7K6CA

Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium abscessus atcc 19977 / dsm 44196 with nadp and inhibitor p218
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
159
Chain Sequence
GTIGLIWAQTRAGVIGADGAIPWRLPEDQARFKRITMGHTVIMGRKTWESLPGSVRPLPGRPNIVLTRDALFEPDGALAVGSADAALAASDEAPWVIGGGEIYRLFLPLAQRCEVTVVEADVPGDALAPELGEGWVVETNDWQTSESGLRYQFLSYRKV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Dihydrofolate reductase
publication title Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218
rcsb
source organism Mycobacteroides abscessus (strain atcc 19977 / dsm 44196 / cip 104536 / jcm 1356
total genus 40
structure length 159
sequence length 159
chains with identical sequence B, C, D, E, F, G
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2020-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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