5I96A

Crystal structure of human mitochondrial isocitrate dehydrogenase (idh2) r140q mutant homodimer in complex with ag-221 (enasidenib) inhibitor.
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
417
structure length
417
Chain Sequence
DKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Isocitrate dehydrogenase [NADP], mitochondrial
publication title AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
pubmed doi rcsb
source organism Homo sapiens
total genus 158
structure length 417
sequence length 417
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2016-02-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 5i96A00
3MASB 3BLVA 4Y1PA 5L58A 1PB1A 5HN5A 2E5MA 5GRIB 4UMYA 2Y41A 3MAPA 3UDOA 4AOUA 1GC9A 5DE1A 4P69C 5HN4A 1CW4A 2ZTWA 2DHTA 3VMLA 1PB3A 5GRHB 2UXRA 3ASJA 5HN6A 6ICDA 3MASA 4JQPA 5HN3A 5GREB 1IDMA 1DR8A 5K10A 4WUOA 5GRIA 2Y3ZA 3INMA 3VL6A 3VL7A 3U1HA 4AJBA 3TSNA 3LXYA 1PS7A 1LWDA 1V94A 3TNGA 1CW1A 5GRHA 4ICDA 3MARA 1GRPA 1PTMA 5K11A 5GREA 2G4OA 3WZWA 5ICDA 4XS3A 3FMXX 3U9EA 2E0CA 1PS6A 3ICDA 4KZOA 1X0LA 1P8FA 3UDUA 2QFWA 2QFVA 3WZVA 2Y42A 5J33A 1GC8A 3WZYA 5J32A 1HJ6A 4I3KA 4AJAA 4L03A 1OSIA 4ATYA 1IDCA 3US8A 1CW7A 5GRFA 4AJCA 4AJ3A 1AI2A 1VI1A 2D4VA 1G2UA 1ZORA 4L04A 1CM7A 1WALA 5I96A 3FLKA 1AI3A 1XGVA 1TYOA 1IDFA 4YB4A 3BLXA 1T09A 1XKDA 5GRFB 8ICDA 4XRXA 4UMXA 1BL5A 3DMSA 1W0DA 4IWHA 3VL3A 1YXOA 1IDDA 1T0LA 1WPWA 3WZXA 4AJSA 3BLXB 1U7NA 4XXVA 3VMJA 1SJSA 4AOYA 1XADA 1XABA 2AYQA 1CNZA 4L06A 5GRLB 1DPZA 1A05A 1VLCA 1IKAA 2QFXA 4F7IA 2D1CA 1GROA 2QFYA 1XACA 3AH3A 4HCXA 3UF6A 3BLVB 3VL2A 1XAAA 1R8KA 5L57A 7ICDA 4JA8A 5LGEA 5J34A 3VKZA 4I3LA 3VL4A 5GRLA 4AJRA 3VMKA 4BNPA 1IDEA 1DR0A 1V53A 2Y40A 2HI1A 3TY4A 3R8WA 2UXQA 3TY3A 5I95A 1YCOA 2IV0A 1HEXA 1V5BA 1IPDA 1HQSA 3LCBC 1ISOA 1OSJA 9ICDA 4AOVA
chains in the Genus database with same CATH superfamily
3MASB 3BLVA 4Y1PA 5L58A 1PB1A 5HN5A 2E5MA 5GRIB 4UMYA 2Y41A 3MAPA 3UDOA 4AOUA 1GC9A 5DE1A 4P69C 5HN4A 1CW4A 2ZTWA 2DHTA 3VMLA 1PB3A 5GRHB 2UXRA 3ASJA 5HN6A 6ICDA 3MASA 4JQPA 5HN3A 5GREB 1IDMA 1DR8A 5K10A 4WUOA 5GRIA 2Y3ZA 3INMA 3VL6A 3VL7A 3U1HA 4AJBA 3TSNA 3LXYA 1PS7A 1LWDA 1V94A 3TNGA 1CW1A 5GRHA 4ICDA 3MARA 1GRPA 1PTMA 5K11A 5GREA 2G4OA 3WZWA 5ICDA 4XS3A 3FMXX 3U9EA 2E0CA 1PS6A 3ICDA 4KZOA 1X0LA 1P8FA 3UDUA 2QFWA 2QFVA 3WZVA 2Y42A 5J33A 1GC8A 3WZYA 5J32A 1HJ6A 4I3KA 4AJAA 4L03A 1OSIA 4ATYA 1IDCA 3US8A 1CW7A 5GRFA 4AJCA 4AJ3A 1AI2A 1VI1A 2D4VA 1G2UA 1ZORA 4L04A 1CM7A 1WALA 5I96A 3FLKA 1AI3A 1XGVA 1TYOA 1IDFA 4YB4A 3BLXA 1T09A 1XKDA 5GRFB 8ICDA 4XRXA 4UMXA 1BL5A 3DMSA 1W0DA 4IWHA 3VL3A 1YXOA 1IDDA 1T0LA 1WPWA 3WZXA 4AJSA 3BLXB 1U7NA 4XXVA 3VMJA 1SJSA 4AOYA 1XADA 1XABA 2AYQA 1CNZA 4L06A 5GRLB 1DPZA 1A05A 1VLCA 1IKAA 2QFXA 4F7IA 2D1CA 1GROA 2QFYA 1XACA 3AH3A 4HCXA 3UF6A 3BLVB 3VL2A 1XAAA 1R8KA 5L57A 7ICDA 4JA8A 5LGEA 5J34A 3VKZA 4I3LA 3VL4A 5GRLA 4AJRA 3VMKA 4BNPA 1IDEA 1DR0A 1V53A 2Y40A 2HI1A 3TY4A 3R8WA 2UXQA 3TY3A 5I95A 1YCOA 2IV0A 1HEXA 1V5BA 1IPDA 1HQSA 3LCBC 1ISOA 1OSJA 9ICDA 4AOVA
chains in the Genus database with same CATH topology
3MASB 3BLVA 4Y1PA 5L58A 1PB1A 5HN5A 2E5MA 5GRIB 4UMYA 2Y41A 3MAPA 3UDOA 4AOUA 1GC9A 5DE1A 4P69C 5HN4A 1CW4A 2ZTWA 2DHTA 3VMLA 1PB3A 5GRHB 2UXRA 3ASJA 5HN6A 6ICDA 3MASA 4JQPA 5HN3A 5GREB 1IDMA 1DR8A 5K10A 4WUOA 5GRIA 2Y3ZA 3INMA 3VL6A 3VL7A 3U1HA 4AJBA 3TSNA 3LXYA 1PS7A 1LWDA 1V94A 3TNGA 1CW1A 5GRHA 4ICDA 3MARA 1GRPA 1PTMA 5K11A 5GREA 2G4OA 3WZWA 5ICDA 4XS3A 3FMXX 3U9EA 2E0CA 1PS6A 3ICDA 4KZOA 1X0LA 1P8FA 3UDUA 2QFWA 2QFVA 3WZVA 2Y42A 5J33A 1GC8A 3WZYA 5J32A 1HJ6A 4I3KA 4AJAA 4L03A 1OSIA 4ATYA 1IDCA 3US8A 1CW7A 5GRFA 4AJCA 4AJ3A 1AI2A 1VI1A 2D4VA 1G2UA 1ZORA 4L04A 1CM7A 1WALA 5I96A 3FLKA 1AI3A 1XGVA 1TYOA 1IDFA 4YB4A 3BLXA 1T09A 1XKDA 5GRFB 8ICDA 4XRXA 4UMXA 1BL5A 3DMSA 1W0DA 4IWHA 3VL3A 1YXOA 1IDDA 1T0LA 1WPWA 3WZXA 4AJSA 3BLXB 1U7NA 4XXVA 3VMJA 1SJSA 4AOYA 1XADA 1XABA 2AYQA 1CNZA 4L06A 5GRLB 1DPZA 1A05A 1VLCA 1IKAA 2QFXA 4F7IA 2D1CA 1GROA 2QFYA 1XACA 3AH3A 4HCXA 3UF6A 3BLVB 3VL2A 1XAAA 1R8KA 5L57A 7ICDA 4JA8A 5LGEA 5J34A 3VKZA 4I3LA 3VL4A 5GRLA 4AJRA 3VMKA 4BNPA 1IDEA 1DR0A 1V53A 2Y40A 2HI1A 3TY4A 3R8WA 2UXQA 3TY3A 5I95A 1YCOA 2IV0A 1HEXA 1V5BA 1IPDA 1HQSA 3LCBC 1ISOA 1OSJA 9ICDA 4AOVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MAS B;  3BLV A;  4Y1P A;  5L58 A;  1PB1 A;  5HN5 A;  2E5M A;  5GRI B;  4UMY A;  2Y41 A;  3MAP A;  3UDO A;  4AOU A;  1GC9 A;  5DE1 A;  4P69 C;  5HN4 A;  1CW4 A;  2ZTW A;  2DHT A;  3VML A;  1PB3 A;  5GRH B;  2UXR A;  3ASJ A;  5HN6 A;  6ICD A;  3MAS A;  4JQP A;  5HN3 A;  5GRE B;  1IDM A;  1DR8 A;  5K10 A;  4WUO A;  5GRI A;  2Y3Z A;  3INM A;  3VL6 A;  3VL7 A;  3U1H A;  4AJB A;  3TSN A;  3LXY A;  1PS7 A;  1LWD A;  1V94 A;  3TNG A;  1CW1 A;  5GRH A;  4ICD A;  3MAR A;  1GRP A;  1PTM A;  5K11 A;  5GRE A;  2G4O A;  3WZW A;  5ICD A;  4XS3 A;  3FMX X;  3U9E A;  2E0C A;  1PS6 A;  3ICD A;  4KZO A;  1X0L A;  1P8F A;  3UDU A;  2QFW A;  2QFV A;  3WZV A;  2Y42 A;  5J33 A;  1GC8 A;  3WZY A;  5J32 A;  1HJ6 A;  4I3K A;  4AJA A;  4L03 A;  1OSI A;  4ATY A;  1IDC A;  3US8 A;  1CW7 A;  5GRF A;  4AJC A;  4AJ3 A;  1AI2 A;  1VI1 A;  2D4V A;  1G2U A;  1ZOR A;  4L04 A;  1CM7 A;  1WAL A;  5I96 A;  3FLK A;  1AI3 A;  1XGV A;  1TYO A;  1IDF A;  4YB4 A;  3BLX A;  1T09 A;  1XKD A;  5GRF B;  8ICD A;  4XRX A;  4UMX A;  1BL5 A;  3DMS A;  1W0D A;  4IWH A;  3VL3 A;  1YXO A;  1IDD A;  1T0L A;  1WPW A;  3WZX A;  4AJS A;  3BLX B;  1U7N A;  4XXV A;  3VMJ A;  1SJS A;  4AOY A;  1XAD A;  1XAB A;  2AYQ A;  1CNZ A;  4L06 A;  5GRL B;  1DPZ A;  1A05 A;  1VLC A;  1IKA A;  2QFX A;  4F7I A;  2D1C A;  1GRO A;  2QFY A;  1XAC A;  3AH3 A;  4HCX A;  3UF6 A;  3BLV B;  3VL2 A;  1XAA A;  1R8K A;  5L57 A;  7ICD A;  4JA8 A;  5LGE A;  5J34 A;  3VKZ A;  4I3L A;  3VL4 A;  5GRL A;  4AJR A;  3VMK A;  4BNP A;  1IDE A;  1DR0 A;  1V53 A;  2Y40 A;  2HI1 A;  3TY4 A;  3R8W A;  2UXQ A;  3TY3 A;  5I95 A;  1YCO A;  2IV0 A;  1HEX A;  1V5B A;  1IPD A;  1HQS A;  3LCB C;  1ISO A;  1OSJ A;  9ICD A;  4AOV A; 
#chains in the Genus database with same CATH topology
 3MAS B;  3BLV A;  4Y1P A;  5L58 A;  1PB1 A;  5HN5 A;  2E5M A;  5GRI B;  4UMY A;  2Y41 A;  3MAP A;  3UDO A;  4AOU A;  1GC9 A;  5DE1 A;  4P69 C;  5HN4 A;  1CW4 A;  2ZTW A;  2DHT A;  3VML A;  1PB3 A;  5GRH B;  2UXR A;  3ASJ A;  5HN6 A;  6ICD A;  3MAS A;  4JQP A;  5HN3 A;  5GRE B;  1IDM A;  1DR8 A;  5K10 A;  4WUO A;  5GRI A;  2Y3Z A;  3INM A;  3VL6 A;  3VL7 A;  3U1H A;  4AJB A;  3TSN A;  3LXY A;  1PS7 A;  1LWD A;  1V94 A;  3TNG A;  1CW1 A;  5GRH A;  4ICD A;  3MAR A;  1GRP A;  1PTM A;  5K11 A;  5GRE A;  2G4O A;  3WZW A;  5ICD A;  4XS3 A;  3FMX X;  3U9E A;  2E0C A;  1PS6 A;  3ICD A;  4KZO A;  1X0L A;  1P8F A;  3UDU A;  2QFW A;  2QFV A;  3WZV A;  2Y42 A;  5J33 A;  1GC8 A;  3WZY A;  5J32 A;  1HJ6 A;  4I3K A;  4AJA A;  4L03 A;  1OSI A;  4ATY A;  1IDC A;  3US8 A;  1CW7 A;  5GRF A;  4AJC A;  4AJ3 A;  1AI2 A;  1VI1 A;  2D4V A;  1G2U A;  1ZOR A;  4L04 A;  1CM7 A;  1WAL A;  5I96 A;  3FLK A;  1AI3 A;  1XGV A;  1TYO A;  1IDF A;  4YB4 A;  3BLX A;  1T09 A;  1XKD A;  5GRF B;  8ICD A;  4XRX A;  4UMX A;  1BL5 A;  3DMS A;  1W0D A;  4IWH A;  3VL3 A;  1YXO A;  1IDD A;  1T0L A;  1WPW A;  3WZX A;  4AJS A;  3BLX B;  1U7N A;  4XXV A;  3VMJ A;  1SJS A;  4AOY A;  1XAD A;  1XAB A;  2AYQ A;  1CNZ A;  4L06 A;  5GRL B;  1DPZ A;  1A05 A;  1VLC A;  1IKA A;  2QFX A;  4F7I A;  2D1C A;  1GRO A;  2QFY A;  1XAC A;  3AH3 A;  4HCX A;  3UF6 A;  3BLV B;  3VL2 A;  1XAA A;  1R8K A;  5L57 A;  7ICD A;  4JA8 A;  5LGE A;  5J34 A;  3VKZ A;  4I3L A;  3VL4 A;  5GRL A;  4AJR A;  3VMK A;  4BNP A;  1IDE A;  1DR0 A;  1V53 A;  2Y40 A;  2HI1 A;  3TY4 A;  3R8W A;  2UXQ A;  3TY3 A;  5I95 A;  1YCO A;  2IV0 A;  1HEX A;  1V5B A;  1IPD A;  1HQS A;  3LCB C;  1ISO A;  1OSJ A;  9ICD A;  4AOV A; 
#chains in the Genus database with same CATH homology
 3MAS B;  3BLV A;  4Y1P A;  5L58 A;  1PB1 A;  5HN5 A;  2E5M A;  5GRI B;  4UMY A;  2Y41 A;  3MAP A;  3UDO A;  4AOU A;  1GC9 A;  5DE1 A;  4P69 C;  5HN4 A;  1CW4 A;  2ZTW A;  2DHT A;  3VML A;  1PB3 A;  5GRH B;  2UXR A;  3ASJ A;  5HN6 A;  6ICD A;  3MAS A;  4JQP A;  5HN3 A;  5GRE B;  1IDM A;  1DR8 A;  5K10 A;  4WUO A;  5GRI A;  2Y3Z A;  3INM A;  3VL6 A;  3VL7 A;  3U1H A;  4AJB A;  3TSN A;  3LXY A;  1PS7 A;  1LWD A;  1V94 A;  3TNG A;  1CW1 A;  5GRH A;  4ICD A;  3MAR A;  1GRP A;  1PTM A;  5K11 A;  5GRE A;  2G4O A;  3WZW A;  5ICD A;  4XS3 A;  3FMX X;  3U9E A;  2E0C A;  1PS6 A;  3ICD A;  4KZO A;  1X0L A;  1P8F A;  3UDU A;  2QFW A;  2QFV A;  3WZV A;  2Y42 A;  5J33 A;  1GC8 A;  3WZY A;  5J32 A;  1HJ6 A;  4I3K A;  4AJA A;  4L03 A;  1OSI A;  4ATY A;  1IDC A;  3US8 A;  1CW7 A;  5GRF A;  4AJC A;  4AJ3 A;  1AI2 A;  1VI1 A;  2D4V A;  1G2U A;  1ZOR A;  4L04 A;  1CM7 A;  1WAL A;  5I96 A;  3FLK A;  1AI3 A;  1XGV A;  1TYO A;  1IDF A;  4YB4 A;  3BLX A;  1T09 A;  1XKD A;  5GRF B;  8ICD A;  4XRX A;  4UMX A;  1BL5 A;  3DMS A;  1W0D A;  4IWH A;  3VL3 A;  1YXO A;  1IDD A;  1T0L A;  1WPW A;  3WZX A;  4AJS A;  3BLX B;  1U7N A;  4XXV A;  3VMJ A;  1SJS A;  4AOY A;  1XAD A;  1XAB A;  2AYQ A;  1CNZ A;  4L06 A;  5GRL B;  1DPZ A;  1A05 A;  1VLC A;  1IKA A;  2QFX A;  4F7I A;  2D1C A;  1GRO A;  2QFY A;  1XAC A;  3AH3 A;  4HCX A;  3UF6 A;  3BLV B;  3VL2 A;  1XAA A;  1R8K A;  5L57 A;  7ICD A;  4JA8 A;  5LGE A;  5J34 A;  3VKZ A;  4I3L A;  3VL4 A;  5GRL A;  4AJR A;  3VMK A;  4BNP A;  1IDE A;  1DR0 A;  1V53 A;  2Y40 A;  2HI1 A;  3TY4 A;  3R8W A;  2UXQ A;  3TY3 A;  5I95 A;  1YCO A;  2IV0 A;  1HEX A;  1V5B A;  1IPD A;  1HQS A;  3LCB C;  1ISO A;  1OSJ A;  9ICD A;  4AOV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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