7DFRA

Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
pubmed doi rcsb
molecule keywords DIHYDROFOLATE REDUCTASE
molecule tags Oxidoreductase
source organism Escherichia coli
total genus 40
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1988-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 7dfrA00
3GI2A 3NU0A 1DYRA 5HI6A 1DREA 1LY4A 1RH3A 1DYJA 4KD7A 3QFXA 1RE7A 3HBBA 3CD2A 4KNEA 4ELFA 3DGAA 3TQAA 2QK8A 1RC4A 4HOFA 4I13A 3ROAA 3GYFA 3FS6A 2ZZAA 1OHKA 4PTHA 3FQCA 1DR5A 4H95A 1U70A 3SRUX 1ZDRA 2FZHA 4PSSA 4HA7A 2BLAA 1IA2A 3NXOA 4TU5X 1LY3A 4M6JA 2D5NA 1BOZA 2W3MA 5E8QA 5ECCA 1DR1A 1HFPA 3QG2A 1J3JA 1DG8A 4XT6A 1RX2A 4LAEX 4M7VA 4ECKA 4HA9A 3SRWX 1DRAA 4OSGA 3JWFA 3DG8A 3FREX 3K45A 2INQA 5HT5A 4QLGA 3D80A 3KGYA 4XT8A 3JW3A 1RX3A 3FRBX 4PDJA 3M08A 5HT4A 4QI9A 4KM0A 3EEMA 2H2QA 4QJCA 4KL9A 3EELA 1DISA 3QLRA 4GH8A 2BL9A 3FYVX 5HF2X 6DFRA 1DYHA 3QYLA 4Q0EA 3F0QX 3F8YA 1D1GA 3FY8X 4KJLA 4ELGA 1RB3A 5HQZA 3IRNA 2ITHA 3JWCA 4I1NA 1DG5A 3M09A 2DHFA 1DR2A 4NX7A 2FZIA 4RGCA 2W9TA 3JTWA 1DHJA 3UM6A 1KMVA 4KFJA 1U72A 3UM5A 4Q6AA 3FQVA 3K47A 3FL9A 3OCHA 3CSEA 3NZCX 4PTJA 1VJ3A 1RX8A 2G6VA 3QGTA 3SAIA 3GHVA 3FL8A 1LUDA 4Q67A 4KY4A 5HUIA 3NXRA 3QL3A 3SRSX 2AZNA 3SA2A 4XT7A 5ECXA 2XW7A 1S3UA 1M7AA 3F0UX 5JG0X 4EIZA 4QLFA 1RA8A 3JWKA 4KJKA 3EEKA 4P3QA 3JSUA 1KMSA 3QLYA 4LAHX 1S3VA 1DR6A 4XT4A 1U71A 3TQ9A 1DDSA 3IROA 3FRFX 3DL6A 3FRDX 2CD2A 2ANQA 4PSTA 4IXED 1DLRA 1DRFA 2C2SA 1DRBA 3SRRX 3TD8A 5JA3A 3DRCA 1J3KA 4KBNA 1CZ3A 3R33A 4LAGX 3EX8A 4HOEA 4P68A 3FQ0A 3QLSA 1KLKA 1RA9A 3KJSA 3I3RA 2C2TA 1RB2A 1RA2A 1DR3A 2DRCA 3L3RA 3SGYA 3UM8A 2OBCA 3DL5A 2HM9A 4EILA 3NRRA 3SRQX 1RX4A 1AO8A 2BLBA 3FQOA 2GD9A 1HFQA 1RX5A 2D0KA 3ZPCA 2OIPA 2W9SA 1AI9A 3JVXA 3NZBX 3NZDA 2ANOA 1E26A 5FDAA 1DIUA 1JOMA 3NTZA 2KGKA 3FYWX 1IA4A 1DLSA 3F91A 2JYBA 4XRBA 4QLEA 3ZPGA 4KY8A 2W9GA 1DR4A 4LEKX 4M7UA 3FY9X 3QLZA 3FQZA 4P3RA 5HVEA 3SQYX 2BLCA 4DPDA 4NX6A 5DFRA 1DDRA 1JOLA 1PDBA 3CL9A 4CD2A 1RX7A 2CIGA 3TQ8A 5HSUA 3QL0A 3RG9A 2LF1A 2W3AA 5HQYA 4KJJA 5HVBA 3QYOA 1TDRA 4DDRA 3NXYA 4OR7A 4KAKA 4QJZD 1S3YA 3K74A 3E0BA 3SH2A 4ELBA 2W3WA 4KYAA 2HXVA 3NZ6X 4P66A 4Q0DA 3DAUA 5DXVA 4H96A 4M6LA 4XECX 4DFRA 3NXTA 4H97A 1DF7A 3SA1A 2W3VA 5CCCA 4KEBA 3I8AX 5U27A 3IX9A 1OHJA 3Q1HA 3EIGA 1AOEA 1DHIA 3EEJA 4G95A 7DFRA 1SEJA 4X5JA 3S9UA 3IA4A 3KFYA 1RX1A 5U26A 4ELHA 3S3VA 4XE6X 1DHFA 3D84X 3QLXA 3F0VX 1CD2A 3INVA 4EIGA 1J3IA 3JWMA 3LG4A 4X5GA 3F0XX 1DYIA 1VDRA 2B3ZA 4X5HA 3HJ3A 1HFRA 3KY8A 3S7AA 1MVSA 1IA3A 4G3MA 3DATA 4PSYA 4FHBA 2P4GA 3N0HA 4XT5A 1IA1A 3NZAX 1DG7A 1DAJA 5HPBA 5HSRA 1RA1A 3F0BX 4X5IA 1S3WA 3KJRA 3F0SX 4ELEA 3FQFA 4M6KA 3QLWA 3GHWA 3GHCA 1M79A 3VCOA 1RF7A 1PD9A 4HOGA 3CLBA 2W3BA 1JUVA 3K2HA 4FGHA 2O7PA 3IA5A 3JW5A 3SR5X 1RX6A 3FRAX 4H98A 4KM2A 2HQPA 4FGGA 3OAFA 4DPHA 4DP3A 1PD8A 2L28A 3F8ZA 1RA3A 5HF0X 1M78A 1DRHA 1RD7A 4KLXA 3NZ9X 5CC9A 2FZJA 8DFRA 1DR7A 4IXFX 3NXXA 2W9HA 4M2XA 1QZFA 4EJ1A 3NXVA 5EAJA 3RO9A 4X5FA 1MVTA 4QHVA 4IXGX 4G8ZX 3TQBA 1YHOA 1RX9A 3DFRA 3IRMA 1BZFA 1RG7A
chains in the Genus database with same CATH superfamily
3GI2A 3NU0A 1DYRA 5HI6A 1DREA 1LY4A 1RH3A 1DYJA 4KD7A 3QFXA 1RE7A 3HBBA 3CD2A 4KNEA 4ELFA 3DGAA 3TQAA 2QK8A 1RC4A 4HOFA 4I13A 3ROAA 3GYFA 3FS6A 2ZZAA 1OHKA 4PTHA 3FQCA 1DR5A 4H95A 1U70A 3SRUX 1ZDRA 2FZHA 4PSSA 4HA7A 2BLAA 1IA2A 3NXOA 4TU5X 1LY3A 4M6JA 2D5NA 1BOZA 2W3MA 5E8QA 5ECCA 1DR1A 1HFPA 3QG2A 1J3JA 1DG8A 4XT6A 1RX2A 4LAEX 4M7VA 4ECKA 4HA9A 3SRWX 1DRAA 4OSGA 3JWFA 3DG8A 3FREX 3K45A 2INQA 5HT5A 4QLGA 3D80A 3KGYA 4XT8A 3JW3A 1RX3A 3FRBX 4PDJA 3M08A 5HT4A 4QI9A 4KM0A 3EEMA 2H2QA 4QJCA 4KL9A 3EELA 1DISA 3QLRA 4GH8A 2BL9A 3FYVX 5HF2X 6DFRA 1DYHA 3QYLA 4Q0EA 3F0QX 3F8YA 1D1GA 3FY8X 4KJLA 4ELGA 1RB3A 5HQZA 3IRNA 2ITHA 3JWCA 4I1NA 1DG5A 3M09A 2DHFA 1DR2A 4NX7A 2FZIA 4RGCA 2W9TA 3JTWA 1DHJA 3UM6A 1KMVA 4KFJA 1U72A 3UM5A 4Q6AA 3FQVA 3K47A 3FL9A 3OCHA 3CSEA 3NZCX 4PTJA 1VJ3A 1RX8A 2G6VA 3QGTA 3SAIA 3GHVA 3FL8A 1LUDA 4Q67A 4KY4A 5HUIA 3NXRA 3QL3A 3SRSX 2AZNA 3SA2A 4XT7A 5ECXA 2XW7A 1S3UA 1M7AA 3F0UX 5JG0X 4EIZA 4QLFA 1RA8A 3JWKA 4KJKA 3EEKA 4P3QA 3JSUA 1KMSA 3QLYA 4LAHX 1S3VA 1DR6A 4XT4A 1U71A 3TQ9A 1DDSA 3IROA 3FRFX 3DL6A 3FRDX 2CD2A 2ANQA 4PSTA 4IXED 1DLRA 1DRFA 2C2SA 1DRBA 3SRRX 3TD8A 5JA3A 3DRCA 1J3KA 4KBNA 1CZ3A 3R33A 4LAGX 3EX8A 4HOEA 4P68A 3FQ0A 3QLSA 1KLKA 1RA9A 3KJSA 3I3RA 2C2TA 1RB2A 1RA2A 1DR3A 2DRCA 3L3RA 3SGYA 3UM8A 2OBCA 3DL5A 2HM9A 4EILA 3NRRA 3SRQX 1RX4A 1AO8A 2BLBA 3FQOA 2GD9A 1HFQA 1RX5A 2D0KA 3ZPCA 2OIPA 2W9SA 1AI9A 3JVXA 3NZBX 3NZDA 2ANOA 1E26A 5FDAA 1DIUA 1JOMA 3NTZA 2KGKA 3FYWX 1IA4A 1DLSA 3F91A 2JYBA 4XRBA 4QLEA 3ZPGA 4KY8A 2W9GA 1DR4A 4LEKX 4M7UA 3FY9X 3QLZA 3FQZA 4P3RA 5HVEA 3SQYX 2BLCA 4DPDA 4NX6A 5DFRA 1DDRA 1JOLA 1PDBA 3CL9A 4CD2A 1RX7A 2CIGA 3TQ8A 5HSUA 3QL0A 3RG9A 2LF1A 2W3AA 5HQYA 4KJJA 5HVBA 3QYOA 1TDRA 4DDRA 3NXYA 4OR7A 4KAKA 4QJZD 1S3YA 3K74A 3E0BA 3SH2A 4ELBA 2W3WA 4KYAA 2HXVA 3NZ6X 4P66A 4Q0DA 3DAUA 5DXVA 4H96A 4M6LA 4XECX 4DFRA 3NXTA 4H97A 1DF7A 3SA1A 2W3VA 5CCCA 4KEBA 3I8AX 5U27A 3IX9A 1OHJA 3Q1HA 3EIGA 1AOEA 1DHIA 3EEJA 4G95A 7DFRA 1SEJA 4X5JA 3S9UA 3IA4A 3KFYA 1RX1A 5U26A 4ELHA 3S3VA 4XE6X 1DHFA 3D84X 3QLXA 3F0VX 1CD2A 3INVA 4EIGA 1J3IA 3JWMA 3LG4A 4X5GA 3F0XX 1DYIA 1VDRA 2B3ZA 4X5HA 3HJ3A 1HFRA 3KY8A 3S7AA 1MVSA 1IA3A 4G3MA 3DATA 4PSYA 4FHBA 2P4GA 3N0HA 4XT5A 1IA1A 3NZAX 1DG7A 1DAJA 5HPBA 5HSRA 1RA1A 3F0BX 4X5IA 1S3WA 3KJRA 3F0SX 4ELEA 3FQFA 4M6KA 3QLWA 3GHWA 3GHCA 1M79A 3VCOA 1RF7A 1PD9A 4HOGA 3CLBA 2W3BA 1JUVA 3K2HA 4FGHA 2O7PA 3IA5A 3JW5A 3SR5X 1RX6A 3FRAX 4H98A 4KM2A 2HQPA 4FGGA 3OAFA 4DPHA 4DP3A 1PD8A 2L28A 3F8ZA 1RA3A 5HF0X 1M78A 1DRHA 1RD7A 4KLXA 3NZ9X 5CC9A 2FZJA 8DFRA 1DR7A 4IXFX 3NXXA 2W9HA 4M2XA 1QZFA 4EJ1A 3NXVA 5EAJA 3RO9A 4X5FA 1MVTA 4QHVA 4IXGX 4G8ZX 3TQBA 1YHOA 1RX9A 3DFRA 3IRMA 1BZFA 1RG7A
chains in the Genus database with same CATH topology
3GI2A 3NU0A 1DYRA 5HI6A 1DREA 1LY4A 1RH3A 1DYJA 4KD7A 3QFXA 1RE7A 3HBBA 3CD2A 4KNEA 4ELFA 3DGAA 3TQAA 2QK8A 1RC4A 4HOFA 4I13A 3ROAA 3GYFA 3FS6A 2ZZAA 1OHKA 4PTHA 3FQCA 1DR5A 4H95A 1U70A 3SRUX 1ZDRA 2FZHA 4PSSA 4HA7A 2BLAA 1IA2A 3NXOA 4TU5X 1LY3A 4M6JA 2D5NA 1BOZA 2W3MA 5E8QA 5ECCA 1DR1A 1HFPA 3QG2A 1J3JA 1DG8A 4XT6A 1RX2A 4LAEX 4M7VA 4ECKA 4HA9A 3SRWX 1DRAA 4OSGA 3JWFA 3DG8A 3FREX 3K45A 2INQA 5HT5A 4QLGA 3D80A 3KGYA 4XT8A 3JW3A 1RX3A 3FRBX 4PDJA 3M08A 5HT4A 4QI9A 4KM0A 3EEMA 2H2QA 4QJCA 4KL9A 3EELA 1DISA 3QLRA 4GH8A 2BL9A 3FYVX 5HF2X 6DFRA 1DYHA 3QYLA 4Q0EA 3F0QX 3F8YA 1D1GA 3FY8X 4KJLA 4ELGA 1RB3A 5HQZA 3IRNA 2ITHA 3JWCA 4I1NA 1DG5A 3M09A 2DHFA 1DR2A 4NX7A 2FZIA 4RGCA 2W9TA 3JTWA 1DHJA 3UM6A 1KMVA 4KFJA 1U72A 3UM5A 4Q6AA 3FQVA 3K47A 3FL9A 3OCHA 3CSEA 3NZCX 4PTJA 1VJ3A 1RX8A 2G6VA 3QGTA 3SAIA 3GHVA 3FL8A 1LUDA 4Q67A 4KY4A 5HUIA 3NXRA 3QL3A 3SRSX 2AZNA 3SA2A 4XT7A 5ECXA 2XW7A 1S3UA 1M7AA 3F0UX 5JG0X 4EIZA 4QLFA 1RA8A 3JWKA 4KJKA 3EEKA 4P3QA 3JSUA 1KMSA 3QLYA 4LAHX 1S3VA 1DR6A 4XT4A 1U71A 3TQ9A 1DDSA 3IROA 3FRFX 3DL6A 3FRDX 2CD2A 2ANQA 4PSTA 4IXED 1DLRA 1DRFA 2C2SA 1DRBA 3SRRX 3TD8A 5JA3A 3DRCA 1J3KA 4KBNA 1CZ3A 3R33A 4LAGX 3EX8A 4HOEA 4P68A 3FQ0A 3QLSA 1KLKA 1RA9A 3KJSA 3I3RA 2C2TA 1RB2A 1RA2A 1DR3A 2DRCA 3L3RA 3SGYA 3UM8A 2OBCA 3DL5A 2HM9A 4EILA 3NRRA 3SRQX 1RX4A 1AO8A 2BLBA 3FQOA 2GD9A 1HFQA 1RX5A 2D0KA 3ZPCA 2OIPA 2W9SA 1AI9A 3JVXA 3NZBX 3NZDA 2ANOA 1E26A 5FDAA 1DIUA 1JOMA 3NTZA 2KGKA 3FYWX 1IA4A 1DLSA 3F91A 2JYBA 4XRBA 4QLEA 3ZPGA 4KY8A 2W9GA 1DR4A 4LEKX 4M7UA 3FY9X 3QLZA 3FQZA 4P3RA 5HVEA 3SQYX 2BLCA 4DPDA 4NX6A 5DFRA 1DDRA 1JOLA 1PDBA 3CL9A 4CD2A 1RX7A 2CIGA 3TQ8A 5HSUA 3QL0A 3RG9A 2LF1A 2W3AA 5HQYA 4KJJA 5HVBA 3QYOA 1TDRA 4DDRA 3NXYA 4OR7A 4KAKA 4QJZD 1S3YA 3K74A 3E0BA 3SH2A 4ELBA 2W3WA 4KYAA 2HXVA 3NZ6X 4P66A 4Q0DA 3DAUA 5DXVA 4H96A 4M6LA 4XECX 4DFRA 3NXTA 4H97A 1DF7A 3SA1A 2W3VA 5CCCA 4KEBA 3I8AX 5U27A 3IX9A 1OHJA 3Q1HA 3EIGA 1AOEA 1DHIA 3EEJA 4G95A 7DFRA 1SEJA 4X5JA 3S9UA 3IA4A 3KFYA 1RX1A 5U26A 4ELHA 3S3VA 4XE6X 1DHFA 3D84X 3QLXA 3F0VX 1CD2A 3INVA 4EIGA 1J3IA 3JWMA 3LG4A 4X5GA 3F0XX 1DYIA 1VDRA 2B3ZA 4X5HA 3HJ3A 1HFRA 3KY8A 3S7AA 1MVSA 1IA3A 4G3MA 3DATA 4PSYA 4FHBA 2P4GA 3N0HA 4XT5A 1IA1A 3NZAX 1DG7A 1DAJA 5HPBA 5HSRA 1RA1A 3F0BX 4X5IA 1S3WA 3KJRA 3F0SX 4ELEA 3FQFA 4M6KA 3QLWA 3GHWA 3GHCA 1M79A 3VCOA 1RF7A 1PD9A 4HOGA 3CLBA 2W3BA 1JUVA 3K2HA 4FGHA 2O7PA 3IA5A 3JW5A 3SR5X 1RX6A 3FRAX 4H98A 4KM2A 2HQPA 4FGGA 3OAFA 4DPHA 4DP3A 1PD8A 2L28A 3F8ZA 1RA3A 5HF0X 1M78A 1DRHA 1RD7A 4KLXA 3NZ9X 5CC9A 2FZJA 8DFRA 1DR7A 4IXFX 3NXXA 2W9HA 4M2XA 1QZFA 4EJ1A 3NXVA 5EAJA 3RO9A 4X5FA 1MVTA 4QHVA 4IXGX 4G8ZX 3TQBA 1YHOA 1RX9A 3DFRA 3IRMA 1BZFA 1RG7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GI2 A;  3NU0 A;  1DYR A;  5HI6 A;  1DRE A;  1LY4 A;  1RH3 A;  1DYJ A;  4KD7 A;  3QFX A;  1RE7 A;  3HBB A;  3CD2 A;  4KNE A;  4ELF A;  3DGA A;  3TQA A;  2QK8 A;  1RC4 A;  4HOF A;  4I13 A;  3ROA A;  3GYF A;  3FS6 A;  2ZZA A;  1OHK A;  4PTH A;  3FQC A;  1DR5 A;  4H95 A;  1U70 A;  3SRU X;  1ZDR A;  2FZH A;  4PSS A;  4HA7 A;  2BLA A;  1IA2 A;  3NXO A;  4TU5 X;  1LY3 A;  4M6J A;  2D5N A;  1BOZ A;  2W3M A;  5E8Q A;  5ECC A;  1DR1 A;  1HFP A;  3QG2 A;  1J3J A;  1DG8 A;  4XT6 A;  1RX2 A;  4LAE X;  4M7V A;  4ECK A;  4HA9 A;  3SRW X;  1DRA A;  4OSG A;  3JWF A;  3DG8 A;  3FRE X;  3K45 A;  2INQ A;  5HT5 A;  4QLG A;  3D80 A;  3KGY A;  4XT8 A;  3JW3 A;  1RX3 A;  3FRB X;  4PDJ A;  3M08 A;  5HT4 A;  4QI9 A;  4KM0 A;  3EEM A;  2H2Q A;  4QJC A;  4KL9 A;  3EEL A;  1DIS A;  3QLR A;  4GH8 A;  2BL9 A;  3FYV X;  5HF2 X;  6DFR A;  1DYH A;  3QYL A;  4Q0E A;  3F0Q X;  3F8Y A;  1D1G A;  3FY8 X;  4KJL A;  4ELG A;  1RB3 A;  5HQZ A;  3IRN A;  2ITH A;  3JWC A;  4I1N A;  1DG5 A;  3M09 A;  2DHF A;  1DR2 A;  4NX7 A;  2FZI A;  4RGC A;  2W9T A;  3JTW A;  1DHJ A;  3UM6 A;  1KMV A;  4KFJ A;  1U72 A;  3UM5 A;  4Q6A A;  3FQV A;  3K47 A;  3FL9 A;  3OCH A;  3CSE A;  3NZC X;  4PTJ A;  1VJ3 A;  1RX8 A;  2G6V A;  3QGT A;  3SAI A;  3GHV A;  3FL8 A;  1LUD A;  4Q67 A;  4KY4 A;  5HUI A;  3NXR A;  3QL3 A;  3SRS X;  2AZN A;  3SA2 A;  4XT7 A;  5ECX A;  2XW7 A;  1S3U A;  1M7A A;  3F0U X;  5JG0 X;  4EIZ A;  4QLF A;  1RA8 A;  3JWK A;  4KJK A;  3EEK A;  4P3Q A;  3JSU A;  1KMS A;  3QLY A;  4LAH X;  1S3V A;  1DR6 A;  4XT4 A;  1U71 A;  3TQ9 A;  1DDS A;  3IRO A;  3FRF X;  3DL6 A;  3FRD X;  2CD2 A;  2ANQ A;  4PST A;  4IXE D;  1DLR A;  1DRF A;  2C2S A;  1DRB A;  3SRR X;  3TD8 A;  5JA3 A;  3DRC A;  1J3K A;  4KBN A;  1CZ3 A;  3R33 A;  4LAG X;  3EX8 A;  4HOE A;  4P68 A;  3FQ0 A;  3QLS A;  1KLK A;  1RA9 A;  3KJS A;  3I3R A;  2C2T A;  1RB2 A;  1RA2 A;  1DR3 A;  2DRC A;  3L3R A;  3SGY A;  3UM8 A;  2OBC A;  3DL5 A;  2HM9 A;  4EIL A;  3NRR A;  3SRQ X;  1RX4 A;  1AO8 A;  2BLB A;  3FQO A;  2GD9 A;  1HFQ A;  1RX5 A;  2D0K A;  3ZPC A;  2OIP A;  2W9S A;  1AI9 A;  3JVX A;  3NZB X;  3NZD A;  2ANO A;  1E26 A;  5FDA A;  1DIU A;  1JOM A;  3NTZ A;  2KGK A;  3FYW X;  1IA4 A;  1DLS A;  3F91 A;  2JYB A;  4XRB A;  4QLE A;  3ZPG A;  4KY8 A;  2W9G A;  1DR4 A;  4LEK X;  4M7U A;  3FY9 X;  3QLZ A;  3FQZ A;  4P3R A;  5HVE A;  3SQY X;  2BLC A;  4DPD A;  4NX6 A;  5DFR A;  1DDR A;  1JOL A;  1PDB A;  3CL9 A;  4CD2 A;  1RX7 A;  2CIG A;  3TQ8 A;  5HSU A;  3QL0 A;  3RG9 A;  2LF1 A;  2W3A A;  5HQY A;  4KJJ A;  5HVB A;  3QYO A;  1TDR A;  4DDR A;  3NXY A;  4OR7 A;  4KAK A;  4QJZ D;  1S3Y A;  3K74 A;  3E0B A;  3SH2 A;  4ELB A;  2W3W A;  4KYA A;  2HXV A;  3NZ6 X;  4P66 A;  4Q0D A;  3DAU A;  5DXV A;  4H96 A;  4M6L A;  4XEC X;  4DFR A;  3NXT A;  4H97 A;  1DF7 A;  3SA1 A;  2W3V A;  5CCC A;  4KEB A;  3I8A X;  5U27 A;  3IX9 A;  1OHJ A;  3Q1H A;  3EIG A;  1AOE A;  1DHI A;  3EEJ A;  4G95 A;  7DFR A;  1SEJ A;  4X5J A;  3S9U A;  3IA4 A;  3KFY A;  1RX1 A;  5U26 A;  4ELH A;  3S3V A;  4XE6 X;  1DHF A;  3D84 X;  3QLX A;  3F0V X;  1CD2 A;  3INV A;  4EIG A;  1J3I A;  3JWM A;  3LG4 A;  4X5G A;  3F0X X;  1DYI A;  1VDR A;  2B3Z A;  4X5H A;  3HJ3 A;  1HFR A;  3KY8 A;  3S7A A;  1MVS A;  1IA3 A;  4G3M A;  3DAT A;  4PSY A;  4FHB A;  2P4G A;  3N0H A;  4XT5 A;  1IA1 A;  3NZA X;  1DG7 A;  1DAJ A;  5HPB A;  5HSR A;  1RA1 A;  3F0B X;  4X5I A;  1S3W A;  3KJR A;  3F0S X;  4ELE A;  3FQF A;  4M6K A;  3QLW A;  3GHW A;  3GHC A;  1M79 A;  3VCO A;  1RF7 A;  1PD9 A;  4HOG A;  3CLB A;  2W3B A;  1JUV A;  3K2H A;  4FGH A;  2O7P A;  3IA5 A;  3JW5 A;  3SR5 X;  1RX6 A;  3FRA X;  4H98 A;  4KM2 A;  2HQP A;  4FGG A;  3OAF A;  4DPH A;  4DP3 A;  1PD8 A;  2L28 A;  3F8Z A;  1RA3 A;  5HF0 X;  1M78 A;  1DRH A;  1RD7 A;  4KLX A;  3NZ9 X;  5CC9 A;  2FZJ A;  8DFR A;  1DR7 A;  4IXF X;  3NXX A;  2W9H A;  4M2X A;  1QZF A;  4EJ1 A;  3NXV A;  5EAJ A;  3RO9 A;  4X5F A;  1MVT A;  4QHV A;  4IXG X;  4G8Z X;  3TQB A;  1YHO A;  1RX9 A;  3DFR A;  3IRM A;  1BZF A;  1RG7 A; 
#chains in the Genus database with same CATH topology
 3GI2 A;  3NU0 A;  1DYR A;  5HI6 A;  1DRE A;  1LY4 A;  1RH3 A;  1DYJ A;  4KD7 A;  3QFX A;  1RE7 A;  3HBB A;  3CD2 A;  4KNE A;  4ELF A;  3DGA A;  3TQA A;  2QK8 A;  1RC4 A;  4HOF A;  4I13 A;  3ROA A;  3GYF A;  3FS6 A;  2ZZA A;  1OHK A;  4PTH A;  3FQC A;  1DR5 A;  4H95 A;  1U70 A;  3SRU X;  1ZDR A;  2FZH A;  4PSS A;  4HA7 A;  2BLA A;  1IA2 A;  3NXO A;  4TU5 X;  1LY3 A;  4M6J A;  2D5N A;  1BOZ A;  2W3M A;  5E8Q A;  5ECC A;  1DR1 A;  1HFP A;  3QG2 A;  1J3J A;  1DG8 A;  4XT6 A;  1RX2 A;  4LAE X;  4M7V A;  4ECK A;  4HA9 A;  3SRW X;  1DRA A;  4OSG A;  3JWF A;  3DG8 A;  3FRE X;  3K45 A;  2INQ A;  5HT5 A;  4QLG A;  3D80 A;  3KGY A;  4XT8 A;  3JW3 A;  1RX3 A;  3FRB X;  4PDJ A;  3M08 A;  5HT4 A;  4QI9 A;  4KM0 A;  3EEM A;  2H2Q A;  4QJC A;  4KL9 A;  3EEL A;  1DIS A;  3QLR A;  4GH8 A;  2BL9 A;  3FYV X;  5HF2 X;  6DFR A;  1DYH A;  3QYL A;  4Q0E A;  3F0Q X;  3F8Y A;  1D1G A;  3FY8 X;  4KJL A;  4ELG A;  1RB3 A;  5HQZ A;  3IRN A;  2ITH A;  3JWC A;  4I1N A;  1DG5 A;  3M09 A;  2DHF A;  1DR2 A;  4NX7 A;  2FZI A;  4RGC A;  2W9T A;  3JTW A;  1DHJ A;  3UM6 A;  1KMV A;  4KFJ A;  1U72 A;  3UM5 A;  4Q6A A;  3FQV A;  3K47 A;  3FL9 A;  3OCH A;  3CSE A;  3NZC X;  4PTJ A;  1VJ3 A;  1RX8 A;  2G6V A;  3QGT A;  3SAI A;  3GHV A;  3FL8 A;  1LUD A;  4Q67 A;  4KY4 A;  5HUI A;  3NXR A;  3QL3 A;  3SRS X;  2AZN A;  3SA2 A;  4XT7 A;  5ECX A;  2XW7 A;  1S3U A;  1M7A A;  3F0U X;  5JG0 X;  4EIZ A;  4QLF A;  1RA8 A;  3JWK A;  4KJK A;  3EEK A;  4P3Q A;  3JSU A;  1KMS A;  3QLY A;  4LAH X;  1S3V A;  1DR6 A;  4XT4 A;  1U71 A;  3TQ9 A;  1DDS A;  3IRO A;  3FRF X;  3DL6 A;  3FRD X;  2CD2 A;  2ANQ A;  4PST A;  4IXE D;  1DLR A;  1DRF A;  2C2S A;  1DRB A;  3SRR X;  3TD8 A;  5JA3 A;  3DRC A;  1J3K A;  4KBN A;  1CZ3 A;  3R33 A;  4LAG X;  3EX8 A;  4HOE A;  4P68 A;  3FQ0 A;  3QLS A;  1KLK A;  1RA9 A;  3KJS A;  3I3R A;  2C2T A;  1RB2 A;  1RA2 A;  1DR3 A;  2DRC A;  3L3R A;  3SGY A;  3UM8 A;  2OBC A;  3DL5 A;  2HM9 A;  4EIL A;  3NRR A;  3SRQ X;  1RX4 A;  1AO8 A;  2BLB A;  3FQO A;  2GD9 A;  1HFQ A;  1RX5 A;  2D0K A;  3ZPC A;  2OIP A;  2W9S A;  1AI9 A;  3JVX A;  3NZB X;  3NZD A;  2ANO A;  1E26 A;  5FDA A;  1DIU A;  1JOM A;  3NTZ A;  2KGK A;  3FYW X;  1IA4 A;  1DLS A;  3F91 A;  2JYB A;  4XRB A;  4QLE A;  3ZPG A;  4KY8 A;  2W9G A;  1DR4 A;  4LEK X;  4M7U A;  3FY9 X;  3QLZ A;  3FQZ A;  4P3R A;  5HVE A;  3SQY X;  2BLC A;  4DPD A;  4NX6 A;  5DFR A;  1DDR A;  1JOL A;  1PDB A;  3CL9 A;  4CD2 A;  1RX7 A;  2CIG A;  3TQ8 A;  5HSU A;  3QL0 A;  3RG9 A;  2LF1 A;  2W3A A;  5HQY A;  4KJJ A;  5HVB A;  3QYO A;  1TDR A;  4DDR A;  3NXY A;  4OR7 A;  4KAK A;  4QJZ D;  1S3Y A;  3K74 A;  3E0B A;  3SH2 A;  4ELB A;  2W3W A;  4KYA A;  2HXV A;  3NZ6 X;  4P66 A;  4Q0D A;  3DAU A;  5DXV A;  4H96 A;  4M6L A;  4XEC X;  4DFR A;  3NXT A;  4H97 A;  1DF7 A;  3SA1 A;  2W3V A;  5CCC A;  4KEB A;  3I8A X;  5U27 A;  3IX9 A;  1OHJ A;  3Q1H A;  3EIG A;  1AOE A;  1DHI A;  3EEJ A;  4G95 A;  7DFR A;  1SEJ A;  4X5J A;  3S9U A;  3IA4 A;  3KFY A;  1RX1 A;  5U26 A;  4ELH A;  3S3V A;  4XE6 X;  1DHF A;  3D84 X;  3QLX A;  3F0V X;  1CD2 A;  3INV A;  4EIG A;  1J3I A;  3JWM A;  3LG4 A;  4X5G A;  3F0X X;  1DYI A;  1VDR A;  2B3Z A;  4X5H A;  3HJ3 A;  1HFR A;  3KY8 A;  3S7A A;  1MVS A;  1IA3 A;  4G3M A;  3DAT A;  4PSY A;  4FHB A;  2P4G A;  3N0H A;  4XT5 A;  1IA1 A;  3NZA X;  1DG7 A;  1DAJ A;  5HPB A;  5HSR A;  1RA1 A;  3F0B X;  4X5I A;  1S3W A;  3KJR A;  3F0S X;  4ELE A;  3FQF A;  4M6K A;  3QLW A;  3GHW A;  3GHC A;  1M79 A;  3VCO A;  1RF7 A;  1PD9 A;  4HOG A;  3CLB A;  2W3B A;  1JUV A;  3K2H A;  4FGH A;  2O7P A;  3IA5 A;  3JW5 A;  3SR5 X;  1RX6 A;  3FRA X;  4H98 A;  4KM2 A;  2HQP A;  4FGG A;  3OAF A;  4DPH A;  4DP3 A;  1PD8 A;  2L28 A;  3F8Z A;  1RA3 A;  5HF0 X;  1M78 A;  1DRH A;  1RD7 A;  4KLX A;  3NZ9 X;  5CC9 A;  2FZJ A;  8DFR A;  1DR7 A;  4IXF X;  3NXX A;  2W9H A;  4M2X A;  1QZF A;  4EJ1 A;  3NXV A;  5EAJ A;  3RO9 A;  4X5F A;  1MVT A;  4QHV A;  4IXG X;  4G8Z X;  3TQB A;  1YHO A;  1RX9 A;  3DFR A;  3IRM A;  1BZF A;  1RG7 A; 
#chains in the Genus database with same CATH homology
 3GI2 A;  3NU0 A;  1DYR A;  5HI6 A;  1DRE A;  1LY4 A;  1RH3 A;  1DYJ A;  4KD7 A;  3QFX A;  1RE7 A;  3HBB A;  3CD2 A;  4KNE A;  4ELF A;  3DGA A;  3TQA A;  2QK8 A;  1RC4 A;  4HOF A;  4I13 A;  3ROA A;  3GYF A;  3FS6 A;  2ZZA A;  1OHK A;  4PTH A;  3FQC A;  1DR5 A;  4H95 A;  1U70 A;  3SRU X;  1ZDR A;  2FZH A;  4PSS A;  4HA7 A;  2BLA A;  1IA2 A;  3NXO A;  4TU5 X;  1LY3 A;  4M6J A;  2D5N A;  1BOZ A;  2W3M A;  5E8Q A;  5ECC A;  1DR1 A;  1HFP A;  3QG2 A;  1J3J A;  1DG8 A;  4XT6 A;  1RX2 A;  4LAE X;  4M7V A;  4ECK A;  4HA9 A;  3SRW X;  1DRA A;  4OSG A;  3JWF A;  3DG8 A;  3FRE X;  3K45 A;  2INQ A;  5HT5 A;  4QLG A;  3D80 A;  3KGY A;  4XT8 A;  3JW3 A;  1RX3 A;  3FRB X;  4PDJ A;  3M08 A;  5HT4 A;  4QI9 A;  4KM0 A;  3EEM A;  2H2Q A;  4QJC A;  4KL9 A;  3EEL A;  1DIS A;  3QLR A;  4GH8 A;  2BL9 A;  3FYV X;  5HF2 X;  6DFR A;  1DYH A;  3QYL A;  4Q0E A;  3F0Q X;  3F8Y A;  1D1G A;  3FY8 X;  4KJL A;  4ELG A;  1RB3 A;  5HQZ A;  3IRN A;  2ITH A;  3JWC A;  4I1N A;  1DG5 A;  3M09 A;  2DHF A;  1DR2 A;  4NX7 A;  2FZI A;  4RGC A;  2W9T A;  3JTW A;  1DHJ A;  3UM6 A;  1KMV A;  4KFJ A;  1U72 A;  3UM5 A;  4Q6A A;  3FQV A;  3K47 A;  3FL9 A;  3OCH A;  3CSE A;  3NZC X;  4PTJ A;  1VJ3 A;  1RX8 A;  2G6V A;  3QGT A;  3SAI A;  3GHV A;  3FL8 A;  1LUD A;  4Q67 A;  4KY4 A;  5HUI A;  3NXR A;  3QL3 A;  3SRS X;  2AZN A;  3SA2 A;  4XT7 A;  5ECX A;  2XW7 A;  1S3U A;  1M7A A;  3F0U X;  5JG0 X;  4EIZ A;  4QLF A;  1RA8 A;  3JWK A;  4KJK A;  3EEK A;  4P3Q A;  3JSU A;  1KMS A;  3QLY A;  4LAH X;  1S3V A;  1DR6 A;  4XT4 A;  1U71 A;  3TQ9 A;  1DDS A;  3IRO A;  3FRF X;  3DL6 A;  3FRD X;  2CD2 A;  2ANQ A;  4PST A;  4IXE D;  1DLR A;  1DRF A;  2C2S A;  1DRB A;  3SRR X;  3TD8 A;  5JA3 A;  3DRC A;  1J3K A;  4KBN A;  1CZ3 A;  3R33 A;  4LAG X;  3EX8 A;  4HOE A;  4P68 A;  3FQ0 A;  3QLS A;  1KLK A;  1RA9 A;  3KJS A;  3I3R A;  2C2T A;  1RB2 A;  1RA2 A;  1DR3 A;  2DRC A;  3L3R A;  3SGY A;  3UM8 A;  2OBC A;  3DL5 A;  2HM9 A;  4EIL A;  3NRR A;  3SRQ X;  1RX4 A;  1AO8 A;  2BLB A;  3FQO A;  2GD9 A;  1HFQ A;  1RX5 A;  2D0K A;  3ZPC A;  2OIP A;  2W9S A;  1AI9 A;  3JVX A;  3NZB X;  3NZD A;  2ANO A;  1E26 A;  5FDA A;  1DIU A;  1JOM A;  3NTZ A;  2KGK A;  3FYW X;  1IA4 A;  1DLS A;  3F91 A;  2JYB A;  4XRB A;  4QLE A;  3ZPG A;  4KY8 A;  2W9G A;  1DR4 A;  4LEK X;  4M7U A;  3FY9 X;  3QLZ A;  3FQZ A;  4P3R A;  5HVE A;  3SQY X;  2BLC A;  4DPD A;  4NX6 A;  5DFR A;  1DDR A;  1JOL A;  1PDB A;  3CL9 A;  4CD2 A;  1RX7 A;  2CIG A;  3TQ8 A;  5HSU A;  3QL0 A;  3RG9 A;  2LF1 A;  2W3A A;  5HQY A;  4KJJ A;  5HVB A;  3QYO A;  1TDR A;  4DDR A;  3NXY A;  4OR7 A;  4KAK A;  4QJZ D;  1S3Y A;  3K74 A;  3E0B A;  3SH2 A;  4ELB A;  2W3W A;  4KYA A;  2HXV A;  3NZ6 X;  4P66 A;  4Q0D A;  3DAU A;  5DXV A;  4H96 A;  4M6L A;  4XEC X;  4DFR A;  3NXT A;  4H97 A;  1DF7 A;  3SA1 A;  2W3V A;  5CCC A;  4KEB A;  3I8A X;  5U27 A;  3IX9 A;  1OHJ A;  3Q1H A;  3EIG A;  1AOE A;  1DHI A;  3EEJ A;  4G95 A;  7DFR A;  1SEJ A;  4X5J A;  3S9U A;  3IA4 A;  3KFY A;  1RX1 A;  5U26 A;  4ELH A;  3S3V A;  4XE6 X;  1DHF A;  3D84 X;  3QLX A;  3F0V X;  1CD2 A;  3INV A;  4EIG A;  1J3I A;  3JWM A;  3LG4 A;  4X5G A;  3F0X X;  1DYI A;  1VDR A;  2B3Z A;  4X5H A;  3HJ3 A;  1HFR A;  3KY8 A;  3S7A A;  1MVS A;  1IA3 A;  4G3M A;  3DAT A;  4PSY A;  4FHB A;  2P4G A;  3N0H A;  4XT5 A;  1IA1 A;  3NZA X;  1DG7 A;  1DAJ A;  5HPB A;  5HSR A;  1RA1 A;  3F0B X;  4X5I A;  1S3W A;  3KJR A;  3F0S X;  4ELE A;  3FQF A;  4M6K A;  3QLW A;  3GHW A;  3GHC A;  1M79 A;  3VCO A;  1RF7 A;  1PD9 A;  4HOG A;  3CLB A;  2W3B A;  1JUV A;  3K2H A;  4FGH A;  2O7P A;  3IA5 A;  3JW5 A;  3SR5 X;  1RX6 A;  3FRA X;  4H98 A;  4KM2 A;  2HQP A;  4FGG A;  3OAF A;  4DPH A;  4DP3 A;  1PD8 A;  2L28 A;  3F8Z A;  1RA3 A;  5HF0 X;  1M78 A;  1DRH A;  1RD7 A;  4KLX A;  3NZ9 X;  5CC9 A;  2FZJ A;  8DFR A;  1DR7 A;  4IXF X;  3NXX A;  2W9H A;  4M2X A;  1QZF A;  4EJ1 A;  3NXV A;  5EAJ A;  3RO9 A;  4X5F A;  1MVT A;  4QHV A;  4IXG X;  4G8Z X;  3TQB A;  1YHO A;  1RX9 A;  3DFR A;  3IRM A;  1BZF A;  1RG7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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