6ZC4A

Small-molecule inhibitors of the pdz domain of dishevelled proteins interrupt wnt signalling
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
95
structure length
88
Chain Sequence
AMSLNIITVTLNMEKYNFLGISIVGQGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Peptide binding protein
molecule keywords Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b
publication title Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
rcsb
source organism Homo sapiens
total genus 16
structure length 88
sequence length 95
chains with identical sequence B
ec nomenclature
pdb deposition date 2020-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00595 PDZ PDZ domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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