4LF3C

Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
95
structure length
95
Chain Sequence
MDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords Fab heavy chain
publication title Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
pubmed doi rcsb
source organism Mus musculus
total genus 25
structure length 95
sequence length 95
chains with identical sequence F
ec nomenclature
pdb deposition date 2013-06-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 4lf3C00
2JNDA 3L2JA 2JODA 1U34A 4ERSA 5II0A 3C5TA 2QKHA 4DLQA 2L27A 3IOLA 4ZGMA 4DLOA 3H3GA 3N7RA 3C4MA 3EHTA 4LF3C 3C59A 3EHSA 3AQFB 3N7PA 3N7SA 3EHUA 4HJ0A 2JNCA 2XDGA
chains in the Genus database with same CATH superfamily
2JNDA 3L2JA 2JODA 1U34A 4ERSA 5II0A 3C5TA 2QKHA 4DLQA 2L27A 3IOLA 4ZGMA 4DLOA 3H3GA 3N7RA 3C4MA 3EHTA 4LF3C 3C59A 3EHSA 3AQFB 3N7PA 3N7SA 3EHUA 4HJ0A 2JNCA 2XDGA
chains in the Genus database with same CATH topology
2JNDA 3L2JA 2JODA 1U34A 4ERSA 5II0A 3C5TA 2QKHA 4DLQA 2L27A 3IOLA 4ZGMA 4DLOA 3H3GA 3N7RA 3C4MA 3EHTA 4LF3C 3C59A 3EHSA 3AQFB 3N7PA 3N7SA 3EHUA 4HJ0A 2JNCA 2XDGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JND A;  3L2J A;  2JOD A;  1U34 A;  4ERS A;  5II0 A;  3C5T A;  2QKH A;  4DLQ A;  2L27 A;  3IOL A;  4ZGM A;  4DLO A;  3H3G A;  3N7R A;  3C4M A;  3EHT A;  4LF3 C;  3C59 A;  3EHS A;  3AQF B;  3N7P A;  3N7S A;  3EHU A;  4HJ0 A;  2JNC A;  2XDG A; 
#chains in the Genus database with same CATH topology
 2JND A;  3L2J A;  2JOD A;  1U34 A;  4ERS A;  5II0 A;  3C5T A;  2QKH A;  4DLQ A;  2L27 A;  3IOL A;  4ZGM A;  4DLO A;  3H3G A;  3N7R A;  3C4M A;  3EHT A;  4LF3 C;  3C59 A;  3EHS A;  3AQF B;  3N7P A;  3N7S A;  3EHU A;  4HJ0 A;  2JNC A;  2XDG A; 
#chains in the Genus database with same CATH homology
 2JND A;  3L2J A;  2JOD A;  1U34 A;  4ERS A;  5II0 A;  3C5T A;  2QKH A;  4DLQ A;  2L27 A;  3IOL A;  4ZGM A;  4DLO A;  3H3G A;  3N7R A;  3C4M A;  3EHT A;  4LF3 C;  3C59 A;  3EHS A;  3AQF B;  3N7P A;  3N7S A;  3EHU A;  4HJ0 A;  2JNC A;  2XDG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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