5CQ2A

Crystal structure of tandem ww domains of itch in complex with txnip peptide
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
80
structure length
76
Chain Sequence
GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
total genus 11
structure length 76
sequence length 80
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2015-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 5cq2A02
2DMVA 3KAIA 2Q5AA 3KAFA 4E5RA 4REXA 3KABA 2XPAA 1K9RA 1NMVA 2ZQTA 2JMFA 2M3OW 2XP9A 1O6WA 2ZR4A 3TDBA 2ZR6A 3WH0A 3M7NA 1YW5A 1EG3A 1JMQA 5AHTA 2YSGA 2YSFA 2F21A 2ZAJA 3LE4A 3KCEA 2ZQSA 3KAGA 2DWVA 2JV4A 2BA1A 2M8JA 2XP4A 2JX8A 4QIBA 4U86A 2ZR5A 4U85A 1ZCNA 2ZQVA 2YSHA 2DK1A 3OOBA 2E45A 2L4JA 2XP6A 2DK7A 1K9QA 2MDIA 2M8IA 1I5HW 1EG4A 2RE3A 2XP7A 2XP3A 2ITKA 3L4HA 3KAHA 2LAJA 2ZQUA 2KXQA 1WMVA 3TCZA 3TC5A 3KADA 2DJYA 2JXWA 2XP5A 1PINA 2XPBA 2EZ5W 2XP8A 3CNGA 1F8AB 2YSBA 3ODKA 3M85A 1WR7A 1TK7A 5CQ2A 2YSIA 4U84A 3NTPA
chains in the Genus database with same CATH superfamily
2DMVA 3KAIA 2Q5AA 5U47A 2QRVA 3KAFA 5E64A 2OWOA 4GLXA 4E5RA 4REXA 3MCBB 3KABA 2YAJB 2XPAA 1K9RA 3LKXB 1NMVA 2ZQTA 2JMFA 2M3OW 2XP9A 1O6WA 5E62A 1RP5A 2ZR4A 3TDBA 2ZR6A 3WH0A 3M7NA 1YW5A 1EG3A 1JMQA 5AHTA 2YSGA 2YSFA 2F21A 2ZAJA 3LE4A 3KCEA 5E66A 2ZQSA 5E5WA 3KAGA 3MCBA 2DWVA 2JV4A 2BA1A 2Y8NB 2M8JA 3LKXA 2XP4A 2JX8A 4QIBA 4U86A 2ZR5A 4U85A 1ZCNA 2ZQVA 2WAEA 2YSHA 3PQHA 1FLCA 2DK1A 3OOBA 2E45A 2L4JA 2XP6A 2DK7A 3MQHA 2MDIA 1K9QA 2M8IA 4A0UA 1I5HW 1EG4A 2RE3A 2XP7A 2XP3A 2ITKA 3L4HA 3KAHA 5E65A 3FSCA 3FS8A 2LAJA 2ZQUA 3FSBA 2KXQA 1WMVA 3TCZA 3TC5A 3KADA 1TR8A 2DJYA 2JXWA 2XP5A 1PINA 2XPBA 4A0TA 3MQGA 2EZ5W 2XP8A 3CNGA 1F8AB 2YSBA 3ODKA 3M85A 1WR7A 1TK7A 5CQ2A 2WADA 2YSIA 4U84A 3NTPA
chains in the Genus database with same CATH topology
2DMVA 3KAIA 2Q5AA 5U47A 2QRVA 3KAFA 5E64A 2OWOA 4GLXA 4E5RA 4REXA 3MCBB 3KABA 2YAJB 2XPAA 1K9RA 3LKXB 1NMVA 2ZQTA 2JMFA 2M3OW 2XP9A 1O6WA 5E62A 1RP5A 2ZR4A 3TDBA 2ZR6A 3WH0A 3M7NA 1YW5A 1EG3A 1JMQA 5AHTA 2YSGA 2YSFA 2F21A 2ZAJA 3LE4A 3KCEA 5E66A 2ZQSA 5E5WA 3KAGA 3MCBA 2DWVA 2JV4A 2BA1A 2Y8NB 2M8JA 3LKXA 2XP4A 2JX8A 4QIBA 4U86A 2ZR5A 4U85A 1ZCNA 2ZQVA 2WAEA 2YSHA 3PQHA 1FLCA 2DK1A 3OOBA 2E45A 2L4JA 2XP6A 2DK7A 3MQHA 2MDIA 1K9QA 2M8IA 4A0UA 1I5HW 1EG4A 2RE3A 2XP7A 2XP3A 2ITKA 3L4HA 3KAHA 5E65A 3FSCA 3FS8A 2LAJA 2ZQUA 3FSBA 2KXQA 1WMVA 3TCZA 3TC5A 3KADA 1TR8A 2DJYA 2JXWA 2XP5A 1PINA 2XPBA 4A0TA 3MQGA 2EZ5W 2XP8A 3CNGA 1F8AB 2YSBA 3ODKA 3M85A 1WR7A 1TK7A 5CQ2A 2WADA 2YSIA 4U84A 3NTPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DMV A;  3KAI A;  2Q5A A;  3KAF A;  4E5R A;  4REX A;  3KAB A;  2XPA A;  1K9R A;  1NMV A;  2ZQT A;  2JMF A;  2M3O W;  2XP9 A;  1O6W A;  2ZR4 A;  3TDB A;  2ZR6 A;  3WH0 A;  3M7N A;  1YW5 A;  1EG3 A;  1JMQ A;  5AHT A;  2YSG A;  2YSF A;  2F21 A;  2ZAJ A;  3LE4 A;  3KCE A;  2ZQS A;  3KAG A;  2DWV A;  2JV4 A;  2BA1 A;  2M8J A;  2XP4 A;  2JX8 A;  4QIB A;  4U86 A;  2ZR5 A;  4U85 A;  1ZCN A;  2ZQV A;  2YSH A;  2DK1 A;  3OOB A;  2E45 A;  2L4J A;  2XP6 A;  2DK7 A;  1K9Q A;  2MDI A;  2M8I A;  1I5H W;  1EG4 A;  2RE3 A;  2XP7 A;  2XP3 A;  2ITK A;  3L4H A;  3KAH A;  2LAJ A;  2ZQU A;  2KXQ A;  1WMV A;  3TCZ A;  3TC5 A;  3KAD A;  2DJY A;  2JXW A;  2XP5 A;  1PIN A;  2XPB A;  2EZ5 W;  2XP8 A;  3CNG A;  1F8A B;  2YSB A;  3ODK A;  3M85 A;  1WR7 A;  1TK7 A;  5CQ2 A;  2YSI A;  4U84 A;  3NTP A; 
#chains in the Genus database with same CATH topology
 2DMV A;  3KAI A;  2Q5A A;  5U47 A;  2QRV A;  3KAF A;  5E64 A;  2OWO A;  4GLX A;  4E5R A;  4REX A;  3MCB B;  3KAB A;  2YAJ B;  2XPA A;  1K9R A;  3LKX B;  1NMV A;  2ZQT A;  2JMF A;  2M3O W;  2XP9 A;  1O6W A;  5E62 A;  1RP5 A;  2ZR4 A;  3TDB A;  2ZR6 A;  3WH0 A;  3M7N A;  1YW5 A;  1EG3 A;  1JMQ A;  5AHT A;  2YSG A;  2YSF A;  2F21 A;  2ZAJ A;  3LE4 A;  3KCE A;  5E66 A;  2ZQS A;  5E5W A;  3KAG A;  3MCB A;  2DWV A;  2JV4 A;  2BA1 A;  2Y8N B;  2M8J A;  3LKX A;  2XP4 A;  2JX8 A;  4QIB A;  4U86 A;  2ZR5 A;  4U85 A;  1ZCN A;  2ZQV A;  2WAE A;  2YSH A;  3PQH A;  1FLC A;  2DK1 A;  3OOB A;  2E45 A;  2L4J A;  2XP6 A;  2DK7 A;  3MQH A;  2MDI A;  1K9Q A;  2M8I A;  4A0U A;  1I5H W;  1EG4 A;  2RE3 A;  2XP7 A;  2XP3 A;  2ITK A;  3L4H A;  3KAH A;  5E65 A;  3FSC A;  3FS8 A;  2LAJ A;  2ZQU A;  3FSB A;  2KXQ A;  1WMV A;  3TCZ A;  3TC5 A;  3KAD A;  1TR8 A;  2DJY A;  2JXW A;  2XP5 A;  1PIN A;  2XPB A;  4A0T A;  3MQG A;  2EZ5 W;  2XP8 A;  3CNG A;  1F8A B;  2YSB A;  3ODK A;  3M85 A;  1WR7 A;  1TK7 A;  5CQ2 A;  2WAD A;  2YSI A;  4U84 A;  3NTP A; 
#chains in the Genus database with same CATH homology
 2DMV A;  3KAI A;  2Q5A A;  5U47 A;  2QRV A;  3KAF A;  5E64 A;  2OWO A;  4GLX A;  4E5R A;  4REX A;  3MCB B;  3KAB A;  2YAJ B;  2XPA A;  1K9R A;  3LKX B;  1NMV A;  2ZQT A;  2JMF A;  2M3O W;  2XP9 A;  1O6W A;  5E62 A;  1RP5 A;  2ZR4 A;  3TDB A;  2ZR6 A;  3WH0 A;  3M7N A;  1YW5 A;  1EG3 A;  1JMQ A;  5AHT A;  2YSG A;  2YSF A;  2F21 A;  2ZAJ A;  3LE4 A;  3KCE A;  5E66 A;  2ZQS A;  5E5W A;  3KAG A;  3MCB A;  2DWV A;  2JV4 A;  2BA1 A;  2Y8N B;  2M8J A;  3LKX A;  2XP4 A;  2JX8 A;  4QIB A;  4U86 A;  2ZR5 A;  4U85 A;  1ZCN A;  2ZQV A;  2WAE A;  2YSH A;  3PQH A;  1FLC A;  2DK1 A;  3OOB A;  2E45 A;  2L4J A;  2XP6 A;  2DK7 A;  3MQH A;  2MDI A;  1K9Q A;  2M8I A;  4A0U A;  1I5H W;  1EG4 A;  2RE3 A;  2XP7 A;  2XP3 A;  2ITK A;  3L4H A;  3KAH A;  5E65 A;  3FSC A;  3FS8 A;  2LAJ A;  2ZQU A;  3FSB A;  2KXQ A;  1WMV A;  3TCZ A;  3TC5 A;  3KAD A;  1TR8 A;  2DJY A;  2JXW A;  2XP5 A;  1PIN A;  2XPB A;  4A0T A;  3MQG A;  2EZ5 W;  2XP8 A;  3CNG A;  1F8A B;  2YSB A;  3ODK A;  3M85 A;  1WR7 A;  1TK7 A;  5CQ2 A;  2WAD A;  2YSI A;  4U84 A;  3NTP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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