7EL9A

Structure of machupo virus l polymerase in complex with z protein and 3'-vrna (dimeric complex)
Total Genus 442
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
442
sequence length
2157
structure length
1731
Chain Sequence
DEYVQELKGLIRKHEFGHQKVTFLSQSPLLTEGFKLLSSLVELESCEAHACQADGFKLTGKTLILLETFVRVNPDEFEKKWKADMSKLLNLKHDLQKTLVPIVDGRSNYNNRFVADWVIERIRWLLIEILKASEDQEYQRLIHSLSNVKNQSLGLENLEHLKRNSLDYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTDRRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERTDTHSNIEKHYLSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRKSGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPEIWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSVKICRHKLFQEMSSFEQMRLFKTLSSISLSLINSMKTSFSSRLLVNEYFGNVRLRECYAQRFYLAESLVGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLAGMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFLMAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFFSRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPSLNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNRGKLKVSGELKNNPFRSPTEFTSISSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGTSLSEEFFHQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVEEVPTLIKTLQSKLSRQSSVASGFIGFCKSMGSKCVRDGKGGFLYIKEVYSGVSACTCEICALKPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQKPLNNQNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSYTDWELGLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELEDDSQIELAELTDFALMVKNQNVSRAMFVEDIAMGYVVSNFEGVRISLSNVMVDGVQLPPQDIGELFGLKAGLVVQIDHVRMSTKFKLKRKMVYSFSLECIMDVGEIQNKEVILKVVAVDQSVSGSGGNHMLLDGVSVVASLPLFTGQASFDLAAMLIESNLAGSNDNFLMRNVTLDLGGFSPELSDKYSYRLSGPENQEDPLVLKDGAFYVGGERLSTYKVEFTGDLVVKALGALEDDESVVSMLHQLWPYLKATSQVILFQQEDFTIVHDLYKKQLTKSIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
rcsb
molecule keywords RNA-directed RNA polymerase L
molecule tags Viral protein/rna
source organism Machupo mammarenavirus
total genus 442
structure length 1731
sequence length 2157
chains with identical sequence D
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2021-04-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF06317 Arena_RNA_pol Arenavirus RNA polymerase
A PF17296 ArenaCapSnatch Arenavirus cap snatching domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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