7Q4AA

Toxoplasma gondii prp4k kinase domain (l715f) bound to altiratinib
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
348
structure length
334
Chain Sequence
WNDSEGYYQATVGELLDDGRYRVESEAIGKGVFSNVLKCYDLQEKRFVAIKCIRHNDMMKKAAEKETSILRLLNSTDKDDKRHIVRLLRHFEYRGHFCLVFEWLWGNLRTALKKYGGGKGLNAPAIHAYSKQLFVALKHLSRCRIIHADLKPDNILLNEKFSSLKVCDFGSASDVSDNEITALVSRFYRAPEIILGCRYDLQIDVWSAAATIYELATGQVLFPGRTNNDMLKCIMEVKGKIPTKMIKAGQLSSHHFDENLDFIYRDRKKEVTRVLHDLRPTRNLTENLIEKKINFLRRKMRQLGDLLEKCLALDPQKRLTPDEALQHPFLKESI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase.
pubmed doi rcsb
molecule tags Splicing
source organism Toxoplasma gondii
molecule keywords Non-specific serine/threonine protein kinase
total genus 120
structure length 334
sequence length 348
chains with identical sequence B
ec nomenclature ec 2.7.11.1: non-specific serine/threonine protein kinase.
pdb deposition date 2021-10-29
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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