5HQYA

Human dihydrofolate reductase complex with nadph and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hqyA00
3E0BA 2W9HA 2W3BA 3JTWA 3SR5X 4KFJA 3FRBX 1RX6A 3K74A 1RX1A 4TU5X 3ZPCA 3DATA 3HBBA 2FZJA 1DAJA 2KGKA 1PDBA 4OR7A 2D0KA 1MVTA 1LUDA 4XECX 5JA3A 5HSUA 2HM9A 4QI9A 2BL9A 4EJ1A 1S3VA 3D84X 4X5GA 1DHFA 4P3QA 1DG5A 4PSYA 3I3RA 4KJJA 1M7AA 3D80A 4XT8A 1RA2A 3IA5A 3NXRA 4XT4A 4H97A 1DR5A 1DYHA 4H98A 1ZDRA 1RX2A 3QLXA 3FS6A 3QYOA 4PTHA 3SH2A 2BLBA 4DDRA 1DYIA 3NZAX 4HOGA 3TQ8A 3JWKA 1HFPA 4M7UA 2FZIA 4PSSA 3DGAA 2CIGA 4H95A 3EEMA 3UM5A 1AI9A 4FGGA 3JSUA 2ITHA 1RF7A 5CCCA 3IRMA 3SQYX 1DDRA 3F8ZA 3S7AA 4LEKX 3OAFA 2L28A 2P4GA 3IA4A 3OCHA 1DR6A 2GD9A 1RA9A 4XT6A 3QL3A 1VDRA 1DF7A 5HT4A 1DR3A 4XT7A 3IROA 4KD7A 3SRQX 4XT5A 3INVA 4FGHA 4HA9A 2W3MA 1RX7A 5DFRA 5HVBA 1DRBA 2QK8A 3IRNA 3F8YA 4X5FA 1E26A 3I8AX 3SA1A 3NXVA 1TDRA 3LG4A 3NXTA 3QG2A 4X5IA 2INQA 4CD2A 1YHOA 1IA1A 2BLAA 1J3IA 1KLKA 3R33A 1DHJA 4G95A 4XE6X 1J3KA 3Q1HA 1DR2A 3QLYA 1KMSA 4KY4A 3FY9X 2W3VA 1IA2A 3FYVX 4QLFA 3SRUX 1DR7A 4ELBA 3NU0A 3JWMA 1RG7A 4ELFA 3K45A 1RX3A 1DG8A 5HPBA 4PDJA 4HOFA 2B3ZA 4P3RA 4NX6A 1U71A 1AOEA 3EIGA 4EIGA 3F0BX 3FQ0A 1DHIA 3FQVA 4GH8A 4ELEA 4ECKA 5HQZA 1CZ3A 1IA4A 4LAEX 4KL9A 3TQBA 1RX9A 2XW7A 1U72A 3QYLA 2CD2A 3EELA 3M09A 2BLCA 3NRRA 4XRBA 1CD2A 3SGYA 5HQYA 1BOZA 3CLBA 4LAGX 3F0QX 2ANQA 3QL0A 3K2HA 4H96A 3DG8A 3JW3A 7DFRA 3TQ9A 4X5JA 2D5NA 3FQOA 3CSEA 1DLRA 2OIPA 1RA1A 3JWFA 8DFRA 1S3WA 1RA3A 4ELGA 4P68A 3NZCX 3EX8A 1DIUA 4M2XA 4M7VA 4KY8A 3F0UX 1DLSA 3HJ3A 5HF2X 3L3RA 3CD2A 3S3VA 2HQPA 4IXGX 5HF0X 3VCOA 2LF1A 1S3YA 4DPHA 1DISA 4M6JA 3SRWX 5HSRA 4OSGA 3GHWA 1PD8A 3F0XX 1MVSA 4Q0EA 3QLRA 1SEJA 3FREX 4IXED 2AZNA 3FQFA 3FRAX 3FRDX 3JVXA 3QFXA 3DAUA 3FYWX 4QJCA 3KFYA 1RH3A 1JUVA 3KY8A 4Q67A 4X5HA 4Q0DA 4I13A 5FDAA 3QLSA 3NZ6X 2O7PA 4I1NA 1S3UA 3DRCA 4KYAA 3FL9A 1DYJA 2W3AA 1U70A 1LY4A 4HOEA 4HA7A 1QZFA 3FQZA 5HT5A 3TD8A 4EILA 3NZ9X 5U26A 1HFRA 4KNEA 3GI2A 3F0VX 3RG9A 3DL6A 4M6LA 2FZHA 2W9SA 4QHVA 5JG0X 4G8ZX 2JYBA 1PD9A 1IA3A 2HXVA 4RGCA 1DR4A 2G6VA 1JOLA 3ROAA 4G3MA 4P66A 1KMVA 3SAIA 1RX5A 3FY8X 3IX9A 3NXXA 1BZFA 1HFQA 3NZDA 1RX8A 1AO8A 1LY3A 5HI6A 3UM6A 1DR1A 3JWCA 3RO9A 3KJSA 4KEBA 1RB2A 6DFRA 5ECCA 2C2TA 5HVEA 4NX7A 3JW5A 3N0HA 3QGTA 1M78A 2OBCA 3EEJA 3QLWA 1RE7A 3NXYA 2W9GA 3FL8A 1RX4A 2ANOA 1DDSA 3KJRA 2DRCA 3DL5A 1OHKA 1M79A 5E8QA 1DRFA 5U27A 4KJLA 3GHCA 3SRRX 2DHFA 5EAJA 4KJKA 2C2SA 5HUIA 3SA2A 3NXOA 3ZPGA 1DG7A 1J3JA 4EIZA 4FHBA 2H2QA 4KM2A 1RD7A 4KBNA 5CC9A 5DXVA 3DFRA 3CL9A 4DFRA 1OHJA 1DREA 3EEKA 4LAHX 2ZZAA 4DPDA 1DRAA 4KLXA 4QLGA 4ELHA 1RB3A 1DRHA 3F0SX 5ECXA 1VJ3A 3M08A 1RA8A 3F91A 1RC4A 3TQAA 3NTZA 4DP3A 4IXFX 4KM0A 3GYFA 3KGYA 3SRSX 4M6KA 1JOMA 1D1GA 3QLZA 3NZBX 3S9UA 4QLEA 3FRFX 1DYRA 4PTJA 3FQCA 4PSTA 3UM8A 4Q6AA 2W3WA 3GHVA 3K47A 4KAKA 4QJZD 2W9TA
chains in the Genus database with same CATH superfamily
3E0BA 2W9HA 2W3BA 3JTWA 3SR5X 4KFJA 3FRBX 1RX6A 3K74A 1RX1A 4TU5X 3ZPCA 3DATA 3HBBA 2FZJA 1DAJA 2KGKA 1PDBA 4OR7A 2D0KA 1MVTA 1LUDA 4XECX 5JA3A 5HSUA 2HM9A 4QI9A 2BL9A 4EJ1A 1S3VA 3D84X 4X5GA 1DHFA 4P3QA 1DG5A 4PSYA 3I3RA 4KJJA 1M7AA 3D80A 4XT8A 1RA2A 3IA5A 3NXRA 4XT4A 4H97A 1DR5A 1DYHA 4H98A 1ZDRA 1RX2A 3QLXA 3FS6A 3QYOA 4PTHA 3SH2A 2BLBA 4DDRA 1DYIA 3NZAX 4HOGA 3TQ8A 3JWKA 1HFPA 4M7UA 2FZIA 4PSSA 3DGAA 2CIGA 4H95A 3EEMA 3UM5A 1AI9A 4FGGA 3JSUA 2ITHA 1RF7A 5CCCA 3IRMA 3SQYX 1DDRA 3F8ZA 3S7AA 4LEKX 3OAFA 2L28A 2P4GA 3IA4A 3OCHA 1DR6A 2GD9A 1RA9A 4XT6A 3QL3A 1VDRA 1DF7A 5HT4A 1DR3A 4XT7A 3IROA 4KD7A 3SRQX 4XT5A 3INVA 4FGHA 4HA9A 2W3MA 1RX7A 5DFRA 5HVBA 1DRBA 2QK8A 3IRNA 3F8YA 4X5FA 1E26A 3I8AX 3SA1A 3NXVA 1TDRA 3LG4A 3NXTA 3QG2A 4X5IA 2INQA 4CD2A 1YHOA 1IA1A 2BLAA 1J3IA 1KLKA 3R33A 1DHJA 4G95A 4XE6X 1J3KA 3Q1HA 1DR2A 3QLYA 1KMSA 4KY4A 3FY9X 2W3VA 1IA2A 3FYVX 4QLFA 3SRUX 1DR7A 4ELBA 3NU0A 3JWMA 1RG7A 4ELFA 3K45A 1RX3A 1DG8A 5HPBA 4PDJA 4HOFA 2B3ZA 4P3RA 4NX6A 1U71A 1AOEA 3EIGA 4EIGA 3F0BX 3FQ0A 1DHIA 3FQVA 4GH8A 4ELEA 4ECKA 5HQZA 1CZ3A 1IA4A 4LAEX 4KL9A 3TQBA 1RX9A 2XW7A 1U72A 3QYLA 2CD2A 3EELA 3M09A 2BLCA 3NRRA 4XRBA 1CD2A 3SGYA 5HQYA 1BOZA 3CLBA 4LAGX 3F0QX 2ANQA 3QL0A 3K2HA 4H96A 3DG8A 3JW3A 7DFRA 3TQ9A 4X5JA 2D5NA 3FQOA 3CSEA 1DLRA 2OIPA 1RA1A 3JWFA 8DFRA 1S3WA 1RA3A 4ELGA 4P68A 3NZCX 3EX8A 1DIUA 4M2XA 4M7VA 4KY8A 3F0UX 1DLSA 3HJ3A 5HF2X 3L3RA 3CD2A 3S3VA 2HQPA 4IXGX 5HF0X 3VCOA 2LF1A 1S3YA 4DPHA 1DISA 4M6JA 3SRWX 5HSRA 4OSGA 3GHWA 1PD8A 3F0XX 1MVSA 4Q0EA 3QLRA 1SEJA 3FREX 4IXED 2AZNA 3FQFA 3FRAX 3FRDX 3JVXA 3QFXA 3DAUA 3FYWX 4QJCA 3KFYA 1RH3A 1JUVA 3KY8A 4Q67A 4X5HA 4Q0DA 4I13A 5FDAA 3QLSA 3NZ6X 2O7PA 4I1NA 1S3UA 3DRCA 4KYAA 3FL9A 1DYJA 2W3AA 1U70A 1LY4A 4HOEA 4HA7A 1QZFA 3FQZA 5HT5A 3TD8A 4EILA 3NZ9X 5U26A 1HFRA 4KNEA 3GI2A 3F0VX 3RG9A 3DL6A 4M6LA 2FZHA 2W9SA 4QHVA 5JG0X 4G8ZX 2JYBA 1PD9A 1IA3A 2HXVA 4RGCA 1DR4A 2G6VA 1JOLA 3ROAA 4G3MA 4P66A 1KMVA 3SAIA 1RX5A 3FY8X 3IX9A 3NXXA 1BZFA 1HFQA 3NZDA 1RX8A 1AO8A 1LY3A 5HI6A 3UM6A 1DR1A 3JWCA 3RO9A 3KJSA 4KEBA 1RB2A 6DFRA 5ECCA 2C2TA 5HVEA 4NX7A 3JW5A 3N0HA 3QGTA 1M78A 2OBCA 3EEJA 3QLWA 1RE7A 3NXYA 2W9GA 3FL8A 1RX4A 2ANOA 1DDSA 3KJRA 2DRCA 3DL5A 1OHKA 1M79A 5E8QA 1DRFA 5U27A 4KJLA 3GHCA 3SRRX 2DHFA 5EAJA 4KJKA 2C2SA 5HUIA 3SA2A 3NXOA 3ZPGA 1DG7A 1J3JA 4EIZA 4FHBA 2H2QA 4KM2A 1RD7A 4KBNA 5CC9A 5DXVA 3DFRA 3CL9A 4DFRA 1OHJA 1DREA 3EEKA 4LAHX 2ZZAA 4DPDA 1DRAA 4KLXA 4QLGA 4ELHA 1RB3A 1DRHA 3F0SX 5ECXA 1VJ3A 3M08A 1RA8A 3F91A 1RC4A 3TQAA 3NTZA 4DP3A 4IXFX 4KM0A 3GYFA 3KGYA 3SRSX 4M6KA 1JOMA 1D1GA 3QLZA 3NZBX 3S9UA 4QLEA 3FRFX 1DYRA 4PTJA 3FQCA 4PSTA 3UM8A 4Q6AA 2W3WA 3GHVA 3K47A 4KAKA 4QJZD 2W9TA
chains in the Genus database with same CATH topology
3E0BA 2W9HA 2W3BA 3JTWA 3SR5X 4KFJA 3FRBX 1RX6A 3K74A 1RX1A 4TU5X 3ZPCA 3DATA 3HBBA 2FZJA 1DAJA 2KGKA 1PDBA 4OR7A 2D0KA 1MVTA 1LUDA 4XECX 5JA3A 5HSUA 2HM9A 4QI9A 2BL9A 4EJ1A 1S3VA 3D84X 4X5GA 1DHFA 4P3QA 1DG5A 4PSYA 3I3RA 4KJJA 1M7AA 3D80A 4XT8A 1RA2A 3IA5A 3NXRA 4XT4A 4H97A 1DR5A 1DYHA 4H98A 1ZDRA 1RX2A 3QLXA 3FS6A 3QYOA 4PTHA 3SH2A 2BLBA 4DDRA 1DYIA 3NZAX 4HOGA 3TQ8A 3JWKA 1HFPA 4M7UA 2FZIA 4PSSA 3DGAA 2CIGA 4H95A 3EEMA 3UM5A 1AI9A 4FGGA 3JSUA 2ITHA 1RF7A 5CCCA 3IRMA 3SQYX 1DDRA 3F8ZA 3S7AA 4LEKX 3OAFA 2L28A 2P4GA 3IA4A 3OCHA 1DR6A 2GD9A 1RA9A 4XT6A 3QL3A 1VDRA 1DF7A 5HT4A 1DR3A 4XT7A 3IROA 4KD7A 3SRQX 4XT5A 3INVA 4FGHA 4HA9A 2W3MA 1RX7A 5DFRA 5HVBA 1DRBA 2QK8A 3IRNA 3F8YA 4X5FA 1E26A 3I8AX 3SA1A 3NXVA 1TDRA 3LG4A 3NXTA 3QG2A 4X5IA 2INQA 4CD2A 1YHOA 1IA1A 2BLAA 1J3IA 1KLKA 3R33A 1DHJA 4G95A 4XE6X 1J3KA 3Q1HA 1DR2A 3QLYA 1KMSA 4KY4A 3FY9X 2W3VA 1IA2A 3FYVX 4QLFA 3SRUX 1DR7A 4ELBA 3NU0A 3JWMA 1RG7A 4ELFA 3K45A 1RX3A 1DG8A 5HPBA 4PDJA 4HOFA 2B3ZA 4P3RA 4NX6A 1U71A 1AOEA 3EIGA 4EIGA 3F0BX 3FQ0A 1DHIA 3FQVA 4GH8A 4ELEA 4ECKA 5HQZA 1CZ3A 1IA4A 4LAEX 4KL9A 3TQBA 1RX9A 2XW7A 1U72A 3QYLA 2CD2A 3EELA 3M09A 2BLCA 3NRRA 4XRBA 1CD2A 3SGYA 5HQYA 1BOZA 3CLBA 4LAGX 3F0QX 2ANQA 3QL0A 3K2HA 4H96A 3DG8A 3JW3A 7DFRA 3TQ9A 4X5JA 2D5NA 3FQOA 3CSEA 1DLRA 2OIPA 1RA1A 3JWFA 8DFRA 1S3WA 1RA3A 4ELGA 4P68A 3NZCX 3EX8A 1DIUA 4M2XA 4M7VA 4KY8A 3F0UX 1DLSA 3HJ3A 5HF2X 3L3RA 3CD2A 3S3VA 2HQPA 4IXGX 5HF0X 3VCOA 2LF1A 1S3YA 4DPHA 1DISA 4M6JA 3SRWX 5HSRA 4OSGA 3GHWA 1PD8A 3F0XX 1MVSA 4Q0EA 3QLRA 1SEJA 3FREX 4IXED 2AZNA 3FQFA 3FRAX 3FRDX 3JVXA 3QFXA 3DAUA 3FYWX 4QJCA 3KFYA 1RH3A 1JUVA 3KY8A 4Q67A 4X5HA 4Q0DA 4I13A 5FDAA 3QLSA 3NZ6X 2O7PA 4I1NA 1S3UA 3DRCA 4KYAA 3FL9A 1DYJA 2W3AA 1U70A 1LY4A 4HOEA 4HA7A 1QZFA 3FQZA 5HT5A 3TD8A 4EILA 3NZ9X 5U26A 1HFRA 4KNEA 3GI2A 3F0VX 3RG9A 3DL6A 4M6LA 2FZHA 2W9SA 4QHVA 5JG0X 4G8ZX 2JYBA 1PD9A 1IA3A 2HXVA 4RGCA 1DR4A 2G6VA 1JOLA 3ROAA 4G3MA 4P66A 1KMVA 3SAIA 1RX5A 3FY8X 3IX9A 3NXXA 1BZFA 1HFQA 3NZDA 1RX8A 1AO8A 1LY3A 5HI6A 3UM6A 1DR1A 3JWCA 3RO9A 3KJSA 4KEBA 1RB2A 6DFRA 5ECCA 2C2TA 5HVEA 4NX7A 3JW5A 3N0HA 3QGTA 1M78A 2OBCA 3EEJA 3QLWA 1RE7A 3NXYA 2W9GA 3FL8A 1RX4A 2ANOA 1DDSA 3KJRA 2DRCA 3DL5A 1OHKA 1M79A 5E8QA 1DRFA 5U27A 4KJLA 3GHCA 3SRRX 2DHFA 5EAJA 4KJKA 2C2SA 5HUIA 3SA2A 3NXOA 3ZPGA 1DG7A 1J3JA 4EIZA 4FHBA 2H2QA 4KM2A 1RD7A 4KBNA 5CC9A 5DXVA 3DFRA 3CL9A 4DFRA 1OHJA 1DREA 3EEKA 4LAHX 2ZZAA 4DPDA 1DRAA 4KLXA 4QLGA 4ELHA 1RB3A 1DRHA 3F0SX 5ECXA 1VJ3A 3M08A 1RA8A 3F91A 1RC4A 3TQAA 3NTZA 4DP3A 4IXFX 4KM0A 3GYFA 3KGYA 3SRSX 4M6KA 1JOMA 1D1GA 3QLZA 3NZBX 3S9UA 4QLEA 3FRFX 1DYRA 4PTJA 3FQCA 4PSTA 3UM8A 4Q6AA 2W3WA 3GHVA 3K47A 4KAKA 4QJZD 2W9TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E0B A;  2W9H A;  2W3B A;  3JTW A;  3SR5 X;  4KFJ A;  3FRB X;  1RX6 A;  3K74 A;  1RX1 A;  4TU5 X;  3ZPC A;  3DAT A;  3HBB A;  2FZJ A;  1DAJ A;  2KGK A;  1PDB A;  4OR7 A;  2D0K A;  1MVT A;  1LUD A;  4XEC X;  5JA3 A;  5HSU A;  2HM9 A;  4QI9 A;  2BL9 A;  4EJ1 A;  1S3V A;  3D84 X;  4X5G A;  1DHF A;  4P3Q A;  1DG5 A;  4PSY A;  3I3R A;  4KJJ A;  1M7A A;  3D80 A;  4XT8 A;  1RA2 A;  3IA5 A;  3NXR A;  4XT4 A;  4H97 A;  1DR5 A;  1DYH A;  4H98 A;  1ZDR A;  1RX2 A;  3QLX A;  3FS6 A;  3QYO A;  4PTH A;  3SH2 A;  2BLB A;  4DDR A;  1DYI A;  3NZA X;  4HOG A;  3TQ8 A;  3JWK A;  1HFP A;  4M7U A;  2FZI A;  4PSS A;  3DGA A;  2CIG A;  4H95 A;  3EEM A;  3UM5 A;  1AI9 A;  4FGG A;  3JSU A;  2ITH A;  1RF7 A;  5CCC A;  3IRM A;  3SQY X;  1DDR A;  3F8Z A;  3S7A A;  4LEK X;  3OAF A;  2L28 A;  2P4G A;  3IA4 A;  3OCH A;  1DR6 A;  2GD9 A;  1RA9 A;  4XT6 A;  3QL3 A;  1VDR A;  1DF7 A;  5HT4 A;  1DR3 A;  4XT7 A;  3IRO A;  4KD7 A;  3SRQ X;  4XT5 A;  3INV A;  4FGH A;  4HA9 A;  2W3M A;  1RX7 A;  5DFR A;  5HVB A;  1DRB A;  2QK8 A;  3IRN A;  3F8Y A;  4X5F A;  1E26 A;  3I8A X;  3SA1 A;  3NXV A;  1TDR A;  3LG4 A;  3NXT A;  3QG2 A;  4X5I A;  2INQ A;  4CD2 A;  1YHO A;  1IA1 A;  2BLA A;  1J3I A;  1KLK A;  3R33 A;  1DHJ A;  4G95 A;  4XE6 X;  1J3K A;  3Q1H A;  1DR2 A;  3QLY A;  1KMS A;  4KY4 A;  3FY9 X;  2W3V A;  1IA2 A;  3FYV X;  4QLF A;  3SRU X;  1DR7 A;  4ELB A;  3NU0 A;  3JWM A;  1RG7 A;  4ELF A;  3K45 A;  1RX3 A;  1DG8 A;  5HPB A;  4PDJ A;  4HOF A;  2B3Z A;  4P3R A;  4NX6 A;  1U71 A;  1AOE A;  3EIG A;  4EIG A;  3F0B X;  3FQ0 A;  1DHI A;  3FQV A;  4GH8 A;  4ELE A;  4ECK A;  5HQZ A;  1CZ3 A;  1IA4 A;  4LAE X;  4KL9 A;  3TQB A;  1RX9 A;  2XW7 A;  1U72 A;  3QYL A;  2CD2 A;  3EEL A;  3M09 A;  2BLC A;  3NRR A;  4XRB A;  1CD2 A;  3SGY A;  5HQY A;  1BOZ A;  3CLB A;  4LAG X;  3F0Q X;  2ANQ A;  3QL0 A;  3K2H A;  4H96 A;  3DG8 A;  3JW3 A;  7DFR A;  3TQ9 A;  4X5J A;  2D5N A;  3FQO A;  3CSE A;  1DLR A;  2OIP A;  1RA1 A;  3JWF A;  8DFR A;  1S3W A;  1RA3 A;  4ELG A;  4P68 A;  3NZC X;  3EX8 A;  1DIU A;  4M2X A;  4M7V A;  4KY8 A;  3F0U X;  1DLS A;  3HJ3 A;  5HF2 X;  3L3R A;  3CD2 A;  3S3V A;  2HQP A;  4IXG X;  5HF0 X;  3VCO A;  2LF1 A;  1S3Y A;  4DPH A;  1DIS A;  4M6J A;  3SRW X;  5HSR A;  4OSG A;  3GHW A;  1PD8 A;  3F0X X;  1MVS A;  4Q0E A;  3QLR A;  1SEJ A;  3FRE X;  4IXE D;  2AZN A;  3FQF A;  3FRA X;  3FRD X;  3JVX A;  3QFX A;  3DAU A;  3FYW X;  4QJC A;  3KFY A;  1RH3 A;  1JUV A;  3KY8 A;  4Q67 A;  4X5H A;  4Q0D A;  4I13 A;  5FDA A;  3QLS A;  3NZ6 X;  2O7P A;  4I1N A;  1S3U A;  3DRC A;  4KYA A;  3FL9 A;  1DYJ A;  2W3A A;  1U70 A;  1LY4 A;  4HOE A;  4HA7 A;  1QZF A;  3FQZ A;  5HT5 A;  3TD8 A;  4EIL A;  3NZ9 X;  5U26 A;  1HFR A;  4KNE A;  3GI2 A;  3F0V X;  3RG9 A;  3DL6 A;  4M6L A;  2FZH A;  2W9S A;  4QHV A;  5JG0 X;  4G8Z X;  2JYB A;  1PD9 A;  1IA3 A;  2HXV A;  4RGC A;  1DR4 A;  2G6V A;  1JOL A;  3ROA A;  4G3M A;  4P66 A;  1KMV A;  3SAI A;  1RX5 A;  3FY8 X;  3IX9 A;  3NXX A;  1BZF A;  1HFQ A;  3NZD A;  1RX8 A;  1AO8 A;  1LY3 A;  5HI6 A;  3UM6 A;  1DR1 A;  3JWC A;  3RO9 A;  3KJS A;  4KEB A;  1RB2 A;  6DFR A;  5ECC A;  2C2T A;  5HVE A;  4NX7 A;  3JW5 A;  3N0H A;  3QGT A;  1M78 A;  2OBC A;  3EEJ A;  3QLW A;  1RE7 A;  3NXY A;  2W9G A;  3FL8 A;  1RX4 A;  2ANO A;  1DDS A;  3KJR A;  2DRC A;  3DL5 A;  1OHK A;  1M79 A;  5E8Q A;  1DRF A;  5U27 A;  4KJL A;  3GHC A;  3SRR X;  2DHF A;  5EAJ A;  4KJK A;  2C2S A;  5HUI A;  3SA2 A;  3NXO A;  3ZPG A;  1DG7 A;  1J3J A;  4EIZ A;  4FHB A;  2H2Q A;  4KM2 A;  1RD7 A;  4KBN A;  5CC9 A;  5DXV A;  3DFR A;  3CL9 A;  4DFR A;  1OHJ A;  1DRE A;  3EEK A;  4LAH X;  2ZZA A;  4DPD A;  1DRA A;  4KLX A;  4QLG A;  4ELH A;  1RB3 A;  1DRH A;  3F0S X;  5ECX A;  1VJ3 A;  3M08 A;  1RA8 A;  3F91 A;  1RC4 A;  3TQA A;  3NTZ A;  4DP3 A;  4IXF X;  4KM0 A;  3GYF A;  3KGY A;  3SRS X;  4M6K A;  1JOM A;  1D1G A;  3QLZ A;  3NZB X;  3S9U A;  4QLE A;  3FRF X;  1DYR A;  4PTJ A;  3FQC A;  4PST A;  3UM8 A;  4Q6A A;  2W3W A;  3GHV A;  3K47 A;  4KAK A;  4QJZ D;  2W9T A; 
#chains in the Genus database with same CATH topology
 3E0B A;  2W9H A;  2W3B A;  3JTW A;  3SR5 X;  4KFJ A;  3FRB X;  1RX6 A;  3K74 A;  1RX1 A;  4TU5 X;  3ZPC A;  3DAT A;  3HBB A;  2FZJ A;  1DAJ A;  2KGK A;  1PDB A;  4OR7 A;  2D0K A;  1MVT A;  1LUD A;  4XEC X;  5JA3 A;  5HSU A;  2HM9 A;  4QI9 A;  2BL9 A;  4EJ1 A;  1S3V A;  3D84 X;  4X5G A;  1DHF A;  4P3Q A;  1DG5 A;  4PSY A;  3I3R A;  4KJJ A;  1M7A A;  3D80 A;  4XT8 A;  1RA2 A;  3IA5 A;  3NXR A;  4XT4 A;  4H97 A;  1DR5 A;  1DYH A;  4H98 A;  1ZDR A;  1RX2 A;  3QLX A;  3FS6 A;  3QYO A;  4PTH A;  3SH2 A;  2BLB A;  4DDR A;  1DYI A;  3NZA X;  4HOG A;  3TQ8 A;  3JWK A;  1HFP A;  4M7U A;  2FZI A;  4PSS A;  3DGA A;  2CIG A;  4H95 A;  3EEM A;  3UM5 A;  1AI9 A;  4FGG A;  3JSU A;  2ITH A;  1RF7 A;  5CCC A;  3IRM A;  3SQY X;  1DDR A;  3F8Z A;  3S7A A;  4LEK X;  3OAF A;  2L28 A;  2P4G A;  3IA4 A;  3OCH A;  1DR6 A;  2GD9 A;  1RA9 A;  4XT6 A;  3QL3 A;  1VDR A;  1DF7 A;  5HT4 A;  1DR3 A;  4XT7 A;  3IRO A;  4KD7 A;  3SRQ X;  4XT5 A;  3INV A;  4FGH A;  4HA9 A;  2W3M A;  1RX7 A;  5DFR A;  5HVB A;  1DRB A;  2QK8 A;  3IRN A;  3F8Y A;  4X5F A;  1E26 A;  3I8A X;  3SA1 A;  3NXV A;  1TDR A;  3LG4 A;  3NXT A;  3QG2 A;  4X5I A;  2INQ A;  4CD2 A;  1YHO A;  1IA1 A;  2BLA A;  1J3I A;  1KLK A;  3R33 A;  1DHJ A;  4G95 A;  4XE6 X;  1J3K A;  3Q1H A;  1DR2 A;  3QLY A;  1KMS A;  4KY4 A;  3FY9 X;  2W3V A;  1IA2 A;  3FYV X;  4QLF A;  3SRU X;  1DR7 A;  4ELB A;  3NU0 A;  3JWM A;  1RG7 A;  4ELF A;  3K45 A;  1RX3 A;  1DG8 A;  5HPB A;  4PDJ A;  4HOF A;  2B3Z A;  4P3R A;  4NX6 A;  1U71 A;  1AOE A;  3EIG A;  4EIG A;  3F0B X;  3FQ0 A;  1DHI A;  3FQV A;  4GH8 A;  4ELE A;  4ECK A;  5HQZ A;  1CZ3 A;  1IA4 A;  4LAE X;  4KL9 A;  3TQB A;  1RX9 A;  2XW7 A;  1U72 A;  3QYL A;  2CD2 A;  3EEL A;  3M09 A;  2BLC A;  3NRR A;  4XRB A;  1CD2 A;  3SGY A;  5HQY A;  1BOZ A;  3CLB A;  4LAG X;  3F0Q X;  2ANQ A;  3QL0 A;  3K2H A;  4H96 A;  3DG8 A;  3JW3 A;  7DFR A;  3TQ9 A;  4X5J A;  2D5N A;  3FQO A;  3CSE A;  1DLR A;  2OIP A;  1RA1 A;  3JWF A;  8DFR A;  1S3W A;  1RA3 A;  4ELG A;  4P68 A;  3NZC X;  3EX8 A;  1DIU A;  4M2X A;  4M7V A;  4KY8 A;  3F0U X;  1DLS A;  3HJ3 A;  5HF2 X;  3L3R A;  3CD2 A;  3S3V A;  2HQP A;  4IXG X;  5HF0 X;  3VCO A;  2LF1 A;  1S3Y A;  4DPH A;  1DIS A;  4M6J A;  3SRW X;  5HSR A;  4OSG A;  3GHW A;  1PD8 A;  3F0X X;  1MVS A;  4Q0E A;  3QLR A;  1SEJ A;  3FRE X;  4IXE D;  2AZN A;  3FQF A;  3FRA X;  3FRD X;  3JVX A;  3QFX A;  3DAU A;  3FYW X;  4QJC A;  3KFY A;  1RH3 A;  1JUV A;  3KY8 A;  4Q67 A;  4X5H A;  4Q0D A;  4I13 A;  5FDA A;  3QLS A;  3NZ6 X;  2O7P A;  4I1N A;  1S3U A;  3DRC A;  4KYA A;  3FL9 A;  1DYJ A;  2W3A A;  1U70 A;  1LY4 A;  4HOE A;  4HA7 A;  1QZF A;  3FQZ A;  5HT5 A;  3TD8 A;  4EIL A;  3NZ9 X;  5U26 A;  1HFR A;  4KNE A;  3GI2 A;  3F0V X;  3RG9 A;  3DL6 A;  4M6L A;  2FZH A;  2W9S A;  4QHV A;  5JG0 X;  4G8Z X;  2JYB A;  1PD9 A;  1IA3 A;  2HXV A;  4RGC A;  1DR4 A;  2G6V A;  1JOL A;  3ROA A;  4G3M A;  4P66 A;  1KMV A;  3SAI A;  1RX5 A;  3FY8 X;  3IX9 A;  3NXX A;  1BZF A;  1HFQ A;  3NZD A;  1RX8 A;  1AO8 A;  1LY3 A;  5HI6 A;  3UM6 A;  1DR1 A;  3JWC A;  3RO9 A;  3KJS A;  4KEB A;  1RB2 A;  6DFR A;  5ECC A;  2C2T A;  5HVE A;  4NX7 A;  3JW5 A;  3N0H A;  3QGT A;  1M78 A;  2OBC A;  3EEJ A;  3QLW A;  1RE7 A;  3NXY A;  2W9G A;  3FL8 A;  1RX4 A;  2ANO A;  1DDS A;  3KJR A;  2DRC A;  3DL5 A;  1OHK A;  1M79 A;  5E8Q A;  1DRF A;  5U27 A;  4KJL A;  3GHC A;  3SRR X;  2DHF A;  5EAJ A;  4KJK A;  2C2S A;  5HUI A;  3SA2 A;  3NXO A;  3ZPG A;  1DG7 A;  1J3J A;  4EIZ A;  4FHB A;  2H2Q A;  4KM2 A;  1RD7 A;  4KBN A;  5CC9 A;  5DXV A;  3DFR A;  3CL9 A;  4DFR A;  1OHJ A;  1DRE A;  3EEK A;  4LAH X;  2ZZA A;  4DPD A;  1DRA A;  4KLX A;  4QLG A;  4ELH A;  1RB3 A;  1DRH A;  3F0S X;  5ECX A;  1VJ3 A;  3M08 A;  1RA8 A;  3F91 A;  1RC4 A;  3TQA A;  3NTZ A;  4DP3 A;  4IXF X;  4KM0 A;  3GYF A;  3KGY A;  3SRS X;  4M6K A;  1JOM A;  1D1G A;  3QLZ A;  3NZB X;  3S9U A;  4QLE A;  3FRF X;  1DYR A;  4PTJ A;  3FQC A;  4PST A;  3UM8 A;  4Q6A A;  2W3W A;  3GHV A;  3K47 A;  4KAK A;  4QJZ D;  2W9T A; 
#chains in the Genus database with same CATH homology
 3E0B A;  2W9H A;  2W3B A;  3JTW A;  3SR5 X;  4KFJ A;  3FRB X;  1RX6 A;  3K74 A;  1RX1 A;  4TU5 X;  3ZPC A;  3DAT A;  3HBB A;  2FZJ A;  1DAJ A;  2KGK A;  1PDB A;  4OR7 A;  2D0K A;  1MVT A;  1LUD A;  4XEC X;  5JA3 A;  5HSU A;  2HM9 A;  4QI9 A;  2BL9 A;  4EJ1 A;  1S3V A;  3D84 X;  4X5G A;  1DHF A;  4P3Q A;  1DG5 A;  4PSY A;  3I3R A;  4KJJ A;  1M7A A;  3D80 A;  4XT8 A;  1RA2 A;  3IA5 A;  3NXR A;  4XT4 A;  4H97 A;  1DR5 A;  1DYH A;  4H98 A;  1ZDR A;  1RX2 A;  3QLX A;  3FS6 A;  3QYO A;  4PTH A;  3SH2 A;  2BLB A;  4DDR A;  1DYI A;  3NZA X;  4HOG A;  3TQ8 A;  3JWK A;  1HFP A;  4M7U A;  2FZI A;  4PSS A;  3DGA A;  2CIG A;  4H95 A;  3EEM A;  3UM5 A;  1AI9 A;  4FGG A;  3JSU A;  2ITH A;  1RF7 A;  5CCC A;  3IRM A;  3SQY X;  1DDR A;  3F8Z A;  3S7A A;  4LEK X;  3OAF A;  2L28 A;  2P4G A;  3IA4 A;  3OCH A;  1DR6 A;  2GD9 A;  1RA9 A;  4XT6 A;  3QL3 A;  1VDR A;  1DF7 A;  5HT4 A;  1DR3 A;  4XT7 A;  3IRO A;  4KD7 A;  3SRQ X;  4XT5 A;  3INV A;  4FGH A;  4HA9 A;  2W3M A;  1RX7 A;  5DFR A;  5HVB A;  1DRB A;  2QK8 A;  3IRN A;  3F8Y A;  4X5F A;  1E26 A;  3I8A X;  3SA1 A;  3NXV A;  1TDR A;  3LG4 A;  3NXT A;  3QG2 A;  4X5I A;  2INQ A;  4CD2 A;  1YHO A;  1IA1 A;  2BLA A;  1J3I A;  1KLK A;  3R33 A;  1DHJ A;  4G95 A;  4XE6 X;  1J3K A;  3Q1H A;  1DR2 A;  3QLY A;  1KMS A;  4KY4 A;  3FY9 X;  2W3V A;  1IA2 A;  3FYV X;  4QLF A;  3SRU X;  1DR7 A;  4ELB A;  3NU0 A;  3JWM A;  1RG7 A;  4ELF A;  3K45 A;  1RX3 A;  1DG8 A;  5HPB A;  4PDJ A;  4HOF A;  2B3Z A;  4P3R A;  4NX6 A;  1U71 A;  1AOE A;  3EIG A;  4EIG A;  3F0B X;  3FQ0 A;  1DHI A;  3FQV A;  4GH8 A;  4ELE A;  4ECK A;  5HQZ A;  1CZ3 A;  1IA4 A;  4LAE X;  4KL9 A;  3TQB A;  1RX9 A;  2XW7 A;  1U72 A;  3QYL A;  2CD2 A;  3EEL A;  3M09 A;  2BLC A;  3NRR A;  4XRB A;  1CD2 A;  3SGY A;  5HQY A;  1BOZ A;  3CLB A;  4LAG X;  3F0Q X;  2ANQ A;  3QL0 A;  3K2H A;  4H96 A;  3DG8 A;  3JW3 A;  7DFR A;  3TQ9 A;  4X5J A;  2D5N A;  3FQO A;  3CSE A;  1DLR A;  2OIP A;  1RA1 A;  3JWF A;  8DFR A;  1S3W A;  1RA3 A;  4ELG A;  4P68 A;  3NZC X;  3EX8 A;  1DIU A;  4M2X A;  4M7V A;  4KY8 A;  3F0U X;  1DLS A;  3HJ3 A;  5HF2 X;  3L3R A;  3CD2 A;  3S3V A;  2HQP A;  4IXG X;  5HF0 X;  3VCO A;  2LF1 A;  1S3Y A;  4DPH A;  1DIS A;  4M6J A;  3SRW X;  5HSR A;  4OSG A;  3GHW A;  1PD8 A;  3F0X X;  1MVS A;  4Q0E A;  3QLR A;  1SEJ A;  3FRE X;  4IXE D;  2AZN A;  3FQF A;  3FRA X;  3FRD X;  3JVX A;  3QFX A;  3DAU A;  3FYW X;  4QJC A;  3KFY A;  1RH3 A;  1JUV A;  3KY8 A;  4Q67 A;  4X5H A;  4Q0D A;  4I13 A;  5FDA A;  3QLS A;  3NZ6 X;  2O7P A;  4I1N A;  1S3U A;  3DRC A;  4KYA A;  3FL9 A;  1DYJ A;  2W3A A;  1U70 A;  1LY4 A;  4HOE A;  4HA7 A;  1QZF A;  3FQZ A;  5HT5 A;  3TD8 A;  4EIL A;  3NZ9 X;  5U26 A;  1HFR A;  4KNE A;  3GI2 A;  3F0V X;  3RG9 A;  3DL6 A;  4M6L A;  2FZH A;  2W9S A;  4QHV A;  5JG0 X;  4G8Z X;  2JYB A;  1PD9 A;  1IA3 A;  2HXV A;  4RGC A;  1DR4 A;  2G6V A;  1JOL A;  3ROA A;  4G3M A;  4P66 A;  1KMV A;  3SAI A;  1RX5 A;  3FY8 X;  3IX9 A;  3NXX A;  1BZF A;  1HFQ A;  3NZD A;  1RX8 A;  1AO8 A;  1LY3 A;  5HI6 A;  3UM6 A;  1DR1 A;  3JWC A;  3RO9 A;  3KJS A;  4KEB A;  1RB2 A;  6DFR A;  5ECC A;  2C2T A;  5HVE A;  4NX7 A;  3JW5 A;  3N0H A;  3QGT A;  1M78 A;  2OBC A;  3EEJ A;  3QLW A;  1RE7 A;  3NXY A;  2W9G A;  3FL8 A;  1RX4 A;  2ANO A;  1DDS A;  3KJR A;  2DRC A;  3DL5 A;  1OHK A;  1M79 A;  5E8Q A;  1DRF A;  5U27 A;  4KJL A;  3GHC A;  3SRR X;  2DHF A;  5EAJ A;  4KJK A;  2C2S A;  5HUI A;  3SA2 A;  3NXO A;  3ZPG A;  1DG7 A;  1J3J A;  4EIZ A;  4FHB A;  2H2Q A;  4KM2 A;  1RD7 A;  4KBN A;  5CC9 A;  5DXV A;  3DFR A;  3CL9 A;  4DFR A;  1OHJ A;  1DRE A;  3EEK A;  4LAH X;  2ZZA A;  4DPD A;  1DRA A;  4KLX A;  4QLG A;  4ELH A;  1RB3 A;  1DRH A;  3F0S X;  5ECX A;  1VJ3 A;  3M08 A;  1RA8 A;  3F91 A;  1RC4 A;  3TQA A;  3NTZ A;  4DP3 A;  4IXF X;  4KM0 A;  3GYF A;  3KGY A;  3SRS X;  4M6K A;  1JOM A;  1D1G A;  3QLZ A;  3NZB X;  3S9U A;  4QLE A;  3FRF X;  1DYR A;  4PTJ A;  3FQC A;  4PST A;  3UM8 A;  4Q6A A;  2W3W A;  3GHV A;  3K47 A;  4KAK A;  4QJZ D;  2W9T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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