6HN4E

Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
294
structure length
202
Chain Sequence
PSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords Insulin receptor,Insulin receptor,General control protein GC
publication title The signalling conformation of the insulin receptor ectodomain.
pubmed doi rcsb
source organism Homo sapiens
total genus 30
structure length 202
sequence length 294
chains with identical sequence F
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2018-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00757 Furin-like Furin-like cysteine rich region
E PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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