5HPBA

Human dihydrofolate reductase complex with nadph and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series offluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 50
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hpbA00
1OHKA 5HSUA 1CD2A 3DL6A 4QJCA 3ROAA 1DHIA 3L3RA 3FQCA 1LUDA 1PD9A 1DR5A 1RF7A 1U70A 3K74A 1SEJA 3EEMA 4ELBA 3NZDA 3TQAA 1D1GA 1DR7A 2OBCA 1E26A 3LG4A 7DFRA 3CSEA 1KMVA 4IXGX 4IXED 4DP3A 1RD7A 3GI2A 5HVBA 4LAGX 3DFRA 2XW7A 3DL5A 4M6KA 3UM5A 3FREX 1RX6A 3QL0A 4GH8A 4XRBA 3NZ9X 3FL9A 4P3QA 5ECXA 2W3AA 4QJZD 3S9UA 1QZFA 4KNEA 3F8YA 3M08A 3FYVX 3JSUA 1JOMA 5CC9A 4M7UA 4X5FA 1LY4A 1RX1A 3KJRA 3FQVA 1JOLA 5HF0X 2ITHA 4KL9A 3NXXA 3CD2A 3TQ9A 2CD2A 1DG7A 3IA5A 3QLYA 5E8QA 4KFJA 3NXTA 4M6JA 5U26A 1DDSA 3CL9A 4ELGA 1RX8A 5HT5A 1BOZA 4XT4A 3K2HA 1AOEA 3IA4A 3NZCX 3IRNA 3DAUA 4XE6X 1M78A 4EILA 3SRUX 1IA4A 3RG9A 3QL3A 4FHBA 4Q0EA 3QGTA 3ZPCA 3QLRA 2BLBA 4G3MA 2W3VA 5HVEA 3IROA 5JG0X 1DYJA 3FRAX 2BL9A 1AI9A 3VCOA 1DG8A 4KY8A 4H98A 5HSRA 2W9HA 3NTZA 4RGCA 2GD9A 1KMSA 5HT4A 1KLKA 3FS6A 1DYIA 4CD2A 3EX8A 3GHWA 1RE7A 4KM0A 2W3MA 3K47A 3QYOA 3R33A 1AO8A 1J3IA 3SAIA 1S3WA 4FGHA 4P66A 4QLEA 4P3RA 4HOFA 4KM2A 2W9GA 4KJKA 1TDRA 3KFYA 3SRSX 4I1NA 3NU0A 1DRAA 1ZDRA 3NZ6X 1RG7A 1U71A 5ECCA 4PTJA 1DLRA 4M6LA 4XT6A 1DYHA 2JYBA 4EIGA 4KBNA 3HBBA 6DFRA 1RX2A 4PSYA 3SRRX 2W3BA 1DIUA 2C2SA 1S3YA 3FRFX 1HFQA 3JTWA 2FZJA 2P4GA 4X5GA 1RB3A 1RH3A 4HOEA 3NRRA 1DR4A 3SA2A 1RA9A 1J3JA 1JUVA 3QLXA 1S3VA 1RX5A 3K45A 3I3RA 3SRQX 4P68A 1M79A 5EAJA 5JA3A 3D80A 1U72A 1RX3A 3QLWA 4PTHA 1J3KA 3FY8X 3GHCA 4KAKA 3F0VX 1DHFA 2H2QA 5DFRA 3NZBX 3KGYA 4HA7A 5HPBA 2HQPA 3NXYA 1RC4A 1DHJA 4DFRA 2INQA 4OR7A 3EEJA 5HI6A 3IRMA 4KYAA 2D0KA 3DG8A 3RO9A 1DYRA 4ELHA 4OSGA 1RA2A 4QHVA 3GHVA 4EIZA 1IA1A 3NXRA 3FQ0A 4I13A 3OAFA 1HFRA 2ZZAA 1DAJA 2LF1A 3IX9A 8DFRA 3F0SX 2HXVA 3F0QX 4DPDA 1DRFA 4H97A 3SR5X 4DPHA 2DHFA 2FZHA 1RX7A 3FYWX 4KJLA 3SRWX 1BZFA 3EELA 3FQOA 1OHJA 4HA9A 3TQBA 3JW5A 3FRDX 1VDRA 4M2XA 1RA3A 1YHOA 3Q1HA 4PDJA 1S3UA 4QI9A 4DDRA 3FQFA 3F0UX 3TD8A 1DR3A 3TQ8A 5HQZA 4G95A 3S7AA 1IA3A 4H95A 4X5HA 4XECX 1VJ3A 1DLSA 4Q67A 1RA8A 3SA1A 1DR2A 3NZAX 4PSSA 4H96A 3QFXA 1RA1A 4HOGA 4M7VA 3SGYA 4KEBA 3N0HA 4Q6AA 4X5IA 3KJSA 3JW3A 1DISA 3FY9X 1DR6A 3S3VA 3UM6A 2DRCA 3FQZA 2CIGA 5FDAA 1MVSA 5HQYA 4EJ1A 1DRBA 2ANOA 2W9TA 1DRHA 3EEKA 1RX9A 2KGKA 3DATA 1HFPA 1PD8A 3NXOA 3JWCA 3NXVA 4Q0DA 5U27A 4KY4A 3FRBX 3INVA 4TU5X 2HM9A 4ECKA 3SH2A 3HJ3A 1RX4A 4QLGA 1PDBA 3F0XX 2O7PA 2BLCA 3D84X 3FL8A 3GYFA 3CLBA 4KLXA 2ANQA 2B3ZA 2C2TA 3DRCA 4XT8A 3F91A 3QYLA 4ELEA 2W9SA 3JWMA 3DGAA 3KY8A 4FGGA 3OCHA 1CZ3A 1RB2A 2AZNA 5HUIA 2G6VA 3M09A 4PSTA 4KD7A 4ELFA 1LY3A 2QK8A 1MVTA 4NX6A 4X5JA 4KJJA 1DREA 3F0BX 1M7AA 3JWKA 5HF2X 2W3WA 1DF7A 2OIPA 3QLSA 2D5NA 2BLAA 3QG2A 3EIGA 2L28A 2FZIA 5DXVA 3F8ZA 5CCCA 3UM8A 4QLFA 3E0BA 1DDRA 3SQYX 3ZPGA 4NX7A 3JWFA 4LAEX 4XT7A 3I8AX 4IXFX 4LEKX 1DR1A 4G8ZX 3QLZA 4XT5A 1IA2A 1DG5A 3JVXA 4LAHX
chains in the Genus database with same CATH superfamily
1OHKA 5HSUA 1CD2A 3DL6A 4QJCA 3ROAA 1DHIA 3L3RA 3FQCA 1LUDA 1PD9A 1DR5A 1RF7A 1U70A 3K74A 1SEJA 3EEMA 4ELBA 3NZDA 3TQAA 1D1GA 1DR7A 2OBCA 1E26A 3LG4A 7DFRA 3CSEA 1KMVA 4IXGX 4IXED 4DP3A 1RD7A 3GI2A 5HVBA 4LAGX 3DFRA 2XW7A 3DL5A 4M6KA 3UM5A 3FREX 1RX6A 3QL0A 4GH8A 4XRBA 3NZ9X 3FL9A 4P3QA 5ECXA 2W3AA 4QJZD 3S9UA 1QZFA 4KNEA 3F8YA 3M08A 3FYVX 3JSUA 1JOMA 5CC9A 4M7UA 4X5FA 1LY4A 1RX1A 3KJRA 3FQVA 1JOLA 5HF0X 2ITHA 4KL9A 3NXXA 3CD2A 3TQ9A 2CD2A 1DG7A 3IA5A 3QLYA 5E8QA 4KFJA 3NXTA 4M6JA 5U26A 1DDSA 3CL9A 4ELGA 1RX8A 5HT5A 1BOZA 4XT4A 3K2HA 1AOEA 3IA4A 3NZCX 3IRNA 3DAUA 4XE6X 1M78A 4EILA 3SRUX 1IA4A 3RG9A 3QL3A 4FHBA 4Q0EA 3QGTA 3ZPCA 3QLRA 2BLBA 4G3MA 2W3VA 5HVEA 3IROA 5JG0X 1DYJA 3FRAX 2BL9A 1AI9A 3VCOA 1DG8A 4KY8A 4H98A 5HSRA 2W9HA 3NTZA 4RGCA 2GD9A 1KMSA 5HT4A 1KLKA 3FS6A 1DYIA 4CD2A 3EX8A 3GHWA 1RE7A 4KM0A 2W3MA 3K47A 3QYOA 3R33A 1AO8A 1J3IA 3SAIA 1S3WA 4FGHA 4P66A 4QLEA 4P3RA 4HOFA 4KM2A 2W9GA 4KJKA 1TDRA 3KFYA 3SRSX 4I1NA 3NU0A 1DRAA 1ZDRA 3NZ6X 1RG7A 1U71A 5ECCA 4PTJA 1DLRA 4M6LA 4XT6A 1DYHA 2JYBA 4EIGA 4KBNA 3HBBA 6DFRA 1RX2A 4PSYA 3SRRX 2W3BA 1DIUA 2C2SA 1S3YA 3FRFX 1HFQA 3JTWA 2FZJA 2P4GA 4X5GA 1RB3A 1RH3A 4HOEA 3NRRA 1DR4A 3SA2A 1RA9A 1J3JA 1JUVA 3QLXA 1S3VA 1RX5A 3K45A 3I3RA 3SRQX 4P68A 1M79A 5EAJA 5JA3A 3D80A 1U72A 1RX3A 3QLWA 4PTHA 1J3KA 3FY8X 3GHCA 4KAKA 3F0VX 1DHFA 2H2QA 5DFRA 3NZBX 3KGYA 4HA7A 5HPBA 2HQPA 3NXYA 1RC4A 1DHJA 4DFRA 2INQA 4OR7A 3EEJA 5HI6A 3IRMA 4KYAA 2D0KA 3DG8A 3RO9A 1DYRA 4ELHA 4OSGA 1RA2A 4QHVA 3GHVA 4EIZA 1IA1A 3NXRA 3FQ0A 4I13A 3OAFA 1HFRA 2ZZAA 1DAJA 2LF1A 3IX9A 8DFRA 3F0SX 2HXVA 3F0QX 4DPDA 1DRFA 4H97A 3SR5X 4DPHA 2DHFA 2FZHA 1RX7A 3FYWX 4KJLA 3SRWX 1BZFA 3EELA 3FQOA 1OHJA 4HA9A 3TQBA 3JW5A 3FRDX 1VDRA 4M2XA 1RA3A 1YHOA 3Q1HA 4PDJA 1S3UA 4QI9A 4DDRA 3FQFA 3F0UX 3TD8A 1DR3A 3TQ8A 5HQZA 4G95A 3S7AA 1IA3A 4H95A 4X5HA 4XECX 1VJ3A 1DLSA 4Q67A 1RA8A 3SA1A 1DR2A 3NZAX 4PSSA 4H96A 3QFXA 1RA1A 4HOGA 4M7VA 3SGYA 4KEBA 3N0HA 4Q6AA 4X5IA 3KJSA 3JW3A 1DISA 3FY9X 1DR6A 3S3VA 3UM6A 2DRCA 3FQZA 2CIGA 5FDAA 1MVSA 5HQYA 4EJ1A 1DRBA 2ANOA 2W9TA 1DRHA 3EEKA 1RX9A 2KGKA 3DATA 1HFPA 1PD8A 3NXOA 3JWCA 3NXVA 4Q0DA 5U27A 4KY4A 3FRBX 3INVA 4TU5X 2HM9A 4ECKA 3SH2A 3HJ3A 1RX4A 4QLGA 1PDBA 3F0XX 2O7PA 2BLCA 3D84X 3FL8A 3GYFA 3CLBA 4KLXA 2ANQA 2B3ZA 2C2TA 3DRCA 4XT8A 3F91A 3QYLA 4ELEA 2W9SA 3JWMA 3DGAA 3KY8A 4FGGA 3OCHA 1CZ3A 1RB2A 2AZNA 5HUIA 2G6VA 3M09A 4PSTA 4KD7A 4ELFA 1LY3A 2QK8A 1MVTA 4NX6A 4X5JA 4KJJA 1DREA 3F0BX 1M7AA 3JWKA 5HF2X 2W3WA 1DF7A 2OIPA 3QLSA 2D5NA 2BLAA 3QG2A 3EIGA 2L28A 2FZIA 5DXVA 3F8ZA 5CCCA 3UM8A 4QLFA 3E0BA 1DDRA 3SQYX 3ZPGA 4NX7A 3JWFA 4LAEX 4XT7A 3I8AX 4IXFX 4LEKX 1DR1A 4G8ZX 3QLZA 4XT5A 1IA2A 1DG5A 3JVXA 4LAHX
chains in the Genus database with same CATH topology
1OHKA 5HSUA 1CD2A 3DL6A 4QJCA 3ROAA 1DHIA 3L3RA 3FQCA 1LUDA 1PD9A 1DR5A 1RF7A 1U70A 3K74A 1SEJA 3EEMA 4ELBA 3NZDA 3TQAA 1D1GA 1DR7A 2OBCA 1E26A 3LG4A 7DFRA 3CSEA 1KMVA 4IXGX 4IXED 4DP3A 1RD7A 3GI2A 5HVBA 4LAGX 3DFRA 2XW7A 3DL5A 4M6KA 3UM5A 3FREX 1RX6A 3QL0A 4GH8A 4XRBA 3NZ9X 3FL9A 4P3QA 5ECXA 2W3AA 4QJZD 3S9UA 1QZFA 4KNEA 3F8YA 3M08A 3FYVX 3JSUA 1JOMA 5CC9A 4M7UA 4X5FA 1LY4A 1RX1A 3KJRA 3FQVA 1JOLA 5HF0X 2ITHA 4KL9A 3NXXA 3CD2A 3TQ9A 2CD2A 1DG7A 3IA5A 3QLYA 5E8QA 4KFJA 3NXTA 4M6JA 5U26A 1DDSA 3CL9A 4ELGA 1RX8A 5HT5A 1BOZA 4XT4A 3K2HA 1AOEA 3IA4A 3NZCX 3IRNA 3DAUA 4XE6X 1M78A 4EILA 3SRUX 1IA4A 3RG9A 3QL3A 4FHBA 4Q0EA 3QGTA 3ZPCA 3QLRA 2BLBA 4G3MA 2W3VA 5HVEA 3IROA 5JG0X 1DYJA 3FRAX 2BL9A 1AI9A 3VCOA 1DG8A 4KY8A 4H98A 5HSRA 2W9HA 3NTZA 4RGCA 2GD9A 1KMSA 5HT4A 1KLKA 3FS6A 1DYIA 4CD2A 3EX8A 3GHWA 1RE7A 4KM0A 2W3MA 3K47A 3QYOA 3R33A 1AO8A 1J3IA 3SAIA 1S3WA 4FGHA 4P66A 4QLEA 4P3RA 4HOFA 4KM2A 2W9GA 4KJKA 1TDRA 3KFYA 3SRSX 4I1NA 3NU0A 1DRAA 1ZDRA 3NZ6X 1RG7A 1U71A 5ECCA 4PTJA 1DLRA 4M6LA 4XT6A 1DYHA 2JYBA 4EIGA 4KBNA 3HBBA 6DFRA 1RX2A 4PSYA 3SRRX 2W3BA 1DIUA 2C2SA 1S3YA 3FRFX 1HFQA 3JTWA 2FZJA 2P4GA 4X5GA 1RB3A 1RH3A 4HOEA 3NRRA 1DR4A 3SA2A 1RA9A 1J3JA 1JUVA 3QLXA 1S3VA 1RX5A 3K45A 3I3RA 3SRQX 4P68A 1M79A 5EAJA 5JA3A 3D80A 1U72A 1RX3A 3QLWA 4PTHA 1J3KA 3FY8X 3GHCA 4KAKA 3F0VX 1DHFA 2H2QA 5DFRA 3NZBX 3KGYA 4HA7A 5HPBA 2HQPA 3NXYA 1RC4A 1DHJA 4DFRA 2INQA 4OR7A 3EEJA 5HI6A 3IRMA 4KYAA 2D0KA 3DG8A 3RO9A 1DYRA 4ELHA 4OSGA 1RA2A 4QHVA 3GHVA 4EIZA 1IA1A 3NXRA 3FQ0A 4I13A 3OAFA 1HFRA 2ZZAA 1DAJA 2LF1A 3IX9A 8DFRA 3F0SX 2HXVA 3F0QX 4DPDA 1DRFA 4H97A 3SR5X 4DPHA 2DHFA 2FZHA 1RX7A 3FYWX 4KJLA 3SRWX 1BZFA 3EELA 3FQOA 1OHJA 4HA9A 3TQBA 3JW5A 3FRDX 1VDRA 4M2XA 1RA3A 1YHOA 3Q1HA 4PDJA 1S3UA 4QI9A 4DDRA 3FQFA 3F0UX 3TD8A 1DR3A 3TQ8A 5HQZA 4G95A 3S7AA 1IA3A 4H95A 4X5HA 4XECX 1VJ3A 1DLSA 4Q67A 1RA8A 3SA1A 1DR2A 3NZAX 4PSSA 4H96A 3QFXA 1RA1A 4HOGA 4M7VA 3SGYA 4KEBA 3N0HA 4Q6AA 4X5IA 3KJSA 3JW3A 1DISA 3FY9X 1DR6A 3S3VA 3UM6A 2DRCA 3FQZA 2CIGA 5FDAA 1MVSA 5HQYA 4EJ1A 1DRBA 2ANOA 2W9TA 1DRHA 3EEKA 1RX9A 2KGKA 3DATA 1HFPA 1PD8A 3NXOA 3JWCA 3NXVA 4Q0DA 5U27A 4KY4A 3FRBX 3INVA 4TU5X 2HM9A 4ECKA 3SH2A 3HJ3A 1RX4A 4QLGA 1PDBA 3F0XX 2O7PA 2BLCA 3D84X 3FL8A 3GYFA 3CLBA 4KLXA 2ANQA 2B3ZA 2C2TA 3DRCA 4XT8A 3F91A 3QYLA 4ELEA 2W9SA 3JWMA 3DGAA 3KY8A 4FGGA 3OCHA 1CZ3A 1RB2A 2AZNA 5HUIA 2G6VA 3M09A 4PSTA 4KD7A 4ELFA 1LY3A 2QK8A 1MVTA 4NX6A 4X5JA 4KJJA 1DREA 3F0BX 1M7AA 3JWKA 5HF2X 2W3WA 1DF7A 2OIPA 3QLSA 2D5NA 2BLAA 3QG2A 3EIGA 2L28A 2FZIA 5DXVA 3F8ZA 5CCCA 3UM8A 4QLFA 3E0BA 1DDRA 3SQYX 3ZPGA 4NX7A 3JWFA 4LAEX 4XT7A 3I8AX 4IXFX 4LEKX 1DR1A 4G8ZX 3QLZA 4XT5A 1IA2A 1DG5A 3JVXA 4LAHX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OHK A;  5HSU A;  1CD2 A;  3DL6 A;  4QJC A;  3ROA A;  1DHI A;  3L3R A;  3FQC A;  1LUD A;  1PD9 A;  1DR5 A;  1RF7 A;  1U70 A;  3K74 A;  1SEJ A;  3EEM A;  4ELB A;  3NZD A;  3TQA A;  1D1G A;  1DR7 A;  2OBC A;  1E26 A;  3LG4 A;  7DFR A;  3CSE A;  1KMV A;  4IXG X;  4IXE D;  4DP3 A;  1RD7 A;  3GI2 A;  5HVB A;  4LAG X;  3DFR A;  2XW7 A;  3DL5 A;  4M6K A;  3UM5 A;  3FRE X;  1RX6 A;  3QL0 A;  4GH8 A;  4XRB A;  3NZ9 X;  3FL9 A;  4P3Q A;  5ECX A;  2W3A A;  4QJZ D;  3S9U A;  1QZF A;  4KNE A;  3F8Y A;  3M08 A;  3FYV X;  3JSU A;  1JOM A;  5CC9 A;  4M7U A;  4X5F A;  1LY4 A;  1RX1 A;  3KJR A;  3FQV A;  1JOL A;  5HF0 X;  2ITH A;  4KL9 A;  3NXX A;  3CD2 A;  3TQ9 A;  2CD2 A;  1DG7 A;  3IA5 A;  3QLY A;  5E8Q A;  4KFJ A;  3NXT A;  4M6J A;  5U26 A;  1DDS A;  3CL9 A;  4ELG A;  1RX8 A;  5HT5 A;  1BOZ A;  4XT4 A;  3K2H A;  1AOE A;  3IA4 A;  3NZC X;  3IRN A;  3DAU A;  4XE6 X;  1M78 A;  4EIL A;  3SRU X;  1IA4 A;  3RG9 A;  3QL3 A;  4FHB A;  4Q0E A;  3QGT A;  3ZPC A;  3QLR A;  2BLB A;  4G3M A;  2W3V A;  5HVE A;  3IRO A;  5JG0 X;  1DYJ A;  3FRA X;  2BL9 A;  1AI9 A;  3VCO A;  1DG8 A;  4KY8 A;  4H98 A;  5HSR A;  2W9H A;  3NTZ A;  4RGC A;  2GD9 A;  1KMS A;  5HT4 A;  1KLK A;  3FS6 A;  1DYI A;  4CD2 A;  3EX8 A;  3GHW A;  1RE7 A;  4KM0 A;  2W3M A;  3K47 A;  3QYO A;  3R33 A;  1AO8 A;  1J3I A;  3SAI A;  1S3W A;  4FGH A;  4P66 A;  4QLE A;  4P3R A;  4HOF A;  4KM2 A;  2W9G A;  4KJK A;  1TDR A;  3KFY A;  3SRS X;  4I1N A;  3NU0 A;  1DRA A;  1ZDR A;  3NZ6 X;  1RG7 A;  1U71 A;  5ECC A;  4PTJ A;  1DLR A;  4M6L A;  4XT6 A;  1DYH A;  2JYB A;  4EIG A;  4KBN A;  3HBB A;  6DFR A;  1RX2 A;  4PSY A;  3SRR X;  2W3B A;  1DIU A;  2C2S A;  1S3Y A;  3FRF X;  1HFQ A;  3JTW A;  2FZJ A;  2P4G A;  4X5G A;  1RB3 A;  1RH3 A;  4HOE A;  3NRR A;  1DR4 A;  3SA2 A;  1RA9 A;  1J3J A;  1JUV A;  3QLX A;  1S3V A;  1RX5 A;  3K45 A;  3I3R A;  3SRQ X;  4P68 A;  1M79 A;  5EAJ A;  5JA3 A;  3D80 A;  1U72 A;  1RX3 A;  3QLW A;  4PTH A;  1J3K A;  3FY8 X;  3GHC A;  4KAK A;  3F0V X;  1DHF A;  2H2Q A;  5DFR A;  3NZB X;  3KGY A;  4HA7 A;  5HPB A;  2HQP A;  3NXY A;  1RC4 A;  1DHJ A;  4DFR A;  2INQ A;  4OR7 A;  3EEJ A;  5HI6 A;  3IRM A;  4KYA A;  2D0K A;  3DG8 A;  3RO9 A;  1DYR A;  4ELH A;  4OSG A;  1RA2 A;  4QHV A;  3GHV A;  4EIZ A;  1IA1 A;  3NXR A;  3FQ0 A;  4I13 A;  3OAF A;  1HFR A;  2ZZA A;  1DAJ A;  2LF1 A;  3IX9 A;  8DFR A;  3F0S X;  2HXV A;  3F0Q X;  4DPD A;  1DRF A;  4H97 A;  3SR5 X;  4DPH A;  2DHF A;  2FZH A;  1RX7 A;  3FYW X;  4KJL A;  3SRW X;  1BZF A;  3EEL A;  3FQO A;  1OHJ A;  4HA9 A;  3TQB A;  3JW5 A;  3FRD X;  1VDR A;  4M2X A;  1RA3 A;  1YHO A;  3Q1H A;  4PDJ A;  1S3U A;  4QI9 A;  4DDR A;  3FQF A;  3F0U X;  3TD8 A;  1DR3 A;  3TQ8 A;  5HQZ A;  4G95 A;  3S7A A;  1IA3 A;  4H95 A;  4X5H A;  4XEC X;  1VJ3 A;  1DLS A;  4Q67 A;  1RA8 A;  3SA1 A;  1DR2 A;  3NZA X;  4PSS A;  4H96 A;  3QFX A;  1RA1 A;  4HOG A;  4M7V A;  3SGY A;  4KEB A;  3N0H A;  4Q6A A;  4X5I A;  3KJS A;  3JW3 A;  1DIS A;  3FY9 X;  1DR6 A;  3S3V A;  3UM6 A;  2DRC A;  3FQZ A;  2CIG A;  5FDA A;  1MVS A;  5HQY A;  4EJ1 A;  1DRB A;  2ANO A;  2W9T A;  1DRH A;  3EEK A;  1RX9 A;  2KGK A;  3DAT A;  1HFP A;  1PD8 A;  3NXO A;  3JWC A;  3NXV A;  4Q0D A;  5U27 A;  4KY4 A;  3FRB X;  3INV A;  4TU5 X;  2HM9 A;  4ECK A;  3SH2 A;  3HJ3 A;  1RX4 A;  4QLG A;  1PDB A;  3F0X X;  2O7P A;  2BLC A;  3D84 X;  3FL8 A;  3GYF A;  3CLB A;  4KLX A;  2ANQ A;  2B3Z A;  2C2T A;  3DRC A;  4XT8 A;  3F91 A;  3QYL A;  4ELE A;  2W9S A;  3JWM A;  3DGA A;  3KY8 A;  4FGG A;  3OCH A;  1CZ3 A;  1RB2 A;  2AZN A;  5HUI A;  2G6V A;  3M09 A;  4PST A;  4KD7 A;  4ELF A;  1LY3 A;  2QK8 A;  1MVT A;  4NX6 A;  4X5J A;  4KJJ A;  1DRE A;  3F0B X;  1M7A A;  3JWK A;  5HF2 X;  2W3W A;  1DF7 A;  2OIP A;  3QLS A;  2D5N A;  2BLA A;  3QG2 A;  3EIG A;  2L28 A;  2FZI A;  5DXV A;  3F8Z A;  5CCC A;  3UM8 A;  4QLF A;  3E0B A;  1DDR A;  3SQY X;  3ZPG A;  4NX7 A;  3JWF A;  4LAE X;  4XT7 A;  3I8A X;  4IXF X;  4LEK X;  1DR1 A;  4G8Z X;  3QLZ A;  4XT5 A;  1IA2 A;  1DG5 A;  3JVX A;  4LAH X; 
#chains in the Genus database with same CATH topology
 1OHK A;  5HSU A;  1CD2 A;  3DL6 A;  4QJC A;  3ROA A;  1DHI A;  3L3R A;  3FQC A;  1LUD A;  1PD9 A;  1DR5 A;  1RF7 A;  1U70 A;  3K74 A;  1SEJ A;  3EEM A;  4ELB A;  3NZD A;  3TQA A;  1D1G A;  1DR7 A;  2OBC A;  1E26 A;  3LG4 A;  7DFR A;  3CSE A;  1KMV A;  4IXG X;  4IXE D;  4DP3 A;  1RD7 A;  3GI2 A;  5HVB A;  4LAG X;  3DFR A;  2XW7 A;  3DL5 A;  4M6K A;  3UM5 A;  3FRE X;  1RX6 A;  3QL0 A;  4GH8 A;  4XRB A;  3NZ9 X;  3FL9 A;  4P3Q A;  5ECX A;  2W3A A;  4QJZ D;  3S9U A;  1QZF A;  4KNE A;  3F8Y A;  3M08 A;  3FYV X;  3JSU A;  1JOM A;  5CC9 A;  4M7U A;  4X5F A;  1LY4 A;  1RX1 A;  3KJR A;  3FQV A;  1JOL A;  5HF0 X;  2ITH A;  4KL9 A;  3NXX A;  3CD2 A;  3TQ9 A;  2CD2 A;  1DG7 A;  3IA5 A;  3QLY A;  5E8Q A;  4KFJ A;  3NXT A;  4M6J A;  5U26 A;  1DDS A;  3CL9 A;  4ELG A;  1RX8 A;  5HT5 A;  1BOZ A;  4XT4 A;  3K2H A;  1AOE A;  3IA4 A;  3NZC X;  3IRN A;  3DAU A;  4XE6 X;  1M78 A;  4EIL A;  3SRU X;  1IA4 A;  3RG9 A;  3QL3 A;  4FHB A;  4Q0E A;  3QGT A;  3ZPC A;  3QLR A;  2BLB A;  4G3M A;  2W3V A;  5HVE A;  3IRO A;  5JG0 X;  1DYJ A;  3FRA X;  2BL9 A;  1AI9 A;  3VCO A;  1DG8 A;  4KY8 A;  4H98 A;  5HSR A;  2W9H A;  3NTZ A;  4RGC A;  2GD9 A;  1KMS A;  5HT4 A;  1KLK A;  3FS6 A;  1DYI A;  4CD2 A;  3EX8 A;  3GHW A;  1RE7 A;  4KM0 A;  2W3M A;  3K47 A;  3QYO A;  3R33 A;  1AO8 A;  1J3I A;  3SAI A;  1S3W A;  4FGH A;  4P66 A;  4QLE A;  4P3R A;  4HOF A;  4KM2 A;  2W9G A;  4KJK A;  1TDR A;  3KFY A;  3SRS X;  4I1N A;  3NU0 A;  1DRA A;  1ZDR A;  3NZ6 X;  1RG7 A;  1U71 A;  5ECC A;  4PTJ A;  1DLR A;  4M6L A;  4XT6 A;  1DYH A;  2JYB A;  4EIG A;  4KBN A;  3HBB A;  6DFR A;  1RX2 A;  4PSY A;  3SRR X;  2W3B A;  1DIU A;  2C2S A;  1S3Y A;  3FRF X;  1HFQ A;  3JTW A;  2FZJ A;  2P4G A;  4X5G A;  1RB3 A;  1RH3 A;  4HOE A;  3NRR A;  1DR4 A;  3SA2 A;  1RA9 A;  1J3J A;  1JUV A;  3QLX A;  1S3V A;  1RX5 A;  3K45 A;  3I3R A;  3SRQ X;  4P68 A;  1M79 A;  5EAJ A;  5JA3 A;  3D80 A;  1U72 A;  1RX3 A;  3QLW A;  4PTH A;  1J3K A;  3FY8 X;  3GHC A;  4KAK A;  3F0V X;  1DHF A;  2H2Q A;  5DFR A;  3NZB X;  3KGY A;  4HA7 A;  5HPB A;  2HQP A;  3NXY A;  1RC4 A;  1DHJ A;  4DFR A;  2INQ A;  4OR7 A;  3EEJ A;  5HI6 A;  3IRM A;  4KYA A;  2D0K A;  3DG8 A;  3RO9 A;  1DYR A;  4ELH A;  4OSG A;  1RA2 A;  4QHV A;  3GHV A;  4EIZ A;  1IA1 A;  3NXR A;  3FQ0 A;  4I13 A;  3OAF A;  1HFR A;  2ZZA A;  1DAJ A;  2LF1 A;  3IX9 A;  8DFR A;  3F0S X;  2HXV A;  3F0Q X;  4DPD A;  1DRF A;  4H97 A;  3SR5 X;  4DPH A;  2DHF A;  2FZH A;  1RX7 A;  3FYW X;  4KJL A;  3SRW X;  1BZF A;  3EEL A;  3FQO A;  1OHJ A;  4HA9 A;  3TQB A;  3JW5 A;  3FRD X;  1VDR A;  4M2X A;  1RA3 A;  1YHO A;  3Q1H A;  4PDJ A;  1S3U A;  4QI9 A;  4DDR A;  3FQF A;  3F0U X;  3TD8 A;  1DR3 A;  3TQ8 A;  5HQZ A;  4G95 A;  3S7A A;  1IA3 A;  4H95 A;  4X5H A;  4XEC X;  1VJ3 A;  1DLS A;  4Q67 A;  1RA8 A;  3SA1 A;  1DR2 A;  3NZA X;  4PSS A;  4H96 A;  3QFX A;  1RA1 A;  4HOG A;  4M7V A;  3SGY A;  4KEB A;  3N0H A;  4Q6A A;  4X5I A;  3KJS A;  3JW3 A;  1DIS A;  3FY9 X;  1DR6 A;  3S3V A;  3UM6 A;  2DRC A;  3FQZ A;  2CIG A;  5FDA A;  1MVS A;  5HQY A;  4EJ1 A;  1DRB A;  2ANO A;  2W9T A;  1DRH A;  3EEK A;  1RX9 A;  2KGK A;  3DAT A;  1HFP A;  1PD8 A;  3NXO A;  3JWC A;  3NXV A;  4Q0D A;  5U27 A;  4KY4 A;  3FRB X;  3INV A;  4TU5 X;  2HM9 A;  4ECK A;  3SH2 A;  3HJ3 A;  1RX4 A;  4QLG A;  1PDB A;  3F0X X;  2O7P A;  2BLC A;  3D84 X;  3FL8 A;  3GYF A;  3CLB A;  4KLX A;  2ANQ A;  2B3Z A;  2C2T A;  3DRC A;  4XT8 A;  3F91 A;  3QYL A;  4ELE A;  2W9S A;  3JWM A;  3DGA A;  3KY8 A;  4FGG A;  3OCH A;  1CZ3 A;  1RB2 A;  2AZN A;  5HUI A;  2G6V A;  3M09 A;  4PST A;  4KD7 A;  4ELF A;  1LY3 A;  2QK8 A;  1MVT A;  4NX6 A;  4X5J A;  4KJJ A;  1DRE A;  3F0B X;  1M7A A;  3JWK A;  5HF2 X;  2W3W A;  1DF7 A;  2OIP A;  3QLS A;  2D5N A;  2BLA A;  3QG2 A;  3EIG A;  2L28 A;  2FZI A;  5DXV A;  3F8Z A;  5CCC A;  3UM8 A;  4QLF A;  3E0B A;  1DDR A;  3SQY X;  3ZPG A;  4NX7 A;  3JWF A;  4LAE X;  4XT7 A;  3I8A X;  4IXF X;  4LEK X;  1DR1 A;  4G8Z X;  3QLZ A;  4XT5 A;  1IA2 A;  1DG5 A;  3JVX A;  4LAH X; 
#chains in the Genus database with same CATH homology
 1OHK A;  5HSU A;  1CD2 A;  3DL6 A;  4QJC A;  3ROA A;  1DHI A;  3L3R A;  3FQC A;  1LUD A;  1PD9 A;  1DR5 A;  1RF7 A;  1U70 A;  3K74 A;  1SEJ A;  3EEM A;  4ELB A;  3NZD A;  3TQA A;  1D1G A;  1DR7 A;  2OBC A;  1E26 A;  3LG4 A;  7DFR A;  3CSE A;  1KMV A;  4IXG X;  4IXE D;  4DP3 A;  1RD7 A;  3GI2 A;  5HVB A;  4LAG X;  3DFR A;  2XW7 A;  3DL5 A;  4M6K A;  3UM5 A;  3FRE X;  1RX6 A;  3QL0 A;  4GH8 A;  4XRB A;  3NZ9 X;  3FL9 A;  4P3Q A;  5ECX A;  2W3A A;  4QJZ D;  3S9U A;  1QZF A;  4KNE A;  3F8Y A;  3M08 A;  3FYV X;  3JSU A;  1JOM A;  5CC9 A;  4M7U A;  4X5F A;  1LY4 A;  1RX1 A;  3KJR A;  3FQV A;  1JOL A;  5HF0 X;  2ITH A;  4KL9 A;  3NXX A;  3CD2 A;  3TQ9 A;  2CD2 A;  1DG7 A;  3IA5 A;  3QLY A;  5E8Q A;  4KFJ A;  3NXT A;  4M6J A;  5U26 A;  1DDS A;  3CL9 A;  4ELG A;  1RX8 A;  5HT5 A;  1BOZ A;  4XT4 A;  3K2H A;  1AOE A;  3IA4 A;  3NZC X;  3IRN A;  3DAU A;  4XE6 X;  1M78 A;  4EIL A;  3SRU X;  1IA4 A;  3RG9 A;  3QL3 A;  4FHB A;  4Q0E A;  3QGT A;  3ZPC A;  3QLR A;  2BLB A;  4G3M A;  2W3V A;  5HVE A;  3IRO A;  5JG0 X;  1DYJ A;  3FRA X;  2BL9 A;  1AI9 A;  3VCO A;  1DG8 A;  4KY8 A;  4H98 A;  5HSR A;  2W9H A;  3NTZ A;  4RGC A;  2GD9 A;  1KMS A;  5HT4 A;  1KLK A;  3FS6 A;  1DYI A;  4CD2 A;  3EX8 A;  3GHW A;  1RE7 A;  4KM0 A;  2W3M A;  3K47 A;  3QYO A;  3R33 A;  1AO8 A;  1J3I A;  3SAI A;  1S3W A;  4FGH A;  4P66 A;  4QLE A;  4P3R A;  4HOF A;  4KM2 A;  2W9G A;  4KJK A;  1TDR A;  3KFY A;  3SRS X;  4I1N A;  3NU0 A;  1DRA A;  1ZDR A;  3NZ6 X;  1RG7 A;  1U71 A;  5ECC A;  4PTJ A;  1DLR A;  4M6L A;  4XT6 A;  1DYH A;  2JYB A;  4EIG A;  4KBN A;  3HBB A;  6DFR A;  1RX2 A;  4PSY A;  3SRR X;  2W3B A;  1DIU A;  2C2S A;  1S3Y A;  3FRF X;  1HFQ A;  3JTW A;  2FZJ A;  2P4G A;  4X5G A;  1RB3 A;  1RH3 A;  4HOE A;  3NRR A;  1DR4 A;  3SA2 A;  1RA9 A;  1J3J A;  1JUV A;  3QLX A;  1S3V A;  1RX5 A;  3K45 A;  3I3R A;  3SRQ X;  4P68 A;  1M79 A;  5EAJ A;  5JA3 A;  3D80 A;  1U72 A;  1RX3 A;  3QLW A;  4PTH A;  1J3K A;  3FY8 X;  3GHC A;  4KAK A;  3F0V X;  1DHF A;  2H2Q A;  5DFR A;  3NZB X;  3KGY A;  4HA7 A;  5HPB A;  2HQP A;  3NXY A;  1RC4 A;  1DHJ A;  4DFR A;  2INQ A;  4OR7 A;  3EEJ A;  5HI6 A;  3IRM A;  4KYA A;  2D0K A;  3DG8 A;  3RO9 A;  1DYR A;  4ELH A;  4OSG A;  1RA2 A;  4QHV A;  3GHV A;  4EIZ A;  1IA1 A;  3NXR A;  3FQ0 A;  4I13 A;  3OAF A;  1HFR A;  2ZZA A;  1DAJ A;  2LF1 A;  3IX9 A;  8DFR A;  3F0S X;  2HXV A;  3F0Q X;  4DPD A;  1DRF A;  4H97 A;  3SR5 X;  4DPH A;  2DHF A;  2FZH A;  1RX7 A;  3FYW X;  4KJL A;  3SRW X;  1BZF A;  3EEL A;  3FQO A;  1OHJ A;  4HA9 A;  3TQB A;  3JW5 A;  3FRD X;  1VDR A;  4M2X A;  1RA3 A;  1YHO A;  3Q1H A;  4PDJ A;  1S3U A;  4QI9 A;  4DDR A;  3FQF A;  3F0U X;  3TD8 A;  1DR3 A;  3TQ8 A;  5HQZ A;  4G95 A;  3S7A A;  1IA3 A;  4H95 A;  4X5H A;  4XEC X;  1VJ3 A;  1DLS A;  4Q67 A;  1RA8 A;  3SA1 A;  1DR2 A;  3NZA X;  4PSS A;  4H96 A;  3QFX A;  1RA1 A;  4HOG A;  4M7V A;  3SGY A;  4KEB A;  3N0H A;  4Q6A A;  4X5I A;  3KJS A;  3JW3 A;  1DIS A;  3FY9 X;  1DR6 A;  3S3V A;  3UM6 A;  2DRC A;  3FQZ A;  2CIG A;  5FDA A;  1MVS A;  5HQY A;  4EJ1 A;  1DRB A;  2ANO A;  2W9T A;  1DRH A;  3EEK A;  1RX9 A;  2KGK A;  3DAT A;  1HFP A;  1PD8 A;  3NXO A;  3JWC A;  3NXV A;  4Q0D A;  5U27 A;  4KY4 A;  3FRB X;  3INV A;  4TU5 X;  2HM9 A;  4ECK A;  3SH2 A;  3HJ3 A;  1RX4 A;  4QLG A;  1PDB A;  3F0X X;  2O7P A;  2BLC A;  3D84 X;  3FL8 A;  3GYF A;  3CLB A;  4KLX A;  2ANQ A;  2B3Z A;  2C2T A;  3DRC A;  4XT8 A;  3F91 A;  3QYL A;  4ELE A;  2W9S A;  3JWM A;  3DGA A;  3KY8 A;  4FGG A;  3OCH A;  1CZ3 A;  1RB2 A;  2AZN A;  5HUI A;  2G6V A;  3M09 A;  4PST A;  4KD7 A;  4ELF A;  1LY3 A;  2QK8 A;  1MVT A;  4NX6 A;  4X5J A;  4KJJ A;  1DRE A;  3F0B X;  1M7A A;  3JWK A;  5HF2 X;  2W3W A;  1DF7 A;  2OIP A;  3QLS A;  2D5N A;  2BLA A;  3QG2 A;  3EIG A;  2L28 A;  2FZI A;  5DXV A;  3F8Z A;  5CCC A;  3UM8 A;  4QLF A;  3E0B A;  1DDR A;  3SQY X;  3ZPG A;  4NX7 A;  3JWF A;  4LAE X;  4XT7 A;  3I8A X;  4IXF X;  4LEK X;  1DR1 A;  4G8Z X;  3QLZ A;  4XT5 A;  1IA2 A;  1DG5 A;  3JVX A;  4LAH X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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