6HUPB

Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with diazepam (valium), gaba and megabody mb38.
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
440
structure length
336
Chain Sequence
NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Membrane protein
molecule keywords Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-amino
publication title GABAAreceptor signalling mechanisms revealed by structural pharmacology.
pubmed doi rcsb
source organism Bos taurus
total genus 85
structure length 336
sequence length 440
chains with identical sequence E
ec nomenclature
pdb deposition date 2018-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
B PF02932 Neur_chan_memb Neurotransmitter-gated ion-channel transmembrane region
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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