5JHWC

Crystal structure of the gdf11:follistatin 288 complex
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
288
structure length
282
Chain Sequence
GNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cytokine/signaling protein
molecule keywords Growth/differentiation factor 11
publication title Structural basis for potency differences between GDF8 and GDF11.
pubmed doi rcsb
source organism Homo sapiens
total genus 65
structure length 282
sequence length 288
chains with identical sequence D
ec nomenclature
pdb deposition date 2016-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF07648 Kazal_2 Kazal-type serine protease inhibitor domain
C PF09289 FOLN Follistatin/Osteonectin-like EGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 5jhwC04
3.30.60.30 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 5jhwC03
3.30.60.250 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 5jhwC02
3.90.290.10 Alpha Beta Alpha-Beta Complex Extracellular Matrix Fibrillin TGF-beta binding (TB) domain 5jhwC01
1Z7KB 1OMTA 1LR9A 1CT0I 3OVOA 2B0UC 5DAEA 1IY6A 2SGPI 2SGFI 3SGBI 1SGRI 2W86A 3TJQA 1CE3A 1TIHA 2QQCA 2QQDA 2V53A 1APJA 1TURA 2N17A 2JXDA 1PJUA 2NU4I 1UUCA 1HJAI 2M5XA 1IY5A 2NU2I 1OMUA 1TGSI 4OVOA 1UZPA 1SGDI 1M8CA 3B4VC 1TBRR 2KMPA 1HDLA 2LEOA 2OVOA 3QTLD 1CT2I 2ARPF 1PCEA 1R0RI 1M8BA 1SGQI 2SGQI 1H0ZA 2P6AC 1CGII 2WCYA 1CSOI 2KMOA 1KMAA 1NUBA 1UZKA 2NU3I 1UVFA 1BMOA 1PPFI 1SGEI 4SGBI 2KMRA 3HH2C 1OYVI 2JZMA 2NU0I 2F3CI 1CGJI 3SGQI 1Y1CA 1SGPI 2BUSA 2GKTI 2ERWA 2GKVA 1CT4I 1SGYI 1Y1BA 1IW4A 5JHWC 1MT1A 1SGNI 1FYBA 1AN1I 4GI3C 1LR7A 2SGDI 1TBQR 1OVOA 1LR8A 4HGUA 1DS3I 2XRCA 2N52A 1CHOI 1UZJA 1UZQA 2NU1I 1HPTA 1UVGA 2N71A 1DS2I 2KCXA 2SGEI 2JYYA 1KSQA 2KMQA 1BUSA 1YTPA 2GKRI 1TUSA 1YU6C 3SEKC 1N13A
chains in the Genus database with same CATH superfamily
1Z7KB 2UZ3A 1OMTA 3UFFA 2WGCA 1LR9A 2ODDA 1CT0I 2DIPA 3OVOA 2B0UC 1TBNA 5DAEA 2GIVA 1PTQA 2RIJA 5FUVA 1IY6A 2SGPI 1V1HA 1FAQA 3BJIA 2SGFI 2YUUA 3OL0A 2PQ8A 2JA1A 3SGBI 1SGRI 2W86A 3TJQA 1CE3A 1ULNA 5FUWA 1TIHA 2QQCA 1W3SA 1XA6A 1KBEA 2QQDA 5HI7A 2V53A 3CXLA 4DNCA 1APJA 1TURA 2B8TA 2N17A 1Y8FA 2JXDA 1Z2IA 2E73A 7WGAA 2DB6A 1PJUA 2JW6A 2L7XA 1WKXA 2NU4I 3R5DA 1UUCA 3TO9A 4FKDA 2LB7A 1HJAI 4A24A 4JCVE 2M5XA 3FSYA 1IY5A 3QWPA 2NU2I 1R79A 2GVIA 1OMUA 1TGSI 4OVOA 4UXJA 1X4SA 2Y0MA 1SGDI 1UZPA 1M8CA 3B4VC 1TBRR 5E3PA 1K7UA 1P9GA 2KMPA 2ORVA 3UEJA 1V1IA 1HDLA 1XX6A 2N1AB 1RFHA 2LEOA 3UGLA 2OVOA 2J9RA 3QTLD 1CT2I 2ARPF 1PCEA 1TOTA 2ENZA 2X52A 2OU2A 3VDPA 1R0RI 2V1CC 2ELIA 1M8BA 1SGQI 2QQEA 1KBFA 2WVJA 2SGQI 1H0ZA 2P6AC 3UEYA 1CGII 4UXIA 2WCYA 1CSOI 3E59A 5EX0A 5CCLA 4E1PA 2CJSC 2KMOA 1S20A 2UVOA 1NUBA 1KMAA 1UZKA 4WP4A 2ENNA 2NU3I 1UVFA 1BMOA 1PPFI 1SGEI 2DKVA 1ULKA 4SGBI 2KMRA 5FUXA 2ROWA 3HH2C 5EX3A 2QQ0A 1P9ZA 1ULMA 3R5CA 1OYVI 1WGCA 2JZMA 1XBTA 2K9HA 2OD1A 1X74A 2LUYA 1VDDA 2NU0I 4B6DA 1HEVA 1MJ9A 2OZUA 2F3CI 1CGJI 5J8FA 3SGQI 3VDUA 1Y1CA 1SGPI 2BUSA 2GKTI 2E5RA 2V1CA 2ERWA 4E1RA 1MJBA 1PTRA 2GKVA 3GOXA 3UGDA 1CT4I 1SGYI 1Y1BA 1IW4A 2CWGA 1WGTA 4L9MA 5JHWC 1MT1A 3TO7A 9WGAA 2QPOA 1TBOA 5E3RA 3UGIA 3VE5A 1SGNI 1FYBA 3KY9A 3FSXA 4MPIA 1AN1I 4GI3C 1FY7A 2FNFX 5HQ8A 1LR7A 1K7VA 2SGDI 3R5BA 3RU0A 5E3QA 3PDNA 1TBQR 2RC4A 3TOBA 1OVOA 1LR8A 1WTJA 3D00A 4HGUA 1DS3I 3E2IA 5CCMA 2XRCA 2A20A 2N52A 1CHOI 2ORWA 1UHAA 1UZJA 3QAHA 5J8CA 1UZQA 2NU1I 3OXLA 1HPTA 2W0TA 1UVGA 2N71A 1DS2I 3TOAA 1FARA 2VRWB 2KCXA 2SGEI 2X3TA 2CWHA 1NXUA 2JYYA 1W4RA 1KSQA 1Q9BA 2J87A 3TO6A 2KMQA 5FUYA 2YQPA 1K7TA 1BUSA 2L8EA 4AMLA 1YTPA 2GKRI 3FC3A 1TUSA 3OXGA 3OXFA 3UOEA 3MEKA 1YU6C 4UXHA 3SEKC 3R5AA 1N13A 2CWFA 1MJAA 1U5KA
chains in the Genus database with same CATH topology
1Z7KB 2UZ3A 1OMTA 3UFFA 1LR9A 2ODDA 1CT0I 2DIPA 3OVOA 2B0UC 1TBNA 5DAEA 1PTQA 5FUVA 1IY6A 2SGPI 1V1HA 1FAQA 3BJIA 2SGFI 2YUUA 3OL0A 2JA1A 3SGBI 1SGRI 2W86A 3TJQA 1CE3A 5FUWA 1TIHA 2QQCA 1W3SA 1XA6A 1KBEA 2QQDA 5HI7A 2V53A 1APJA 1TURA 2B8TA 2N17A 1Y8FA 2JXDA 2E73A 2DB6A 1PJUA 2JW6A 2L7XA 2NU4I 1UUCA 4FKDA 1HJAI 4A24A 4JCVE 2M5XA 1IY5A 3QWPA 2NU2I 1R79A 2GVIA 1OMUA 1TGSI 4OVOA 4UXJA 1X4SA 1UZPA 1SGDI 1M8CA 3B4VC 1TBRR 3UEJA 2KMPA 2ORVA 1V1IA 1HDLA 1XX6A 2N1AB 1RFHA 2LEOA 3UGLA 2OVOA 2J9RA 3QTLD 1CT2I 2ARPF 1PCEA 1TOTA 2ENZA 3VDPA 1R0RI 2V1CC 2ELIA 1M8BA 1SGQI 2QQEA 1KBFA 2WVJA 2SGQI 1H0ZA 2P6AC 3UEYA 1CGII 4UXIA 2WCYA 1CSOI 3E59A 5EX0A 5CCLA 4E1PA 2CJSC 2KMOA 1KMAA 1NUBA 1UZKA 2ENNA 2NU3I 1UVFA 1BMOA 1PPFI 1SGEI 4SGBI 2KMRA 5FUXA 2ROWA 3HH2C 5EX3A 2QQ0A 1OYVI 2JZMA 1XBTA 2K9HA 2OD1A 1X74A 2LUYA 1VDDA 2NU0I 4B6DA 2F3CI 1CGJI 3SGQI 3VDUA 1Y1CA 1SGPI 2BUSA 2GKTI 2E5RA 2V1CA 2ERWA 4E1RA 2GKVA 1PTRA 3GOXA 3UGDA 1CT4I 1SGYI 1Y1BA 1IW4A 4L9MA 5JHWC 1MT1A 2QPOA 1TBOA 3VE5A 3UGIA 1SGNI 1FYBA 3KY9A 1AN1I 4GI3C 2FNFX 5HQ8A 1LR7A 2SGDI 3RU0A 3PDNA 1TBQR 1OVOA 1LR8A 3D00A 4HGUA 1DS3I 3E2IA 5CCMA 2XRCA 2A20A 2N52A 1CHOI 2ORWA 1UZJA 1UZQA 2NU1I 3OXLA 1HPTA 2W0TA 1UVGA 2N71A 1DS2I 1FARA 2VRWB 2KCXA 2SGEI 2JYYA 1W4RA 1KSQA 2J87A 2KMQA 5FUYA 2YQPA 1BUSA 2L8EA 1YTPA 2GKRI 3FC3A 1TUSA 3OXGA 3OXFA 3MEKA 1YU6C 4UXHA 3SEKC 1N13A 3CXLA 1U5KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z7K B;  1OMT A;  1LR9 A;  1CT0 I;  3OVO A;  2B0U C;  5DAE A;  1IY6 A;  2SGP I;  2SGF I;  3SGB I;  1SGR I;  2W86 A;  3TJQ A;  1CE3 A;  1TIH A;  2QQC A;  2QQD A;  2V53 A;  1APJ A;  1TUR A;  2N17 A;  2JXD A;  1PJU A;  2NU4 I;  1UUC A;  1HJA I;  2M5X A;  1IY5 A;  2NU2 I;  1OMU A;  1TGS I;  4OVO A;  1UZP A;  1SGD I;  1M8C A;  3B4V C;  1TBR R;  2KMP A;  1HDL A;  2LEO A;  2OVO A;  3QTL D;  1CT2 I;  2ARP F;  1PCE A;  1R0R I;  1M8B A;  1SGQ I;  2SGQ I;  1H0Z A;  2P6A C;  1CGI I;  2WCY A;  1CSO I;  2KMO A;  1KMA A;  1NUB A;  1UZK A;  2NU3 I;  1UVF A;  1BMO A;  1PPF I;  1SGE I;  4SGB I;  2KMR A;  3HH2 C;  1OYV I;  2JZM A;  2NU0 I;  2F3C I;  1CGJ I;  3SGQ I;  1Y1C A;  1SGP I;  2BUS A;  2GKT I;  2ERW A;  2GKV A;  1CT4 I;  1SGY I;  1Y1B A;  1IW4 A;  5JHW C;  1MT1 A;  1SGN I;  1FYB A;  1AN1 I;  4GI3 C;  1LR7 A;  2SGD I;  1TBQ R;  1OVO A;  1LR8 A;  4HGU A;  1DS3 I;  2XRC A;  2N52 A;  1CHO I;  1UZJ A;  1UZQ A;  2NU1 I;  1HPT A;  1UVG A;  2N71 A;  1DS2 I;  2KCX A;  2SGE I;  2JYY A;  1KSQ A;  2KMQ A;  1BUS A;  1YTP A;  2GKR I;  1TUS A;  1YU6 C;  3SEK C;  1N13 A; 
#chains in the Genus database with same CATH topology
 1Z7K B;  2UZ3 A;  1OMT A;  3UFF A;  2WGC A;  1LR9 A;  2ODD A;  1CT0 I;  2DIP A;  3OVO A;  2B0U C;  1TBN A;  5DAE A;  2GIV A;  1PTQ A;  2RIJ A;  5FUV A;  1IY6 A;  2SGP I;  1V1H A;  1FAQ A;  3BJI A;  2SGF I;  2YUU A;  3OL0 A;  2PQ8 A;  2JA1 A;  3SGB I;  1SGR I;  2W86 A;  3TJQ A;  1CE3 A;  1ULN A;  5FUW A;  1TIH A;  2QQC A;  1W3S A;  1XA6 A;  1KBE A;  2QQD A;  5HI7 A;  2V53 A;  3CXL A;  4DNC A;  1APJ A;  1TUR A;  2B8T A;  2N17 A;  1Y8F A;  2JXD A;  1Z2I A;  2E73 A;  7WGA A;  2DB6 A;  1PJU A;  2JW6 A;  2L7X A;  1WKX A;  2NU4 I;  3R5D A;  1UUC A;  3TO9 A;  4FKD A;  2LB7 A;  1HJA I;  4A24 A;  4JCV E;  2M5X A;  3FSY A;  1IY5 A;  3QWP A;  2NU2 I;  1R79 A;  2GVI A;  1OMU A;  1TGS I;  4OVO A;  4UXJ A;  1X4S A;  2Y0M A;  1SGD I;  1UZP A;  1M8C A;  3B4V C;  1TBR R;  5E3P A;  1K7U A;  1P9G A;  2KMP A;  2ORV A;  3UEJ A;  1V1I A;  1HDL A;  1XX6 A;  2N1A B;  1RFH A;  2LEO A;  3UGL A;  2OVO A;  2J9R A;  3QTL D;  1CT2 I;  2ARP F;  1PCE A;  1TOT A;  2ENZ A;  2X52 A;  2OU2 A;  3VDP A;  1R0R I;  2V1C C;  2ELI A;  1M8B A;  1SGQ I;  2QQE A;  1KBF A;  2WVJ A;  2SGQ I;  1H0Z A;  2P6A C;  3UEY A;  1CGI I;  4UXI A;  2WCY A;  1CSO I;  3E59 A;  5EX0 A;  5CCL A;  4E1P A;  2CJS C;  2KMO A;  1S20 A;  2UVO A;  1NUB A;  1KMA A;  1UZK A;  4WP4 A;  2ENN A;  2NU3 I;  1UVF A;  1BMO A;  1PPF I;  1SGE I;  2DKV A;  1ULK A;  4SGB I;  2KMR A;  5FUX A;  2ROW A;  3HH2 C;  5EX3 A;  2QQ0 A;  1P9Z A;  1ULM A;  3R5C A;  1OYV I;  1WGC A;  2JZM A;  1XBT A;  2K9H A;  2OD1 A;  1X74 A;  2LUY A;  1VDD A;  2NU0 I;  4B6D A;  1HEV A;  1MJ9 A;  2OZU A;  2F3C I;  1CGJ I;  5J8F A;  3SGQ I;  3VDU A;  1Y1C A;  1SGP I;  2BUS A;  2GKT I;  2E5R A;  2V1C A;  2ERW A;  4E1R A;  1MJB A;  1PTR A;  2GKV A;  3GOX A;  3UGD A;  1CT4 I;  1SGY I;  1Y1B A;  1IW4 A;  2CWG A;  1WGT A;  4L9M A;  5JHW C;  1MT1 A;  3TO7 A;  9WGA A;  2QPO A;  1TBO A;  5E3R A;  3UGI A;  3VE5 A;  1SGN I;  1FYB A;  3KY9 A;  3FSX A;  4MPI A;  1AN1 I;  4GI3 C;  1FY7 A;  2FNF X;  5HQ8 A;  1LR7 A;  1K7V A;  2SGD I;  3R5B A;  3RU0 A;  5E3Q A;  3PDN A;  1TBQ R;  2RC4 A;  3TOB A;  1OVO A;  1LR8 A;  1WTJ A;  3D00 A;  4HGU A;  1DS3 I;  3E2I A;  5CCM A;  2XRC A;  2A20 A;  2N52 A;  1CHO I;  2ORW A;  1UHA A;  1UZJ A;  3QAH A;  5J8C A;  1UZQ A;  2NU1 I;  3OXL A;  1HPT A;  2W0T A;  1UVG A;  2N71 A;  1DS2 I;  3TOA A;  1FAR A;  2VRW B;  2KCX A;  2SGE I;  2X3T A;  2CWH A;  1NXU A;  2JYY A;  1W4R A;  1KSQ A;  1Q9B A;  2J87 A;  3TO6 A;  2KMQ A;  5FUY A;  2YQP A;  1K7T A;  1BUS A;  2L8E A;  4AML A;  1YTP A;  2GKR I;  3FC3 A;  1TUS A;  3OXG A;  3OXF A;  3UOE A;  3MEK A;  1YU6 C;  4UXH A;  3SEK C;  3R5A A;  1N13 A;  2CWF A;  1MJA A;  1U5K A; 
#chains in the Genus database with same CATH homology
 1Z7K B;  2UZ3 A;  1OMT A;  3UFF A;  1LR9 A;  2ODD A;  1CT0 I;  2DIP A;  3OVO A;  2B0U C;  1TBN A;  5DAE A;  1PTQ A;  5FUV A;  1IY6 A;  2SGP I;  1V1H A;  1FAQ A;  3BJI A;  2SGF I;  2YUU A;  3OL0 A;  2JA1 A;  3SGB I;  1SGR I;  2W86 A;  3TJQ A;  1CE3 A;  5FUW A;  1TIH A;  2QQC A;  1W3S A;  1XA6 A;  1KBE A;  2QQD A;  5HI7 A;  2V53 A;  1APJ A;  1TUR A;  2B8T A;  2N17 A;  1Y8F A;  2JXD A;  2E73 A;  2DB6 A;  1PJU A;  2JW6 A;  2L7X A;  2NU4 I;  1UUC A;  4FKD A;  1HJA I;  4A24 A;  4JCV E;  2M5X A;  1IY5 A;  3QWP A;  2NU2 I;  1R79 A;  2GVI A;  1OMU A;  1TGS I;  4OVO A;  4UXJ A;  1X4S A;  1UZP A;  1SGD I;  1M8C A;  3B4V C;  1TBR R;  3UEJ A;  2KMP A;  2ORV A;  1V1I A;  1HDL A;  1XX6 A;  2N1A B;  1RFH A;  2LEO A;  3UGL A;  2OVO A;  2J9R A;  3QTL D;  1CT2 I;  2ARP F;  1PCE A;  1TOT A;  2ENZ A;  3VDP A;  1R0R I;  2V1C C;  2ELI A;  1M8B A;  1SGQ I;  2QQE A;  1KBF A;  2WVJ A;  2SGQ I;  1H0Z A;  2P6A C;  3UEY A;  1CGI I;  4UXI A;  2WCY A;  1CSO I;  3E59 A;  5EX0 A;  5CCL A;  4E1P A;  2CJS C;  2KMO A;  1KMA A;  1NUB A;  1UZK A;  2ENN A;  2NU3 I;  1UVF A;  1BMO A;  1PPF I;  1SGE I;  4SGB I;  2KMR A;  5FUX A;  2ROW A;  3HH2 C;  5EX3 A;  2QQ0 A;  1OYV I;  2JZM A;  1XBT A;  2K9H A;  2OD1 A;  1X74 A;  2LUY A;  1VDD A;  2NU0 I;  4B6D A;  2F3C I;  1CGJ I;  3SGQ I;  3VDU A;  1Y1C A;  1SGP I;  2BUS A;  2GKT I;  2E5R A;  2V1C A;  2ERW A;  4E1R A;  2GKV A;  1PTR A;  3GOX A;  3UGD A;  1CT4 I;  1SGY I;  1Y1B A;  1IW4 A;  4L9M A;  5JHW C;  1MT1 A;  2QPO A;  1TBO A;  3VE5 A;  3UGI A;  1SGN I;  1FYB A;  3KY9 A;  1AN1 I;  4GI3 C;  2FNF X;  5HQ8 A;  1LR7 A;  2SGD I;  3RU0 A;  3PDN A;  1TBQ R;  1OVO A;  1LR8 A;  3D00 A;  4HGU A;  1DS3 I;  3E2I A;  5CCM A;  2XRC A;  2A20 A;  2N52 A;  1CHO I;  2ORW A;  1UZJ A;  1UZQ A;  2NU1 I;  3OXL A;  1HPT A;  2W0T A;  1UVG A;  2N71 A;  1DS2 I;  1FAR A;  2VRW B;  2KCX A;  2SGE I;  2JYY A;  1W4R A;  1KSQ A;  2J87 A;  2KMQ A;  5FUY A;  2YQP A;  1BUS A;  2L8E A;  1YTP A;  2GKR I;  3FC3 A;  1TUS A;  3OXG A;  3OXF A;  3MEK A;  1YU6 C;  4UXH A;  3SEK C;  1N13 A;  3CXL A;  1U5K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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