5CGJA

Crystal structure of murine keap1 in complex with ra839, a non-covalent small-molecule binder to keap1 and selective activator of nrf2 signalling.
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
molecule keywords Kelch-like ECH-associated protein 1
publication title Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
pubmed doi rcsb
source organism Mus musculus
total genus 61
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2015-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5cgjA00
4ZGCA 3ADEA 5FNQA 5FNTA 2ZZKA 5F72C 4CHBA 5FNUA 4L7CA 4IFLX 1X2RA 4IFJA 2ZW9A 5FZJA 3ZGDA 4CH9A 4L7DA 2VPJA 4IQKA 4L7BA 5CGJA 1U6DX 3WN7A 4ASCA 4YY8A 1X2JA 4IFNX 5FNRA 5FZNA 4IN4A 2Z32A 3II7A 3WDZA 2DYHA 2WOZA 4ZY3A 2XN4A 5FNSA 1ZGKA 3ZGCA 4N1BA 3VNGA 3VNHA 2FLUX 4XMBA 2ZWAA
chains in the Genus database with same CATH superfamily
3TI6A 3CL0A 1NPEA 4FJ6A 5FNQA 4WEFA 2F27A 4XE9A 4UOUA 1IUCA 3T1EA 4H52A 1N1VA 1N1TA 1Q7FA 2F25A 2VPJA 1NNCA 3SALA 2GVVA 1U6DX 4GNCA 4YY8A 2SLIA 1Z50A 3D12A 1N6DA 4CPYA 4GJTA 1W1XA 1NCBN 3VNGA 4MX0A 2QWEA 5EO7A 2F26A 1KITA 1INGA 1NMCA 2FP8A 3ADEA 4MWQA 4MJUA 1MS1A 4YZ1A 2VK6A 4QN3A 4GNBA 4FZHA 1MR5A 4FPYA 3Q6KA 4YZ2A 4XJWA 1W21A 1DILA 1ZI0A 2QWKA 2QWCA 3WW9A 3ALXA 4CSDA 2C4LA 3NN9A 2VSMA 3CKZA 4JMLA 1W20A 4CPZA 1X2JA 4XIKA 4IN4A 5GX5A 2DYHA 4MWVA 1NCCN 3SRGA 4B7MA 4KS4A 2B8HA 4YW4A 1ZGKA 3ZGCA 3AMRA 2GVUA 2HTYA 2QE8A 4K1KA 4XOGA 4CPOA 2DG0A 3CYEA 2HTQA 4IFLX 3K37A 3TI4A 2P4OA 3ZGDA 1INYA 1NMBN 4A0PA 2JKBA 4ASCA 2CMLA 2QWBA 4O5SA 1N1SA 3WDZA 3V65B 3O9KA 4AGTA 2ZB6A 2W38A 5GX3A 4FP3A 4CPLA 1SO7A 4CPNA 4KS5A 3VNHA 4FOYA 4QNPA 2FLUX 4HZZA 4KS1A 4WEGA 2ZWAA 5FWWA 3SOVA 5GTQA 2POOA 3GVKA 1NN2A 3SLIA 2AH2A 3S94A 4L7DA 3INBA 4B7RA 1V0ZA 4C1YB 2VWDA 1RWLA 4FOWA 2HU4A 4D52C 2IAWA 4GN9A 4M4VA 1MS3A 1NSBA 4MZEA 4XJ9A 1IVDA 2F13A 1V3BA 2YA7A 1S0IA 3B69A 5M1ZA 1IUBA 2YA5A 4XJUA 3DR2A 3B7EA 1IVBA 3WWAA 5HUGA 1IJQA 4HZYA 2XZIA 1QBIA 2VK7A 1MWEA 2YA6A 3O9JA 1MS4A 2F28A 4MWWA 4XJQA 2HT5A 4FPGA 3TC9A 1B9TA 3KYAA 2WOZA 3HLHA 1F8EA 5EX7A 1V2IA 1N7DA 2VSKA 4XMBA 4CH9A 6NN9A 5GX1A 1XOEA 4GB1A 4FPEA 3S8ZA 4FVKA 4D4UA 4MWXA 5D9DA 4MWJA 4FPHA 3H6JA 4C1YA 2W8BB 3TIAA 2IAPA 1F8CA 1Z4YA 4QN7A 4YZ3A 4SLIA 3IAXA 1C9UA 4Q1UA 1NSDA 1USRA 2F0ZA 2HTUA 2A75A 3NO0A 2FPBA 5D9CA 4MWLA 4GEZA 2W20A 4HW6A 4XILA 3G4EA 1X2RA 2IATA 3K39A 4B7NA 4X47A 2H2NA 1CRZA 1E8TA 2HTWA 1DIMA 4IQKA 4HHQA 1Z4VA 4AGIA 3Q6PA 1INFA 1IVFA 3BYCA 4M4NA 3Q6TA 2XN4A 4GZOA 4CPMA 3GVJA 4YW2A 1S18A 4BBWA 4CHBA 2HT7A 3LI4A 1A4GA 4IFJA 1POOA 5FZJA 1NMAN 3HRPA 4K1IA 4L7BA 2ZB5A 1SUUA 4Q6KA 4H53A 2F11A 2AGSA 4NC5A 2YA4A 1NCAN 5D9BA 1N6EA 3SOBB 4HZWA 3G4HA 3K38A 3U0SA 2VAQA 1Z4ZA 2BERA 1SLLA 1MZ6A 4FOQA 2BF6A 1IVGA 4HHOA 3NSSA 2YDTA 4XJZA 4AHAA 4X6KA 1INWA 5GX4A 2IASA 4K3YA 3E5ZA 1OFZA 2DG1A 2QWGA 3K3AA 4WA5A 3D11A 1W0PA 3I1CA 2V91A 4IMBA 4B7QA 4GZWA 5B2CA 4N1BA 1CRUA 4YZ5A 1INHA 2C4AA 2IAQA 3FW0A 2VW1A 4WA4A 2FPCA 3SOQA 2W5OA 2FHRA 2ZZKA 4DGRA 3V64C 3KGGA 2YA8A 2HTRA 1CQ1A 3AMSA 2SIMA 2BZDA 1SLIA 2X9MA 3HLIA 4XJRA 1PJXA 2QWIA 5FNRA 1L7GA 4XIOA 3TI8A 1Z4WA 5HUNA 3SILA 4GZSA 2ISMA 1USXA 3BEQA 2HTVA 2GHSA 1MS0A 3L6VA 4MJVA 4FPLA 1WP5A 4G3NA 2XZKA 1F8BA 4YW3A 3S2KA 1MZ5A 1WCSA 1NNAA 3JU4A 1CVMA 1H6LA 5HUMA 4FPCA 2FP9A 3TI5A 5FZNA 3GVLA 3UC1A 2IAXA 4XYXA 4HZVA 4FQ4A 2VK5A 3DASA 1E8VA 1S0JA 2YDPA 5FNTA 2H2UA 5F72C 2QWJA 1SNTA 3A72A 2IAOA 1W0OA 2W5NA 4L7CA 2HU0A 2VW0A 5HUKA 4GDJA 2BATA 4MZAA 4XJAA 4GZQA 1L7HA 7NN9A 4GZPA 4XHXA 5JYYA 1F8DA 4K1HA 2GVXA 3A9GA 3II7A 1XOGA 4JF7A 5GX2A 4FPKA 1V3CA 2QWFA 4XMIA 4FOVA 3H73A 4GN7A 1MS5A 4GZXA 2F24A 4HZXA 4XMAA 4M3MA 1K32A 4QN5A 5EO8A 3S8VA 1BJIA 4D8SA 1W8OA 3K36A 4O5TA 1V0EA 1MS8A 1VCUA 1WCQA 3OPZA 3PJQA 4D52B 2F10A 2ZW9A 4HIZA 4FPJA 5CGJA 4MC7A 1EUUA 2OJHA 4MWUA 3WN7A 3SREA 5HX0A 1IVEA 1QLGA 1N6FA 2GVWA 2W8BA 3H72A 4X4AA 4M4UA 1NCDN 4B7JA 2QWDA 4K1JA 4QN6A 4UF7A 2G8SA 2VW2A 2RKCA 1INVA 2HT8A 4ZGCA 2IARA 3A9HA 4X49A 4GN8A 1A4QA 1E1AA 4ZLRA 4YZ4A 2F12A 1B9SA 1W8NA 4MWRA 3TICA 4GDIA 4XHBA 4AH4A 1EUTA 4QN4A 3P5BL 4WA3A 3O4PA 4I00A 1Z4XA 4FPFA 3CL2A 2AEPA 5H47A 1MS9A 4PWZA 5NN9A 4NN9A 1S1DA 2XZJA 4NCSA 5FNUA 4KS2A 2VVZA 1B9VA 1INXA 4D52A 1RWIA 3FVZA 4KS3A 2XCYA 3SANA 3LI3A 1EUSA 4FPOB 1V3EA 2DSOA 1EURA 2SILA 4J9TA 3W09A 2Z32A 2AEQA 4YW1A 4ZY3A 4DG6A 1N1YA 1NSCA 3H71A 1C5KA 1E8UA 4MWYA 2QWAA 3A71A 5B2DA 1V0FA 2F29A 4YW5A 4GNAA 1L7FA 3TI3A 1V04A 1NNBA 2IAVA 3LI5A 3TIBA 1A14N 4XJ8A 3ALWA 4IFNX 4R40A 4GZTA 2QWHA 1IVCA 5FNSA 2IVZA 4IYGA 3V1SA 1V3DA 2IAUA 1VCJA 4FP2A 5F9TA 2HQSA
chains in the Genus database with same CATH topology
4ZGCA 3ADEA 5FNQA 5FNTA 2ZZKA 5F72C 4CHBA 5FNUA 4L7CA 4IFLX 1X2RA 4IFJA 2ZW9A 5FZJA 3ZGDA 4CH9A 4L7DA 2VPJA 4IQKA 4L7BA 5CGJA 1U6DX 3WN7A 4ASCA 4YY8A 1X2JA 4IFNX 5FNRA 5FZNA 4IN4A 2Z32A 3II7A 3WDZA 2DYHA 2WOZA 4ZY3A 2XN4A 5FNSA 1ZGKA 3ZGCA 4N1BA 3VNGA 3VNHA 2FLUX 4XMBA 2ZWAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZGC A;  3ADE A;  5FNQ A;  5FNT A;  2ZZK A;  5F72 C;  4CHB A;  5FNU A;  4L7C A;  4IFL X;  1X2R A;  4IFJ A;  2ZW9 A;  5FZJ A;  3ZGD A;  4CH9 A;  4L7D A;  2VPJ A;  4IQK A;  4L7B A;  5CGJ A;  1U6D X;  3WN7 A;  4ASC A;  4YY8 A;  1X2J A;  4IFN X;  5FNR A;  5FZN A;  4IN4 A;  2Z32 A;  3II7 A;  3WDZ A;  2DYH A;  2WOZ A;  4ZY3 A;  2XN4 A;  5FNS A;  1ZGK A;  3ZGC A;  4N1B A;  3VNG A;  3VNH A;  2FLU X;  4XMB A;  2ZWA A; 
#chains in the Genus database with same CATH topology
 3TI6 A;  3CL0 A;  1NPE A;  4FJ6 A;  5FNQ A;  4WEF A;  2F27 A;  4XE9 A;  4UOU A;  1IUC A;  3T1E A;  4H52 A;  1N1V A;  1N1T A;  1Q7F A;  2F25 A;  2VPJ A;  1NNC A;  3SAL A;  2GVV A;  1U6D X;  4GNC A;  4YY8 A;  2SLI A;  1Z50 A;  3D12 A;  1N6D A;  4CPY A;  4GJT A;  1W1X A;  1NCB N;  3VNG A;  4MX0 A;  2QWE A;  5EO7 A;  2F26 A;  1KIT A;  1ING A;  1NMC A;  2FP8 A;  3ADE A;  4MWQ A;  4MJU A;  1MS1 A;  4YZ1 A;  2VK6 A;  4QN3 A;  4GNB A;  4FZH A;  1MR5 A;  4FPY A;  3Q6K A;  4YZ2 A;  4XJW A;  1W21 A;  1DIL A;  1ZI0 A;  2QWK A;  2QWC A;  3WW9 A;  3ALX A;  4CSD A;  2C4L A;  3NN9 A;  2VSM A;  3CKZ A;  4JML A;  1W20 A;  4CPZ A;  1X2J A;  4XIK A;  4IN4 A;  5GX5 A;  2DYH A;  4MWV A;  1NCC N;  3SRG A;  4B7M A;  4KS4 A;  2B8H A;  4YW4 A;  1ZGK A;  3ZGC A;  3AMR A;  2GVU A;  2HTY A;  2QE8 A;  4K1K A;  4XOG A;  4CPO A;  2DG0 A;  3CYE A;  2HTQ A;  4IFL X;  3K37 A;  3TI4 A;  2P4O A;  3ZGD A;  1INY A;  1NMB N;  4A0P A;  2JKB A;  4ASC A;  2CML A;  2QWB A;  4O5S A;  1N1S A;  3WDZ A;  3V65 B;  3O9K A;  4AGT A;  2ZB6 A;  2W38 A;  5GX3 A;  4FP3 A;  4CPL A;  1SO7 A;  4CPN A;  4KS5 A;  3VNH A;  4FOY A;  4QNP A;  2FLU X;  4HZZ A;  4KS1 A;  4WEG A;  2ZWA A;  5FWW A;  3SOV A;  5GTQ A;  2POO A;  3GVK A;  1NN2 A;  3SLI A;  2AH2 A;  3S94 A;  4L7D A;  3INB A;  4B7R A;  1V0Z A;  4C1Y B;  2VWD A;  1RWL A;  4FOW A;  2HU4 A;  4D52 C;  2IAW A;  4GN9 A;  4M4V A;  1MS3 A;  1NSB A;  4MZE A;  4XJ9 A;  1IVD A;  2F13 A;  1V3B A;  2YA7 A;  1S0I A;  3B69 A;  5M1Z A;  1IUB A;  2YA5 A;  4XJU A;  3DR2 A;  3B7E A;  1IVB A;  3WWA A;  5HUG A;  1IJQ A;  4HZY A;  2XZI A;  1QBI A;  2VK7 A;  1MWE A;  2YA6 A;  3O9J A;  1MS4 A;  2F28 A;  4MWW A;  4XJQ A;  2HT5 A;  4FPG A;  3TC9 A;  1B9T A;  3KYA A;  2WOZ A;  3HLH A;  1F8E A;  5EX7 A;  1V2I A;  1N7D A;  2VSK A;  4XMB A;  4CH9 A;  6NN9 A;  5GX1 A;  1XOE A;  4GB1 A;  4FPE A;  3S8Z A;  4FVK A;  4D4U A;  4MWX A;  5D9D A;  4MWJ A;  4FPH A;  3H6J A;  4C1Y A;  2W8B B;  3TIA A;  2IAP A;  1F8C A;  1Z4Y A;  4QN7 A;  4YZ3 A;  4SLI A;  3IAX A;  1C9U A;  4Q1U A;  1NSD A;  1USR A;  2F0Z A;  2HTU A;  2A75 A;  3NO0 A;  2FPB A;  5D9C A;  4MWL A;  4GEZ A;  2W20 A;  4HW6 A;  4XIL A;  3G4E A;  1X2R A;  2IAT A;  3K39 A;  4B7N A;  4X47 A;  2H2N A;  1CRZ A;  1E8T A;  2HTW A;  1DIM A;  4IQK A;  4HHQ A;  1Z4V A;  4AGI A;  3Q6P A;  1INF A;  1IVF A;  3BYC A;  4M4N A;  3Q6T A;  2XN4 A;  4GZO A;  4CPM A;  3GVJ A;  4YW2 A;  1S18 A;  4BBW A;  4CHB A;  2HT7 A;  3LI4 A;  1A4G A;  4IFJ A;  1POO A;  5FZJ A;  1NMA N;  3HRP A;  4K1I A;  4L7B A;  2ZB5 A;  1SUU A;  4Q6K A;  4H53 A;  2F11 A;  2AGS A;  4NC5 A;  2YA4 A;  1NCA N;  5D9B A;  1N6E A;  3SOB B;  4HZW A;  3G4H A;  3K38 A;  3U0S A;  2VAQ A;  1Z4Z A;  2BER A;  1SLL A;  1MZ6 A;  4FOQ A;  2BF6 A;  1IVG A;  4HHO A;  3NSS A;  2YDT A;  4XJZ A;  4AHA A;  4X6K A;  1INW A;  5GX4 A;  2IAS A;  4K3Y A;  3E5Z A;  1OFZ A;  2DG1 A;  2QWG A;  3K3A A;  4WA5 A;  3D11 A;  1W0P A;  3I1C A;  2V91 A;  4IMB A;  4B7Q A;  4GZW A;  5B2C A;  4N1B A;  1CRU A;  4YZ5 A;  1INH A;  2C4A A;  2IAQ A;  3FW0 A;  2VW1 A;  4WA4 A;  2FPC A;  3SOQ A;  2W5O A;  2FHR A;  2ZZK A;  4DGR A;  3V64 C;  3KGG A;  2YA8 A;  2HTR A;  1CQ1 A;  3AMS A;  2SIM A;  2BZD A;  1SLI A;  2X9M A;  3HLI A;  4XJR A;  1PJX A;  2QWI A;  5FNR A;  1L7G A;  4XIO A;  3TI8 A;  1Z4W A;  5HUN A;  3SIL A;  4GZS A;  2ISM A;  1USX A;  3BEQ A;  2HTV A;  2GHS A;  1MS0 A;  3L6V A;  4MJV A;  4FPL A;  1WP5 A;  4G3N A;  2XZK A;  1F8B A;  4YW3 A;  3S2K A;  1MZ5 A;  1WCS A;  1NNA A;  3JU4 A;  1CVM A;  1H6L A;  5HUM A;  4FPC A;  2FP9 A;  3TI5 A;  5FZN A;  3GVL A;  3UC1 A;  2IAX A;  4XYX A;  4HZV A;  4FQ4 A;  2VK5 A;  3DAS A;  1E8V A;  1S0J A;  2YDP A;  5FNT A;  2H2U A;  5F72 C;  2QWJ A;  1SNT A;  3A72 A;  2IAO A;  1W0O A;  2W5N A;  4L7C A;  2HU0 A;  2VW0 A;  5HUK A;  4GDJ A;  2BAT A;  4MZA A;  4XJA A;  4GZQ A;  1L7H A;  7NN9 A;  4GZP A;  4XHX A;  5JYY A;  1F8D A;  4K1H A;  2GVX A;  3A9G A;  3II7 A;  1XOG A;  4JF7 A;  5GX2 A;  4FPK A;  1V3C A;  2QWF A;  4XMI A;  4FOV A;  3H73 A;  4GN7 A;  1MS5 A;  4GZX A;  2F24 A;  4HZX A;  4XMA A;  4M3M A;  1K32 A;  4QN5 A;  5EO8 A;  3S8V A;  1BJI A;  4D8S A;  1W8O A;  3K36 A;  4O5T A;  1V0E A;  1MS8 A;  1VCU A;  1WCQ A;  3OPZ A;  3PJQ A;  4D52 B;  2F10 A;  2ZW9 A;  4HIZ A;  4FPJ A;  5CGJ A;  4MC7 A;  1EUU A;  2OJH A;  4MWU A;  3WN7 A;  3SRE A;  5HX0 A;  1IVE A;  1QLG A;  1N6F A;  2GVW A;  2W8B A;  3H72 A;  4X4A A;  4M4U A;  1NCD N;  4B7J A;  2QWD A;  4K1J A;  4QN6 A;  4UF7 A;  2G8S A;  2VW2 A;  2RKC A;  1INV A;  2HT8 A;  4ZGC A;  2IAR A;  3A9H A;  4X49 A;  4GN8 A;  1A4Q A;  1E1A A;  4ZLR A;  4YZ4 A;  2F12 A;  1B9S A;  1W8N A;  4MWR A;  3TIC A;  4GDI A;  4XHB A;  4AH4 A;  1EUT A;  4QN4 A;  3P5B L;  4WA3 A;  3O4P A;  4I00 A;  1Z4X A;  4FPF A;  3CL2 A;  2AEP A;  5H47 A;  1MS9 A;  4PWZ A;  5NN9 A;  4NN9 A;  1S1D A;  2XZJ A;  4NCS A;  5FNU A;  4KS2 A;  2VVZ A;  1B9V A;  1INX A;  4D52 A;  1RWI A;  3FVZ A;  4KS3 A;  2XCY A;  3SAN A;  3LI3 A;  1EUS A;  4FPO B;  1V3E A;  2DSO A;  1EUR A;  2SIL A;  4J9T A;  3W09 A;  2Z32 A;  2AEQ A;  4YW1 A;  4ZY3 A;  4DG6 A;  1N1Y A;  1NSC A;  3H71 A;  1C5K A;  1E8U A;  4MWY A;  2QWA A;  3A71 A;  5B2D A;  1V0F A;  2F29 A;  4YW5 A;  4GNA A;  1L7F A;  3TI3 A;  1V04 A;  1NNB A;  2IAV A;  3LI5 A;  3TIB A;  1A14 N;  4XJ8 A;  3ALW A;  4IFN X;  4R40 A;  4GZT A;  2QWH A;  1IVC A;  5FNS A;  2IVZ A;  4IYG A;  3V1S A;  1V3D A;  2IAU A;  1VCJ A;  4FP2 A;  5F9T A;  2HQS A; 
#chains in the Genus database with same CATH homology
 4ZGC A;  3ADE A;  5FNQ A;  5FNT A;  2ZZK A;  5F72 C;  4CHB A;  5FNU A;  4L7C A;  4IFL X;  1X2R A;  4IFJ A;  2ZW9 A;  5FZJ A;  3ZGD A;  4CH9 A;  4L7D A;  2VPJ A;  4IQK A;  4L7B A;  5CGJ A;  1U6D X;  3WN7 A;  4ASC A;  4YY8 A;  1X2J A;  4IFN X;  5FNR A;  5FZN A;  4IN4 A;  2Z32 A;  3II7 A;  3WDZ A;  2DYH A;  2WOZ A;  4ZY3 A;  2XN4 A;  5FNS A;  1ZGK A;  3ZGC A;  4N1B A;  3VNG A;  3VNH A;  2FLU X;  4XMB A;  2ZWA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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