5HT5A

6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines
rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5ht5A00
2ANOA 1M78A 5CCCA 3EEJA 4DPHA 4ELHA 1DHIA 3R33A 3SH2A 4LAGX 2O7PA 7DFRA 6DFRA 1DG7A 1E26A 3Q1HA 3FQCA 3I8AX 3GHVA 1D1GA 1RG7A 3KJSA 5JG0X 4PTHA 1DDRA 3F91A 4EIZA 3EELA 3FRAX 4H95A 3N0HA 1S3UA 1AI9A 1M79A 4HOEA 5HQYA 1IA1A 3NXTA 3K74A 1DRBA 3FRBX 3UM5A 2DRCA 4XT5A 4XT7A 2OBCA 5HF2X 4DP3A 4X5HA 1PD9A 3NZ9X 3ZPCA 2KGKA 4M6LA 2W9TA 4OSGA 1M7AA 3NU0A 2HXVA 3K47A 4G8ZX 2FZIA 1DLRA 3KFYA 3DL5A 3GHWA 3QLRA 3CD2A 3OAFA 3F0XX 3JWFA 3L3RA 4KBNA 3F0VX 5JA3A 4X5GA 1YHOA 3FYWX 1DREA 3NTZA 5HSRA 1RA1A 1U72A 3LG4A 3M09A 4P3QA 4XT8A 2JYBA 1TDRA 4H96A 2BL9A 3FQFA 1RX8A 1DRHA 3SA1A 4QLFA 1LY4A 4NX7A 4HA7A 4QJZD 4KM2A 3NZAX 3NXOA 1DHFA 2W3WA 2GD9A 3CL9A 3D80A 2INQA 1DLSA 4XRBA 1PDBA 3SRWX 4KJLA 4TU5X 3SA2A 4M6KA 4KNEA 5HI6A 1VDRA 1BOZA 4KD7A 1RA8A 1CZ3A 1DRFA 3JW5A 1U70A 1RB2A 3SAIA 4PDJA 1DR6A 4IXFX 1KLKA 2ZZAA 4M7UA 4QJCA 3SGYA 2D5NA 4G3MA 3SQYX 2W3VA 1RX5A 3DFRA 3QLWA 1RF7A 2W9SA 4FHBA 1RB3A 1J3IA 2W9HA 3FL9A 3FQZA 1JOMA 4LEKX 4Q0DA 4H98A 3FY8X 1MVSA 3JWMA 2ITHA 1RX6A 1RA9A 1JUVA 5HQZA 3DAUA 3EIGA 1JOLA 3D84X 2BLCA 4PSYA 3SR5X 2C2TA 1DR3A 3NXVA 1DISA 1RA2A 3IRNA 3FQVA 3KGYA 1DYHA 3ZPGA 3QGTA 5HT5A 3JTWA 1RD7A 5HUIA 2D0KA 3HBBA 1AO8A 3TQAA 3DG8A 3NXXA 4HOFA 4KAKA 4PSTA 5CC9A 1DR2A 5U26A 1DYRA 3JVXA 1OHKA 2OIPA 2BLBA 1J3JA 2HQPA 3SRUX 3JWKA 5HVBA 2CIGA 3EEMA 1RX2A 2W9GA 4M2XA 3FY9X 3QL0A 4FGHA 2ANQA 3KY8A 4LAEX 1DYJA 3CLBA 1DAJA 3K45A 1SEJA 1HFRA 4DPDA 3S9UA 4KEBA 4ELFA 3NZDA 4KFJA 4KY4A 4QLEA 1DG5A 3UM8A 3I3RA 4KL9A 3JSUA 3S7AA 3TQ9A 4OR7A 2L28A 1RX1A 3F0BX 5U27A 3INVA 1DG8A 3FRFX 4KY8A 1MVTA 3FRDX 2FZJA 3FQ0A 3NZ6X 5HPBA 3GI2A 4M6JA 4HA9A 4KYAA 3IX9A 3SRQX 2C2SA 5FDAA 4XT6A 3SRRX 1U71A 4X5FA 4X5JA 3DL6A 3NZBX 4ELGA 1QZFA 5HSUA 5HVEA 1S3WA 2W3AA 3F0SX 4KM0A 3UM6A 1HFQA 4X5IA 4DFRA 4P3RA 4P68A 2FZHA 1S3VA 1KMSA 3IA4A 3FYVX 4IXGX 3RO9A 2HM9A 4KLXA 1RC4A 3IRMA 1DR7A 3NZCX 1PD8A 3QLXA 4I1NA 3OCHA 3F8YA 4RGCA 4DDRA 1RE7A 4I13A 3QFXA 4NX6A 4GH8A 1DDSA 4XE6X 3F8ZA 5DFRA 3SRSX 4IXED 3FS6A 1RA3A 4P66A 3IROA 3QYLA 2DHFA 3S3VA 4KJJA 2B3ZA 2G6VA 3QYOA 1IA4A 1HFPA 4QLGA 4G95A 4ELEA 1KMVA 4FGGA 1DHJA 1CD2A 3EEKA 1DYIA 4LAHX 3JW3A 1RH3A 5HT4A 1LY3A 4PSSA 1OHJA 4H97A 1RX9A 1DR5A 3F0UX 5EAJA 4QHVA 3ROAA 2XW7A 3DRCA 3IA5A 3DGAA 3NXYA 4Q0EA 4M7VA 3FREX 1BZFA 2H2QA 3JWCA 1S3YA 1VJ3A 2AZNA 4EIGA 4ECKA 3QL3A 1IA2A 3KJRA 3K2HA 2LF1A 3CSEA 1IA3A 5ECCA 3TQ8A 1LUDA 4CD2A 3RG9A 1DR4A 1RX7A 3E0BA 2BLAA 1DIUA 3HJ3A 1DRAA 3GYFA 4PTJA 3FL8A 4XECX 3DATA 3QLZA 5HF0X 2W3BA 2W3MA 4EILA 3EX8A 2QK8A 4QI9A 4ELBA 1DF7A 2CD2A 8DFRA 3F0QX 4HOGA 3QLYA 3TQBA 3VCOA 1J3KA 4Q67A 5ECXA 4EJ1A 3NRRA 3M08A 1AOEA 3QLSA 1RX4A 4Q6AA 1RX3A 2P4GA 3GHCA 3NXRA 4XT4A 3QG2A 5E8QA 3TD8A 4KJKA 1ZDRA 3FQOA 5DXVA 1DR1A
chains in the Genus database with same CATH superfamily
2ANOA 1M78A 5CCCA 3EEJA 4DPHA 4ELHA 1DHIA 3R33A 3SH2A 4LAGX 2O7PA 7DFRA 6DFRA 1DG7A 1E26A 3Q1HA 3FQCA 3I8AX 3GHVA 1D1GA 1RG7A 3KJSA 5JG0X 4PTHA 1DDRA 3F91A 4EIZA 3EELA 3FRAX 4H95A 3N0HA 1S3UA 1AI9A 1M79A 4HOEA 5HQYA 1IA1A 3NXTA 3K74A 1DRBA 3FRBX 3UM5A 2DRCA 4XT5A 4XT7A 2OBCA 5HF2X 4DP3A 4X5HA 1PD9A 3NZ9X 3ZPCA 2KGKA 4M6LA 2W9TA 4OSGA 1M7AA 3NU0A 2HXVA 3K47A 4G8ZX 2FZIA 1DLRA 3KFYA 3DL5A 3GHWA 3QLRA 3CD2A 3OAFA 3F0XX 3JWFA 3L3RA 4KBNA 3F0VX 5JA3A 4X5GA 1YHOA 3FYWX 1DREA 3NTZA 5HSRA 1RA1A 1U72A 3LG4A 3M09A 4P3QA 4XT8A 2JYBA 1TDRA 4H96A 2BL9A 3FQFA 1RX8A 1DRHA 3SA1A 4QLFA 1LY4A 4NX7A 4HA7A 4QJZD 4KM2A 3NZAX 3NXOA 1DHFA 2W3WA 2GD9A 3CL9A 3D80A 2INQA 1DLSA 4XRBA 1PDBA 3SRWX 4KJLA 4TU5X 3SA2A 4M6KA 4KNEA 5HI6A 1VDRA 1BOZA 4KD7A 1RA8A 1CZ3A 1DRFA 3JW5A 1U70A 1RB2A 3SAIA 4PDJA 1DR6A 4IXFX 1KLKA 2ZZAA 4M7UA 4QJCA 3SGYA 2D5NA 4G3MA 3SQYX 2W3VA 1RX5A 3DFRA 3QLWA 1RF7A 2W9SA 4FHBA 1RB3A 1J3IA 2W9HA 3FL9A 3FQZA 1JOMA 4LEKX 4Q0DA 4H98A 3FY8X 1MVSA 3JWMA 2ITHA 1RX6A 1RA9A 1JUVA 5HQZA 3DAUA 3EIGA 1JOLA 3D84X 2BLCA 4PSYA 3SR5X 2C2TA 1DR3A 3NXVA 1DISA 1RA2A 3IRNA 3FQVA 3KGYA 1DYHA 3ZPGA 3QGTA 5HT5A 3JTWA 1RD7A 5HUIA 2D0KA 3HBBA 1AO8A 3TQAA 3DG8A 3NXXA 4HOFA 4KAKA 4PSTA 5CC9A 1DR2A 5U26A 1DYRA 3JVXA 1OHKA 2OIPA 2BLBA 1J3JA 2HQPA 3SRUX 3JWKA 5HVBA 2CIGA 3EEMA 1RX2A 2W9GA 4M2XA 3FY9X 3QL0A 4FGHA 2ANQA 3KY8A 4LAEX 1DYJA 3CLBA 1DAJA 3K45A 1SEJA 1HFRA 4DPDA 3S9UA 4KEBA 4ELFA 3NZDA 4KFJA 4KY4A 4QLEA 1DG5A 3UM8A 3I3RA 4KL9A 3JSUA 3S7AA 3TQ9A 4OR7A 2L28A 1RX1A 3F0BX 5U27A 3INVA 1DG8A 3FRFX 4KY8A 1MVTA 3FRDX 2FZJA 3FQ0A 3NZ6X 5HPBA 3GI2A 4M6JA 4HA9A 4KYAA 3IX9A 3SRQX 2C2SA 5FDAA 4XT6A 3SRRX 1U71A 4X5FA 4X5JA 3DL6A 3NZBX 4ELGA 1QZFA 5HSUA 5HVEA 1S3WA 2W3AA 3F0SX 4KM0A 3UM6A 1HFQA 4X5IA 4DFRA 4P3RA 4P68A 2FZHA 1S3VA 1KMSA 3IA4A 3FYVX 4IXGX 3RO9A 2HM9A 4KLXA 1RC4A 3IRMA 1DR7A 3NZCX 1PD8A 3QLXA 4I1NA 3OCHA 3F8YA 4RGCA 4DDRA 1RE7A 4I13A 3QFXA 4NX6A 4GH8A 1DDSA 4XE6X 3F8ZA 5DFRA 3SRSX 4IXED 3FS6A 1RA3A 4P66A 3IROA 3QYLA 2DHFA 3S3VA 4KJJA 2B3ZA 2G6VA 3QYOA 1IA4A 1HFPA 4QLGA 4G95A 4ELEA 1KMVA 4FGGA 1DHJA 1CD2A 3EEKA 1DYIA 4LAHX 3JW3A 1RH3A 5HT4A 1LY3A 4PSSA 1OHJA 4H97A 1RX9A 1DR5A 3F0UX 5EAJA 4QHVA 3ROAA 2XW7A 3DRCA 3IA5A 3DGAA 3NXYA 4Q0EA 4M7VA 3FREX 1BZFA 2H2QA 3JWCA 1S3YA 1VJ3A 2AZNA 4EIGA 4ECKA 3QL3A 1IA2A 3KJRA 3K2HA 2LF1A 3CSEA 1IA3A 5ECCA 3TQ8A 1LUDA 4CD2A 3RG9A 1DR4A 1RX7A 3E0BA 2BLAA 1DIUA 3HJ3A 1DRAA 3GYFA 4PTJA 3FL8A 4XECX 3DATA 3QLZA 5HF0X 2W3BA 2W3MA 4EILA 3EX8A 2QK8A 4QI9A 4ELBA 1DF7A 2CD2A 8DFRA 3F0QX 4HOGA 3QLYA 3TQBA 3VCOA 1J3KA 4Q67A 5ECXA 4EJ1A 3NRRA 3M08A 1AOEA 3QLSA 1RX4A 4Q6AA 1RX3A 2P4GA 3GHCA 3NXRA 4XT4A 3QG2A 5E8QA 3TD8A 4KJKA 1ZDRA 3FQOA 5DXVA 1DR1A
chains in the Genus database with same CATH topology
2ANOA 1M78A 5CCCA 3EEJA 4DPHA 4ELHA 1DHIA 3R33A 3SH2A 4LAGX 2O7PA 7DFRA 6DFRA 1DG7A 1E26A 3Q1HA 3FQCA 3I8AX 3GHVA 1D1GA 1RG7A 3KJSA 5JG0X 4PTHA 1DDRA 3F91A 4EIZA 3EELA 3FRAX 4H95A 3N0HA 1S3UA 1AI9A 1M79A 4HOEA 5HQYA 1IA1A 3NXTA 3K74A 1DRBA 3FRBX 3UM5A 2DRCA 4XT5A 4XT7A 2OBCA 5HF2X 4DP3A 4X5HA 1PD9A 3NZ9X 3ZPCA 2KGKA 4M6LA 2W9TA 4OSGA 1M7AA 3NU0A 2HXVA 3K47A 4G8ZX 2FZIA 1DLRA 3KFYA 3DL5A 3GHWA 3QLRA 3CD2A 3OAFA 3F0XX 3JWFA 3L3RA 4KBNA 3F0VX 5JA3A 4X5GA 1YHOA 3FYWX 1DREA 3NTZA 5HSRA 1RA1A 1U72A 3LG4A 3M09A 4P3QA 4XT8A 2JYBA 1TDRA 4H96A 2BL9A 3FQFA 1RX8A 1DRHA 3SA1A 4QLFA 1LY4A 4NX7A 4HA7A 4QJZD 4KM2A 3NZAX 3NXOA 1DHFA 2W3WA 2GD9A 3CL9A 3D80A 2INQA 1DLSA 4XRBA 1PDBA 3SRWX 4KJLA 4TU5X 3SA2A 4M6KA 4KNEA 5HI6A 1VDRA 1BOZA 4KD7A 1RA8A 1CZ3A 1DRFA 3JW5A 1U70A 1RB2A 3SAIA 4PDJA 1DR6A 4IXFX 1KLKA 2ZZAA 4M7UA 4QJCA 3SGYA 2D5NA 4G3MA 3SQYX 2W3VA 1RX5A 3DFRA 3QLWA 1RF7A 2W9SA 4FHBA 1RB3A 1J3IA 2W9HA 3FL9A 3FQZA 1JOMA 4LEKX 4Q0DA 4H98A 3FY8X 1MVSA 3JWMA 2ITHA 1RX6A 1RA9A 1JUVA 5HQZA 3DAUA 3EIGA 1JOLA 3D84X 2BLCA 4PSYA 3SR5X 2C2TA 1DR3A 3NXVA 1DISA 1RA2A 3IRNA 3FQVA 3KGYA 1DYHA 3ZPGA 3QGTA 5HT5A 3JTWA 1RD7A 5HUIA 2D0KA 3HBBA 1AO8A 3TQAA 3DG8A 3NXXA 4HOFA 4KAKA 4PSTA 5CC9A 1DR2A 5U26A 1DYRA 3JVXA 1OHKA 2OIPA 2BLBA 1J3JA 2HQPA 3SRUX 3JWKA 5HVBA 2CIGA 3EEMA 1RX2A 2W9GA 4M2XA 3FY9X 3QL0A 4FGHA 2ANQA 3KY8A 4LAEX 1DYJA 3CLBA 1DAJA 3K45A 1SEJA 1HFRA 4DPDA 3S9UA 4KEBA 4ELFA 3NZDA 4KFJA 4KY4A 4QLEA 1DG5A 3UM8A 3I3RA 4KL9A 3JSUA 3S7AA 3TQ9A 4OR7A 2L28A 1RX1A 3F0BX 5U27A 3INVA 1DG8A 3FRFX 4KY8A 1MVTA 3FRDX 2FZJA 3FQ0A 3NZ6X 5HPBA 3GI2A 4M6JA 4HA9A 4KYAA 3IX9A 3SRQX 2C2SA 5FDAA 4XT6A 3SRRX 1U71A 4X5FA 4X5JA 3DL6A 3NZBX 4ELGA 1QZFA 5HSUA 5HVEA 1S3WA 2W3AA 3F0SX 4KM0A 3UM6A 1HFQA 4X5IA 4DFRA 4P3RA 4P68A 2FZHA 1S3VA 1KMSA 3IA4A 3FYVX 4IXGX 3RO9A 2HM9A 4KLXA 1RC4A 3IRMA 1DR7A 3NZCX 1PD8A 3QLXA 4I1NA 3OCHA 3F8YA 4RGCA 4DDRA 1RE7A 4I13A 3QFXA 4NX6A 4GH8A 1DDSA 4XE6X 3F8ZA 5DFRA 3SRSX 4IXED 3FS6A 1RA3A 4P66A 3IROA 3QYLA 2DHFA 3S3VA 4KJJA 2B3ZA 2G6VA 3QYOA 1IA4A 1HFPA 4QLGA 4G95A 4ELEA 1KMVA 4FGGA 1DHJA 1CD2A 3EEKA 1DYIA 4LAHX 3JW3A 1RH3A 5HT4A 1LY3A 4PSSA 1OHJA 4H97A 1RX9A 1DR5A 3F0UX 5EAJA 4QHVA 3ROAA 2XW7A 3DRCA 3IA5A 3DGAA 3NXYA 4Q0EA 4M7VA 3FREX 1BZFA 2H2QA 3JWCA 1S3YA 1VJ3A 2AZNA 4EIGA 4ECKA 3QL3A 1IA2A 3KJRA 3K2HA 2LF1A 3CSEA 1IA3A 5ECCA 3TQ8A 1LUDA 4CD2A 3RG9A 1DR4A 1RX7A 3E0BA 2BLAA 1DIUA 3HJ3A 1DRAA 3GYFA 4PTJA 3FL8A 4XECX 3DATA 3QLZA 5HF0X 2W3BA 2W3MA 4EILA 3EX8A 2QK8A 4QI9A 4ELBA 1DF7A 2CD2A 8DFRA 3F0QX 4HOGA 3QLYA 3TQBA 3VCOA 1J3KA 4Q67A 5ECXA 4EJ1A 3NRRA 3M08A 1AOEA 3QLSA 1RX4A 4Q6AA 1RX3A 2P4GA 3GHCA 3NXRA 4XT4A 3QG2A 5E8QA 3TD8A 4KJKA 1ZDRA 3FQOA 5DXVA 1DR1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ANO A;  1M78 A;  5CCC A;  3EEJ A;  4DPH A;  4ELH A;  1DHI A;  3R33 A;  3SH2 A;  4LAG X;  2O7P A;  7DFR A;  6DFR A;  1DG7 A;  1E26 A;  3Q1H A;  3FQC A;  3I8A X;  3GHV A;  1D1G A;  1RG7 A;  3KJS A;  5JG0 X;  4PTH A;  1DDR A;  3F91 A;  4EIZ A;  3EEL A;  3FRA X;  4H95 A;  3N0H A;  1S3U A;  1AI9 A;  1M79 A;  4HOE A;  5HQY A;  1IA1 A;  3NXT A;  3K74 A;  1DRB A;  3FRB X;  3UM5 A;  2DRC A;  4XT5 A;  4XT7 A;  2OBC A;  5HF2 X;  4DP3 A;  4X5H A;  1PD9 A;  3NZ9 X;  3ZPC A;  2KGK A;  4M6L A;  2W9T A;  4OSG A;  1M7A A;  3NU0 A;  2HXV A;  3K47 A;  4G8Z X;  2FZI A;  1DLR A;  3KFY A;  3DL5 A;  3GHW A;  3QLR A;  3CD2 A;  3OAF A;  3F0X X;  3JWF A;  3L3R A;  4KBN A;  3F0V X;  5JA3 A;  4X5G A;  1YHO A;  3FYW X;  1DRE A;  3NTZ A;  5HSR A;  1RA1 A;  1U72 A;  3LG4 A;  3M09 A;  4P3Q A;  4XT8 A;  2JYB A;  1TDR A;  4H96 A;  2BL9 A;  3FQF A;  1RX8 A;  1DRH A;  3SA1 A;  4QLF A;  1LY4 A;  4NX7 A;  4HA7 A;  4QJZ D;  4KM2 A;  3NZA X;  3NXO A;  1DHF A;  2W3W A;  2GD9 A;  3CL9 A;  3D80 A;  2INQ A;  1DLS A;  4XRB A;  1PDB A;  3SRW X;  4KJL A;  4TU5 X;  3SA2 A;  4M6K A;  4KNE A;  5HI6 A;  1VDR A;  1BOZ A;  4KD7 A;  1RA8 A;  1CZ3 A;  1DRF A;  3JW5 A;  1U70 A;  1RB2 A;  3SAI A;  4PDJ A;  1DR6 A;  4IXF X;  1KLK A;  2ZZA A;  4M7U A;  4QJC A;  3SGY A;  2D5N A;  4G3M A;  3SQY X;  2W3V A;  1RX5 A;  3DFR A;  3QLW A;  1RF7 A;  2W9S A;  4FHB A;  1RB3 A;  1J3I A;  2W9H A;  3FL9 A;  3FQZ A;  1JOM A;  4LEK X;  4Q0D A;  4H98 A;  3FY8 X;  1MVS A;  3JWM A;  2ITH A;  1RX6 A;  1RA9 A;  1JUV A;  5HQZ A;  3DAU A;  3EIG A;  1JOL A;  3D84 X;  2BLC A;  4PSY A;  3SR5 X;  2C2T A;  1DR3 A;  3NXV A;  1DIS A;  1RA2 A;  3IRN A;  3FQV A;  3KGY A;  1DYH A;  3ZPG A;  3QGT A;  5HT5 A;  3JTW A;  1RD7 A;  5HUI A;  2D0K A;  3HBB A;  1AO8 A;  3TQA A;  3DG8 A;  3NXX A;  4HOF A;  4KAK A;  4PST A;  5CC9 A;  1DR2 A;  5U26 A;  1DYR A;  3JVX A;  1OHK A;  2OIP A;  2BLB A;  1J3J A;  2HQP A;  3SRU X;  3JWK A;  5HVB A;  2CIG A;  3EEM A;  1RX2 A;  2W9G A;  4M2X A;  3FY9 X;  3QL0 A;  4FGH A;  2ANQ A;  3KY8 A;  4LAE X;  1DYJ A;  3CLB A;  1DAJ A;  3K45 A;  1SEJ A;  1HFR A;  4DPD A;  3S9U A;  4KEB A;  4ELF A;  3NZD A;  4KFJ A;  4KY4 A;  4QLE A;  1DG5 A;  3UM8 A;  3I3R A;  4KL9 A;  3JSU A;  3S7A A;  3TQ9 A;  4OR7 A;  2L28 A;  1RX1 A;  3F0B X;  5U27 A;  3INV A;  1DG8 A;  3FRF X;  4KY8 A;  1MVT A;  3FRD X;  2FZJ A;  3FQ0 A;  3NZ6 X;  5HPB A;  3GI2 A;  4M6J A;  4HA9 A;  4KYA A;  3IX9 A;  3SRQ X;  2C2S A;  5FDA A;  4XT6 A;  3SRR X;  1U71 A;  4X5F A;  4X5J A;  3DL6 A;  3NZB X;  4ELG A;  1QZF A;  5HSU A;  5HVE A;  1S3W A;  2W3A A;  3F0S X;  4KM0 A;  3UM6 A;  1HFQ A;  4X5I A;  4DFR A;  4P3R A;  4P68 A;  2FZH A;  1S3V A;  1KMS A;  3IA4 A;  3FYV X;  4IXG X;  3RO9 A;  2HM9 A;  4KLX A;  1RC4 A;  3IRM A;  1DR7 A;  3NZC X;  1PD8 A;  3QLX A;  4I1N A;  3OCH A;  3F8Y A;  4RGC A;  4DDR A;  1RE7 A;  4I13 A;  3QFX A;  4NX6 A;  4GH8 A;  1DDS A;  4XE6 X;  3F8Z A;  5DFR A;  3SRS X;  4IXE D;  3FS6 A;  1RA3 A;  4P66 A;  3IRO A;  3QYL A;  2DHF A;  3S3V A;  4KJJ A;  2B3Z A;  2G6V A;  3QYO A;  1IA4 A;  1HFP A;  4QLG A;  4G95 A;  4ELE A;  1KMV A;  4FGG A;  1DHJ A;  1CD2 A;  3EEK A;  1DYI A;  4LAH X;  3JW3 A;  1RH3 A;  5HT4 A;  1LY3 A;  4PSS A;  1OHJ A;  4H97 A;  1RX9 A;  1DR5 A;  3F0U X;  5EAJ A;  4QHV A;  3ROA A;  2XW7 A;  3DRC A;  3IA5 A;  3DGA A;  3NXY A;  4Q0E A;  4M7V A;  3FRE X;  1BZF A;  2H2Q A;  3JWC A;  1S3Y A;  1VJ3 A;  2AZN A;  4EIG A;  4ECK A;  3QL3 A;  1IA2 A;  3KJR A;  3K2H A;  2LF1 A;  3CSE A;  1IA3 A;  5ECC A;  3TQ8 A;  1LUD A;  4CD2 A;  3RG9 A;  1DR4 A;  1RX7 A;  3E0B A;  2BLA A;  1DIU A;  3HJ3 A;  1DRA A;  3GYF A;  4PTJ A;  3FL8 A;  4XEC X;  3DAT A;  3QLZ A;  5HF0 X;  2W3B A;  2W3M A;  4EIL A;  3EX8 A;  2QK8 A;  4QI9 A;  4ELB A;  1DF7 A;  2CD2 A;  8DFR A;  3F0Q X;  4HOG A;  3QLY A;  3TQB A;  3VCO A;  1J3K A;  4Q67 A;  5ECX A;  4EJ1 A;  3NRR A;  3M08 A;  1AOE A;  3QLS A;  1RX4 A;  4Q6A A;  1RX3 A;  2P4G A;  3GHC A;  3NXR A;  4XT4 A;  3QG2 A;  5E8Q A;  3TD8 A;  4KJK A;  1ZDR A;  3FQO A;  5DXV A;  1DR1 A; 
#chains in the Genus database with same CATH topology
 2ANO A;  1M78 A;  5CCC A;  3EEJ A;  4DPH A;  4ELH A;  1DHI A;  3R33 A;  3SH2 A;  4LAG X;  2O7P A;  7DFR A;  6DFR A;  1DG7 A;  1E26 A;  3Q1H A;  3FQC A;  3I8A X;  3GHV A;  1D1G A;  1RG7 A;  3KJS A;  5JG0 X;  4PTH A;  1DDR A;  3F91 A;  4EIZ A;  3EEL A;  3FRA X;  4H95 A;  3N0H A;  1S3U A;  1AI9 A;  1M79 A;  4HOE A;  5HQY A;  1IA1 A;  3NXT A;  3K74 A;  1DRB A;  3FRB X;  3UM5 A;  2DRC A;  4XT5 A;  4XT7 A;  2OBC A;  5HF2 X;  4DP3 A;  4X5H A;  1PD9 A;  3NZ9 X;  3ZPC A;  2KGK A;  4M6L A;  2W9T A;  4OSG A;  1M7A A;  3NU0 A;  2HXV A;  3K47 A;  4G8Z X;  2FZI A;  1DLR A;  3KFY A;  3DL5 A;  3GHW A;  3QLR A;  3CD2 A;  3OAF A;  3F0X X;  3JWF A;  3L3R A;  4KBN A;  3F0V X;  5JA3 A;  4X5G A;  1YHO A;  3FYW X;  1DRE A;  3NTZ A;  5HSR A;  1RA1 A;  1U72 A;  3LG4 A;  3M09 A;  4P3Q A;  4XT8 A;  2JYB A;  1TDR A;  4H96 A;  2BL9 A;  3FQF A;  1RX8 A;  1DRH A;  3SA1 A;  4QLF A;  1LY4 A;  4NX7 A;  4HA7 A;  4QJZ D;  4KM2 A;  3NZA X;  3NXO A;  1DHF A;  2W3W A;  2GD9 A;  3CL9 A;  3D80 A;  2INQ A;  1DLS A;  4XRB A;  1PDB A;  3SRW X;  4KJL A;  4TU5 X;  3SA2 A;  4M6K A;  4KNE A;  5HI6 A;  1VDR A;  1BOZ A;  4KD7 A;  1RA8 A;  1CZ3 A;  1DRF A;  3JW5 A;  1U70 A;  1RB2 A;  3SAI A;  4PDJ A;  1DR6 A;  4IXF X;  1KLK A;  2ZZA A;  4M7U A;  4QJC A;  3SGY A;  2D5N A;  4G3M A;  3SQY X;  2W3V A;  1RX5 A;  3DFR A;  3QLW A;  1RF7 A;  2W9S A;  4FHB A;  1RB3 A;  1J3I A;  2W9H A;  3FL9 A;  3FQZ A;  1JOM A;  4LEK X;  4Q0D A;  4H98 A;  3FY8 X;  1MVS A;  3JWM A;  2ITH A;  1RX6 A;  1RA9 A;  1JUV A;  5HQZ A;  3DAU A;  3EIG A;  1JOL A;  3D84 X;  2BLC A;  4PSY A;  3SR5 X;  2C2T A;  1DR3 A;  3NXV A;  1DIS A;  1RA2 A;  3IRN A;  3FQV A;  3KGY A;  1DYH A;  3ZPG A;  3QGT A;  5HT5 A;  3JTW A;  1RD7 A;  5HUI A;  2D0K A;  3HBB A;  1AO8 A;  3TQA A;  3DG8 A;  3NXX A;  4HOF A;  4KAK A;  4PST A;  5CC9 A;  1DR2 A;  5U26 A;  1DYR A;  3JVX A;  1OHK A;  2OIP A;  2BLB A;  1J3J A;  2HQP A;  3SRU X;  3JWK A;  5HVB A;  2CIG A;  3EEM A;  1RX2 A;  2W9G A;  4M2X A;  3FY9 X;  3QL0 A;  4FGH A;  2ANQ A;  3KY8 A;  4LAE X;  1DYJ A;  3CLB A;  1DAJ A;  3K45 A;  1SEJ A;  1HFR A;  4DPD A;  3S9U A;  4KEB A;  4ELF A;  3NZD A;  4KFJ A;  4KY4 A;  4QLE A;  1DG5 A;  3UM8 A;  3I3R A;  4KL9 A;  3JSU A;  3S7A A;  3TQ9 A;  4OR7 A;  2L28 A;  1RX1 A;  3F0B X;  5U27 A;  3INV A;  1DG8 A;  3FRF X;  4KY8 A;  1MVT A;  3FRD X;  2FZJ A;  3FQ0 A;  3NZ6 X;  5HPB A;  3GI2 A;  4M6J A;  4HA9 A;  4KYA A;  3IX9 A;  3SRQ X;  2C2S A;  5FDA A;  4XT6 A;  3SRR X;  1U71 A;  4X5F A;  4X5J A;  3DL6 A;  3NZB X;  4ELG A;  1QZF A;  5HSU A;  5HVE A;  1S3W A;  2W3A A;  3F0S X;  4KM0 A;  3UM6 A;  1HFQ A;  4X5I A;  4DFR A;  4P3R A;  4P68 A;  2FZH A;  1S3V A;  1KMS A;  3IA4 A;  3FYV X;  4IXG X;  3RO9 A;  2HM9 A;  4KLX A;  1RC4 A;  3IRM A;  1DR7 A;  3NZC X;  1PD8 A;  3QLX A;  4I1N A;  3OCH A;  3F8Y A;  4RGC A;  4DDR A;  1RE7 A;  4I13 A;  3QFX A;  4NX6 A;  4GH8 A;  1DDS A;  4XE6 X;  3F8Z A;  5DFR A;  3SRS X;  4IXE D;  3FS6 A;  1RA3 A;  4P66 A;  3IRO A;  3QYL A;  2DHF A;  3S3V A;  4KJJ A;  2B3Z A;  2G6V A;  3QYO A;  1IA4 A;  1HFP A;  4QLG A;  4G95 A;  4ELE A;  1KMV A;  4FGG A;  1DHJ A;  1CD2 A;  3EEK A;  1DYI A;  4LAH X;  3JW3 A;  1RH3 A;  5HT4 A;  1LY3 A;  4PSS A;  1OHJ A;  4H97 A;  1RX9 A;  1DR5 A;  3F0U X;  5EAJ A;  4QHV A;  3ROA A;  2XW7 A;  3DRC A;  3IA5 A;  3DGA A;  3NXY A;  4Q0E A;  4M7V A;  3FRE X;  1BZF A;  2H2Q A;  3JWC A;  1S3Y A;  1VJ3 A;  2AZN A;  4EIG A;  4ECK A;  3QL3 A;  1IA2 A;  3KJR A;  3K2H A;  2LF1 A;  3CSE A;  1IA3 A;  5ECC A;  3TQ8 A;  1LUD A;  4CD2 A;  3RG9 A;  1DR4 A;  1RX7 A;  3E0B A;  2BLA A;  1DIU A;  3HJ3 A;  1DRA A;  3GYF A;  4PTJ A;  3FL8 A;  4XEC X;  3DAT A;  3QLZ A;  5HF0 X;  2W3B A;  2W3M A;  4EIL A;  3EX8 A;  2QK8 A;  4QI9 A;  4ELB A;  1DF7 A;  2CD2 A;  8DFR A;  3F0Q X;  4HOG A;  3QLY A;  3TQB A;  3VCO A;  1J3K A;  4Q67 A;  5ECX A;  4EJ1 A;  3NRR A;  3M08 A;  1AOE A;  3QLS A;  1RX4 A;  4Q6A A;  1RX3 A;  2P4G A;  3GHC A;  3NXR A;  4XT4 A;  3QG2 A;  5E8Q A;  3TD8 A;  4KJK A;  1ZDR A;  3FQO A;  5DXV A;  1DR1 A; 
#chains in the Genus database with same CATH homology
 2ANO A;  1M78 A;  5CCC A;  3EEJ A;  4DPH A;  4ELH A;  1DHI A;  3R33 A;  3SH2 A;  4LAG X;  2O7P A;  7DFR A;  6DFR A;  1DG7 A;  1E26 A;  3Q1H A;  3FQC A;  3I8A X;  3GHV A;  1D1G A;  1RG7 A;  3KJS A;  5JG0 X;  4PTH A;  1DDR A;  3F91 A;  4EIZ A;  3EEL A;  3FRA X;  4H95 A;  3N0H A;  1S3U A;  1AI9 A;  1M79 A;  4HOE A;  5HQY A;  1IA1 A;  3NXT A;  3K74 A;  1DRB A;  3FRB X;  3UM5 A;  2DRC A;  4XT5 A;  4XT7 A;  2OBC A;  5HF2 X;  4DP3 A;  4X5H A;  1PD9 A;  3NZ9 X;  3ZPC A;  2KGK A;  4M6L A;  2W9T A;  4OSG A;  1M7A A;  3NU0 A;  2HXV A;  3K47 A;  4G8Z X;  2FZI A;  1DLR A;  3KFY A;  3DL5 A;  3GHW A;  3QLR A;  3CD2 A;  3OAF A;  3F0X X;  3JWF A;  3L3R A;  4KBN A;  3F0V X;  5JA3 A;  4X5G A;  1YHO A;  3FYW X;  1DRE A;  3NTZ A;  5HSR A;  1RA1 A;  1U72 A;  3LG4 A;  3M09 A;  4P3Q A;  4XT8 A;  2JYB A;  1TDR A;  4H96 A;  2BL9 A;  3FQF A;  1RX8 A;  1DRH A;  3SA1 A;  4QLF A;  1LY4 A;  4NX7 A;  4HA7 A;  4QJZ D;  4KM2 A;  3NZA X;  3NXO A;  1DHF A;  2W3W A;  2GD9 A;  3CL9 A;  3D80 A;  2INQ A;  1DLS A;  4XRB A;  1PDB A;  3SRW X;  4KJL A;  4TU5 X;  3SA2 A;  4M6K A;  4KNE A;  5HI6 A;  1VDR A;  1BOZ A;  4KD7 A;  1RA8 A;  1CZ3 A;  1DRF A;  3JW5 A;  1U70 A;  1RB2 A;  3SAI A;  4PDJ A;  1DR6 A;  4IXF X;  1KLK A;  2ZZA A;  4M7U A;  4QJC A;  3SGY A;  2D5N A;  4G3M A;  3SQY X;  2W3V A;  1RX5 A;  3DFR A;  3QLW A;  1RF7 A;  2W9S A;  4FHB A;  1RB3 A;  1J3I A;  2W9H A;  3FL9 A;  3FQZ A;  1JOM A;  4LEK X;  4Q0D A;  4H98 A;  3FY8 X;  1MVS A;  3JWM A;  2ITH A;  1RX6 A;  1RA9 A;  1JUV A;  5HQZ A;  3DAU A;  3EIG A;  1JOL A;  3D84 X;  2BLC A;  4PSY A;  3SR5 X;  2C2T A;  1DR3 A;  3NXV A;  1DIS A;  1RA2 A;  3IRN A;  3FQV A;  3KGY A;  1DYH A;  3ZPG A;  3QGT A;  5HT5 A;  3JTW A;  1RD7 A;  5HUI A;  2D0K A;  3HBB A;  1AO8 A;  3TQA A;  3DG8 A;  3NXX A;  4HOF A;  4KAK A;  4PST A;  5CC9 A;  1DR2 A;  5U26 A;  1DYR A;  3JVX A;  1OHK A;  2OIP A;  2BLB A;  1J3J A;  2HQP A;  3SRU X;  3JWK A;  5HVB A;  2CIG A;  3EEM A;  1RX2 A;  2W9G A;  4M2X A;  3FY9 X;  3QL0 A;  4FGH A;  2ANQ A;  3KY8 A;  4LAE X;  1DYJ A;  3CLB A;  1DAJ A;  3K45 A;  1SEJ A;  1HFR A;  4DPD A;  3S9U A;  4KEB A;  4ELF A;  3NZD A;  4KFJ A;  4KY4 A;  4QLE A;  1DG5 A;  3UM8 A;  3I3R A;  4KL9 A;  3JSU A;  3S7A A;  3TQ9 A;  4OR7 A;  2L28 A;  1RX1 A;  3F0B X;  5U27 A;  3INV A;  1DG8 A;  3FRF X;  4KY8 A;  1MVT A;  3FRD X;  2FZJ A;  3FQ0 A;  3NZ6 X;  5HPB A;  3GI2 A;  4M6J A;  4HA9 A;  4KYA A;  3IX9 A;  3SRQ X;  2C2S A;  5FDA A;  4XT6 A;  3SRR X;  1U71 A;  4X5F A;  4X5J A;  3DL6 A;  3NZB X;  4ELG A;  1QZF A;  5HSU A;  5HVE A;  1S3W A;  2W3A A;  3F0S X;  4KM0 A;  3UM6 A;  1HFQ A;  4X5I A;  4DFR A;  4P3R A;  4P68 A;  2FZH A;  1S3V A;  1KMS A;  3IA4 A;  3FYV X;  4IXG X;  3RO9 A;  2HM9 A;  4KLX A;  1RC4 A;  3IRM A;  1DR7 A;  3NZC X;  1PD8 A;  3QLX A;  4I1N A;  3OCH A;  3F8Y A;  4RGC A;  4DDR A;  1RE7 A;  4I13 A;  3QFX A;  4NX6 A;  4GH8 A;  1DDS A;  4XE6 X;  3F8Z A;  5DFR A;  3SRS X;  4IXE D;  3FS6 A;  1RA3 A;  4P66 A;  3IRO A;  3QYL A;  2DHF A;  3S3V A;  4KJJ A;  2B3Z A;  2G6V A;  3QYO A;  1IA4 A;  1HFP A;  4QLG A;  4G95 A;  4ELE A;  1KMV A;  4FGG A;  1DHJ A;  1CD2 A;  3EEK A;  1DYI A;  4LAH X;  3JW3 A;  1RH3 A;  5HT4 A;  1LY3 A;  4PSS A;  1OHJ A;  4H97 A;  1RX9 A;  1DR5 A;  3F0U X;  5EAJ A;  4QHV A;  3ROA A;  2XW7 A;  3DRC A;  3IA5 A;  3DGA A;  3NXY A;  4Q0E A;  4M7V A;  3FRE X;  1BZF A;  2H2Q A;  3JWC A;  1S3Y A;  1VJ3 A;  2AZN A;  4EIG A;  4ECK A;  3QL3 A;  1IA2 A;  3KJR A;  3K2H A;  2LF1 A;  3CSE A;  1IA3 A;  5ECC A;  3TQ8 A;  1LUD A;  4CD2 A;  3RG9 A;  1DR4 A;  1RX7 A;  3E0B A;  2BLA A;  1DIU A;  3HJ3 A;  1DRA A;  3GYF A;  4PTJ A;  3FL8 A;  4XEC X;  3DAT A;  3QLZ A;  5HF0 X;  2W3B A;  2W3M A;  4EIL A;  3EX8 A;  2QK8 A;  4QI9 A;  4ELB A;  1DF7 A;  2CD2 A;  8DFR A;  3F0Q X;  4HOG A;  3QLY A;  3TQB A;  3VCO A;  1J3K A;  4Q67 A;  5ECX A;  4EJ1 A;  3NRR A;  3M08 A;  1AOE A;  3QLS A;  1RX4 A;  4Q6A A;  1RX3 A;  2P4G A;  3GHC A;  3NXR A;  4XT4 A;  3QG2 A;  5E8Q A;  3TD8 A;  4KJK A;  1ZDR A;  3FQO A;  5DXV A;  1DR1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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