6TMZAAA

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
362
structure length
337
Chain Sequence
GSAPKYIEHFSKFSPSPLSMKQFLDFGNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozym
publication title Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
doi rcsb
source organism Homo sapiens
total genus 112
structure length 337
sequence length 362
ec nomenclature
pdb deposition date 2019-12-05
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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