5HVTA

Crystal structure of macrophage migration inhibitory factor (mif) with a potent inhibitor (nvs-2)
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
114
structure length
114
Chain Sequence
PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Isomerase/isomerase inhibitor
molecule keywords Macrophage migration inhibitory factor
publication title A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 34
structure length 114
sequence length 114
chains with identical sequence B, C
ec nomenclature ec 5.3.2.1: Phenylpyruvate tautomerase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01187 MIF Macrophage migration inhibitory factor (MIF)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 5hvtA00
4P7SA 3L5PA 1U9DA 4GUMA 4GRUA 3N4GA 3IJJA 3RY0A 2GDGA 4XX8A 1CGQA 4NWPE 1GYJA 3C6VA 3L5TA 1P1GA 1DPTA 1GYYA 4GRRA 3N4DA 1HFOA 2XCZA 2WKFA 3N4HA 4X1CC 5CLOA 4LHOA 3EJ7A 4WR8A 2AAGA 3EJ3B 3HOFA 4X1CA 1OTGA 1CA7A 3GADA 4M1AA 1S0YB 4OTAA 4PKKA 3U18A 3B9SA 3WNTA 3L5RA 3SMBA 5BSCA 3B64A 3M20A 4LKBA 3JSGA 3IJGA 5HVTA 4Z1UA 4JJ9A 1GYXA 2FLTA 5B4OA 5CLNA 3FWTA 4XX7A 2X4KA 4LHPA 3ABFA 4WRBA 2OS5A 3T5SA 3KERA 4P7MA 4TRFA 4K9GA 3WNRA 3FWUA 4JCUA 5HVVA 3EJ9B 4EUIA 3DJHA 3MB2A 4PKZA 2AALA 2FM7A 4Z15A 3DJIA 1GIFA 4P01A 5BS9A 4FAZA 3JTUA 3CE4A 1GCZA 4FDXA 1BJPA 2OOZA 3SMCA 5BSIA 4F2KA 2AAJA 3RF4A 4OTCA 4OSFA 2OPAA 4GRPA 1GD0A 1MFFA 2OOWA 4OTBA 1MFIA 1FIMA 2WKFB 2ORMA 4GRNA 3EJ3A 4GROA 3L5VA 1MIFA 3M21A 1S0YA 5EIZA 3L5UA 4ETGA 4Z1TA 3WNSA 3KANA 3MLCA 3RF5A 4PLUA 3MJZA 2FLZA 3JSFA 3L5SA 3MF7A 4EVGA 5BSJA 4Q3FA 4U5PA 3MF8A 5HVSA 4DH4A 1UIZA 1MWWA 4OYQA 4NWQB 2OOHA 2WKBA 4X19A 1OTFA 3GACA 2OP8A 4P0HA 5J7QA 3E6QA 5J7PA 3EJ7B 3EJ9A 4GRQA 4TRUA 3MB2B 4U5RA 1LJTA
chains in the Genus database with same CATH superfamily
4P7SA 3L5PA 1U9DA 4GUMA 4GRUA 3N4GA 3IJJA 3RY0A 2GDGA 4XX8A 1CGQA 4NWPE 1GYJA 3C6VA 3L5TA 1P1GA 1DPTA 1GYYA 4GRRA 3N4DA 1HFOA 2XCZA 2WKFA 3N4HA 4X1CC 5CLOA 4LHOA 3EJ7A 4WR8A 2AAGA 3EJ3B 3HOFA 4X1CA 1OTGA 1CA7A 3GADA 4M1AA 1S0YB 4OTAA 4PKKA 3U18A 3B9SA 3WNTA 3L5RA 3SMBA 5BSCA 3B64A 3M20A 4LKBA 3JSGA 3IJGA 5HVTA 4Z1UA 4JJ9A 1GYXA 2FLTA 5B4OA 5CLNA 3FWTA 4XX7A 2X4KA 4LHPA 3ABFA 4WRBA 2OS5A 3T5SA 3KERA 4P7MA 4TRFA 4K9GA 3WNRA 3FWUA 4JCUA 5HVVA 3EJ9B 4EUIA 3DJHA 3MB2A 4PKZA 2AALA 2FM7A 4Z15A 3DJIA 1GIFA 4P01A 5BS9A 4FAZA 3JTUA 3CE4A 1GCZA 4FDXA 1BJPA 2OOZA 3SMCA 5BSIA 4F2KA 2AAJA 3RF4A 4OTCA 4OSFA 2OPAA 4GRPA 1GD0A 1MFFA 2OOWA 4OTBA 1MFIA 1FIMA 2WKFB 2ORMA 4GRNA 3EJ3A 4GROA 3L5VA 1MIFA 3M21A 1S0YA 5EIZA 3L5UA 4ETGA 4Z1TA 3WNSA 3KANA 3MLCA 3RF5A 4PLUA 3MJZA 2FLZA 3JSFA 3L5SA 3MF7A 4EVGA 5BSJA 4Q3FA 4U5PA 3MF8A 5HVSA 4DH4A 1UIZA 1MWWA 4OYQA 4NWQB 2OOHA 2WKBA 4X19A 1OTFA 3GACA 2OP8A 4P0HA 5J7QA 3E6QA 5J7PA 3EJ7B 3EJ9A 4GRQA 4TRUA 3MB2B 4U5RA 1LJTA
chains in the Genus database with same CATH topology
4P7SA 3L5PA 1U9DA 4GUMA 4GRUA 3N4GA 3IJJA 3RY0A 2GDGA 4XX8A 1CGQA 4NWPE 1GYJA 3C6VA 3L5TA 1P1GA 1DPTA 1GYYA 4GRRA 3N4DA 1HFOA 2XCZA 2WKFA 3N4HA 4X1CC 5CLOA 4LHOA 3EJ7A 4WR8A 2AAGA 3EJ3B 3HOFA 4X1CA 1OTGA 1CA7A 3GADA 4M1AA 1S0YB 4OTAA 4PKKA 3U18A 3B9SA 3WNTA 3L5RA 3SMBA 5BSCA 3B64A 3M20A 4LKBA 3JSGA 3IJGA 5HVTA 4Z1UA 4JJ9A 1GYXA 2FLTA 5B4OA 5CLNA 3FWTA 4XX7A 2X4KA 4LHPA 3ABFA 4WRBA 2OS5A 3T5SA 3KERA 4P7MA 4TRFA 4K9GA 3WNRA 3FWUA 4JCUA 5HVVA 3EJ9B 4EUIA 3DJHA 3MB2A 4PKZA 2AALA 2FM7A 4Z15A 3DJIA 1GIFA 4P01A 5BS9A 4FAZA 3JTUA 3CE4A 1GCZA 4FDXA 1BJPA 2OOZA 3SMCA 5BSIA 4F2KA 2AAJA 3RF4A 4OTCA 4OSFA 2OPAA 4GRPA 1GD0A 1MFFA 2OOWA 4OTBA 1MFIA 1FIMA 2WKFB 2ORMA 4GRNA 3EJ3A 4GROA 3L5VA 1MIFA 3M21A 1S0YA 5EIZA 3L5UA 4ETGA 4Z1TA 3WNSA 3KANA 3MLCA 3RF5A 4PLUA 3MJZA 2FLZA 3JSFA 3L5SA 3MF7A 4EVGA 5BSJA 4Q3FA 4U5PA 3MF8A 5HVSA 4DH4A 1UIZA 1MWWA 4OYQA 4NWQB 2OOHA 2WKBA 4X19A 1OTFA 3GACA 2OP8A 4P0HA 5J7QA 3E6QA 5J7PA 3EJ7B 3EJ9A 4GRQA 4TRUA 3MB2B 4U5RA 1LJTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P7S A;  3L5P A;  1U9D A;  4GUM A;  4GRU A;  3N4G A;  3IJJ A;  3RY0 A;  2GDG A;  4XX8 A;  1CGQ A;  4NWP E;  1GYJ A;  3C6V A;  3L5T A;  1P1G A;  1DPT A;  1GYY A;  4GRR A;  3N4D A;  1HFO A;  2XCZ A;  2WKF A;  3N4H A;  4X1C C;  5CLO A;  4LHO A;  3EJ7 A;  4WR8 A;  2AAG A;  3EJ3 B;  3HOF A;  4X1C A;  1OTG A;  1CA7 A;  3GAD A;  4M1A A;  1S0Y B;  4OTA A;  4PKK A;  3U18 A;  3B9S A;  3WNT A;  3L5R A;  3SMB A;  5BSC A;  3B64 A;  3M20 A;  4LKB A;  3JSG A;  3IJG A;  5HVT A;  4Z1U A;  4JJ9 A;  1GYX A;  2FLT A;  5B4O A;  5CLN A;  3FWT A;  4XX7 A;  2X4K A;  4LHP A;  3ABF A;  4WRB A;  2OS5 A;  3T5S A;  3KER A;  4P7M A;  4TRF A;  4K9G A;  3WNR A;  3FWU A;  4JCU A;  5HVV A;  3EJ9 B;  4EUI A;  3DJH A;  3MB2 A;  4PKZ A;  2AAL A;  2FM7 A;  4Z15 A;  3DJI A;  1GIF A;  4P01 A;  5BS9 A;  4FAZ A;  3JTU A;  3CE4 A;  1GCZ A;  4FDX A;  1BJP A;  2OOZ A;  3SMC A;  5BSI A;  4F2K A;  2AAJ A;  3RF4 A;  4OTC A;  4OSF A;  2OPA A;  4GRP A;  1GD0 A;  1MFF A;  2OOW A;  4OTB A;  1MFI A;  1FIM A;  2WKF B;  2ORM A;  4GRN A;  3EJ3 A;  4GRO A;  3L5V A;  1MIF A;  3M21 A;  1S0Y A;  5EIZ A;  3L5U A;  4ETG A;  4Z1T A;  3WNS A;  3KAN A;  3MLC A;  3RF5 A;  4PLU A;  3MJZ A;  2FLZ A;  3JSF A;  3L5S A;  3MF7 A;  4EVG A;  5BSJ A;  4Q3F A;  4U5P A;  3MF8 A;  5HVS A;  4DH4 A;  1UIZ A;  1MWW A;  4OYQ A;  4NWQ B;  2OOH A;  2WKB A;  4X19 A;  1OTF A;  3GAC A;  2OP8 A;  4P0H A;  5J7Q A;  3E6Q A;  5J7P A;  3EJ7 B;  3EJ9 A;  4GRQ A;  4TRU A;  3MB2 B;  4U5R A;  1LJT A; 
#chains in the Genus database with same CATH topology
 4P7S A;  3L5P A;  1U9D A;  4GUM A;  4GRU A;  3N4G A;  3IJJ A;  3RY0 A;  2GDG A;  4XX8 A;  1CGQ A;  4NWP E;  1GYJ A;  3C6V A;  3L5T A;  1P1G A;  1DPT A;  1GYY A;  4GRR A;  3N4D A;  1HFO A;  2XCZ A;  2WKF A;  3N4H A;  4X1C C;  5CLO A;  4LHO A;  3EJ7 A;  4WR8 A;  2AAG A;  3EJ3 B;  3HOF A;  4X1C A;  1OTG A;  1CA7 A;  3GAD A;  4M1A A;  1S0Y B;  4OTA A;  4PKK A;  3U18 A;  3B9S A;  3WNT A;  3L5R A;  3SMB A;  5BSC A;  3B64 A;  3M20 A;  4LKB A;  3JSG A;  3IJG A;  5HVT A;  4Z1U A;  4JJ9 A;  1GYX A;  2FLT A;  5B4O A;  5CLN A;  3FWT A;  4XX7 A;  2X4K A;  4LHP A;  3ABF A;  4WRB A;  2OS5 A;  3T5S A;  3KER A;  4P7M A;  4TRF A;  4K9G A;  3WNR A;  3FWU A;  4JCU A;  5HVV A;  3EJ9 B;  4EUI A;  3DJH A;  3MB2 A;  4PKZ A;  2AAL A;  2FM7 A;  4Z15 A;  3DJI A;  1GIF A;  4P01 A;  5BS9 A;  4FAZ A;  3JTU A;  3CE4 A;  1GCZ A;  4FDX A;  1BJP A;  2OOZ A;  3SMC A;  5BSI A;  4F2K A;  2AAJ A;  3RF4 A;  4OTC A;  4OSF A;  2OPA A;  4GRP A;  1GD0 A;  1MFF A;  2OOW A;  4OTB A;  1MFI A;  1FIM A;  2WKF B;  2ORM A;  4GRN A;  3EJ3 A;  4GRO A;  3L5V A;  1MIF A;  3M21 A;  1S0Y A;  5EIZ A;  3L5U A;  4ETG A;  4Z1T A;  3WNS A;  3KAN A;  3MLC A;  3RF5 A;  4PLU A;  3MJZ A;  2FLZ A;  3JSF A;  3L5S A;  3MF7 A;  4EVG A;  5BSJ A;  4Q3F A;  4U5P A;  3MF8 A;  5HVS A;  4DH4 A;  1UIZ A;  1MWW A;  4OYQ A;  4NWQ B;  2OOH A;  2WKB A;  4X19 A;  1OTF A;  3GAC A;  2OP8 A;  4P0H A;  5J7Q A;  3E6Q A;  5J7P A;  3EJ7 B;  3EJ9 A;  4GRQ A;  4TRU A;  3MB2 B;  4U5R A;  1LJT A; 
#chains in the Genus database with same CATH homology
 4P7S A;  3L5P A;  1U9D A;  4GUM A;  4GRU A;  3N4G A;  3IJJ A;  3RY0 A;  2GDG A;  4XX8 A;  1CGQ A;  4NWP E;  1GYJ A;  3C6V A;  3L5T A;  1P1G A;  1DPT A;  1GYY A;  4GRR A;  3N4D A;  1HFO A;  2XCZ A;  2WKF A;  3N4H A;  4X1C C;  5CLO A;  4LHO A;  3EJ7 A;  4WR8 A;  2AAG A;  3EJ3 B;  3HOF A;  4X1C A;  1OTG A;  1CA7 A;  3GAD A;  4M1A A;  1S0Y B;  4OTA A;  4PKK A;  3U18 A;  3B9S A;  3WNT A;  3L5R A;  3SMB A;  5BSC A;  3B64 A;  3M20 A;  4LKB A;  3JSG A;  3IJG A;  5HVT A;  4Z1U A;  4JJ9 A;  1GYX A;  2FLT A;  5B4O A;  5CLN A;  3FWT A;  4XX7 A;  2X4K A;  4LHP A;  3ABF A;  4WRB A;  2OS5 A;  3T5S A;  3KER A;  4P7M A;  4TRF A;  4K9G A;  3WNR A;  3FWU A;  4JCU A;  5HVV A;  3EJ9 B;  4EUI A;  3DJH A;  3MB2 A;  4PKZ A;  2AAL A;  2FM7 A;  4Z15 A;  3DJI A;  1GIF A;  4P01 A;  5BS9 A;  4FAZ A;  3JTU A;  3CE4 A;  1GCZ A;  4FDX A;  1BJP A;  2OOZ A;  3SMC A;  5BSI A;  4F2K A;  2AAJ A;  3RF4 A;  4OTC A;  4OSF A;  2OPA A;  4GRP A;  1GD0 A;  1MFF A;  2OOW A;  4OTB A;  1MFI A;  1FIM A;  2WKF B;  2ORM A;  4GRN A;  3EJ3 A;  4GRO A;  3L5V A;  1MIF A;  3M21 A;  1S0Y A;  5EIZ A;  3L5U A;  4ETG A;  4Z1T A;  3WNS A;  3KAN A;  3MLC A;  3RF5 A;  4PLU A;  3MJZ A;  2FLZ A;  3JSF A;  3L5S A;  3MF7 A;  4EVG A;  5BSJ A;  4Q3F A;  4U5P A;  3MF8 A;  5HVS A;  4DH4 A;  1UIZ A;  1MWW A;  4OYQ A;  4NWQ B;  2OOH A;  2WKB A;  4X19 A;  1OTF A;  3GAC A;  2OP8 A;  4P0H A;  5J7Q A;  3E6Q A;  5J7P A;  3EJ7 B;  3EJ9 A;  4GRQ A;  4TRU A;  3MB2 B;  4U5R A;  1LJT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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