3QS8A

Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174)
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
346
structure length
346
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
molecule keywords Anthranilate phosphoribosyltransferase
publication title The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 115
structure length 346
sequence length 346
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2011-02-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 3qs8A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 3qs8A02
3TWPA 1OTPA 4N5VA 4X5EA 4X5BA 4N93A 4GA4A 4ZTVA 4OWQA 4XR5A 4ZOJA 4HKMA 4MUOA 4GIUA 4X5CA 2GVQA 2ELCA 5EY3A 4OWSA 4M0RA 4GA6A 3GBRA 3R88A 4EAFA 1KHDA 4OWOA 4GA5A 1VQUA 4OWNA 5BNEA 4YYYA 5C2LA 2DSJA 1BRWA 5BYTA 1ZXYA 2TPTA 4X59A 3QS8A 3R6CA 2BPQA 3QR9A 4X5DA 4OWUA 1KGZA 3UU1A 1AZYA 4ZOKA 2J0FA 5C7SA 1GXBA 3QSAA 4X5AA 4GKMA 4YI7A 4X58A 4ZOFA 5EP8A 1ZYKA 1ZVWA 2WK5A 4YEKA 3H5QA 1UOUA 1O17A 4N8QA 4LHMA 4OWVA 4IJ1A 4EADA 4GTNA 3QQSA 5BO2A 4X46A 1V8GA 2WK6A 5C1RA 4OWMA 5BO3A
chains in the Genus database with same CATH superfamily
3TWPA 1OTPA 4N5VA 4X5EA 4X5BA 4N93A 4GA4A 4ZTVA 4OWQA 4XR5A 4ZOJA 4HKMA 4MUOA 4GIUA 4X5CA 2GVQA 2ELCA 5EY3A 4OWSA 4M0RA 4GA6A 3GBRA 3R88A 4EAFA 1KHDA 4OWOA 1RF8B 4GA5A 1VQUA 4OWNA 4F3FC 5BNEA 4YYYA 5C2LA 2DSJA 1BRWA 5BYTA 1ZXYA 2TPTA 4X59A 3QS8A 3R6CA 2BPQA 3QR9A 4X5DA 4OWUA 1KGZA 3UU1A 1AZYA 4ZOKA 2J0FA 5C7SA 1GXBA 3QSAA 4X5AA 4GKMA 4YI7A 4X58A 4ZOFA 5EP8A 1ZYKA 1ZVWA 2WK5A 4YEKA 1RRZA 3H5QA 1UOUA 1O17A 4N8QA 4LHMA 4OWVA 4IJ1A 4EADA 4GTNA 3QQSA 5BO2A 4X46A 1V8GA 2WK6A 5C1RA 4OWMA 5BO3A
chains in the Genus database with same CATH topology
3TWPA 1OTPA 4N5VA 4X5EA 4X5BA 4N93A 4GA4A 4ZTVA 4OWQA 4XR5A 4ZOJA 4HKMA 4MUOA 4GIUA 4X5CA 2GVQA 2ELCA 5EY3A 4OWSA 4M0RA 4GA6A 3GBRA 3R88A 4EAFA 1KHDA 4OWOA 4GA5A 1VQUA 4OWNA 5BNEA 4YYYA 5C2LA 2DSJA 1BRWA 5BYTA 1ZXYA 2TPTA 4X59A 3QS8A 3R6CA 2BPQA 3QR9A 4X5DA 4OWUA 1KGZA 3UU1A 1AZYA 4ZOKA 2J0FA 5C7SA 1GXBA 3QSAA 4X5AA 4GKMA 4YI7A 4X58A 4ZOFA 5EP8A 1ZYKA 1ZVWA 2WK5A 4YEKA 3H5QA 1UOUA 1O17A 4N8QA 4LHMA 4OWVA 4IJ1A 4EADA 4GTNA 3QQSA 5BO2A 4X46A 1V8GA 2WK6A 5C1RA 4OWMA 5BO3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TWP A;  1OTP A;  4N5V A;  4X5E A;  4X5B A;  4N93 A;  4GA4 A;  4ZTV A;  4OWQ A;  4XR5 A;  4ZOJ A;  4HKM A;  4MUO A;  4GIU A;  4X5C A;  2GVQ A;  2ELC A;  5EY3 A;  4OWS A;  4M0R A;  4GA6 A;  3GBR A;  3R88 A;  4EAF A;  1KHD A;  4OWO A;  4GA5 A;  1VQU A;  4OWN A;  5BNE A;  4YYY A;  5C2L A;  2DSJ A;  1BRW A;  5BYT A;  1ZXY A;  2TPT A;  4X59 A;  3QS8 A;  3R6C A;  2BPQ A;  3QR9 A;  4X5D A;  4OWU A;  1KGZ A;  3UU1 A;  1AZY A;  4ZOK A;  2J0F A;  5C7S A;  1GXB A;  3QSA A;  4X5A A;  4GKM A;  4YI7 A;  4X58 A;  4ZOF A;  5EP8 A;  1ZYK A;  1ZVW A;  2WK5 A;  4YEK A;  3H5Q A;  1UOU A;  1O17 A;  4N8Q A;  4LHM A;  4OWV A;  4IJ1 A;  4EAD A;  4GTN A;  3QQS A;  5BO2 A;  4X46 A;  1V8G A;  2WK6 A;  5C1R A;  4OWM A;  5BO3 A; 
#chains in the Genus database with same CATH topology
 3TWP A;  1OTP A;  4N5V A;  4X5E A;  4X5B A;  4N93 A;  4GA4 A;  4ZTV A;  4OWQ A;  4XR5 A;  4ZOJ A;  4HKM A;  4MUO A;  4GIU A;  4X5C A;  2GVQ A;  2ELC A;  5EY3 A;  4OWS A;  4M0R A;  4GA6 A;  3GBR A;  3R88 A;  4EAF A;  1KHD A;  4OWO A;  1RF8 B;  4GA5 A;  1VQU A;  4OWN A;  4F3F C;  5BNE A;  4YYY A;  5C2L A;  2DSJ A;  1BRW A;  5BYT A;  1ZXY A;  2TPT A;  4X59 A;  3QS8 A;  3R6C A;  2BPQ A;  3QR9 A;  4X5D A;  4OWU A;  1KGZ A;  3UU1 A;  1AZY A;  4ZOK A;  2J0F A;  5C7S A;  1GXB A;  3QSA A;  4X5A A;  4GKM A;  4YI7 A;  4X58 A;  4ZOF A;  5EP8 A;  1ZYK A;  1ZVW A;  2WK5 A;  4YEK A;  1RRZ A;  3H5Q A;  1UOU A;  1O17 A;  4N8Q A;  4LHM A;  4OWV A;  4IJ1 A;  4EAD A;  4GTN A;  3QQS A;  5BO2 A;  4X46 A;  1V8G A;  2WK6 A;  5C1R A;  4OWM A;  5BO3 A; 
#chains in the Genus database with same CATH homology
 3TWP A;  1OTP A;  4N5V A;  4X5E A;  4X5B A;  4N93 A;  4GA4 A;  4ZTV A;  4OWQ A;  4XR5 A;  4ZOJ A;  4HKM A;  4MUO A;  4GIU A;  4X5C A;  2GVQ A;  2ELC A;  5EY3 A;  4OWS A;  4M0R A;  4GA6 A;  3GBR A;  3R88 A;  4EAF A;  1KHD A;  4OWO A;  4GA5 A;  1VQU A;  4OWN A;  5BNE A;  4YYY A;  5C2L A;  2DSJ A;  1BRW A;  5BYT A;  1ZXY A;  2TPT A;  4X59 A;  3QS8 A;  3R6C A;  2BPQ A;  3QR9 A;  4X5D A;  4OWU A;  1KGZ A;  3UU1 A;  1AZY A;  4ZOK A;  2J0F A;  5C7S A;  1GXB A;  3QSA A;  4X5A A;  4GKM A;  4YI7 A;  4X58 A;  4ZOF A;  5EP8 A;  1ZYK A;  1ZVW A;  2WK5 A;  4YEK A;  3H5Q A;  1UOU A;  1O17 A;  4N8Q A;  4LHM A;  4OWV A;  4IJ1 A;  4EAD A;  4GTN A;  3QQS A;  5BO2 A;  4X46 A;  1V8G A;  2WK6 A;  5C1R A;  4OWM A;  5BO3 A; 
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