5KP8B

Crystal structure of the curacin biosynthetic pathway hmg synthase in complex with acetyl donor-acp
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
78
structure length
78
Chain Sequence
MSKEQVLKIIKKYTREIAPELEDSPLEPTDSLKKLGIDSVNRAEIIMMVMEDLSLNIPRIELAGAKNIGELADLFAAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
pubmed doi rcsb
molecule tags Transferase
source organism Moorea producens 3l
molecule keywords CurD
total genus 26
structure length 78
sequence length 78
ec nomenclature
pdb deposition date 2016-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00550 PP-binding Phosphopantetheine attachment site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A ACP-like 5kp8B00
4H2YC 4MRTC 5KP6B 4IZ6A 2N5HA 2KOPA 2QNWA 2CQ8A 1OR5A 2FVAA 2JU1A 1AF8A 2LL8A 2LTEA 1KLPA 2FQ1A 2FAEA 4BPGA 2LOLA 2CNRA 2N98A 2JU2A 2KG9A 2LKIA 2K92A 2MVUA 2LMLA 2KOQA 4NEOA 2EHSA 2ROQA 2FVFA 2L9FA 2JGPA 2LIUA 2MD9A 2K93A 3EJBA 2KGEA 2KORA 4HKGA 3CE7A 2EHTA 2AF8A 2KG6A 2KGCA 1L0HA 2FACA 2DNWA 4PXHB 2N6ZA 5EJDA 2KG8A 1HQBA 2VSQA 2FADA 2KW2A 3LMOA 5KP8B 5KP7B 2M5RA 2N50A 4R0MA 2KOSA 2KWLA 1DV5A 2MVVA 1X3OA 2KOOA 2AVAA 2X2BA 3GZMA 2K2QA 3EJDA 5HV8A 2N5IA 2KGDA 2XZ0D 2AFDA 1HY8A 2CGQA 2L22A 2FQ2A 2N6YA 2K0XA 2K94A 4BPFA 5HVCA 2LIWA 2GDWA 3EJEA 1T8KA 2MY5A 1NQ4A 1VKUA 2XZ1C 2FHSC 3RG2A 4CA3A 2GDYA 4PWVB 2LPKA 2KR5A 4H2XC 2MR7A 1ACPA 5CZDB 2K0YA 2FQ0A 1F80D 2KGAA 4BPHA 4DG9A 2AFEA 3NY7B 4H2WC 2FVEA 2PNGA 2GDXA 2L4BA 2L0QA 1L0IA 1DNYA 3GZLA 2CG5B 2JQ4A 2MF4A 2MR8A
chains in the Genus database with same CATH superfamily
4MRTC 1K9MQ 2LF4A 1N8RQ 3CCRP 2DGYA 2N5HA 2EFJA 1OR5A 2FVAA 3H0DA 1Q82Q 7CEIA 2BHVA 1AF8A 1KLPA 2LTEA 2FQ1A 2JB0A 2LOLA 1E0HA 3VRLC 2PEJA 2CWOA 3CCSP 2LMLA 4NEOA 4WYMA 2FVFA 1IUQA 1GPJA 2MD9A 3EJBA 1A8OA 5HGNA 1RNIA 2Z45A 4QNBA 1QVFO 2M8NA 2PEIA 2DNWA 1M6EX 1YIJP 5KP8B 2M5RA 3WBHA 3G71P 2GZIA 2KWLA 2MVVA 1X3OA 3P05A 2GZGA 3DTJA 2K2QA 2QEXP 3M1MA 2E1MA 2K0DX 2KGDA 1HY8A 2L22A 3B4QA 2GDWA 3EJEA 5BS2A 4COCA 1NQ4A 3RG2A 4CA3A 1S72P 2LPKA 2PY8A 4GR2A 1VQNP 1BAJA 2KR5A 1VQ7P 3HYBA 2GZEA 3H47A 1QVGO 3CC2P 3MGEA 1KD1Q 2KGAA 4BPHA 4DG9A 4GR6A 2PEKA 2AFEA 4PH0A 2GDXA 2L4BA 3E2DA 2L0QA 4U0BA 1A43A 2P9XA 1FR2A 3NTEA 2FQ0A 4XFXA 1W2BO 3DS2A 4IZ6A 2KOPA 2CQ8A 1YJNP 1QRJA 1KC8Q 2JU1A 2M8PA 3CC4P 3DS0A 2CNRA 2ERHA 3DPHA 1VHNA 2N98A 2KG9A 2LKIA 3G4SP 2JGPA 1KQSO 3DS1A 4U0FA 2PEOA 3HZQA 2KORA 3I55P 2AF8A 1VQKP 3G28A 2KGCA 1NJIQ 5EJDA 2KW2A 1K30A 1Z6MA 5KP7B 5HGOA 2Z46A 3G21A 1VQLP 1YHQP 2K5XA 4U0AA 1ZNVA 2JO0A 2N5IA 3GJNA 2CGQA 2N6YA 3CD6P 3CCUP 4IPYA 1E6JP 2VLNA 5JPAA 2JYGA 1K8AQ 2NO8A 4PH1A 4H2XC 5BS1A 3G1GA 1MZ8A 2MR7A 2QA4P 1GXGA 3DS4A 1CEIA 1D1DA 2XT1A 2Z44A 4QKOA 2JAZA 2K0YA 1VQ6P 1F80D 3NY7B 2GZJA 2FVEA 2PNGA 4XFZA 5F2OA 4F37A 1L0IA 3GZLA 1UNKA 4U0DA 2MF4A 2MR8A 1Q81Q 1Q7YQ 1VQ5P 4XFYA 1ZMBA 2ONTA 2LL8A 4BPGA 5F2KA 3G6EP 3CCQP 2MVUA 3G0VA 2L9FA 2LIUA 4M0IA 2K93A 5HGMA 2XXMA 3CPWO 4HKGA 3CE7A 2EHTA 5I4TG 2XV6A 1VQMP 2KG6A 1BXIA 2FACA 1HQBA 3Q20A 3B5IA 3RG6C 2N50A 2KOSA 1RO2A 2KOOA 2L6EA 2AVAA 3GKLC 3H4EA 3LRYA 2EIAA 2XZ0D 2AFDA 1YJWP 3I56P 2PEMA 1VQOP 2K94A 4BPFA 5HVCA 2LIWA 1M90Q 3CXCO 2MY5A 1UJZA 2XZ1C 2FHSC 2GDYA 4PWVB 3G29A 1YITP 5F2NA 2VLOA 2JYLA 4U0CA 3CCLP 1ACPA 5CZDB 2KODA 1EOQA 1GXHA 2VLPA 3G1IA 1M74A 3CCVP 1DNYA 3CMEP 1VQ4P 2M8LA 4H2YC 5KP6B 4XRQA 2QNWA 3CCEP 1VQ8P 1M6NA 2OARA 2GYKA 2WPTA 2FAEA 1AUMA 2EG5A 1AYIA 1EMVA 2JU2A 2K92A 2KOQA 2EHSA 2ROQA 2KGEA 1VQPP 1RO0A 1JJ2O 3CCMP 2OTLP 1L0HA 3OW2O 1IMQA 4UHPB 4PXHB 2N6ZA 2KG8A 2VLQA 2VSQA 2FADA 3LMOA 4R0MA 1DV5A 1VQ9P 2BUOA 3DS5A 1IMPA 3G26A 4U0EA 3CCJP 2X2BA 3DS3A 1Q86Q 3GZMA 3EJDA 5HV8A 2FQ2A 4COPA 2K0XA 1YI2P 1T8KA 2GZFA 1VKUA 2OTJP 3U43A 5EW5E 2PENA 5HGLA 1YJ9P 2PEQA 3CC7P 3CMAP 2JBGA 4H2WC 1M1KQ 4XROA 5DCKA 1EIAA 1K73Q 2CG5B 2JQ4A
chains in the Genus database with same CATH topology
4H2YC 4MRTC 5KP6B 4IZ6A 2N5HA 2KOPA 2QNWA 2CQ8A 1OR5A 2FVAA 2JU1A 1AF8A 2LL8A 2LTEA 1KLPA 2FQ1A 2FAEA 4BPGA 2LOLA 2CNRA 2N98A 2JU2A 2KG9A 2LKIA 2K92A 2MVUA 2LMLA 2KOQA 4NEOA 2EHSA 2ROQA 2FVFA 2L9FA 2JGPA 2LIUA 2MD9A 2K93A 3EJBA 2KGEA 2KORA 4HKGA 3CE7A 2EHTA 2AF8A 2KG6A 2KGCA 1L0HA 2FACA 2DNWA 4PXHB 2N6ZA 5EJDA 2KG8A 1HQBA 2VSQA 2FADA 2KW2A 3LMOA 5KP8B 5KP7B 2M5RA 2N50A 4R0MA 2KOSA 2KWLA 1DV5A 2MVVA 1X3OA 2KOOA 2AVAA 2X2BA 3GZMA 2K2QA 3EJDA 5HV8A 2N5IA 2KGDA 2XZ0D 2AFDA 1HY8A 2CGQA 2L22A 2FQ2A 2N6YA 2K0XA 2K94A 4BPFA 5HVCA 2LIWA 2GDWA 3EJEA 1T8KA 2MY5A 1NQ4A 1VKUA 2XZ1C 2FHSC 3RG2A 4CA3A 2GDYA 4PWVB 2LPKA 2KR5A 4H2XC 2MR7A 1ACPA 5CZDB 2K0YA 2FQ0A 1F80D 2KGAA 4BPHA 4DG9A 2AFEA 3NY7B 4H2WC 2FVEA 2PNGA 2GDXA 2L4BA 2L0QA 1L0IA 1DNYA 3GZLA 2CG5B 2JQ4A 2MF4A 2MR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H2Y C;  4MRT C;  5KP6 B;  4IZ6 A;  2N5H A;  2KOP A;  2QNW A;  2CQ8 A;  1OR5 A;  2FVA A;  2JU1 A;  1AF8 A;  2LL8 A;  2LTE A;  1KLP A;  2FQ1 A;  2FAE A;  4BPG A;  2LOL A;  2CNR A;  2N98 A;  2JU2 A;  2KG9 A;  2LKI A;  2K92 A;  2MVU A;  2LML A;  2KOQ A;  4NEO A;  2EHS A;  2ROQ A;  2FVF A;  2L9F A;  2JGP A;  2LIU A;  2MD9 A;  2K93 A;  3EJB A;  2KGE A;  2KOR A;  4HKG A;  3CE7 A;  2EHT A;  2AF8 A;  2KG6 A;  2KGC A;  1L0H A;  2FAC A;  2DNW A;  4PXH B;  2N6Z A;  5EJD A;  2KG8 A;  1HQB A;  2VSQ A;  2FAD A;  2KW2 A;  3LMO A;  5KP8 B;  5KP7 B;  2M5R A;  2N50 A;  4R0M A;  2KOS A;  2KWL A;  1DV5 A;  2MVV A;  1X3O A;  2KOO A;  2AVA A;  2X2B A;  3GZM A;  2K2Q A;  3EJD A;  5HV8 A;  2N5I A;  2KGD A;  2XZ0 D;  2AFD A;  1HY8 A;  2CGQ A;  2L22 A;  2FQ2 A;  2N6Y A;  2K0X A;  2K94 A;  4BPF A;  5HVC A;  2LIW A;  2GDW A;  3EJE A;  1T8K A;  2MY5 A;  1NQ4 A;  1VKU A;  2XZ1 C;  2FHS C;  3RG2 A;  4CA3 A;  2GDY A;  4PWV B;  2LPK A;  2KR5 A;  4H2X C;  2MR7 A;  1ACP A;  5CZD B;  2K0Y A;  2FQ0 A;  1F80 D;  2KGA A;  4BPH A;  4DG9 A;  2AFE A;  3NY7 B;  4H2W C;  2FVE A;  2PNG A;  2GDX A;  2L4B A;  2L0Q A;  1L0I A;  1DNY A;  3GZL A;  2CG5 B;  2JQ4 A;  2MF4 A;  2MR8 A; 
#chains in the Genus database with same CATH topology
 4MRT C;  1K9M Q;  2LF4 A;  1N8R Q;  3CCR P;  2DGY A;  2N5H A;  2EFJ A;  1OR5 A;  2FVA A;  3H0D A;  1Q82 Q;  7CEI A;  2BHV A;  1AF8 A;  1KLP A;  2LTE A;  2FQ1 A;  2JB0 A;  2LOL A;  1E0H A;  3VRL C;  2PEJ A;  2CWO A;  3CCS P;  2LML A;  4NEO A;  4WYM A;  2FVF A;  1IUQ A;  1GPJ A;  2MD9 A;  3EJB A;  1A8O A;  5HGN A;  1RNI A;  2Z45 A;  4QNB A;  1QVF O;  2M8N A;  2PEI A;  2DNW A;  1M6E X;  1YIJ P;  5KP8 B;  2M5R A;  3WBH A;  3G71 P;  2GZI A;  2KWL A;  2MVV A;  1X3O A;  3P05 A;  2GZG A;  3DTJ A;  2K2Q A;  2QEX P;  3M1M A;  2E1M A;  2K0D X;  2KGD A;  1HY8 A;  2L22 A;  3B4Q A;  2GDW A;  3EJE A;  5BS2 A;  4COC A;  1NQ4 A;  3RG2 A;  4CA3 A;  1S72 P;  2LPK A;  2PY8 A;  4GR2 A;  1VQN P;  1BAJ A;  2KR5 A;  1VQ7 P;  3HYB A;  2GZE A;  3H47 A;  1QVG O;  3CC2 P;  3MGE A;  1KD1 Q;  2KGA A;  4BPH A;  4DG9 A;  4GR6 A;  2PEK A;  2AFE A;  4PH0 A;  2GDX A;  2L4B A;  3E2D A;  2L0Q A;  4U0B A;  1A43 A;  2P9X A;  1FR2 A;  3NTE A;  2FQ0 A;  4XFX A;  1W2B O;  3DS2 A;  4IZ6 A;  2KOP A;  2CQ8 A;  1YJN P;  1QRJ A;  1KC8 Q;  2JU1 A;  2M8P A;  3CC4 P;  3DS0 A;  2CNR A;  2ERH A;  3DPH A;  1VHN A;  2N98 A;  2KG9 A;  2LKI A;  3G4S P;  2JGP A;  1KQS O;  3DS1 A;  4U0F A;  2PEO A;  3HZQ A;  2KOR A;  3I55 P;  2AF8 A;  1VQK P;  3G28 A;  2KGC A;  1NJI Q;  5EJD A;  2KW2 A;  1K30 A;  1Z6M A;  5KP7 B;  5HGO A;  2Z46 A;  3G21 A;  1VQL P;  1YHQ P;  2K5X A;  4U0A A;  1ZNV A;  2JO0 A;  2N5I A;  3GJN A;  2CGQ A;  2N6Y A;  3CD6 P;  3CCU P;  4IPY A;  1E6J P;  2VLN A;  5JPA A;  2JYG A;  1K8A Q;  2NO8 A;  4PH1 A;  4H2X C;  5BS1 A;  3G1G A;  1MZ8 A;  2MR7 A;  2QA4 P;  1GXG A;  3DS4 A;  1CEI A;  1D1D A;  2XT1 A;  2Z44 A;  4QKO A;  2JAZ A;  2K0Y A;  1VQ6 P;  1F80 D;  3NY7 B;  2GZJ A;  2FVE A;  2PNG A;  4XFZ A;  5F2O A;  4F37 A;  1L0I A;  3GZL A;  1UNK A;  4U0D A;  2MF4 A;  2MR8 A;  1Q81 Q;  1Q7Y Q;  1VQ5 P;  4XFY A;  1ZMB A;  2ONT A;  2LL8 A;  4BPG A;  5F2K A;  3G6E P;  3CCQ P;  2MVU A;  3G0V A;  2L9F A;  2LIU A;  4M0I A;  2K93 A;  5HGM A;  2XXM A;  3CPW O;  4HKG A;  3CE7 A;  2EHT A;  5I4T G;  2XV6 A;  1VQM P;  2KG6 A;  1BXI A;  2FAC A;  1HQB A;  3Q20 A;  3B5I A;  3RG6 C;  2N50 A;  2KOS A;  1RO2 A;  2KOO A;  2L6E A;  2AVA A;  3GKL C;  3H4E A;  3LRY A;  2EIA A;  2XZ0 D;  2AFD A;  1YJW P;  3I56 P;  2PEM A;  1VQO P;  2K94 A;  4BPF A;  5HVC A;  2LIW A;  1M90 Q;  3CXC O;  2MY5 A;  1UJZ A;  2XZ1 C;  2FHS C;  2GDY A;  4PWV B;  3G29 A;  1YIT P;  5F2N A;  2VLO A;  2JYL A;  4U0C A;  3CCL P;  1ACP A;  5CZD B;  2KOD A;  1EOQ A;  1GXH A;  2VLP A;  3G1I A;  1M74 A;  3CCV P;  1DNY A;  3CME P;  1VQ4 P;  2M8L A;  4H2Y C;  5KP6 B;  4XRQ A;  2QNW A;  3CCE P;  1VQ8 P;  1M6N A;  2OAR A;  2GYK A;  2WPT A;  2FAE A;  1AUM A;  2EG5 A;  1AYI A;  1EMV A;  2JU2 A;  2K92 A;  2KOQ A;  2EHS A;  2ROQ A;  2KGE A;  1VQP P;  1RO0 A;  1JJ2 O;  3CCM P;  2OTL P;  1L0H A;  3OW2 O;  1IMQ A;  4UHP B;  4PXH B;  2N6Z A;  2KG8 A;  2VLQ A;  2VSQ A;  2FAD A;  3LMO A;  4R0M A;  1DV5 A;  1VQ9 P;  2BUO A;  3DS5 A;  1IMP A;  3G26 A;  4U0E A;  3CCJ P;  2X2B A;  3DS3 A;  1Q86 Q;  3GZM A;  3EJD A;  5HV8 A;  2FQ2 A;  4COP A;  2K0X A;  1YI2 P;  1T8K A;  2GZF A;  1VKU A;  2OTJ P;  3U43 A;  5EW5 E;  2PEN A;  5HGL A;  1YJ9 P;  2PEQ A;  3CC7 P;  3CMA P;  2JBG A;  4H2W C;  1M1K Q;  4XRO A;  5DCK A;  1EIA A;  1K73 Q;  2CG5 B;  2JQ4 A; 
#chains in the Genus database with same CATH homology
 4H2Y C;  4MRT C;  5KP6 B;  4IZ6 A;  2N5H A;  2KOP A;  2QNW A;  2CQ8 A;  1OR5 A;  2FVA A;  2JU1 A;  1AF8 A;  2LL8 A;  2LTE A;  1KLP A;  2FQ1 A;  2FAE A;  4BPG A;  2LOL A;  2CNR A;  2N98 A;  2JU2 A;  2KG9 A;  2LKI A;  2K92 A;  2MVU A;  2LML A;  2KOQ A;  4NEO A;  2EHS A;  2ROQ A;  2FVF A;  2L9F A;  2JGP A;  2LIU A;  2MD9 A;  2K93 A;  3EJB A;  2KGE A;  2KOR A;  4HKG A;  3CE7 A;  2EHT A;  2AF8 A;  2KG6 A;  2KGC A;  1L0H A;  2FAC A;  2DNW A;  4PXH B;  2N6Z A;  5EJD A;  2KG8 A;  1HQB A;  2VSQ A;  2FAD A;  2KW2 A;  3LMO A;  5KP8 B;  5KP7 B;  2M5R A;  2N50 A;  4R0M A;  2KOS A;  2KWL A;  1DV5 A;  2MVV A;  1X3O A;  2KOO A;  2AVA A;  2X2B A;  3GZM A;  2K2Q A;  3EJD A;  5HV8 A;  2N5I A;  2KGD A;  2XZ0 D;  2AFD A;  1HY8 A;  2CGQ A;  2L22 A;  2FQ2 A;  2N6Y A;  2K0X A;  2K94 A;  4BPF A;  5HVC A;  2LIW A;  2GDW A;  3EJE A;  1T8K A;  2MY5 A;  1NQ4 A;  1VKU A;  2XZ1 C;  2FHS C;  3RG2 A;  4CA3 A;  2GDY A;  4PWV B;  2LPK A;  2KR5 A;  4H2X C;  2MR7 A;  1ACP A;  5CZD B;  2K0Y A;  2FQ0 A;  1F80 D;  2KGA A;  4BPH A;  4DG9 A;  2AFE A;  3NY7 B;  4H2W C;  2FVE A;  2PNG A;  2GDX A;  2L4B A;  2L0Q A;  1L0I A;  1DNY A;  3GZL A;  2CG5 B;  2JQ4 A;  2MF4 A;  2MR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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