2R0OA

Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(k255e)
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
227
structure length
227
Chain Sequence
FAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEEAIMTYVSSFYHAFSGAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Actin-binding protein
molecule keywords Alpha-actinin-4
publication title Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.
pubmed doi rcsb
source organism Homo sapiens
total genus 83
structure length 227
sequence length 227
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2r0oA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2r0oA01
2WA7A 2EE7A 2D88A 3KMUB 3FERA 1WYLA 1WYPA 4Q57B 1V5KA 2EYNA 1UJOA 5A38A 2QJZA 2L3GA 3HOCA 4TXKA 1RT8A 2DK9A 1UEGA 4Q58A 5A36A 5BVRA 2WA6A 1QAGA 1VKAA 1WYOA 2D86A 3JALM 2RR8A 3HORA 1MB8A 1AOAA 1WYMA 1WYQA 1SH5A 2YRNA 2QJXA 1PXYA 1H67A 2D87A 2K2RA 2D85A 2VZDA 1AA2A 4EDLA 2VZIB 3JAKM 1BKRA 1SH6A 3REPB 2VZCA 2E9KA 2JV9A 1WKUA 3CO1A 1WYRA 2R8UA 1TJTA 1BHDA 2K3SA 1P5SA 2WFNA 1WJOA 1PA7A 1P2XA 4B7LA 3KMWB 5A4BA 1DXXA 2WA5A 5L0OA 1WIXA 4EDMA 3F7PA 4EDNA 1WYNA 2EYIA 3KY9A 4Q59A 2VZGB 3I6XA 2R0OA 3HOPA 5A37A 3JARM 2D89A 4TXIA 5J8EA
chains in the Genus database with same CATH superfamily
2WA7A 2EE7A 2D88A 3KMUB 3FERA 1WYLA 1WYPA 3EAYA 4Q57B 1V5KA 2EYNA 1UJOA 5A38A 2QJZA 2L3GA 3HOCA 4TXKA 1RT8A 2DK9A 1UEGA 4Q58A 5A36A 2VE7A 5BVRA 2WA6A 1QAGA 1VKAA 1WYOA 2D86A 2EQOA 3JALM 2RR8A 3HORA 1MB8A 1AOAA 2VE7C 1WYMA 1WYQA 1EUVA 1SH5A 2YRNA 2QJXA 2WDTA 1PXYA 1H67A 2D87A 2K2RA 2D85A 2VZDA 1AA2A 5FMUA 4EDLA 2VZIB 3JAKM 1BKRA 1SH6A 2HL8A 3REPB 2VZCA 2E9KA 2JV9A 1WKUA 3CO1A 5FMTA 1WYRA 2R8UA 1TJTA 3VP7A 1BHDA 2K3SA 1P5SA 2HKPA 2WFNA 4LVPA 1WJOA 1PA7A 1P2XA 4B7LA 3KMWB 5A4BA 1DXXA 2WA5A 5L0OA 4DDPA 1WIXA 4EDMA 2HL9A 3F7PA 4EDNA 4LVRA 1WYNA 2EYIA 3KY9A 4Q59A 2VZGB 3I6XA 2IGPA 2WE6A 2R0OA 3HOPA 5A37A 3JARM 2D89A 4TXIA 5J8EA
chains in the Genus database with same CATH topology
2WA7A 2EE7A 2D88A 3KMUB 3FERA 1WYLA 1WYPA 4Q57B 1V5KA 2EYNA 1UJOA 5A38A 2QJZA 2L3GA 3HOCA 4TXKA 1RT8A 2DK9A 1UEGA 4Q58A 5A36A 5BVRA 2WA6A 1QAGA 1VKAA 1WYOA 2D86A 3JALM 2RR8A 3HORA 1MB8A 1AOAA 1WYMA 1WYQA 1SH5A 2YRNA 2QJXA 1PXYA 1H67A 2D87A 2K2RA 2D85A 2VZDA 1AA2A 4EDLA 2VZIB 3JAKM 1BKRA 1SH6A 3REPB 2VZCA 2E9KA 2JV9A 1WKUA 3CO1A 1WYRA 2R8UA 1TJTA 1BHDA 2K3SA 1P5SA 2WFNA 1WJOA 1PA7A 1P2XA 4B7LA 3KMWB 5A4BA 1DXXA 2WA5A 5L0OA 1WIXA 4EDMA 3F7PA 4EDNA 1WYNA 2EYIA 3KY9A 4Q59A 2VZGB 3I6XA 2R0OA 3HOPA 5A37A 3JARM 2D89A 4TXIA 5J8EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WA7 A;  2EE7 A;  2D88 A;  3KMU B;  3FER A;  1WYL A;  1WYP A;  4Q57 B;  1V5K A;  2EYN A;  1UJO A;  5A38 A;  2QJZ A;  2L3G A;  3HOC A;  4TXK A;  1RT8 A;  2DK9 A;  1UEG A;  4Q58 A;  5A36 A;  5BVR A;  2WA6 A;  1QAG A;  1VKA A;  1WYO A;  2D86 A;  3JAL M;  2RR8 A;  3HOR A;  1MB8 A;  1AOA A;  1WYM A;  1WYQ A;  1SH5 A;  2YRN A;  2QJX A;  1PXY A;  1H67 A;  2D87 A;  2K2R A;  2D85 A;  2VZD A;  1AA2 A;  4EDL A;  2VZI B;  3JAK M;  1BKR A;  1SH6 A;  3REP B;  2VZC A;  2E9K A;  2JV9 A;  1WKU A;  3CO1 A;  1WYR A;  2R8U A;  1TJT A;  1BHD A;  2K3S A;  1P5S A;  2WFN A;  1WJO A;  1PA7 A;  1P2X A;  4B7L A;  3KMW B;  5A4B A;  1DXX A;  2WA5 A;  5L0O A;  1WIX A;  4EDM A;  3F7P A;  4EDN A;  1WYN A;  2EYI A;  3KY9 A;  4Q59 A;  2VZG B;  3I6X A;  2R0O A;  3HOP A;  5A37 A;  3JAR M;  2D89 A;  4TXI A;  5J8E A; 
#chains in the Genus database with same CATH topology
 2WA7 A;  2EE7 A;  2D88 A;  3KMU B;  3FER A;  1WYL A;  1WYP A;  3EAY A;  4Q57 B;  1V5K A;  2EYN A;  1UJO A;  5A38 A;  2QJZ A;  2L3G A;  3HOC A;  4TXK A;  1RT8 A;  2DK9 A;  1UEG A;  4Q58 A;  5A36 A;  2VE7 A;  5BVR A;  2WA6 A;  1QAG A;  1VKA A;  1WYO A;  2D86 A;  2EQO A;  3JAL M;  2RR8 A;  3HOR A;  1MB8 A;  1AOA A;  2VE7 C;  1WYM A;  1WYQ A;  1EUV A;  1SH5 A;  2YRN A;  2QJX A;  2WDT A;  1PXY A;  1H67 A;  2D87 A;  2K2R A;  2D85 A;  2VZD A;  1AA2 A;  5FMU A;  4EDL A;  2VZI B;  3JAK M;  1BKR A;  1SH6 A;  2HL8 A;  3REP B;  2VZC A;  2E9K A;  2JV9 A;  1WKU A;  3CO1 A;  5FMT A;  1WYR A;  2R8U A;  1TJT A;  3VP7 A;  1BHD A;  2K3S A;  1P5S A;  2HKP A;  2WFN A;  4LVP A;  1WJO A;  1PA7 A;  1P2X A;  4B7L A;  3KMW B;  5A4B A;  1DXX A;  2WA5 A;  5L0O A;  4DDP A;  1WIX A;  4EDM A;  2HL9 A;  3F7P A;  4EDN A;  4LVR A;  1WYN A;  2EYI A;  3KY9 A;  4Q59 A;  2VZG B;  3I6X A;  2IGP A;  2WE6 A;  2R0O A;  3HOP A;  5A37 A;  3JAR M;  2D89 A;  4TXI A;  5J8E A; 
#chains in the Genus database with same CATH homology
 2WA7 A;  2EE7 A;  2D88 A;  3KMU B;  3FER A;  1WYL A;  1WYP A;  4Q57 B;  1V5K A;  2EYN A;  1UJO A;  5A38 A;  2QJZ A;  2L3G A;  3HOC A;  4TXK A;  1RT8 A;  2DK9 A;  1UEG A;  4Q58 A;  5A36 A;  5BVR A;  2WA6 A;  1QAG A;  1VKA A;  1WYO A;  2D86 A;  3JAL M;  2RR8 A;  3HOR A;  1MB8 A;  1AOA A;  1WYM A;  1WYQ A;  1SH5 A;  2YRN A;  2QJX A;  1PXY A;  1H67 A;  2D87 A;  2K2R A;  2D85 A;  2VZD A;  1AA2 A;  4EDL A;  2VZI B;  3JAK M;  1BKR A;  1SH6 A;  3REP B;  2VZC A;  2E9K A;  2JV9 A;  1WKU A;  3CO1 A;  1WYR A;  2R8U A;  1TJT A;  1BHD A;  2K3S A;  1P5S A;  2WFN A;  1WJO A;  1PA7 A;  1P2X A;  4B7L A;  3KMW B;  5A4B A;  1DXX A;  2WA5 A;  5L0O A;  1WIX A;  4EDM A;  3F7P A;  4EDN A;  1WYN A;  2EYI A;  3KY9 A;  4Q59 A;  2VZG B;  3I6X A;  2R0O A;  3HOP A;  5A37 A;  3JAR M;  2D89 A;  4TXI A;  5J8E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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