5HVBA

5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(1-napthylthio)[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hvbA00
3SRUX 4G95A 1D1GA 4RGCA 1RX7A 4ELFA 3S3VA 3SAIA 4PTJA 2DHFA 1U70A 3S9UA 1RA2A 2QK8A 4PSSA 5U26A 2D5NA 3ROAA 1RX4A 4P68A 2L28A 3KGYA 4LAGX 1DR3A 4I1NA 3DGAA 4KY4A 3INVA 1VDRA 1JUVA 5DFRA 1S3VA 4DFRA 3HJ3A 1DR7A 2W3MA 3SRRX 2W9GA 3JSUA 1CD2A 1DDRA 3CLBA 3NTZA 4HOEA 3DG8A 3D84X 2W3AA 2G6VA 2LF1A 1BOZA 2C2SA 8DFRA 1DR2A 1DISA 3NXXA 2O7PA 3DATA 2OBCA 1RA1A 2W9TA 1HFRA 4ELGA 4QJCA 4H95A 3QLXA 5EAJA 2FZIA 5E8QA 3TQ8A 4P66A 1RB2A 4M6LA 1RA3A 3KFYA 1ZDRA 3N0HA 3GYFA 3NXVA 5ECCA 4M7UA 3GHWA 1DG5A 5HSUA 4EIZA 3NXRA 3IX9A 1DYRA 3QFXA 5HSRA 3DAUA 4QI9A 3SH2A 3QLZA 1PD9A 3R33A 3SRWX 4KAKA 1E26A 3F0UX 1DRAA 1DF7A 1RD7A 1KMVA 3FY9X 2ANQA 3FQFA 3UM5A 1HFPA 4Q67A 1IA1A 1QZFA 7DFRA 4DPHA 5HQYA 3QYLA 3NZCX 3DL6A 2HXVA 3NZ6X 5HPBA 3K45A 4EJ1A 1CZ3A 3ZPCA 1RX2A 4CD2A 1M7AA 3SA1A 3QGTA 2H2QA 1RH3A 2GD9A 4XT8A 1JOMA 5CCCA 1VJ3A 4ECKA 4KEBA 3TQBA 1LUDA 4PTHA 3QL3A 3I8AX 4P3QA 4M6KA 1DLSA 1BZFA 1RC4A 4KBNA 4KLXA 4Q0DA 3EEKA 1DR1A 2CD2A 3KY8A 2FZJA 3FQCA 2AZNA 1DR5A 1DDSA 2HQPA 4FGGA 3GI2A 4KY8A 4ELHA 3I3RA 1DRBA 3RG9A 3K47A 3IROA 3EELA 3K2HA 3FS6A 3SR5X 4EIGA 1DYIA 1IA4A 1OHJA 4KYAA 1RX6A 3ZPGA 3IRMA 4X5FA 4P3RA 3OAFA 1DIUA 3UM8A 3JTWA 3DL5A 3QG2A 2C2TA 3FL8A 3Q1HA 3QLSA 1RF7A 3GHVA 4LEKX 3VCOA 3LG4A 1DR6A 1U71A 1DG7A 4HOFA 4Q6AA 4HOGA 4DPDA 4HA9A 1DYHA 4FGHA 1M79A 1YHOA 4KM2A 4GH8A 1S3WA 1J3IA 3FRBX 4XECX 1DHIA 1DRHA 4IXED 4X5JA 4XT5A 2BLCA 3E0BA 4QLGA 3NZAX 1LY3A 3GHCA 3CSEA 4Q0EA 3EEJA 3SGYA 3FY8X 1RX9A 4KM0A 2ITHA 4KL9A 4X5HA 3FYVX 3CL9A 2KGKA 3FRFX 4M2XA 5FDAA 4XE6X 3QLYA 4KNEA 3OCHA 5HF2X 2XW7A 5U27A 1DR4A 1LY4A 4XT4A 3FQZA 3TQAA 1M78A 1AOEA 4I13A 1DREA 4FHBA 3FYWX 3FQOA 4QJZD 1AO8A 3L3RA 3FRAX 3NXTA 3SRQX 3CD2A 2W9HA 4LAHX 4OSGA 4LAEX 3KJRA 4IXFX 4QLEA 1IA3A 4PSTA 1S3YA 3M09A 4X5GA 2DRCA 3F0SX 4ELEA 3UM6A 3EEMA 1KMSA 4NX6A 3K74A 1S3UA 3F0VX 3SA2A 3IRNA 3IA5A 3F0QX 3SQYX 3KJSA 4H97A 4TU5X 3F91A 2OIPA 2ANOA 1RA9A 4NX7A 3F0XX 1MVSA 1DRFA 3S7AA 1U72A 3FRDX 3EIGA 1RE7A 2W3BA 3EX8A 1AI9A 2P4GA 5HUIA 1JOLA 2W3VA 4PDJA 5DXVA 3DRCA 4HA7A 2HM9A 1RG7A 3NXOA 3NRRA 3F8YA 2BLAA 2W9SA 4IXGX 2FZHA 4KJJA 1HFQA 2INQA 4M6JA 4QLFA 4XRBA 3RO9A 1SEJA 1RX8A 2BLBA 3JW5A 1PDBA 3NZBX 3NU0A 4KJKA 3QYOA 1OHKA 3NZDA 2ZZAA 3JW3A 1PD8A 3SRSX 3JVXA 4KFJA 4OR7A 3NXYA 4EILA 5HQZA 1RX3A 3QLRA 3D80A 1DG8A 3FQ0A 3QL0A 5CC9A 3TD8A 1MVTA 4H96A 3TQ9A 3FL9A 3JWCA 5JG0X 1IA2A 4G3MA 4KD7A 5ECXA 1DLRA 1DAJA 1DHJA 3FREX 4XT6A 2JYBA 4H98A 5HVBA 5HVEA 5HT4A 1TDRA 1RA8A 4XT7A 1J3KA 2W3WA 1KLKA 5HI6A 4PSYA 3F8ZA 2CIGA 4DP3A 1RX5A 2BL9A 4X5IA 1DYJA 1J3JA 5HF0X 3QLWA 5JA3A 4M7VA 3NZ9X 3F0BX 1RX1A 6DFRA 3FQVA 3IA4A 3HBBA 3JWFA 4KJLA 3JWMA 1DHFA 3DFRA 4DDRA 1RB3A 3M08A 4QHVA 2B3ZA 4ELBA 5HT5A 2D0KA 4G8ZX 3JWKA
chains in the Genus database with same CATH superfamily
3SRUX 4G95A 1D1GA 4RGCA 1RX7A 4ELFA 3S3VA 3SAIA 4PTJA 2DHFA 1U70A 3S9UA 1RA2A 2QK8A 4PSSA 5U26A 2D5NA 3ROAA 1RX4A 4P68A 2L28A 3KGYA 4LAGX 1DR3A 4I1NA 3DGAA 4KY4A 3INVA 1VDRA 1JUVA 5DFRA 1S3VA 4DFRA 3HJ3A 1DR7A 2W3MA 3SRRX 2W9GA 3JSUA 1CD2A 1DDRA 3CLBA 3NTZA 4HOEA 3DG8A 3D84X 2W3AA 2G6VA 2LF1A 1BOZA 2C2SA 8DFRA 1DR2A 1DISA 3NXXA 2O7PA 3DATA 2OBCA 1RA1A 2W9TA 1HFRA 4ELGA 4QJCA 4H95A 3QLXA 5EAJA 2FZIA 5E8QA 3TQ8A 4P66A 1RB2A 4M6LA 1RA3A 3KFYA 1ZDRA 3N0HA 3GYFA 3NXVA 5ECCA 4M7UA 3GHWA 1DG5A 5HSUA 4EIZA 3NXRA 3IX9A 1DYRA 3QFXA 5HSRA 3DAUA 4QI9A 3SH2A 3QLZA 1PD9A 3R33A 3SRWX 4KAKA 1E26A 3F0UX 1DRAA 1DF7A 1RD7A 1KMVA 3FY9X 2ANQA 3FQFA 3UM5A 1HFPA 4Q67A 1IA1A 1QZFA 7DFRA 4DPHA 5HQYA 3QYLA 3NZCX 3DL6A 2HXVA 3NZ6X 5HPBA 3K45A 4EJ1A 1CZ3A 3ZPCA 1RX2A 4CD2A 1M7AA 3SA1A 3QGTA 2H2QA 1RH3A 2GD9A 4XT8A 1JOMA 5CCCA 1VJ3A 4ECKA 4KEBA 3TQBA 1LUDA 4PTHA 3QL3A 3I8AX 4P3QA 4M6KA 1DLSA 1BZFA 1RC4A 4KBNA 4KLXA 4Q0DA 3EEKA 1DR1A 2CD2A 3KY8A 2FZJA 3FQCA 2AZNA 1DR5A 1DDSA 2HQPA 4FGGA 3GI2A 4KY8A 4ELHA 3I3RA 1DRBA 3RG9A 3K47A 3IROA 3EELA 3K2HA 3FS6A 3SR5X 4EIGA 1DYIA 1IA4A 1OHJA 4KYAA 1RX6A 3ZPGA 3IRMA 4X5FA 4P3RA 3OAFA 1DIUA 3UM8A 3JTWA 3DL5A 3QG2A 2C2TA 3FL8A 3Q1HA 3QLSA 1RF7A 3GHVA 4LEKX 3VCOA 3LG4A 1DR6A 1U71A 1DG7A 4HOFA 4Q6AA 4HOGA 4DPDA 4HA9A 1DYHA 4FGHA 1M79A 1YHOA 4KM2A 4GH8A 1S3WA 1J3IA 3FRBX 4XECX 1DHIA 1DRHA 4IXED 4X5JA 4XT5A 2BLCA 3E0BA 4QLGA 3NZAX 1LY3A 3GHCA 3CSEA 4Q0EA 3EEJA 3SGYA 3FY8X 1RX9A 4KM0A 2ITHA 4KL9A 4X5HA 3FYVX 3CL9A 2KGKA 3FRFX 4M2XA 5FDAA 4XE6X 3QLYA 4KNEA 3OCHA 5HF2X 2XW7A 5U27A 1DR4A 1LY4A 4XT4A 3FQZA 3TQAA 1M78A 1AOEA 4I13A 1DREA 4FHBA 3FYWX 3FQOA 4QJZD 1AO8A 3L3RA 3FRAX 3NXTA 3SRQX 3CD2A 2W9HA 4LAHX 4OSGA 4LAEX 3KJRA 4IXFX 4QLEA 1IA3A 4PSTA 1S3YA 3M09A 4X5GA 2DRCA 3F0SX 4ELEA 3UM6A 3EEMA 1KMSA 4NX6A 3K74A 1S3UA 3F0VX 3SA2A 3IRNA 3IA5A 3F0QX 3SQYX 3KJSA 4H97A 4TU5X 3F91A 2OIPA 2ANOA 1RA9A 4NX7A 3F0XX 1MVSA 1DRFA 3S7AA 1U72A 3FRDX 3EIGA 1RE7A 2W3BA 3EX8A 1AI9A 2P4GA 5HUIA 1JOLA 2W3VA 4PDJA 5DXVA 3DRCA 4HA7A 2HM9A 1RG7A 3NXOA 3NRRA 3F8YA 2BLAA 2W9SA 4IXGX 2FZHA 4KJJA 1HFQA 2INQA 4M6JA 4QLFA 4XRBA 3RO9A 1SEJA 1RX8A 2BLBA 3JW5A 1PDBA 3NZBX 3NU0A 4KJKA 3QYOA 1OHKA 3NZDA 2ZZAA 3JW3A 1PD8A 3SRSX 3JVXA 4KFJA 4OR7A 3NXYA 4EILA 5HQZA 1RX3A 3QLRA 3D80A 1DG8A 3FQ0A 3QL0A 5CC9A 3TD8A 1MVTA 4H96A 3TQ9A 3FL9A 3JWCA 5JG0X 1IA2A 4G3MA 4KD7A 5ECXA 1DLRA 1DAJA 1DHJA 3FREX 4XT6A 2JYBA 4H98A 5HVBA 5HVEA 5HT4A 1TDRA 1RA8A 4XT7A 1J3KA 2W3WA 1KLKA 5HI6A 4PSYA 3F8ZA 2CIGA 4DP3A 1RX5A 2BL9A 4X5IA 1DYJA 1J3JA 5HF0X 3QLWA 5JA3A 4M7VA 3NZ9X 3F0BX 1RX1A 6DFRA 3FQVA 3IA4A 3HBBA 3JWFA 4KJLA 3JWMA 1DHFA 3DFRA 4DDRA 1RB3A 3M08A 4QHVA 2B3ZA 4ELBA 5HT5A 2D0KA 4G8ZX 3JWKA
chains in the Genus database with same CATH topology
3SRUX 4G95A 1D1GA 4RGCA 1RX7A 4ELFA 3S3VA 3SAIA 4PTJA 2DHFA 1U70A 3S9UA 1RA2A 2QK8A 4PSSA 5U26A 2D5NA 3ROAA 1RX4A 4P68A 2L28A 3KGYA 4LAGX 1DR3A 4I1NA 3DGAA 4KY4A 3INVA 1VDRA 1JUVA 5DFRA 1S3VA 4DFRA 3HJ3A 1DR7A 2W3MA 3SRRX 2W9GA 3JSUA 1CD2A 1DDRA 3CLBA 3NTZA 4HOEA 3DG8A 3D84X 2W3AA 2G6VA 2LF1A 1BOZA 2C2SA 8DFRA 1DR2A 1DISA 3NXXA 2O7PA 3DATA 2OBCA 1RA1A 2W9TA 1HFRA 4ELGA 4QJCA 4H95A 3QLXA 5EAJA 2FZIA 5E8QA 3TQ8A 4P66A 1RB2A 4M6LA 1RA3A 3KFYA 1ZDRA 3N0HA 3GYFA 3NXVA 5ECCA 4M7UA 3GHWA 1DG5A 5HSUA 4EIZA 3NXRA 3IX9A 1DYRA 3QFXA 5HSRA 3DAUA 4QI9A 3SH2A 3QLZA 1PD9A 3R33A 3SRWX 4KAKA 1E26A 3F0UX 1DRAA 1DF7A 1RD7A 1KMVA 3FY9X 2ANQA 3FQFA 3UM5A 1HFPA 4Q67A 1IA1A 1QZFA 7DFRA 4DPHA 5HQYA 3QYLA 3NZCX 3DL6A 2HXVA 3NZ6X 5HPBA 3K45A 4EJ1A 1CZ3A 3ZPCA 1RX2A 4CD2A 1M7AA 3SA1A 3QGTA 2H2QA 1RH3A 2GD9A 4XT8A 1JOMA 5CCCA 1VJ3A 4ECKA 4KEBA 3TQBA 1LUDA 4PTHA 3QL3A 3I8AX 4P3QA 4M6KA 1DLSA 1BZFA 1RC4A 4KBNA 4KLXA 4Q0DA 3EEKA 1DR1A 2CD2A 3KY8A 2FZJA 3FQCA 2AZNA 1DR5A 1DDSA 2HQPA 4FGGA 3GI2A 4KY8A 4ELHA 3I3RA 1DRBA 3RG9A 3K47A 3IROA 3EELA 3K2HA 3FS6A 3SR5X 4EIGA 1DYIA 1IA4A 1OHJA 4KYAA 1RX6A 3ZPGA 3IRMA 4X5FA 4P3RA 3OAFA 1DIUA 3UM8A 3JTWA 3DL5A 3QG2A 2C2TA 3FL8A 3Q1HA 3QLSA 1RF7A 3GHVA 4LEKX 3VCOA 3LG4A 1DR6A 1U71A 1DG7A 4HOFA 4Q6AA 4HOGA 4DPDA 4HA9A 1DYHA 4FGHA 1M79A 1YHOA 4KM2A 4GH8A 1S3WA 1J3IA 3FRBX 4XECX 1DHIA 1DRHA 4IXED 4X5JA 4XT5A 2BLCA 3E0BA 4QLGA 3NZAX 1LY3A 3GHCA 3CSEA 4Q0EA 3EEJA 3SGYA 3FY8X 1RX9A 4KM0A 2ITHA 4KL9A 4X5HA 3FYVX 3CL9A 2KGKA 3FRFX 4M2XA 5FDAA 4XE6X 3QLYA 4KNEA 3OCHA 5HF2X 2XW7A 5U27A 1DR4A 1LY4A 4XT4A 3FQZA 3TQAA 1M78A 1AOEA 4I13A 1DREA 4FHBA 3FYWX 3FQOA 4QJZD 1AO8A 3L3RA 3FRAX 3NXTA 3SRQX 3CD2A 2W9HA 4LAHX 4OSGA 4LAEX 3KJRA 4IXFX 4QLEA 1IA3A 4PSTA 1S3YA 3M09A 4X5GA 2DRCA 3F0SX 4ELEA 3UM6A 3EEMA 1KMSA 4NX6A 3K74A 1S3UA 3F0VX 3SA2A 3IRNA 3IA5A 3F0QX 3SQYX 3KJSA 4H97A 4TU5X 3F91A 2OIPA 2ANOA 1RA9A 4NX7A 3F0XX 1MVSA 1DRFA 3S7AA 1U72A 3FRDX 3EIGA 1RE7A 2W3BA 3EX8A 1AI9A 2P4GA 5HUIA 1JOLA 2W3VA 4PDJA 5DXVA 3DRCA 4HA7A 2HM9A 1RG7A 3NXOA 3NRRA 3F8YA 2BLAA 2W9SA 4IXGX 2FZHA 4KJJA 1HFQA 2INQA 4M6JA 4QLFA 4XRBA 3RO9A 1SEJA 1RX8A 2BLBA 3JW5A 1PDBA 3NZBX 3NU0A 4KJKA 3QYOA 1OHKA 3NZDA 2ZZAA 3JW3A 1PD8A 3SRSX 3JVXA 4KFJA 4OR7A 3NXYA 4EILA 5HQZA 1RX3A 3QLRA 3D80A 1DG8A 3FQ0A 3QL0A 5CC9A 3TD8A 1MVTA 4H96A 3TQ9A 3FL9A 3JWCA 5JG0X 1IA2A 4G3MA 4KD7A 5ECXA 1DLRA 1DAJA 1DHJA 3FREX 4XT6A 2JYBA 4H98A 5HVBA 5HVEA 5HT4A 1TDRA 1RA8A 4XT7A 1J3KA 2W3WA 1KLKA 5HI6A 4PSYA 3F8ZA 2CIGA 4DP3A 1RX5A 2BL9A 4X5IA 1DYJA 1J3JA 5HF0X 3QLWA 5JA3A 4M7VA 3NZ9X 3F0BX 1RX1A 6DFRA 3FQVA 3IA4A 3HBBA 3JWFA 4KJLA 3JWMA 1DHFA 3DFRA 4DDRA 1RB3A 3M08A 4QHVA 2B3ZA 4ELBA 5HT5A 2D0KA 4G8ZX 3JWKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SRU X;  4G95 A;  1D1G A;  4RGC A;  1RX7 A;  4ELF A;  3S3V A;  3SAI A;  4PTJ A;  2DHF A;  1U70 A;  3S9U A;  1RA2 A;  2QK8 A;  4PSS A;  5U26 A;  2D5N A;  3ROA A;  1RX4 A;  4P68 A;  2L28 A;  3KGY A;  4LAG X;  1DR3 A;  4I1N A;  3DGA A;  4KY4 A;  3INV A;  1VDR A;  1JUV A;  5DFR A;  1S3V A;  4DFR A;  3HJ3 A;  1DR7 A;  2W3M A;  3SRR X;  2W9G A;  3JSU A;  1CD2 A;  1DDR A;  3CLB A;  3NTZ A;  4HOE A;  3DG8 A;  3D84 X;  2W3A A;  2G6V A;  2LF1 A;  1BOZ A;  2C2S A;  8DFR A;  1DR2 A;  1DIS A;  3NXX A;  2O7P A;  3DAT A;  2OBC A;  1RA1 A;  2W9T A;  1HFR A;  4ELG A;  4QJC A;  4H95 A;  3QLX A;  5EAJ A;  2FZI A;  5E8Q A;  3TQ8 A;  4P66 A;  1RB2 A;  4M6L A;  1RA3 A;  3KFY A;  1ZDR A;  3N0H A;  3GYF A;  3NXV A;  5ECC A;  4M7U A;  3GHW A;  1DG5 A;  5HSU A;  4EIZ A;  3NXR A;  3IX9 A;  1DYR A;  3QFX A;  5HSR A;  3DAU A;  4QI9 A;  3SH2 A;  3QLZ A;  1PD9 A;  3R33 A;  3SRW X;  4KAK A;  1E26 A;  3F0U X;  1DRA A;  1DF7 A;  1RD7 A;  1KMV A;  3FY9 X;  2ANQ A;  3FQF A;  3UM5 A;  1HFP A;  4Q67 A;  1IA1 A;  1QZF A;  7DFR A;  4DPH A;  5HQY A;  3QYL A;  3NZC X;  3DL6 A;  2HXV A;  3NZ6 X;  5HPB A;  3K45 A;  4EJ1 A;  1CZ3 A;  3ZPC A;  1RX2 A;  4CD2 A;  1M7A A;  3SA1 A;  3QGT A;  2H2Q A;  1RH3 A;  2GD9 A;  4XT8 A;  1JOM A;  5CCC A;  1VJ3 A;  4ECK A;  4KEB A;  3TQB A;  1LUD A;  4PTH A;  3QL3 A;  3I8A X;  4P3Q A;  4M6K A;  1DLS A;  1BZF A;  1RC4 A;  4KBN A;  4KLX A;  4Q0D A;  3EEK A;  1DR1 A;  2CD2 A;  3KY8 A;  2FZJ A;  3FQC A;  2AZN A;  1DR5 A;  1DDS A;  2HQP A;  4FGG A;  3GI2 A;  4KY8 A;  4ELH A;  3I3R A;  1DRB A;  3RG9 A;  3K47 A;  3IRO A;  3EEL A;  3K2H A;  3FS6 A;  3SR5 X;  4EIG A;  1DYI A;  1IA4 A;  1OHJ A;  4KYA A;  1RX6 A;  3ZPG A;  3IRM A;  4X5F A;  4P3R A;  3OAF A;  1DIU A;  3UM8 A;  3JTW A;  3DL5 A;  3QG2 A;  2C2T A;  3FL8 A;  3Q1H A;  3QLS A;  1RF7 A;  3GHV A;  4LEK X;  3VCO A;  3LG4 A;  1DR6 A;  1U71 A;  1DG7 A;  4HOF A;  4Q6A A;  4HOG A;  4DPD A;  4HA9 A;  1DYH A;  4FGH A;  1M79 A;  1YHO A;  4KM2 A;  4GH8 A;  1S3W A;  1J3I A;  3FRB X;  4XEC X;  1DHI A;  1DRH A;  4IXE D;  4X5J A;  4XT5 A;  2BLC A;  3E0B A;  4QLG A;  3NZA X;  1LY3 A;  3GHC A;  3CSE A;  4Q0E A;  3EEJ A;  3SGY A;  3FY8 X;  1RX9 A;  4KM0 A;  2ITH A;  4KL9 A;  4X5H A;  3FYV X;  3CL9 A;  2KGK A;  3FRF X;  4M2X A;  5FDA A;  4XE6 X;  3QLY A;  4KNE A;  3OCH A;  5HF2 X;  2XW7 A;  5U27 A;  1DR4 A;  1LY4 A;  4XT4 A;  3FQZ A;  3TQA A;  1M78 A;  1AOE A;  4I13 A;  1DRE A;  4FHB A;  3FYW X;  3FQO A;  4QJZ D;  1AO8 A;  3L3R A;  3FRA X;  3NXT A;  3SRQ X;  3CD2 A;  2W9H A;  4LAH X;  4OSG A;  4LAE X;  3KJR A;  4IXF X;  4QLE A;  1IA3 A;  4PST A;  1S3Y A;  3M09 A;  4X5G A;  2DRC A;  3F0S X;  4ELE A;  3UM6 A;  3EEM A;  1KMS A;  4NX6 A;  3K74 A;  1S3U A;  3F0V X;  3SA2 A;  3IRN A;  3IA5 A;  3F0Q X;  3SQY X;  3KJS A;  4H97 A;  4TU5 X;  3F91 A;  2OIP A;  2ANO A;  1RA9 A;  4NX7 A;  3F0X X;  1MVS A;  1DRF A;  3S7A A;  1U72 A;  3FRD X;  3EIG A;  1RE7 A;  2W3B A;  3EX8 A;  1AI9 A;  2P4G A;  5HUI A;  1JOL A;  2W3V A;  4PDJ A;  5DXV A;  3DRC A;  4HA7 A;  2HM9 A;  1RG7 A;  3NXO A;  3NRR A;  3F8Y A;  2BLA A;  2W9S A;  4IXG X;  2FZH A;  4KJJ A;  1HFQ A;  2INQ A;  4M6J A;  4QLF A;  4XRB A;  3RO9 A;  1SEJ A;  1RX8 A;  2BLB A;  3JW5 A;  1PDB A;  3NZB X;  3NU0 A;  4KJK A;  3QYO A;  1OHK A;  3NZD A;  2ZZA A;  3JW3 A;  1PD8 A;  3SRS X;  3JVX A;  4KFJ A;  4OR7 A;  3NXY A;  4EIL A;  5HQZ A;  1RX3 A;  3QLR A;  3D80 A;  1DG8 A;  3FQ0 A;  3QL0 A;  5CC9 A;  3TD8 A;  1MVT A;  4H96 A;  3TQ9 A;  3FL9 A;  3JWC A;  5JG0 X;  1IA2 A;  4G3M A;  4KD7 A;  5ECX A;  1DLR A;  1DAJ A;  1DHJ A;  3FRE X;  4XT6 A;  2JYB A;  4H98 A;  5HVB A;  5HVE A;  5HT4 A;  1TDR A;  1RA8 A;  4XT7 A;  1J3K A;  2W3W A;  1KLK A;  5HI6 A;  4PSY A;  3F8Z A;  2CIG A;  4DP3 A;  1RX5 A;  2BL9 A;  4X5I A;  1DYJ A;  1J3J A;  5HF0 X;  3QLW A;  5JA3 A;  4M7V A;  3NZ9 X;  3F0B X;  1RX1 A;  6DFR A;  3FQV A;  3IA4 A;  3HBB A;  3JWF A;  4KJL A;  3JWM A;  1DHF A;  3DFR A;  4DDR A;  1RB3 A;  3M08 A;  4QHV A;  2B3Z A;  4ELB A;  5HT5 A;  2D0K A;  4G8Z X;  3JWK A; 
#chains in the Genus database with same CATH topology
 3SRU X;  4G95 A;  1D1G A;  4RGC A;  1RX7 A;  4ELF A;  3S3V A;  3SAI A;  4PTJ A;  2DHF A;  1U70 A;  3S9U A;  1RA2 A;  2QK8 A;  4PSS A;  5U26 A;  2D5N A;  3ROA A;  1RX4 A;  4P68 A;  2L28 A;  3KGY A;  4LAG X;  1DR3 A;  4I1N A;  3DGA A;  4KY4 A;  3INV A;  1VDR A;  1JUV A;  5DFR A;  1S3V A;  4DFR A;  3HJ3 A;  1DR7 A;  2W3M A;  3SRR X;  2W9G A;  3JSU A;  1CD2 A;  1DDR A;  3CLB A;  3NTZ A;  4HOE A;  3DG8 A;  3D84 X;  2W3A A;  2G6V A;  2LF1 A;  1BOZ A;  2C2S A;  8DFR A;  1DR2 A;  1DIS A;  3NXX A;  2O7P A;  3DAT A;  2OBC A;  1RA1 A;  2W9T A;  1HFR A;  4ELG A;  4QJC A;  4H95 A;  3QLX A;  5EAJ A;  2FZI A;  5E8Q A;  3TQ8 A;  4P66 A;  1RB2 A;  4M6L A;  1RA3 A;  3KFY A;  1ZDR A;  3N0H A;  3GYF A;  3NXV A;  5ECC A;  4M7U A;  3GHW A;  1DG5 A;  5HSU A;  4EIZ A;  3NXR A;  3IX9 A;  1DYR A;  3QFX A;  5HSR A;  3DAU A;  4QI9 A;  3SH2 A;  3QLZ A;  1PD9 A;  3R33 A;  3SRW X;  4KAK A;  1E26 A;  3F0U X;  1DRA A;  1DF7 A;  1RD7 A;  1KMV A;  3FY9 X;  2ANQ A;  3FQF A;  3UM5 A;  1HFP A;  4Q67 A;  1IA1 A;  1QZF A;  7DFR A;  4DPH A;  5HQY A;  3QYL A;  3NZC X;  3DL6 A;  2HXV A;  3NZ6 X;  5HPB A;  3K45 A;  4EJ1 A;  1CZ3 A;  3ZPC A;  1RX2 A;  4CD2 A;  1M7A A;  3SA1 A;  3QGT A;  2H2Q A;  1RH3 A;  2GD9 A;  4XT8 A;  1JOM A;  5CCC A;  1VJ3 A;  4ECK A;  4KEB A;  3TQB A;  1LUD A;  4PTH A;  3QL3 A;  3I8A X;  4P3Q A;  4M6K A;  1DLS A;  1BZF A;  1RC4 A;  4KBN A;  4KLX A;  4Q0D A;  3EEK A;  1DR1 A;  2CD2 A;  3KY8 A;  2FZJ A;  3FQC A;  2AZN A;  1DR5 A;  1DDS A;  2HQP A;  4FGG A;  3GI2 A;  4KY8 A;  4ELH A;  3I3R A;  1DRB A;  3RG9 A;  3K47 A;  3IRO A;  3EEL A;  3K2H A;  3FS6 A;  3SR5 X;  4EIG A;  1DYI A;  1IA4 A;  1OHJ A;  4KYA A;  1RX6 A;  3ZPG A;  3IRM A;  4X5F A;  4P3R A;  3OAF A;  1DIU A;  3UM8 A;  3JTW A;  3DL5 A;  3QG2 A;  2C2T A;  3FL8 A;  3Q1H A;  3QLS A;  1RF7 A;  3GHV A;  4LEK X;  3VCO A;  3LG4 A;  1DR6 A;  1U71 A;  1DG7 A;  4HOF A;  4Q6A A;  4HOG A;  4DPD A;  4HA9 A;  1DYH A;  4FGH A;  1M79 A;  1YHO A;  4KM2 A;  4GH8 A;  1S3W A;  1J3I A;  3FRB X;  4XEC X;  1DHI A;  1DRH A;  4IXE D;  4X5J A;  4XT5 A;  2BLC A;  3E0B A;  4QLG A;  3NZA X;  1LY3 A;  3GHC A;  3CSE A;  4Q0E A;  3EEJ A;  3SGY A;  3FY8 X;  1RX9 A;  4KM0 A;  2ITH A;  4KL9 A;  4X5H A;  3FYV X;  3CL9 A;  2KGK A;  3FRF X;  4M2X A;  5FDA A;  4XE6 X;  3QLY A;  4KNE A;  3OCH A;  5HF2 X;  2XW7 A;  5U27 A;  1DR4 A;  1LY4 A;  4XT4 A;  3FQZ A;  3TQA A;  1M78 A;  1AOE A;  4I13 A;  1DRE A;  4FHB A;  3FYW X;  3FQO A;  4QJZ D;  1AO8 A;  3L3R A;  3FRA X;  3NXT A;  3SRQ X;  3CD2 A;  2W9H A;  4LAH X;  4OSG A;  4LAE X;  3KJR A;  4IXF X;  4QLE A;  1IA3 A;  4PST A;  1S3Y A;  3M09 A;  4X5G A;  2DRC A;  3F0S X;  4ELE A;  3UM6 A;  3EEM A;  1KMS A;  4NX6 A;  3K74 A;  1S3U A;  3F0V X;  3SA2 A;  3IRN A;  3IA5 A;  3F0Q X;  3SQY X;  3KJS A;  4H97 A;  4TU5 X;  3F91 A;  2OIP A;  2ANO A;  1RA9 A;  4NX7 A;  3F0X X;  1MVS A;  1DRF A;  3S7A A;  1U72 A;  3FRD X;  3EIG A;  1RE7 A;  2W3B A;  3EX8 A;  1AI9 A;  2P4G A;  5HUI A;  1JOL A;  2W3V A;  4PDJ A;  5DXV A;  3DRC A;  4HA7 A;  2HM9 A;  1RG7 A;  3NXO A;  3NRR A;  3F8Y A;  2BLA A;  2W9S A;  4IXG X;  2FZH A;  4KJJ A;  1HFQ A;  2INQ A;  4M6J A;  4QLF A;  4XRB A;  3RO9 A;  1SEJ A;  1RX8 A;  2BLB A;  3JW5 A;  1PDB A;  3NZB X;  3NU0 A;  4KJK A;  3QYO A;  1OHK A;  3NZD A;  2ZZA A;  3JW3 A;  1PD8 A;  3SRS X;  3JVX A;  4KFJ A;  4OR7 A;  3NXY A;  4EIL A;  5HQZ A;  1RX3 A;  3QLR A;  3D80 A;  1DG8 A;  3FQ0 A;  3QL0 A;  5CC9 A;  3TD8 A;  1MVT A;  4H96 A;  3TQ9 A;  3FL9 A;  3JWC A;  5JG0 X;  1IA2 A;  4G3M A;  4KD7 A;  5ECX A;  1DLR A;  1DAJ A;  1DHJ A;  3FRE X;  4XT6 A;  2JYB A;  4H98 A;  5HVB A;  5HVE A;  5HT4 A;  1TDR A;  1RA8 A;  4XT7 A;  1J3K A;  2W3W A;  1KLK A;  5HI6 A;  4PSY A;  3F8Z A;  2CIG A;  4DP3 A;  1RX5 A;  2BL9 A;  4X5I A;  1DYJ A;  1J3J A;  5HF0 X;  3QLW A;  5JA3 A;  4M7V A;  3NZ9 X;  3F0B X;  1RX1 A;  6DFR A;  3FQV A;  3IA4 A;  3HBB A;  3JWF A;  4KJL A;  3JWM A;  1DHF A;  3DFR A;  4DDR A;  1RB3 A;  3M08 A;  4QHV A;  2B3Z A;  4ELB A;  5HT5 A;  2D0K A;  4G8Z X;  3JWK A; 
#chains in the Genus database with same CATH homology
 3SRU X;  4G95 A;  1D1G A;  4RGC A;  1RX7 A;  4ELF A;  3S3V A;  3SAI A;  4PTJ A;  2DHF A;  1U70 A;  3S9U A;  1RA2 A;  2QK8 A;  4PSS A;  5U26 A;  2D5N A;  3ROA A;  1RX4 A;  4P68 A;  2L28 A;  3KGY A;  4LAG X;  1DR3 A;  4I1N A;  3DGA A;  4KY4 A;  3INV A;  1VDR A;  1JUV A;  5DFR A;  1S3V A;  4DFR A;  3HJ3 A;  1DR7 A;  2W3M A;  3SRR X;  2W9G A;  3JSU A;  1CD2 A;  1DDR A;  3CLB A;  3NTZ A;  4HOE A;  3DG8 A;  3D84 X;  2W3A A;  2G6V A;  2LF1 A;  1BOZ A;  2C2S A;  8DFR A;  1DR2 A;  1DIS A;  3NXX A;  2O7P A;  3DAT A;  2OBC A;  1RA1 A;  2W9T A;  1HFR A;  4ELG A;  4QJC A;  4H95 A;  3QLX A;  5EAJ A;  2FZI A;  5E8Q A;  3TQ8 A;  4P66 A;  1RB2 A;  4M6L A;  1RA3 A;  3KFY A;  1ZDR A;  3N0H A;  3GYF A;  3NXV A;  5ECC A;  4M7U A;  3GHW A;  1DG5 A;  5HSU A;  4EIZ A;  3NXR A;  3IX9 A;  1DYR A;  3QFX A;  5HSR A;  3DAU A;  4QI9 A;  3SH2 A;  3QLZ A;  1PD9 A;  3R33 A;  3SRW X;  4KAK A;  1E26 A;  3F0U X;  1DRA A;  1DF7 A;  1RD7 A;  1KMV A;  3FY9 X;  2ANQ A;  3FQF A;  3UM5 A;  1HFP A;  4Q67 A;  1IA1 A;  1QZF A;  7DFR A;  4DPH A;  5HQY A;  3QYL A;  3NZC X;  3DL6 A;  2HXV A;  3NZ6 X;  5HPB A;  3K45 A;  4EJ1 A;  1CZ3 A;  3ZPC A;  1RX2 A;  4CD2 A;  1M7A A;  3SA1 A;  3QGT A;  2H2Q A;  1RH3 A;  2GD9 A;  4XT8 A;  1JOM A;  5CCC A;  1VJ3 A;  4ECK A;  4KEB A;  3TQB A;  1LUD A;  4PTH A;  3QL3 A;  3I8A X;  4P3Q A;  4M6K A;  1DLS A;  1BZF A;  1RC4 A;  4KBN A;  4KLX A;  4Q0D A;  3EEK A;  1DR1 A;  2CD2 A;  3KY8 A;  2FZJ A;  3FQC A;  2AZN A;  1DR5 A;  1DDS A;  2HQP A;  4FGG A;  3GI2 A;  4KY8 A;  4ELH A;  3I3R A;  1DRB A;  3RG9 A;  3K47 A;  3IRO A;  3EEL A;  3K2H A;  3FS6 A;  3SR5 X;  4EIG A;  1DYI A;  1IA4 A;  1OHJ A;  4KYA A;  1RX6 A;  3ZPG A;  3IRM A;  4X5F A;  4P3R A;  3OAF A;  1DIU A;  3UM8 A;  3JTW A;  3DL5 A;  3QG2 A;  2C2T A;  3FL8 A;  3Q1H A;  3QLS A;  1RF7 A;  3GHV A;  4LEK X;  3VCO A;  3LG4 A;  1DR6 A;  1U71 A;  1DG7 A;  4HOF A;  4Q6A A;  4HOG A;  4DPD A;  4HA9 A;  1DYH A;  4FGH A;  1M79 A;  1YHO A;  4KM2 A;  4GH8 A;  1S3W A;  1J3I A;  3FRB X;  4XEC X;  1DHI A;  1DRH A;  4IXE D;  4X5J A;  4XT5 A;  2BLC A;  3E0B A;  4QLG A;  3NZA X;  1LY3 A;  3GHC A;  3CSE A;  4Q0E A;  3EEJ A;  3SGY A;  3FY8 X;  1RX9 A;  4KM0 A;  2ITH A;  4KL9 A;  4X5H A;  3FYV X;  3CL9 A;  2KGK A;  3FRF X;  4M2X A;  5FDA A;  4XE6 X;  3QLY A;  4KNE A;  3OCH A;  5HF2 X;  2XW7 A;  5U27 A;  1DR4 A;  1LY4 A;  4XT4 A;  3FQZ A;  3TQA A;  1M78 A;  1AOE A;  4I13 A;  1DRE A;  4FHB A;  3FYW X;  3FQO A;  4QJZ D;  1AO8 A;  3L3R A;  3FRA X;  3NXT A;  3SRQ X;  3CD2 A;  2W9H A;  4LAH X;  4OSG A;  4LAE X;  3KJR A;  4IXF X;  4QLE A;  1IA3 A;  4PST A;  1S3Y A;  3M09 A;  4X5G A;  2DRC A;  3F0S X;  4ELE A;  3UM6 A;  3EEM A;  1KMS A;  4NX6 A;  3K74 A;  1S3U A;  3F0V X;  3SA2 A;  3IRN A;  3IA5 A;  3F0Q X;  3SQY X;  3KJS A;  4H97 A;  4TU5 X;  3F91 A;  2OIP A;  2ANO A;  1RA9 A;  4NX7 A;  3F0X X;  1MVS A;  1DRF A;  3S7A A;  1U72 A;  3FRD X;  3EIG A;  1RE7 A;  2W3B A;  3EX8 A;  1AI9 A;  2P4G A;  5HUI A;  1JOL A;  2W3V A;  4PDJ A;  5DXV A;  3DRC A;  4HA7 A;  2HM9 A;  1RG7 A;  3NXO A;  3NRR A;  3F8Y A;  2BLA A;  2W9S A;  4IXG X;  2FZH A;  4KJJ A;  1HFQ A;  2INQ A;  4M6J A;  4QLF A;  4XRB A;  3RO9 A;  1SEJ A;  1RX8 A;  2BLB A;  3JW5 A;  1PDB A;  3NZB X;  3NU0 A;  4KJK A;  3QYO A;  1OHK A;  3NZD A;  2ZZA A;  3JW3 A;  1PD8 A;  3SRS X;  3JVX A;  4KFJ A;  4OR7 A;  3NXY A;  4EIL A;  5HQZ A;  1RX3 A;  3QLR A;  3D80 A;  1DG8 A;  3FQ0 A;  3QL0 A;  5CC9 A;  3TD8 A;  1MVT A;  4H96 A;  3TQ9 A;  3FL9 A;  3JWC A;  5JG0 X;  1IA2 A;  4G3M A;  4KD7 A;  5ECX A;  1DLR A;  1DAJ A;  1DHJ A;  3FRE X;  4XT6 A;  2JYB A;  4H98 A;  5HVB A;  5HVE A;  5HT4 A;  1TDR A;  1RA8 A;  4XT7 A;  1J3K A;  2W3W A;  1KLK A;  5HI6 A;  4PSY A;  3F8Z A;  2CIG A;  4DP3 A;  1RX5 A;  2BL9 A;  4X5I A;  1DYJ A;  1J3J A;  5HF0 X;  3QLW A;  5JA3 A;  4M7V A;  3NZ9 X;  3F0B X;  1RX1 A;  6DFR A;  3FQV A;  3IA4 A;  3HBB A;  3JWF A;  4KJL A;  3JWM A;  1DHF A;  3DFR A;  4DDR A;  1RB3 A;  3M08 A;  4QHV A;  2B3Z A;  4ELB A;  5HT5 A;  2D0K A;  4G8Z X;  3JWK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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