8EIDA

Co-crystal structure of chaetomium glucosidase with compound 14
Total Genus 265
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
265
sequence length
776
structure length
763
Chain Sequence
SEIGRLNNQSLLWGPYRPNIYFGTRPRIGKSLMTGLMWGKIESYTDFQHTVRYTCEQNEGMKGYGWDEYDPRRGGIQSIHDIQNGLDITTSFVKIPGGAHGGSWAARIKGTLNDDAPKDQKTIVVFYVSQEGENSELEAVPSENEFGYEGDVILKGRSEALGNYKLVVTKGKGVIPQSDHDLSRLRGPGQTVVQSLTYPDEVLWQAKPILFQQLKAGIDWLVENKYDVADPPPPWQVYLLANKPGSGNVHIVQKVFEGDFEFDILFSSESAGKEVTSKDLEREVKQATEVFGERFARVFDLKAPFQGDNYKKFGKSMFSNLIGGIGYFYGHSLVDRSYAPEYDEENEGFWEDAAEARARHQEALEGPYELFTSIPSRPFFPRGFLWDEGFHLLPIADWDIDLALEIIKSWYNLMDEDGWIAREQILGAEARSKVPKEFQTQYPHYANPPTLFLVLDNFVERLRKLDETLSTASVDNPEVGLEYLRRLYPLLRRQFDWFRKTQAGDIKSYDREAYSTKEAYRWRGRTVSHCLTSGLDDYPRPQPPHPGELHVDLMSWVGVMVKSLISIGSLLGATEDVEFYTKVLDAIEHNLDDLHWSEKEGCYCDATIDEFEEHKLVCHKGYISLFPFLTGLLKPDSPKLGKLLALIGDESELWSPYGLRSLSKKDEFYGTAENYWRSPVWININYLAIVQLYNIATQDGPYKETARDLYTRLRKNIVETVYRNWEETGFAWEQYNPETGKGQRTQHFTGWTSLVVKIMSGHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.
pubmed doi rcsb
molecule tags Hydrolase/inhibitor
source organism Thermochaetoides thermophila
molecule keywords Chaetomium alpha glucosidase
total genus 265
structure length 763
sequence length 776
chains with identical sequence B
ec nomenclature ec 3.2.1.106: mannosyl-oligosaccharide glucosidase.
pdb deposition date 2022-09-14
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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