7N33A

Sars-cov-2 nsp15 endoribonuclease pre-cleavage state
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
346
structure length
346
Chain Sequence
EMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Characterization of SARS2 Nsp15 Nuclease Activity Reveals its Mad About U
rcsb
molecule keywords Uridylate-specific endoribonuclease
molecule tags Viral protein/rna
source organism Severe acute respiratory syndrome coronavirus 2
total genus 85
structure length 346
sequence length 346
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2021-05-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF19215 CoV_NSP15_C Coronavirus replicase NSP15, uridylate-specific endoribonuclease
A PF19216 CoV_NSP15_M Coronavirus replicase NSP15, middle domain
A PF19219 CoV_NSP15_N Coronavirus replicase NSP15, N-terminal oligomerisation
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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