7ELAA

Structure of lassa virus polymerase in complex with 3'-vrna and z mutant (f36a)
Total Genus 422
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
422
sequence length
1824
structure length
1402
Chain Sequence
MEEDIACVKDLVSKYLANNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCIEVDSCNANGCEHNSEDKSVERILHDHGVLTPSLCFVVPDGYKLTGNVLILLECFVRSSPANFEQKYVEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNEQIPDWVNDKLRDTLFSLLKYAQESNSLFEESEYSRLCESLSMTESLNALLDNRSNHYEEVIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLRKGEIEGQFLKVEKNQLLNEFNNLYADKVAEKDSVEHLTHQFKRASPILRFLYANISECQMQCWRSFLNKVKSMRILNTRRKLLLIFDALILLASKHDQVRKKPLRGWLGTCFVSVNDRLVSLESTKKDLKKWVERRQQVECPSKNQILNSIFQKTISKATTALRDVGISVDHYKIDMEVICPDGYDLIMDFDVSGVTPTISYQRSEEEAFPYIMGDVDLLKTTDLERLSSLSLALVNSMKTSSTVKEAYCQEFSLGETEFQLIYQKTGECSKCYAINDNRVGEVCSFYADPKRYFPAIFSAEVLQTTVSTMISWIEDCNELEEQLDKIRSLTKMILILILAHPSKRSQKLLQNLRYFIMAYVSDYYHKDLIDKVREELITDVEFLLYRLLRTLMGLVLSEDVKSMMTNRFKFILNISYMCHFITKETPDRLTDQIKCFEKFLEPKVKFGHVSINPADTATEEELDDMVYNAKKFLSKGGCTSAKGPSYKKPGVSKKYLSLLTSSFNNGSLFKQESPQSYNSVGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSSQLSGSCLNNEKEFENAILSMKLNVSMAHVSYSMDHSKWGPMMCPFLFLTVLQNLIFLSIKGRDYLSTLLMWHMHKMVEIPFNVVSAMMKSFIKAQLGTKQSITEDFFYSNFQIGVVPSHISSILDMGQGILHNTSDFYALITERFINYAISCVCGGTIDAYTSSDDQISLFDQTLTELLHRDPEEFRALMEFHYYMSDQLNKFVSPKSVIGRFVAEFKSRFFVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIVDQSVANGVPVHLCNLIQIRTLSLLQYARYPIDPFLLNCETDVRDWVDGNRSYRIMRQIEGLIPDACSKIRSMLRRLYNRLKTGQLHEEFTTNYLSSEHLSSLKNLCELLGVEPPSESDLEYSWLNLAAHHPLRMVIPTIVKTIQNSSIASGFVGLCRTLGSKCVRGPNKENLYIKSIQSLITGTQGIELLTNSIGVQYWRVPLGLRNKSESVVSYFRPLLWDYMCISLSTAIELGAWVLGDPKTTNPCDYFPLKPTASKLLEDRVGLNHIIHSLRRLYPSVFEKHILIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRFSHTRT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Viral protein/rna
molecule keywords RING finger protein Z
publication title Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
rcsb
source organism Lassa mammarenavirus
total genus 422
structure length 1402
sequence length 1824
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2021-04-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF06317 Arena_RNA_pol Arenavirus RNA polymerase
A PF17296 ArenaCapSnatch Arenavirus cap snatching domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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