6VW2A

Cryo-em structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
24
structure length
24
Chain Sequence
NFLVHSSNNFGAILSSTNVGSNTY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein fibril
molecule keywords Islet amyloid polypeptide (SUMO-tagged)
publication title Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
pubmed doi rcsb
source organism Saccharomyces cerevisiae (strain atcc 204508 / s288c)
total genus 1
structure length 24
sequence length 24
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2020-02-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00240 ubiquitin Ubiquitin family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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