7EA8L

Human setd2 bound to a nucleosome containing oncohistone mutations
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
245
structure length
245
Chain Sequence
DDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Gene regulation
molecule keywords Histone-lysine N-methyltransferase SETD2
publication title Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations.
pubmed doi rcsb
source organism Homo sapiens
total genus 25
structure length 245
sequence length 245
ec nomenclature ec 2.1.1.359: [Histone H3]-lysine(36) N-trimethyltransferase.
pdb deposition date 2021-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00856 SET SET domain
L PF17907 AWS AWS domain
Image from the rcsb pdb (www.rcsb.org)
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