3BDYV 1KATW 4AY9B 1MKKA 2X1WA 1MJVA 3HH2A 1VPFA 2R53A 4UI1A 1HCFA 4QHUC 1XWDA 4EAXA 5HI5A 3JVFA 1SGFB 5HHCA 4UHZA 1WQ8A 3BUKA 3QTKA 1B8MB 1FZVA 4KV5A 2ASKA 2GYZA 4HR9A 4LXSJ 5BPUA 4ZBNA 5FV1V 2PJYA 5JZ7A 1TZHV 5F3HI 1AOCA 2BHKA 3E07A 5HHDA 3EVSB 1WQ9A 1REUA 3V6BA 1ES7A 3FUBB 5HHXA 2FJGV 3B4VA 5BQBA 2ARPA 4FAOA 3SEKB 4ZFFC 3S1KV 2QCWA 1HRPB 1QTYR 1QFWB 2QJBA 4EC7A 3EO1C 1S4YB 4HSAA 2QJAA 4UI2B 1BNDA 2H64A 2FJHV 2QCQA 1B8MA 2GH0C 4MIDA 1REWA 1FLTV 1TFGA 5HK5E 1BTGA 4N1DA 5BQEB 4BV4L 1SG1A 4LXRJ 4XPJA 2VXSA 2H62A 4EFVA 1FL7B 3P9WA 2B0UA 2XV7A 1M4UA 2V5EB 4QCIC 5AEJA 4MQWA 5HI3A 5HK5A 4EDXV 5BQ8B 1HRPA 1B8KA 5BQ8D 1QFWA 1DZ7A 3S1BV 5HI4A 4AY9A 1JPYA 1XWDB 4KZNA 5E4GA 2R52A 5FV2V 2IFGE 5HHVA 2GOOA 4YCGC 2GYRA 4MPLA 1KTZA 1LXIA 4UHYA 2QJ9A 2XACA 1LX5A 5BQEA 3BMPA 4X1JA 2GNNA 2VWEA 4WPBA 4HQXA 1AGQA 4UI0A 3RJRA 3MJKA 1E9JA 1HCNB 1WAQA 5BQ8A 3V2AA 3KFDA 1TGKA 4HQUA
chains in the Genus database with same CATH superfamily
1BJ1V 1ZKZA 4QAFC 4GLSE 2X1XE 2KD3A 4YCIC 3QB4A 1BNDB 1KLAA 1M4UL 1HD4A 4KXZA 1NYSB 2C7WA 1CZ8V 2ARVA 5BQCA 1RV6V 1WWWV 2VPFA 1VPPV 1NT3A 1MKGA 1BMPA 2TGIA 3BK3A 1NYUB 5F3BC 4EDWV 1WQ9B 1KLCA 1FL7A 3IJ2A 4MQWB 1HCNA 1TGJA 2QR0C 1B98A 1TZIV 1PDGA 1BETA 2P6AA 3MJGA 4GLNE 3BDYV 1KATW 4AY9B 1MKKA 2X1WA 1MJVA 3HH2A 1VPFA 2R53A 4UI1A 1HCFA 4QHUC 1XWDA 4EAXA 5HI5A 3JVFA 1SGFB 5HHCA 4UHZA 1WQ8A 3BUKA 3QTKA 1B8MB 1FZVA 4KV5A 2ASKA 2GYZA 4HR9A 4LXSJ 5BPUA 4ZBNA 5FV1V 2PJYA 5JZ7A 1TZHV 5F3HI 1AOCA 2BHKA 3E07A 5HHDA 3EVSB 1WQ9A 1REUA 3V6BA 1ES7A 3FUBB 5HHXA 2FJGV 3B4VA 5BQBA 2ARPA 4FAOA 3SEKB 4ZFFC 3S1KV 2QCWA 1HRPB 1QTYR 1QFWB 2QJBA 4EC7A 3EO1C 1S4YB 4HSAA 2QJAA 4UI2B 1BNDA 2H64A 2FJHV 2QCQA 1B8MA 2GH0C 4MIDA 1REWA 1FLTV 1TFGA 5HK5E 1BTGA 4N1DA 5BQEB 4BV4L 1SG1A 4LXRJ 4XPJA 2VXSA 2H62A 4EFVA 1FL7B 3P9WA 2B0UA 2XV7A 1M4UA 2V5EB 4QCIC 5AEJA 4MQWA 5HI3A 5HK5A 4EDXV 5BQ8B 1HRPA 1B8KA 5BQ8D 1QFWA 1DZ7A 3S1BV 5HI4A 4AY9A 1JPYA 1XWDB 4KZNA 5E4GA 2R52A 5FV2V 2IFGE 5HHVA 2GOOA 4YCGC 2GYRA 4MPLA 1KTZA 1LXIA 4UHYA 2QJ9A 2XACA 1LX5A 5BQEA 3BMPA 4X1JA 2GNNA 2VWEA 4WPBA 4HQXA 1AGQA 4UI0A 3RJRA 3MJKA 1E9JA 1HCNB 1WAQA 5BQ8A 3V2AA 3KFDA 1TGKA 4HQUA
chains in the Genus database with same CATH topology
1BJ1V 1ZKZA 4QAFC 4GLSE 2X1XE 2KD3A 4YCIC 3QB4A 1BNDB 1KLAA 1M4UL 1HD4A 4KXZA 1NYSB 2C7WA 1CZ8V 2ARVA 5BQCA 1RV6V 1WWWV 2VPFA 1VPPV 1NT3A 1MKGA 1BMPA 2TGIA 3BK3A 1NYUB 5F3BC 4EDWV 1WQ9B 1KLCA 1FL7A 3IJ2A 4MQWB 1HCNA 1TGJA 2QR0C 1B98A 1TZIV 1PDGA 1BETA 2P6AA 3MJGA 4GLNE 3BDYV 1KATW 4AY9B 1MKKA 2X1WA 1MJVA 3HH2A 1VPFA 2R53A 4UI1A 1HCFA 4QHUC 1XWDA 4EAXA 5HI5A 3JVFA 1SGFB 5HHCA 4UHZA 1WQ8A 3BUKA 3QTKA 1B8MB 1FZVA 4KV5A 2ASKA 2GYZA 4HR9A 4LXSJ 5BPUA 4ZBNA 5FV1V 2PJYA 5JZ7A 1TZHV 5F3HI 1AOCA 2BHKA 3E07A 5HHDA 3EVSB 1WQ9A 1REUA 3V6BA 1ES7A 3FUBB 5HHXA 2FJGV 3B4VA 5BQBA 2ARPA 4FAOA 3SEKB 4ZFFC 3S1KV 2QCWA 1HRPB 1QTYR 1QFWB 2QJBA 4EC7A 3EO1C 1S4YB 4HSAA 2QJAA 4UI2B 1BNDA 2H64A 2FJHV 2QCQA 1B8MA 2GH0C 4MIDA 1REWA 1FLTV 1TFGA 5HK5E 1BTGA 4N1DA 5BQEB 4BV4L 1SG1A 4LXRJ 4XPJA 2VXSA 2H62A 4EFVA 1FL7B 3P9WA 2B0UA 2XV7A 1M4UA 2V5EB 4QCIC 5AEJA 4MQWA 5HI3A 5HK5A 4EDXV 5BQ8B 1HRPA 1B8KA 5BQ8D 1QFWA 1DZ7A 3S1BV 5HI4A 4AY9A 1JPYA 1XWDB 4KZNA 5E4GA 2R52A 5FV2V 2IFGE 5HHVA 2GOOA 4YCGC 2GYRA 4MPLA 1KTZA 1LXIA 4UHYA 2QJ9A 2XACA 1LX5A 5BQEA 3BMPA 4X1JA 2GNNA 2VWEA 4WPBA 4HQXA 1AGQA 4UI0A 3RJRA 3MJKA 1E9JA 1HCNB 1WAQA 5BQ8A 3V2AA 3KFDA 1TGKA 4HQUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BJ1 V;  1ZKZ A;  4QAF C;  4GLS E;  2X1X E;  2KD3 A;  4YCI C;  3QB4 A;  1BND B;  1KLA A;  1M4U L;  1HD4 A;  4KXZ A;  1NYS B;  2C7W A;  1CZ8 V;  2ARV A;  5BQC A;  1RV6 V;  1WWW V;  2VPF A;  1VPP V;  1NT3 A;  1MKG A;  1BMP A;  2TGI A;  3BK3 A;  1NYU B;  5F3B C;  4EDW V;  1WQ9 B;  1KLC A;  1FL7 A;  3IJ2 A;  4MQW B;  1HCN A;  1TGJ A;  2QR0 C;  1B98 A;  1TZI V;  1PDG A;  1BET A;  2P6A A;  3MJG A;  4GLN E;  3BDY V;  1KAT W;  4AY9 B;  1MKK A;  2X1W A;  1MJV A;  3HH2 A;  1VPF A;  2R53 A;  4UI1 A;  1HCF A;  4QHU C;  1XWD A;  4EAX A;  5HI5 A;  3JVF A;  1SGF B;  5HHC A;  4UHZ A;  1WQ8 A;  3BUK A;  3QTK A;  1B8M B;  1FZV A;  4KV5 A;  2ASK A;  2GYZ A;  4HR9 A;  4LXS J;  5BPU A;  4ZBN A;  5FV1 V;  2PJY A;  5JZ7 A;  1TZH V;  5F3H I;  1AOC A;  2BHK A;  3E07 A;  5HHD A;  3EVS B;  1WQ9 A;  1REU A;  3V6B A;  1ES7 A;  3FUB B;  5HHX A;  2FJG V;  3B4V A;  5BQB A;  2ARP A;  4FAO A;  3SEK B;  4ZFF C;  3S1K V;  2QCW A;  1HRP B;  1QTY R;  1QFW B;  2QJB A;  4EC7 A;  3EO1 C;  1S4Y B;  4HSA A;  2QJA A;  4UI2 B;  1BND A;  2H64 A;  2FJH V;  2QCQ A;  1B8M A;  2GH0 C;  4MID A;  1REW A;  1FLT V;  1TFG A;  5HK5 E;  1BTG A;  4N1D A;  5BQE B;  4BV4 L;  1SG1 A;  4LXR J;  4XPJ A;  2VXS A;  2H62 A;  4EFV A;  1FL7 B;  3P9W A;  2B0U A;  2XV7 A;  1M4U A;  2V5E B;  4QCI C;  5AEJ A;  4MQW A;  5HI3 A;  5HK5 A;  4EDX V;  5BQ8 B;  1HRP A;  1B8K A;  5BQ8 D;  1QFW A;  1DZ7 A;  3S1B V;  5HI4 A;  4AY9 A;  1JPY A;  1XWD B;  4KZN A;  5E4G A;  2R52 A;  5FV2 V;  2IFG E;  5HHV A;  2GOO A;  4YCG C;  2GYR A;  4MPL A;  1KTZ A;  1LXI A;  4UHY A;  2QJ9 A;  2XAC A;  1LX5 A;  5BQE A;  3BMP A;  4X1J A;  2GNN A;  2VWE A;  4WPB A;  4HQX A;  1AGQ A;  4UI0 A;  3RJR A;  3MJK A;  1E9J A;  1HCN B;  1WAQ A;  5BQ8 A;  3V2A A;  3KFD A;  1TGK A;  4HQU A; 
#chains in the Genus database with same CATH topology
 1BJ1 V;  1ZKZ A;  4QAF C;  4GLS E;  2X1X E;  2KD3 A;  4YCI C;  3QB4 A;  1BND B;  1KLA A;  1M4U L;  1HD4 A;  4KXZ A;  1NYS B;  2C7W A;  1CZ8 V;  2ARV A;  5BQC A;  1RV6 V;  1WWW V;  2VPF A;  1VPP V;  1NT3 A;  1MKG A;  1BMP A;  2TGI A;  3BK3 A;  1NYU B;  5F3B C;  4EDW V;  1WQ9 B;  1KLC A;  1FL7 A;  3IJ2 A;  4MQW B;  1HCN A;  1TGJ A;  2QR0 C;  1B98 A;  1TZI V;  1PDG A;  1BET A;  2P6A A;  3MJG A;  4GLN E;  3BDY V;  1KAT W;  4AY9 B;  1MKK A;  2X1W A;  1MJV A;  3HH2 A;  1VPF A;  2R53 A;  4UI1 A;  1HCF A;  4QHU C;  1XWD A;  4EAX A;  5HI5 A;  3JVF A;  1SGF B;  5HHC A;  4UHZ A;  1WQ8 A;  3BUK A;  3QTK A;  1B8M B;  1FZV A;  4KV5 A;  2ASK A;  2GYZ A;  4HR9 A;  4LXS J;  5BPU A;  4ZBN A;  5FV1 V;  2PJY A;  5JZ7 A;  1TZH V;  5F3H I;  1AOC A;  2BHK A;  3E07 A;  5HHD A;  3EVS B;  1WQ9 A;  1REU A;  3V6B A;  1ES7 A;  3FUB B;  5HHX A;  2FJG V;  3B4V A;  5BQB A;  2ARP A;  4FAO A;  3SEK B;  4ZFF C;  3S1K V;  2QCW A;  1HRP B;  1QTY R;  1QFW B;  2QJB A;  4EC7 A;  3EO1 C;  1S4Y B;  4HSA A;  2QJA A;  4UI2 B;  1BND A;  2H64 A;  2FJH V;  2QCQ A;  1B8M A;  2GH0 C;  4MID A;  1REW A;  1FLT V;  1TFG A;  5HK5 E;  1BTG A;  4N1D A;  5BQE B;  4BV4 L;  1SG1 A;  4LXR J;  4XPJ A;  2VXS A;  2H62 A;  4EFV A;  1FL7 B;  3P9W A;  2B0U A;  2XV7 A;  1M4U A;  2V5E B;  4QCI C;  5AEJ A;  4MQW A;  5HI3 A;  5HK5 A;  4EDX V;  5BQ8 B;  1HRP A;  1B8K A;  5BQ8 D;  1QFW A;  1DZ7 A;  3S1B V;  5HI4 A;  4AY9 A;  1JPY A;  1XWD B;  4KZN A;  5E4G A;  2R52 A;  5FV2 V;  2IFG E;  5HHV A;  2GOO A;  4YCG C;  2GYR A;  4MPL A;  1KTZ A;  1LXI A;  4UHY A;  2QJ9 A;  2XAC A;  1LX5 A;  5BQE A;  3BMP A;  4X1J A;  2GNN A;  2VWE A;  4WPB A;  4HQX A;  1AGQ A;  4UI0 A;  3RJR A;  3MJK A;  1E9J A;  1HCN B;  1WAQ A;  5BQ8 A;  3V2A A;  3KFD A;  1TGK A;  4HQU A; 
#chains in the Genus database with same CATH homology
 1BJ1 V;  1ZKZ A;  4QAF C;  4GLS E;  2X1X E;  2KD3 A;  4YCI C;  3QB4 A;  1BND B;  1KLA A;  1M4U L;  1HD4 A;  4KXZ A;  1NYS B;  2C7W A;  1CZ8 V;  2ARV A;  5BQC A;  1RV6 V;  1WWW V;  2VPF A;  1VPP V;  1NT3 A;  1MKG A;  1BMP A;  2TGI A;  3BK3 A;  1NYU B;  5F3B C;  4EDW V;  1WQ9 B;  1KLC A;  1FL7 A;  3IJ2 A;  4MQW B;  1HCN A;  1TGJ A;  2QR0 C;  1B98 A;  1TZI V;  1PDG A;  1BET A;  2P6A A;  3MJG A;  4GLN E;  3BDY V;  1KAT W;  4AY9 B;  1MKK A;  2X1W A;  1MJV A;  3HH2 A;  1VPF A;  2R53 A;  4UI1 A;  1HCF A;  4QHU C;  1XWD A;  4EAX A;  5HI5 A;  3JVF A;  1SGF B;  5HHC A;  4UHZ A;  1WQ8 A;  3BUK A;  3QTK A;  1B8M B;  1FZV A;  4KV5 A;  2ASK A;  2GYZ A;  4HR9 A;  4LXS J;  5BPU A;  4ZBN A;  5FV1 V;  2PJY A;  5JZ7 A;  1TZH V;  5F3H I;  1AOC A;  2BHK A;  3E07 A;  5HHD A;  3EVS B;  1WQ9 A;  1REU A;  3V6B A;  1ES7 A;  3FUB B;  5HHX A;  2FJG V;  3B4V A;  5BQB A;  2ARP A;  4FAO A;  3SEK B;  4ZFF C;  3S1K V;  2QCW A;  1HRP B;  1QTY R;  1QFW B;  2QJB A;  4EC7 A;  3EO1 C;  1S4Y B;  4HSA A;  2QJA A;  4UI2 B;  1BND A;  2H64 A;  2FJH V;  2QCQ A;  1B8M A;  2GH0 C;  4MID A;  1REW A;  1FLT V;  1TFG A;  5HK5 E;  1BTG A;  4N1D A;  5BQE B;  4BV4 L;  1SG1 A;  4LXR J;  4XPJ A;  2VXS A;  2H62 A;  4EFV A;  1FL7 B;  3P9W A;  2B0U A;  2XV7 A;  1M4U A;  2V5E B;  4QCI C;  5AEJ A;  4MQW A;  5HI3 A;  5HK5 A;  4EDX V;  5BQ8 B;  1HRP A;  1B8K A;  5BQ8 D;  1QFW A;  1DZ7 A;  3S1B V;  5HI4 A;  4AY9 A;  1JPY A;  1XWD B;  4KZN A;  5E4G A;  2R52 A;  5FV2 V;  2IFG E;  5HHV A;  2GOO A;  4YCG C;  2GYR A;  4MPL A;  1KTZ A;  1LXI A;  4UHY A;  2QJ9 A;  2XAC A;  1LX5 A;  5BQE A;  3BMP A;  4X1J A;  2GNN A;  2VWE A;  4WPB A;  4HQX A;  1AGQ A;  4UI0 A;  3RJR A;  3MJK A;  1E9J A;  1HCN B;  1WAQ A;  5BQ8 A;  3V2A A;  3KFD A;  1TGK A;  4HQU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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