6G1XA

Cryoem structure of the mda5-dsrna filament with 91-degree helical twist
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
696
structure length
648
Chain Sequence
LQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLRNNDLKKAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADNPFKEKLLEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNLDETDEFLMNLFFDNKKMLKKLAENPEKLIKLRNTILEQFTRSSSRGIIFTKTRQSTYALSQWIMENAVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTINLLIATTVAGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFPKKQYKKWVELPIRFPDLDYSEYCL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords Interferon-induced helicase C domain-containing protein 1
publication title Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
pubmed doi rcsb
source organism Mus musculus
total genus 155
structure length 648
sequence length 696
ec nomenclature ec 3.6.4.13: RNA helicase.
pdb deposition date 2018-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00271 Helicase_C Helicase conserved C-terminal domain
A PF11648 RIG-I_C-RD C-terminal domain of RIG-I
A PF18119 RIG-I_C RIG-I receptor C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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