7KHJA

Crystal structure of kit kinase domain with a small molecule inhibitor, plx8512 in the dfg-in state
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
308
structure length
288
Chain Sequence
NNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGGKVVEATAQGLIKSDAAMTVAVKMLKPSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDSFHNALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVDKARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEHAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISES
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Mast/stem cell growth factor receptor Kit
publication title Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients with Refractory Gastrointestinal Stromal Tumors
rcsb
source organism Homo sapiens
total genus 91
structure length 288
sequence length 308
chains with identical sequence B
ec nomenclature
pdb deposition date 2020-10-21
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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