Found 190 chains in Genus chains table. Displaying 51 - 100. Applied filters: Proteins

Search results query ec: 3.1.4.35

Total Genus Sequence Length pdb Title
128 315 3wymA Crystal structure of the catalytic domain of pde10a complexed with 1-(2-fluoro-4-(1h-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1h-pyrazol-5-yl)pyridazin-4(1h)-one
127 324 3ws8A Crystal structure of pde10a in complex with a benzimidazole inhibitor
125 315 3wykA Crystal structure of the catalytic domain of pde10a complexed with 3-(1-phenyl-1h-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1h)-one
123 324 3ws9A Crystal structure of pde10a in complex with a benzimdazole inhibitor
126 305 3uuoA The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as pde10 inhibitors for the treatment of schizophrenia
124 315 3ui7A Discovery of orally active pyrazoloquinoline as a potent pde10 inhibitor for the management of schizophrenia
129 322 3snlA Highly potent, selective, and orally active phosphodiestarase 10a inhibitors
116 325 3shzA Crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
123 322 3sniA Highly potent, selective, and orally active phosphodiestarase 10a inhibitors
115 323 3sieA Crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
136 322 3sn7A Highly potent, selective, and orally active phosphodiestarase 10a inhibitors
114 325 3shyA Crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
137 324 2ounA Crystal structure of pde10a2 in complex with amp
138 325 2ouvA Crystal structure of pde10a2 mutant of d564n
137 324 2oupA Crystal structure of pde10a
132 323 5uwfC Crystal structure of human pde10a in complex with inhibitor 16d
134 323 5jo3B Pde5a for nav1.7
127 315 5b4kA Crystal structure of the catalytic domain of human pde10a complexed with n-(4-((5-methyl-5h-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1h-benzimidazol-2-amine
132 315 5axqA Crystal structure of the catalytic domain of pde10a complexed with highly potent and brain-penetrant pde10a inhibitor with 2-oxindole scaffold
129 315 5axpA Crystal structure of the catalytic domain of pde10a complexed with 1-(2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl-1h-pyrazol-5-yl)pyridazin-4(1h)-one
125 320 5ediB Human pde10a, 6-chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2h-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20a, h3, rfree=23.5%
125 314 5edeA Human pde10a in complex with 1-(4-chloro-phenyl)-3-methyl-1h-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2a
124 315 5edgB Human pde10a in complex with 3-(2-chloro-5-phenyl-3h-imidazol-4-yl)-1-(3-trifluoromethoxy-phenyl)-1h-pyridazin-4-one at 2.30a
123 312 5edhA Human pde10a, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03a, h3, rfree=22.7%
128 315 5edeB Human pde10a in complex with 1-(4-chloro-phenyl)-3-methyl-1h-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2a
123 313 5ediA Human pde10a, 6-chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2h-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20a, h3, rfree=23.5%
127 313 5edgA Human pde10a in complex with 3-(2-chloro-5-phenyl-3h-imidazol-4-yl)-1-(3-trifluoromethoxy-phenyl)-1h-pyridazin-4-one at 2.30a
124 323 5dh5A Pde10 complexed with n-[(1-methylpyrazol-4-yl)methyl]-5-[[(1s,2s)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine
125 307 5dh4A Pde10 complexed with 5-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine
129 323 4zo5A Pde10 complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)isoindoline-1,3-dione
129 322 4y8cA Crystal structure of phosphodiesterase 9 in complex with (s)-c33
124 322 4y87A Crystal structure of phosphodiesterase 9 in complex with (r)-c33 (6-{[(1r)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one)
130 322 4y86A Crystal structure of pde9 in complex with racemic inhibitor c33
130 324 4xy2A Crystal structure of pde10a in complex with asp9436
122 324 4wn1A Crystal structure of pde10a in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1h-pyrazol-4-yl)pyridin-2(1h)-one
123 305 4tppA 2-(3-alkoxy-1-azetidinyl) quinolines as novel pde10a inhibitors
115 303 4tpmA Crystal structure of 2-(3-alkoxy-1-azetidinyl) quinolines as pde10a inhibitors
133 322 4qgeA Phosphodiesterase-9a in complex with inhibitor wyq-c36d
127 307 4p0nA Crystal structure of pde10a with a novel imidazo[4,5-b]pyridine inhibitor
133 318 4p1rA Crystal structure of pde10a with imidazo[4,5-b]pyridines as potent and selective inhibitors
122 305 4phwA Crystal structure of pde10a with 1h-benzimidazol-2-yl(4-((3-(tetrahydro-2h-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone
125 324 4oewA Crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
123 327 4oexA Crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
136 330 4msaA Crystal structure of pde10a2 with fragment zt0449 (5-nitro-1h-benzimidazole)
118 326 4md6A Crystal structure of pde5 in complex with inhibitor 5r
136 330 4lkqA Crystal structure of pde10a2 with fragment zt017
135 330 4llpA Crystal structure of pde10a2 with fragment zt401
128 318 4muwA Crystal structure of pde10a with novel keto-benzimidazole inhibitor
138 330 4mrzA Crystal structure of pde10a2 with fragment zt0429 (4-methyl-3-nitropyridin-2-amine)
133 329 4lljA Crystal structure of pde10a2 with fragment zt214