6M13a

Crystal structure of rnase l in complex with toceranib
Total Genus 221
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
221
sequence length
706
structure length
681
Chain Sequence
SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKAGPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Ribonuclease L
publication title Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
pubmed doi rcsb
source organism Sus scrofa
total genus 221
structure length 681
sequence length 706
chains with identical sequence b
ec nomenclature
pdb deposition date 2020-02-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
a PF00069 Pkinase Protein kinase domain
a PF06479 Ribonuc_2-5A Ribonuclease 2-5A
a PF12796 Ank_2 Ankyrin repeats (3 copies)
a PF13606 Ank_3 Ankyrin repeat
a PF13637 Ank_4 Ankyrin repeats (many copies)
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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