7K45B

Sars-cov-2 spike in complex with the s2e12 neutralizing antibody fab fragment (local refinement of the rbd and fab variable domains)
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
194
structure length
194
Chain Sequence
NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Viral protein/immune system
molecule keywords S2E12 neutralizing antibody Fab fragment (heavy chain)
publication title Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
pubmed doi rcsb
source organism Homo sapiens
total genus 35
structure length 194
sequence length 194
ec nomenclature
pdb deposition date 2020-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09408 bCoV_S1_RBD Betacoronavirus spike glycoprotein S1, receptor binding
B PF16451 bCoV_S1_N Betacoronavirus-like spike glycoprotein S1, N-terminal
B PF19209 CoV_S1_C Coronavirus spike glycoprotein S1, C-terminal
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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