7W3DA

Crystal structure of brd4 bromodomain 1 (bd1) in complex with n2-(1,2,3-benzotriazol-5-yl)-n3-(dimethylsulfamoyl)-n6-[(2s)-1-methoxypropan-2-yl]pyridine-2,3,6-triamine
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
116
structure length
110
Chain Sequence
NPPPPETSNPNKPKRTQLYLLRVVLLWHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of BET specific bromodomain inhibitors with a novel scaffold.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Bromodomain-containing protein 4
total genus 34
structure length 110
sequence length 116
ec nomenclature
pdb deposition date 2021-11-25
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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