7AHUD

Anti-fx fab of mim8 in complex with human fxa
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
52
structure length
52
Chain Sequence
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title FVIIIa-mimetic bispecific antibody (Mim8) ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
pubmed doi rcsb
molecule keywords Anti-FX Fab of mim8 light chain
molecule tags Blood clotting
source organism Homo sapiens
total genus 9
structure length 52
sequence length 52
chains with identical sequence F
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2020-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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