6E3SB

Crystal structure of the heterodimeric hif-2 complex with antagonist pt2385
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
333
structure length
290
Chain Sequence
SKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVALETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription/transcription inhibitor
molecule keywords Aryl hydrocarbon receptor nuclear translocator
publication title Bidirectional modulation of HIF-2 activity through chemical ligands.
pubmed doi rcsb
source organism Mus musculus
total genus 76
structure length 290
sequence length 333
ec nomenclature
pdb deposition date 2018-07-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00989 PAS PAS fold
B PF08447 PAS_3 PAS fold
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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