8FY2D

E3:protac:target ternary complex structure (vcb/wh244/bcl-2)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
196
structure length
141
Chain Sequence
VYDNREIVMKYIHYKLSQRGYEWDGPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords von Hippel-Lindau disease tumor suppressor
total genus 49
structure length 141
sequence length 196
ec nomenclature
pdb deposition date 2023-01-25
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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