5VFRf

Nucleotide-driven triple-state remodeling of the aaa-atpase channel in the activated human 26s proteasome
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
sequence length
799
structure length
689
Chain Sequence
RDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYNKRFAADIISVLAMTMSGERECLKYRLVGAGEVAKEWQELDDAEKVQREPLLTLVKEIVPLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSHDADPEVSYNSIFAARLAAMLRQLAQYHAKKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords 26S proteasome non-ATPase regulatory subunit 1
total genus 167
structure length 689
sequence length 799
ec nomenclature
pdb deposition date 2017-04-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
f PF01851 PC_rep Proteasome/cyclosome repeat
f PF17781 RPN1_RPN2_N RPN1/RPN2 N-terminal domain
f PF18051 RPN1_C 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Image from the rcsb pdb (www.rcsb.org)
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