6V7NA

Crystal structure of a human lysosome resident glycoprotein, lysosomal acid lipase, and its implications in cholesteryl ester storage disease (cesd)
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
376
structure length
369
Chain Sequence
DPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRPKPVVFLQHGLLADSSNWVTNLAQSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYQQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQASENNL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of human Lysosomal Acid Lipase and its Implications in Cholesteryl Ester Storage Disease (CESD).
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Lysosomal acid lipase/cholesteryl ester hydrolase
total genus 136
structure length 369
sequence length 376
chains with identical sequence B
ec nomenclature ec 3.1.1.13: Sterol esterase.
pdb deposition date 2019-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00561 Abhydrolase_1 alpha/beta hydrolase fold
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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