1VYQA

Novel inhibitors of plasmodium falciparum dutpase provide a platform for anti-malarial drug design
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
158
structure length
139
Chain Sequence
MHLKIVCLSDEVREMYKNHKTHHDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKSNYYIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDET
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE
publication title Dutpase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors.
pubmed doi rcsb
source organism Plasmodium falciparum
total genus 28
structure length 139
sequence length 158
chains with identical sequence B, C
ec nomenclature ec 3.6.1.23: dUTP diphosphatase.
pdb deposition date 2004-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00692 dUTPase dUTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.40.10 Mainly Beta Distorted Sandwich Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A 1vyqA01
1MQ7A 1VYQA 2WE0A 1XS1A 3TP1A 2R9QA 3P48A 1SLHA 2OKEA 2D4MA 2PY4A 1Q5HA 4OOPA 2HXBA 4A6AA 4OOQA 3GF0A 3ZF0A 3ECYA 3CA9A 4LHRA 2HQUA 3ZF4A 1DUPA 3MDXA 1DUNA 1XS4A 1DUCA 2OKDA 2QLPA 2J4HA 1PKJA 3TRLA 1F7DA 3I93A 2XX6A 3H6DA 2XY3A 1SMCA 1XS6A 3ZF5A 4AO5A 3TPWA 5CCTA 3ARAA 1F7NA 1SM8A 3TPYA 1OGHA 2BSYA 2HXDA 2J4QA 2Y1TA 3LQWA 2WE1A 3TRNA 5CCOA 1F7KA 2BT1A 2HRMA 5EDDA 4B0HA 4GK6A 1SYLA 1F7RA 1SIXA 3ZF6A 2WE3A 1RNJA 3EHWA 4WRKA 3TQ5A 3ZF2A 3LOJA 4APZ1 2QXXA 1SEHA 1F7OA 3TQZA 3TTAA 2PC5A 2OL0A 1Q5UX 2HR6A 1F7QA 3HZAA 1PKHA 1PKKA 4XJCA 1DUTA 5F9KA 3T6YA 3TS6A 4AOOA 3C3IA 3C2TA 4AOZA 4DHKA 3H6XA 1EUWA 3KM3A 2V9XA 3TQ3A 3TPSA 3T70A 2YZJA 1RN8A 2WE2A 2D4NA 2D4LA 3T60A 4GV8A 5ECTA 3ZEZA 1SNFA 2ZDCA 3F4FA 3ZF3A 2OL1A 3T64A 2XCDA 3MBQA 1SJNA 3SO2A 1F7PA 2Y8CA 2BAZA 3TPNA 3TQ4A 3ARNA 1EU5A 3TSLA 3ZF1A 2XCEA 2OKBA 1DUDA 4GCYA 3HHQA
chains in the Genus database with same CATH superfamily
1MQ7A 1VYQA 2WE0A 1XS1A 3TP1A 2R9QA 3P48A 1SLHA 2OKEA 2D4MA 2PY4A 1Q5HA 4OOPA 2HXBA 4A6AA 4OOQA 3GF0A 3ZF0A 3ECYA 3CA9A 4LHRA 2HQUA 3ZF4A 1DUPA 3MDXA 1DUNA 1XS4A 1DUCA 2OKDA 2QLPA 2J4HA 1PKJA 3TRLA 1F7DA 3I93A 2XX6A 3H6DA 2XY3A 1SMCA 1XS6A 3ZF5A 4AO5A 3TPWA 5CCTA 3ARAA 1F7NA 1SM8A 3TPYA 1OGHA 2BSYA 2HXDA 2J4QA 2Y1TA 3LQWA 2WE1A 3TRNA 5CCOA 1F7KA 2BT1A 2HRMA 5EDDA 4B0HA 4GK6A 1SYLA 1F7RA 1SIXA 3ZF6A 2WE3A 1RNJA 3EHWA 4WRKA 3TQ5A 3ZF2A 3LOJA 4APZ1 2QXXA 1SEHA 1F7OA 3TQZA 3TTAA 2PC5A 2OL0A 1Q5UX 2HR6A 1F7QA 3HZAA 1PKHA 1PKKA 4XJCA 1DUTA 5F9KA 3T6YA 3TS6A 4AOOA 3C3IA 3C2TA 4AOZA 4DHKA 3H6XA 1EUWA 3KM3A 2V9XA 3TQ3A 3TPSA 3T70A 2YZJA 1RN8A 2WE2A 2D4NA 2D4LA 3T60A 4GV8A 5ECTA 3ZEZA 1SNFA 2ZDCA 3F4FA 3ZF3A 2OL1A 3T64A 2XCDA 3MBQA 1SJNA 3SO2A 1F7PA 2Y8CA 2BAZA 3TPNA 3TQ4A 3ARNA 1EU5A 3TSLA 3ZF1A 2XCEA 2OKBA 1DUDA 1TULA 4GCYA 3HHQA
chains in the Genus database with same CATH topology
1MQ7A 1VYQA 2WE0A 1XS1A 3TP1A 2R9QA 3P48A 1SLHA 2OKEA 2D4MA 2PY4A 1Q5HA 4OOPA 2HXBA 4A6AA 4OOQA 3GF0A 3ZF0A 3ECYA 3CA9A 4LHRA 2HQUA 3ZF4A 1DUPA 3MDXA 1DUNA 1XS4A 1DUCA 2OKDA 2QLPA 2J4HA 1PKJA 3TRLA 1F7DA 3I93A 2XX6A 3H6DA 2XY3A 1SMCA 1XS6A 3ZF5A 4AO5A 3TPWA 5CCTA 3ARAA 1F7NA 1SM8A 3TPYA 1OGHA 2BSYA 2HXDA 2J4QA 2Y1TA 3LQWA 2WE1A 3TRNA 5CCOA 1F7KA 2BT1A 2HRMA 5EDDA 4B0HA 4GK6A 1SYLA 1F7RA 1SIXA 3ZF6A 2WE3A 1RNJA 3EHWA 4WRKA 3TQ5A 3ZF2A 3LOJA 4APZ1 2QXXA 1SEHA 1F7OA 3TQZA 3TTAA 2PC5A 2OL0A 1Q5UX 2HR6A 1F7QA 3HZAA 1PKHA 1PKKA 4XJCA 1DUTA 5F9KA 3T6YA 3TS6A 4AOOA 3C3IA 3C2TA 4AOZA 4DHKA 3H6XA 1EUWA 3KM3A 2V9XA 3TQ3A 3TPSA 3T70A 2YZJA 1RN8A 2WE2A 2D4NA 2D4LA 3T60A 4GV8A 5ECTA 3ZEZA 1SNFA 2ZDCA 3F4FA 3ZF3A 2OL1A 3T64A 2XCDA 3MBQA 1SJNA 3SO2A 1F7PA 2Y8CA 2BAZA 3TPNA 3TQ4A 3ARNA 1EU5A 3TSLA 3ZF1A 2XCEA 2OKBA 1DUDA 4GCYA 3HHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MQ7 A;  1VYQ A;  2WE0 A;  1XS1 A;  3TP1 A;  2R9Q A;  3P48 A;  1SLH A;  2OKE A;  2D4M A;  2PY4 A;  1Q5H A;  4OOP A;  2HXB A;  4A6A A;  4OOQ A;  3GF0 A;  3ZF0 A;  3ECY A;  3CA9 A;  4LHR A;  2HQU A;  3ZF4 A;  1DUP A;  3MDX A;  1DUN A;  1XS4 A;  1DUC A;  2OKD A;  2QLP A;  2J4H A;  1PKJ A;  3TRL A;  1F7D A;  3I93 A;  2XX6 A;  3H6D A;  2XY3 A;  1SMC A;  1XS6 A;  3ZF5 A;  4AO5 A;  3TPW A;  5CCT A;  3ARA A;  1F7N A;  1SM8 A;  3TPY A;  1OGH A;  2BSY A;  2HXD A;  2J4Q A;  2Y1T A;  3LQW A;  2WE1 A;  3TRN A;  5CCO A;  1F7K A;  2BT1 A;  2HRM A;  5EDD A;  4B0H A;  4GK6 A;  1SYL A;  1F7R A;  1SIX A;  3ZF6 A;  2WE3 A;  1RNJ A;  3EHW A;  4WRK A;  3TQ5 A;  3ZF2 A;  3LOJ A;  4APZ 1;  2QXX A;  1SEH A;  1F7O A;  3TQZ A;  3TTA A;  2PC5 A;  2OL0 A;  1Q5U X;  2HR6 A;  1F7Q A;  3HZA A;  1PKH A;  1PKK A;  4XJC A;  1DUT A;  5F9K A;  3T6Y A;  3TS6 A;  4AOO A;  3C3I A;  3C2T A;  4AOZ A;  4DHK A;  3H6X A;  1EUW A;  3KM3 A;  2V9X A;  3TQ3 A;  3TPS A;  3T70 A;  2YZJ A;  1RN8 A;  2WE2 A;  2D4N A;  2D4L A;  3T60 A;  4GV8 A;  5ECT A;  3ZEZ A;  1SNF A;  2ZDC A;  3F4F A;  3ZF3 A;  2OL1 A;  3T64 A;  2XCD A;  3MBQ A;  1SJN A;  3SO2 A;  1F7P A;  2Y8C A;  2BAZ A;  3TPN A;  3TQ4 A;  3ARN A;  1EU5 A;  3TSL A;  3ZF1 A;  2XCE A;  2OKB A;  1DUD A;  4GCY A;  3HHQ A; 
#chains in the Genus database with same CATH topology
 1MQ7 A;  1VYQ A;  2WE0 A;  1XS1 A;  3TP1 A;  2R9Q A;  3P48 A;  1SLH A;  2OKE A;  2D4M A;  2PY4 A;  1Q5H A;  4OOP A;  2HXB A;  4A6A A;  4OOQ A;  3GF0 A;  3ZF0 A;  3ECY A;  3CA9 A;  4LHR A;  2HQU A;  3ZF4 A;  1DUP A;  3MDX A;  1DUN A;  1XS4 A;  1DUC A;  2OKD A;  2QLP A;  2J4H A;  1PKJ A;  3TRL A;  1F7D A;  3I93 A;  2XX6 A;  3H6D A;  2XY3 A;  1SMC A;  1XS6 A;  3ZF5 A;  4AO5 A;  3TPW A;  5CCT A;  3ARA A;  1F7N A;  1SM8 A;  3TPY A;  1OGH A;  2BSY A;  2HXD A;  2J4Q A;  2Y1T A;  3LQW A;  2WE1 A;  3TRN A;  5CCO A;  1F7K A;  2BT1 A;  2HRM A;  5EDD A;  4B0H A;  4GK6 A;  1SYL A;  1F7R A;  1SIX A;  3ZF6 A;  2WE3 A;  1RNJ A;  3EHW A;  4WRK A;  3TQ5 A;  3ZF2 A;  3LOJ A;  4APZ 1;  2QXX A;  1SEH A;  1F7O A;  3TQZ A;  3TTA A;  2PC5 A;  2OL0 A;  1Q5U X;  2HR6 A;  1F7Q A;  3HZA A;  1PKH A;  1PKK A;  4XJC A;  1DUT A;  5F9K A;  3T6Y A;  3TS6 A;  4AOO A;  3C3I A;  3C2T A;  4AOZ A;  4DHK A;  3H6X A;  1EUW A;  3KM3 A;  2V9X A;  3TQ3 A;  3TPS A;  3T70 A;  2YZJ A;  1RN8 A;  2WE2 A;  2D4N A;  2D4L A;  3T60 A;  4GV8 A;  5ECT A;  3ZEZ A;  1SNF A;  2ZDC A;  3F4F A;  3ZF3 A;  2OL1 A;  3T64 A;  2XCD A;  3MBQ A;  1SJN A;  3SO2 A;  1F7P A;  2Y8C A;  2BAZ A;  3TPN A;  3TQ4 A;  3ARN A;  1EU5 A;  3TSL A;  3ZF1 A;  2XCE A;  2OKB A;  1DUD A;  1TUL A;  4GCY A;  3HHQ A; 
#chains in the Genus database with same CATH homology
 1MQ7 A;  1VYQ A;  2WE0 A;  1XS1 A;  3TP1 A;  2R9Q A;  3P48 A;  1SLH A;  2OKE A;  2D4M A;  2PY4 A;  1Q5H A;  4OOP A;  2HXB A;  4A6A A;  4OOQ A;  3GF0 A;  3ZF0 A;  3ECY A;  3CA9 A;  4LHR A;  2HQU A;  3ZF4 A;  1DUP A;  3MDX A;  1DUN A;  1XS4 A;  1DUC A;  2OKD A;  2QLP A;  2J4H A;  1PKJ A;  3TRL A;  1F7D A;  3I93 A;  2XX6 A;  3H6D A;  2XY3 A;  1SMC A;  1XS6 A;  3ZF5 A;  4AO5 A;  3TPW A;  5CCT A;  3ARA A;  1F7N A;  1SM8 A;  3TPY A;  1OGH A;  2BSY A;  2HXD A;  2J4Q A;  2Y1T A;  3LQW A;  2WE1 A;  3TRN A;  5CCO A;  1F7K A;  2BT1 A;  2HRM A;  5EDD A;  4B0H A;  4GK6 A;  1SYL A;  1F7R A;  1SIX A;  3ZF6 A;  2WE3 A;  1RNJ A;  3EHW A;  4WRK A;  3TQ5 A;  3ZF2 A;  3LOJ A;  4APZ 1;  2QXX A;  1SEH A;  1F7O A;  3TQZ A;  3TTA A;  2PC5 A;  2OL0 A;  1Q5U X;  2HR6 A;  1F7Q A;  3HZA A;  1PKH A;  1PKK A;  4XJC A;  1DUT A;  5F9K A;  3T6Y A;  3TS6 A;  4AOO A;  3C3I A;  3C2T A;  4AOZ A;  4DHK A;  3H6X A;  1EUW A;  3KM3 A;  2V9X A;  3TQ3 A;  3TPS A;  3T70 A;  2YZJ A;  1RN8 A;  2WE2 A;  2D4N A;  2D4L A;  3T60 A;  4GV8 A;  5ECT A;  3ZEZ A;  1SNF A;  2ZDC A;  3F4F A;  3ZF3 A;  2OL1 A;  3T64 A;  2XCD A;  3MBQ A;  1SJN A;  3SO2 A;  1F7P A;  2Y8C A;  2BAZ A;  3TPN A;  3TQ4 A;  3ARN A;  1EU5 A;  3TSL A;  3ZF1 A;  2XCE A;  2OKB A;  1DUD A;  4GCY A;  3HHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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