5JVHS

The crystal structure large ribosomal subunit (50s) of deinococcus radiodurans in complex with evernimicin
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
179
structure length
179
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPRLTAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 19
structure length 179
sequence length 179
ec nomenclature
pdb deposition date 2016-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 5jvhS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 5jvhS02
5JVGS 4P2BA 3PIOS 2RD2A 3AIIA 4WFNS 5JVHS 4IOCS 4UY88 5DM7S 3DLLS 1O0BA 1EUYA 1QTQA 3PIPS 4WFAS 2RE8A 1B75A 5GAHW 4IO9S 4WF9S 1EUQA 1GTSA 2HZ7A 1QRUA 1FEUA 4IOAS 5IZNA 1EXDA 1GTRA 3CF5S 2ZJPS 1QRSA 5BNZA 1DFUP 2ZJQS 5GAEW 4WCES 4JXXA 5HL7S 1O0CA 5GAGW 3J7ZV 5DM6S 4JYZA 4JXZA 1D6KA 4H3SA 2ZJRS 1ZJWA 4U67S 1NYLA 1QRTA 4WFBS 5GADW
chains in the Genus database with same CATH superfamily
2WB1D 2B63C 2G6GA 1BDFA 3HOWC 2EGVA 4IOCS 4UY88 1NYLA 4G7ZA 5DM7S 2E2HC 4A3LC 3WODA 3S1RC 1Z85A 5IP9C 4OINA 2A6HA 3GTGC 1VHYA 4GZYA 2PNWA 4ZH4A 4A3MC 4A3EC 5TMFA 3GTQC 3W2WB 4OIQA 3S2HC 2PICA 3CF5S 3GTPC 4YG2A 4E8BA 2E2IC 3S1MC 3KW2A 4WCES 2KQ1A 3M3YC 5GAGW 4A93C 5C4XC 3GTMC 4BBSC 2YU9C 2R93C 1NXZA 3DXJA 3K7AC 1TWGC 4YFNA 1UDXA 1ZJWA 3S17C 4QIWD 1IW7A 4BXXC 4H4KA 4WFBS 4P2BA 2RD2A 2R92C 3LYWA 1YNNA 3DLLS 1O0BA 1QTQA 2WAQD 3H0GC 4A3JC 3GTOC 4WFAS 1TWHC 2BE5A 2R7ZC 3PO2C 2O5JA 2JA6C 2NVYC 4A3IC 4A3KC 4MQ9A 5C3EC 1QRUA 2KPUA 1FEUA 2Y0SD 5IZNA 2NWAA 1EXDA 3GTKC 1TWAC 2NVQC 3I4MC 1I3QC 3M4OC 3HOZC 3I4NC 4G7OA 4C3IC 4LJZA 5DM6S 4QJVA 2CW0A 3PO3C 1D6KA 2ZJRS 2VUMC 4XLPA 4Y52C 3S16C 2L3UA 4NOIA 5GADW 3S1NC 4BBRC 3PIOS 2PI8A 5IYBC 3AIIA 4KMUA 1Y1WC 4LLGA 5JVHS 4V194 4KN7A 1Y1VC 1EUYA 3HOVC 3PIPS 2RE8A 4A3BC 2G5DA 2A68A 1B75A 4XLNA 5TMCA 4A3DC 1EUQA 4C3HC 1YNJA 4A3GC 3RZOC 2HZ7A 2GAEA 3X1LB 3EQLA 4IOAS 3CZBA 1GTRA 2NVXC 2ZJPS 3RZDC 3S2DC 4AYBD 2PJJA 4YFXA 1TWFC 2ZJQS 4JXXA 1ZYRA 1SFOC 2KXYA 1O0CA 4XSZA 4JXZA 4JYZA 3FKIC 3HKZD 2JA5C 4OIRA 5D4DA 1I6VA 4H3SA 1VHKA 1SMYA 3CQZC 5FLMC 4U67S 4OIOA 2PA8D 4X6AC 2EGWA 1QRTA 1HQMA 4LK0A 3HOXC 3GTLC 4BY7C 2O5IA 4WFNS 4JK1A 1WCMC 4C2MC 5C4JC 4KN4A 4OIPA 4Y7NC 2NVTC 5GAHW 4IO9S 4WF9S 4LK1A 4XSXA 1I6HC 1R9TC 2PPBA 2A69A 5IP7C 2CX8A 4G7HA 1GTSA 2JA8C 2E2JC 2PMZD 3W2VB 4YFKA 2L5NA 4MEXA 3S14C 2A6EA 1QRSA 3GTJC 4Q5SA 5BNZA 1TWCC 1DFUP 2JA7C 5GAEW 1I50C 5HQHA 5HL7S 4BY1C 2AE0X 4C3JC 3J7ZV 1V6ZA 5C44C 2Z0YA 4L69A 3S1QC 1K83C 3HOYC 4MEYA 5IYDC 3HOUC 3S15C 5IYCC 4A3FC 4A3CC 3H3VD 4J3CA 5JVGS 4Q4ZA
chains in the Genus database with same CATH topology
5JVGS 4P2BA 3PIOS 2RD2A 3AIIA 4WFNS 5JVHS 4IOCS 4UY88 4V194 5DM7S 3DLLS 1O0BA 1EUYA 1QTQA 3PIPS 4WFAS 2RE8A 1B75A 5GAHW 4IO9S 4WF9S 1EUQA 1GTSA 2HZ7A 3W2WB 1QRUA 3X1LB 1FEUA 4IOAS 5IZNA 3W2VB 1EXDA 1GTRA 3CF5S 2ZJPS 1QRSA 5BNZA 1DFUP 2ZJQS 5GAEW 4WCES 4JXXA 5HL7S 1O0CA 5GAGW 3J7ZV 5DM6S 4JYZA 4JXZA 1D6KA 1UDXA 4H3SA 2ZJRS 1ZJWA 4U67S 4H4KA 1NYLA 1QRTA 4WFBS 5GADW
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JVG S;  4P2B A;  3PIO S;  2RD2 A;  3AII A;  4WFN S;  5JVH S;  4IOC S;  4UY8 8;  5DM7 S;  3DLL S;  1O0B A;  1EUY A;  1QTQ A;  3PIP S;  4WFA S;  2RE8 A;  1B75 A;  5GAH W;  4IO9 S;  4WF9 S;  1EUQ A;  1GTS A;  2HZ7 A;  1QRU A;  1FEU A;  4IOA S;  5IZN A;  1EXD A;  1GTR A;  3CF5 S;  2ZJP S;  1QRS A;  5BNZ A;  1DFU P;  2ZJQ S;  5GAE W;  4WCE S;  4JXX A;  5HL7 S;  1O0C A;  5GAG W;  3J7Z V;  5DM6 S;  4JYZ A;  4JXZ A;  1D6K A;  4H3S A;  2ZJR S;  1ZJW A;  4U67 S;  1NYL A;  1QRT A;  4WFB S;  5GAD W; 
#chains in the Genus database with same CATH topology
 2WB1 D;  2B63 C;  2G6G A;  1BDF A;  3HOW C;  2EGV A;  4IOC S;  4UY8 8;  1NYL A;  4G7Z A;  5DM7 S;  2E2H C;  4A3L C;  3WOD A;  3S1R C;  1Z85 A;  5IP9 C;  4OIN A;  2A6H A;  3GTG C;  1VHY A;  4GZY A;  2PNW A;  4ZH4 A;  4A3M C;  4A3E C;  5TMF A;  3GTQ C;  3W2W B;  4OIQ A;  3S2H C;  2PIC A;  3CF5 S;  3GTP C;  4YG2 A;  4E8B A;  2E2I C;  3S1M C;  3KW2 A;  4WCE S;  2KQ1 A;  3M3Y C;  5GAG W;  4A93 C;  5C4X C;  3GTM C;  4BBS C;  2YU9 C;  2R93 C;  1NXZ A;  3DXJ A;  3K7A C;  1TWG C;  4YFN A;  1UDX A;  1ZJW A;  3S17 C;  4QIW D;  1IW7 A;  4BXX C;  4H4K A;  4WFB S;  4P2B A;  2RD2 A;  2R92 C;  3LYW A;  1YNN A;  3DLL S;  1O0B A;  1QTQ A;  2WAQ D;  3H0G C;  4A3J C;  3GTO C;  4WFA S;  1TWH C;  2BE5 A;  2R7Z C;  3PO2 C;  2O5J A;  2JA6 C;  2NVY C;  4A3I C;  4A3K C;  4MQ9 A;  5C3E C;  1QRU A;  2KPU A;  1FEU A;  2Y0S D;  5IZN A;  2NWA A;  1EXD A;  3GTK C;  1TWA C;  2NVQ C;  3I4M C;  1I3Q C;  3M4O C;  3HOZ C;  3I4N C;  4G7O A;  4C3I C;  4LJZ A;  5DM6 S;  4QJV A;  2CW0 A;  3PO3 C;  1D6K A;  2ZJR S;  2VUM C;  4XLP A;  4Y52 C;  3S16 C;  2L3U A;  4NOI A;  5GAD W;  3S1N C;  4BBR C;  3PIO S;  2PI8 A;  5IYB C;  3AII A;  4KMU A;  1Y1W C;  4LLG A;  5JVH S;  4V19 4;  4KN7 A;  1Y1V C;  1EUY A;  3HOV C;  3PIP S;  2RE8 A;  4A3B C;  2G5D A;  2A68 A;  1B75 A;  4XLN A;  5TMC A;  4A3D C;  1EUQ A;  4C3H C;  1YNJ A;  4A3G C;  3RZO C;  2HZ7 A;  2GAE A;  3X1L B;  3EQL A;  4IOA S;  3CZB A;  1GTR A;  2NVX C;  2ZJP S;  3RZD C;  3S2D C;  4AYB D;  2PJJ A;  4YFX A;  1TWF C;  2ZJQ S;  4JXX A;  1ZYR A;  1SFO C;  2KXY A;  1O0C A;  4XSZ A;  4JXZ A;  4JYZ A;  3FKI C;  3HKZ D;  2JA5 C;  4OIR A;  5D4D A;  1I6V A;  4H3S A;  1VHK A;  1SMY A;  3CQZ C;  5FLM C;  4U67 S;  4OIO A;  2PA8 D;  4X6A C;  2EGW A;  1QRT A;  1HQM A;  4LK0 A;  3HOX C;  3GTL C;  4BY7 C;  2O5I A;  4WFN S;  4JK1 A;  1WCM C;  4C2M C;  5C4J C;  4KN4 A;  4OIP A;  4Y7N C;  2NVT C;  5GAH W;  4IO9 S;  4WF9 S;  4LK1 A;  4XSX A;  1I6H C;  1R9T C;  2PPB A;  2A69 A;  5IP7 C;  2CX8 A;  4G7H A;  1GTS A;  2JA8 C;  2E2J C;  2PMZ D;  3W2V B;  4YFK A;  2L5N A;  4MEX A;  3S14 C;  2A6E A;  1QRS A;  3GTJ C;  4Q5S A;  5BNZ A;  1TWC C;  1DFU P;  2JA7 C;  5GAE W;  1I50 C;  5HQH A;  5HL7 S;  4BY1 C;  2AE0 X;  4C3J C;  3J7Z V;  1V6Z A;  5C44 C;  2Z0Y A;  4L69 A;  3S1Q C;  1K83 C;  3HOY C;  4MEY A;  5IYD C;  3HOU C;  3S15 C;  5IYC C;  4A3F C;  4A3C C;  3H3V D;  4J3C A;  5JVG S;  4Q4Z A; 
#chains in the Genus database with same CATH homology
 5JVG S;  4P2B A;  3PIO S;  2RD2 A;  3AII A;  4WFN S;  5JVH S;  4IOC S;  4UY8 8;  4V19 4;  5DM7 S;  3DLL S;  1O0B A;  1EUY A;  1QTQ A;  3PIP S;  4WFA S;  2RE8 A;  1B75 A;  5GAH W;  4IO9 S;  4WF9 S;  1EUQ A;  1GTS A;  2HZ7 A;  3W2W B;  1QRU A;  3X1L B;  1FEU A;  4IOA S;  5IZN A;  3W2V B;  1EXD A;  1GTR A;  3CF5 S;  2ZJP S;  1QRS A;  5BNZ A;  1DFU P;  2ZJQ S;  5GAE W;  4WCE S;  4JXX A;  5HL7 S;  1O0C A;  5GAG W;  3J7Z V;  5DM6 S;  4JYZ A;  4JXZ A;  1D6K A;  1UDX A;  4H3S A;  2ZJR S;  1ZJW A;  4U67 S;  4H4K A;  1NYL A;  1QRT A;  4WFB S;  5GAD W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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