5HPWA

Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: binding studies and structure determination
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
595
structure length
595
Chain Sequence
SWEVGCGAPVPLVTCDEQSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCVQGDECFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFINTTAHVPCFQAGDSRASEQILLATVHTLLLREHNRLARELKRLNPHWDGEMLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKNSKLMNQNKMVTSELRNKLFQPTHKVHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQAVLKNKVLAKKLLDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Oxidoreductase
molecule keywords Lactoperoxidase
publication title Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination
rcsb
total genus 174
structure length 595
sequence length 595
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2016-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03098 An_peroxidase Animal haem peroxidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 5hpwA00
2QRBA 1IGZA 1CX2A 2R5LA 5KIRA 4OTJA 2QQTA 2O86A 3HS6A 2IKCA 1DIYA 1IGXA 3N8YA 4M11A 4RUTA 1DNUC 3NT1A 5JVZA 4RRXA 3GCKA 5JW1A 3BXIA 4KSZA 5F19A 3OLTA 4IG5A 5IKVA 3KRKA 5IKRA 1CVUA 5FDQA 3GC1A 1DNWC 3HS5A 1PGEA 6COXA 3Q9KA 3ZS1C 5COXA 3FAQA 4OEKA 4M10A 3F9PC 1D7WC 2PT3A 3I6NA 3QMOA 1CXPC 4KVJA 3N8FA 2E9EA 3PGHA 4QJQA 1D2VC 5HPWA 4COXA 5JVYA 4C1MC 2NQXA 3RR3A 3Q7DA 2IPSA 3QH0A 1PRHA 4KVLA 3N8ZA 4DL1C 3ERHA 4GN6A 1HT8A 1EQHA 4NT3A 3HS7A 4MSFA 3N8WA 4RS0A 4RRYA 3NTBA 4LJJA 3QF1A 3RKEA 5IKTA 1PTHA 4RRWA 4PH9A 3OGWA 5IKQA 4PNXA 3FNLA 4HHRA 1CQEA 4Z0LA 3OLUA 5GH0A 4N7AA 2Z5ZA 3QL6A 4HHSA 5FIWC 3S4FA 3R5OA 3N8XA 2EHAA 2OJVA 3LN0A 1DDXA 3MDLA 3LN1A 3UBAA 5B72A 2PUMA 1PXXA 3NIUA 3N8YB 3ERIA 4O1ZA 3N8VA 1HT5A 4RRZA 2EFBA 3TGYA 4OTYA 1U67A 2QPKA 3NYHA 4Y55A 3SXVA 2GJMA 3R5QA 1MHLC 3R55A 3GCLA 3TZIA 1Q4GA 4KVKA 4GM7A 3ZS0C 3N8WB 4NJBA 3NAKA 3PY4A 2OYEP 1EQGA 3NTGA 1EBVA 1FE2A 1D5LC 3KK6A 4E1GA 3R4XA 3MQEA 5FF1A 2AYLA 3KRQA 5F1AA 3GCJA 1MYPC 4QYQA 5GLSA 4FM5A 2OYUP 3V6QA
chains in the Genus database with same CATH superfamily
2QRBA 1IGZA 1CX2A 2R5LA 5KIRA 4OTJA 2QQTA 2O86A 3HS6A 2IKCA 1DIYA 1IGXA 3N8YA 4M11A 4RUTA 1DNUC 3NT1A 5JVZA 4RRXA 3GCKA 5JW1A 3BXIA 4KSZA 5F19A 3OLTA 4IG5A 5IKVA 3KRKA 5IKRA 1CVUA 5FDQA 3GC1A 1DNWC 3HS5A 1PGEA 6COXA 3Q9KA 3ZS1C 5COXA 3FAQA 4OEKA 4M10A 3F9PC 1D7WC 2PT3A 3I6NA 3QMOA 1CXPC 4KVJA 3N8FA 2E9EA 3PGHA 4QJQA 1D2VC 5HPWA 4COXA 5JVYA 4C1MC 2NQXA 3RR3A 3Q7DA 2IPSA 3QH0A 1PRHA 4KVLA 3N8ZA 4DL1C 3ERHA 4GN6A 1HT8A 1EQHA 4NT3A 3HS7A 4MSFA 3N8WA 4RS0A 4RRYA 3NTBA 4LJJA 3QF1A 3RKEA 5IKTA 1PTHA 4RRWA 4PH9A 3OGWA 5IKQA 4PNXA 3FNLA 4HHRA 1CQEA 4Z0LA 3OLUA 5GH0A 4N7AA 2Z5ZA 3QL6A 4HHSA 5FIWC 3S4FA 3R5OA 3N8XA 2EHAA 2OJVA 3LN0A 1DDXA 3MDLA 3LN1A 3UBAA 5B72A 2PUMA 1PXXA 3NIUA 3N8YB 3ERIA 4O1ZA 3N8VA 1HT5A 4RRZA 2EFBA 3TGYA 4OTYA 1U67A 2QPKA 3NYHA 4Y55A 3SXVA 2GJMA 3R5QA 1MHLC 3R55A 3GCLA 3TZIA 1Q4GA 4KVKA 4GM7A 3ZS0C 3N8WB 4NJBA 3NAKA 3PY4A 2OYEP 1EQGA 3NTGA 1EBVA 1FE2A 1D5LC 3KK6A 4E1GA 3R4XA 3MQEA 5FF1A 2AYLA 3KRQA 5F1AA 3GCJA 1MYPC 4QYQA 5GLSA 4FM5A 2OYUP 3V6QA
chains in the Genus database with same CATH topology
2QRBA 1IGZA 1CX2A 2R5LA 5KIRA 4OTJA 2QQTA 2O86A 3HS6A 2IKCA 1DIYA 1IGXA 3N8YA 4M11A 4RUTA 1DNUC 3NT1A 5JVZA 4RRXA 3GCKA 5JW1A 3BXIA 4KSZA 5F19A 3OLTA 4IG5A 5IKVA 3KRKA 5IKRA 1CVUA 5FDQA 3GC1A 1DNWC 3HS5A 1PGEA 6COXA 3Q9KA 3ZS1C 5COXA 3FAQA 4OEKA 4M10A 3F9PC 1D7WC 2PT3A 3I6NA 3QMOA 1CXPC 4KVJA 3N8FA 2E9EA 3PGHA 4QJQA 1D2VC 5HPWA 4COXA 5JVYA 4C1MC 2NQXA 3RR3A 3Q7DA 2IPSA 3QH0A 1PRHA 4KVLA 3N8ZA 4DL1C 3ERHA 4GN6A 1HT8A 1EQHA 4NT3A 3HS7A 4MSFA 3N8WA 4RS0A 4RRYA 3NTBA 4LJJA 3QF1A 3RKEA 5IKTA 1PTHA 4RRWA 4PH9A 3OGWA 5IKQA 4PNXA 3FNLA 4HHRA 1CQEA 4Z0LA 3OLUA 5GH0A 4N7AA 2Z5ZA 3QL6A 4HHSA 5FIWC 3S4FA 3R5OA 3N8XA 2EHAA 2OJVA 3LN0A 1DDXA 3MDLA 3LN1A 3UBAA 5B72A 2PUMA 1PXXA 3NIUA 3N8YB 3ERIA 4O1ZA 3N8VA 1HT5A 4RRZA 2EFBA 3TGYA 4OTYA 1U67A 2QPKA 3NYHA 4Y55A 3SXVA 2GJMA 3R5QA 1MHLC 3R55A 3GCLA 3TZIA 1Q4GA 4KVKA 4GM7A 3ZS0C 3N8WB 4NJBA 3NAKA 3PY4A 2OYEP 1EQGA 3NTGA 1EBVA 1FE2A 1D5LC 3KK6A 4E1GA 3R4XA 3MQEA 5FF1A 2AYLA 3KRQA 5F1AA 3GCJA 1MYPC 4QYQA 5GLSA 4FM5A 2OYUP 3V6QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QRB A;  1IGZ A;  1CX2 A;  2R5L A;  5KIR A;  4OTJ A;  2QQT A;  2O86 A;  3HS6 A;  2IKC A;  1DIY A;  1IGX A;  3N8Y A;  4M11 A;  4RUT A;  1DNU C;  3NT1 A;  5JVZ A;  4RRX A;  3GCK A;  5JW1 A;  3BXI A;  4KSZ A;  5F19 A;  3OLT A;  4IG5 A;  5IKV A;  3KRK A;  5IKR A;  1CVU A;  5FDQ A;  3GC1 A;  1DNW C;  3HS5 A;  1PGE A;  6COX A;  3Q9K A;  3ZS1 C;  5COX A;  3FAQ A;  4OEK A;  4M10 A;  3F9P C;  1D7W C;  2PT3 A;  3I6N A;  3QMO A;  1CXP C;  4KVJ A;  3N8F A;  2E9E A;  3PGH A;  4QJQ A;  1D2V C;  5HPW A;  4COX A;  5JVY A;  4C1M C;  2NQX A;  3RR3 A;  3Q7D A;  2IPS A;  3QH0 A;  1PRH A;  4KVL A;  3N8Z A;  4DL1 C;  3ERH A;  4GN6 A;  1HT8 A;  1EQH A;  4NT3 A;  3HS7 A;  4MSF A;  3N8W A;  4RS0 A;  4RRY A;  3NTB A;  4LJJ A;  3QF1 A;  3RKE A;  5IKT A;  1PTH A;  4RRW A;  4PH9 A;  3OGW A;  5IKQ A;  4PNX A;  3FNL A;  4HHR A;  1CQE A;  4Z0L A;  3OLU A;  5GH0 A;  4N7A A;  2Z5Z A;  3QL6 A;  4HHS A;  5FIW C;  3S4F A;  3R5O A;  3N8X A;  2EHA A;  2OJV A;  3LN0 A;  1DDX A;  3MDL A;  3LN1 A;  3UBA A;  5B72 A;  2PUM A;  1PXX A;  3NIU A;  3N8Y B;  3ERI A;  4O1Z A;  3N8V A;  1HT5 A;  4RRZ A;  2EFB A;  3TGY A;  4OTY A;  1U67 A;  2QPK A;  3NYH A;  4Y55 A;  3SXV A;  2GJM A;  3R5Q A;  1MHL C;  3R55 A;  3GCL A;  3TZI A;  1Q4G A;  4KVK A;  4GM7 A;  3ZS0 C;  3N8W B;  4NJB A;  3NAK A;  3PY4 A;  2OYE P;  1EQG A;  3NTG A;  1EBV A;  1FE2 A;  1D5L C;  3KK6 A;  4E1G A;  3R4X A;  3MQE A;  5FF1 A;  2AYL A;  3KRQ A;  5F1A A;  3GCJ A;  1MYP C;  4QYQ A;  5GLS A;  4FM5 A;  2OYU P;  3V6Q A; 
#chains in the Genus database with same CATH topology
 2QRB A;  1IGZ A;  1CX2 A;  2R5L A;  5KIR A;  4OTJ A;  2QQT A;  2O86 A;  3HS6 A;  2IKC A;  1DIY A;  1IGX A;  3N8Y A;  4M11 A;  4RUT A;  1DNU C;  3NT1 A;  5JVZ A;  4RRX A;  3GCK A;  5JW1 A;  3BXI A;  4KSZ A;  5F19 A;  3OLT A;  4IG5 A;  5IKV A;  3KRK A;  5IKR A;  1CVU A;  5FDQ A;  3GC1 A;  1DNW C;  3HS5 A;  1PGE A;  6COX A;  3Q9K A;  3ZS1 C;  5COX A;  3FAQ A;  4OEK A;  4M10 A;  3F9P C;  1D7W C;  2PT3 A;  3I6N A;  3QMO A;  1CXP C;  4KVJ A;  3N8F A;  2E9E A;  3PGH A;  4QJQ A;  1D2V C;  5HPW A;  4COX A;  5JVY A;  4C1M C;  2NQX A;  3RR3 A;  3Q7D A;  2IPS A;  3QH0 A;  1PRH A;  4KVL A;  3N8Z A;  4DL1 C;  3ERH A;  4GN6 A;  1HT8 A;  1EQH A;  4NT3 A;  3HS7 A;  4MSF A;  3N8W A;  4RS0 A;  4RRY A;  3NTB A;  4LJJ A;  3QF1 A;  3RKE A;  5IKT A;  1PTH A;  4RRW A;  4PH9 A;  3OGW A;  5IKQ A;  4PNX A;  3FNL A;  4HHR A;  1CQE A;  4Z0L A;  3OLU A;  5GH0 A;  4N7A A;  2Z5Z A;  3QL6 A;  4HHS A;  5FIW C;  3S4F A;  3R5O A;  3N8X A;  2EHA A;  2OJV A;  3LN0 A;  1DDX A;  3MDL A;  3LN1 A;  3UBA A;  5B72 A;  2PUM A;  1PXX A;  3NIU A;  3N8Y B;  3ERI A;  4O1Z A;  3N8V A;  1HT5 A;  4RRZ A;  2EFB A;  3TGY A;  4OTY A;  1U67 A;  2QPK A;  3NYH A;  4Y55 A;  3SXV A;  2GJM A;  3R5Q A;  1MHL C;  3R55 A;  3GCL A;  3TZI A;  1Q4G A;  4KVK A;  4GM7 A;  3ZS0 C;  3N8W B;  4NJB A;  3NAK A;  3PY4 A;  2OYE P;  1EQG A;  3NTG A;  1EBV A;  1FE2 A;  1D5L C;  3KK6 A;  4E1G A;  3R4X A;  3MQE A;  5FF1 A;  2AYL A;  3KRQ A;  5F1A A;  3GCJ A;  1MYP C;  4QYQ A;  5GLS A;  4FM5 A;  2OYU P;  3V6Q A; 
#chains in the Genus database with same CATH homology
 2QRB A;  1IGZ A;  1CX2 A;  2R5L A;  5KIR A;  4OTJ A;  2QQT A;  2O86 A;  3HS6 A;  2IKC A;  1DIY A;  1IGX A;  3N8Y A;  4M11 A;  4RUT A;  1DNU C;  3NT1 A;  5JVZ A;  4RRX A;  3GCK A;  5JW1 A;  3BXI A;  4KSZ A;  5F19 A;  3OLT A;  4IG5 A;  5IKV A;  3KRK A;  5IKR A;  1CVU A;  5FDQ A;  3GC1 A;  1DNW C;  3HS5 A;  1PGE A;  6COX A;  3Q9K A;  3ZS1 C;  5COX A;  3FAQ A;  4OEK A;  4M10 A;  3F9P C;  1D7W C;  2PT3 A;  3I6N A;  3QMO A;  1CXP C;  4KVJ A;  3N8F A;  2E9E A;  3PGH A;  4QJQ A;  1D2V C;  5HPW A;  4COX A;  5JVY A;  4C1M C;  2NQX A;  3RR3 A;  3Q7D A;  2IPS A;  3QH0 A;  1PRH A;  4KVL A;  3N8Z A;  4DL1 C;  3ERH A;  4GN6 A;  1HT8 A;  1EQH A;  4NT3 A;  3HS7 A;  4MSF A;  3N8W A;  4RS0 A;  4RRY A;  3NTB A;  4LJJ A;  3QF1 A;  3RKE A;  5IKT A;  1PTH A;  4RRW A;  4PH9 A;  3OGW A;  5IKQ A;  4PNX A;  3FNL A;  4HHR A;  1CQE A;  4Z0L A;  3OLU A;  5GH0 A;  4N7A A;  2Z5Z A;  3QL6 A;  4HHS A;  5FIW C;  3S4F A;  3R5O A;  3N8X A;  2EHA A;  2OJV A;  3LN0 A;  1DDX A;  3MDL A;  3LN1 A;  3UBA A;  5B72 A;  2PUM A;  1PXX A;  3NIU A;  3N8Y B;  3ERI A;  4O1Z A;  3N8V A;  1HT5 A;  4RRZ A;  2EFB A;  3TGY A;  4OTY A;  1U67 A;  2QPK A;  3NYH A;  4Y55 A;  3SXV A;  2GJM A;  3R5Q A;  1MHL C;  3R55 A;  3GCL A;  3TZI A;  1Q4G A;  4KVK A;  4GM7 A;  3ZS0 C;  3N8W B;  4NJB A;  3NAK A;  3PY4 A;  2OYE P;  1EQG A;  3NTG A;  1EBV A;  1FE2 A;  1D5L C;  3KK6 A;  4E1G A;  3R4X A;  3MQE A;  5FF1 A;  2AYL A;  3KRQ A;  5F1A A;  3GCJ A;  1MYP C;  4QYQ A;  5GLS A;  4FM5 A;  2OYU P;  3V6Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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