6VPJA

Tpx2 residues 7-20 fused to aurora a residues 116-389 c247v + c319v double mutant dephosphorylated, and in complex with amp-pnp
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
289
structure length
279
Chain Sequence
MSYSYDAPSDFINFSSKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYVHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLVYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Redox priming promotes Aurora A activation during mitosis.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TPX2 fragment - Aurora A kinase domain fusion
total genus 78
structure length 279
sequence length 289
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2020-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00069 Pkinase Protein kinase domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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