7O24A

Structure of the foamy viral protease-reverse transcriptase in complex with dsdna.
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
476
structure length
476
Chain Sequence
PLELTVKLPVQDFKKELINKANINNEEKKQLAKLLDKYDVLWQQWENQVGHRKIPPHNIATGTVAPRPQRQYHINTKAKPSIQQVIDDLLKQGVLIKQTSVMNTPIYPVPKPDGKWRMVLDYRAVNKTVPLIGAQNQHSLGILTNLVRQKYKSTIDLSNGFWAHPITKDSQWITAFTWEGKQHVWTRLPQGFLNSPALFTADVVDLLKNIPGISVYVDDIYFSTETVSEHLKILEKVFKILLEAGYIVSLKKSALLRYEVTFLGFSITQTGRGLTSEFKDKIQNITSPRTLKELQSILGLFNFARNFVPNFSEIIKPLYSLISTAEGNNIKWTSEHTRYLEEIVSALNHAGNLEQRDNESPLVVKLNASPKTGYIRYYNKGGQKPIAYASHVFTNTELKFTPLEKLLVTMHKALIKAIDLALGQPIEVYSPIISMQKLQKTPLPERKALSTRWITWLSYLEDPRITFYYDKTLPDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Viral protein
molecule keywords Pr125Pol
publication title Crystal structures of foamy viral protease-reverse transcriptase reveal switching between monomeric and dimeric protein forms during reverse transcription
rcsb
source organism White-tufted-ear marmoset simian foamy virus
total genus 102
structure length 476
sequence length 476
chains with identical sequence B, C
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2021-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00075 RNase_H RNase H
A PF00078 RVT_1 Reverse transcriptase (RNA-dependent DNA polymerase)
A PF03539 Spuma_A9PTase Spumavirus aspartic protease (A9)
A PF17919 RT_RNaseH_2 RNase H-like domain found in reverse transcriptase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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