2TGPI

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Complex (proteinase/inhibitor)
molecule keywords TRYPSINOGEN
publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
source organism Bos taurus
total genus 12
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2tgpI00
1TPAI 3D65I 1D0DB 1BRCI 2FTLI 1P2JI 1PITA 1BTHP 1BRBI 2ZVXA 4WXVC 4Y0ZI 1CBWD 1P2MB 1T8MB 1K6UA 3TPII 1BZ5A 3P95E 3P92E 3BTTI 3L3TE 2KAII 3U1JE 3L33E 1BF0A 4BQDA 1P2II 1BIKA 1P2NB 2DDJA 1LD5A 1T8LB 1T8OB 3AUIA 2ZJXA 4Y10I 3TGKI 4ISNB 1Y62A 2TGPI 3BTGI 6PTIA 1DENA 1SHPA 3CI7A 2ODYE 4NTXB 3OTJI 1ZJDB 1T7CB 1B0CA 1ADZA 2LFKA 5C67C 2FI4I 1TFXC 3GYMI 4U30W 3WNYA 4ISOB 1JC6A 1D0DA 2J6DA 1AAPA 2CA7A 1FY8I 1QLQA 1BUNB 1TAWB 3BTKI 4NTYB 1G6XA 1OA55 2LFLA 1JV9A 3BTEI 1P2KI 1UUAA 1BPTA 3BTWI 3UIRC 1KUNA 3BTFI 1FANA 1ZR0B 4ISLB 5JB7A 4Y11I 4Y0YI 1YLCB 4U32X 3BTDI 3T62D 5JB4A 4BNRI 4TPII 1EJMB 1YKTB 1P2QB 1CO7I 4PTIA 3AUBA 3OFWA 1LD6A 1KIGI 1KTHA 2UUXA 3BTQI 4BD9B 1UUBA 9PTIA 1TCPA 3LDIA 1MTND 1BPIA 3TGJI 1EAWB 2R9PE 3AUGA 3TGII 2KNTA 2FI5I 5JB6A 2M01A 2M99A 8PTIA 1F5RI 2KCRA 1TAPA 1NAGA 1TOCR 3AUEA 1FAKI 3AUCA 3FP7J 5JB5A 7PTIA 5PTIA 4DTGK 2FI3I 4NTWB 1T8NB 4WWYC 3UOUB 4DG4C 1YLDB 1JV8A 1KNTA 1YC0I 2RA3C 1OA65 3FP8I 3M7QB 2HEXA 1AALA 2W8XA 1IRHA 1F7ZI 2DDIA 1DEMA 2JOTA 2IJOI 1P2OB 2TPII 1DTXA 3BYBA 1BHCA 3LDMA 3AUDA 3BTHI 1DTKA 1BZXI 2PTCI 1BTIA 3AUHA 2UUYB 2FTMB 1CA0D 3FP6I 3BTMI 3LDJA
chains in the Genus database with same CATH superfamily
1TPAI 3D65I 1D0DB 1BRCI 2FTLI 1P2JI 1PITA 1BTHP 1BRBI 2ZVXA 4WXVC 4Y0ZI 1CBWD 1P2MB 1T8MB 1K6UA 3TPII 1BZ5A 3P95E 3P92E 3BTTI 3L3TE 2KAII 3U1JE 3L33E 1BF0A 4BQDA 1P2II 1BIKA 1P2NB 2DDJA 1LD5A 1T8LB 1T8OB 3AUIA 2ZJXA 4Y10I 3TGKI 4ISNB 1Y62A 2TGPI 3BTGI 6PTIA 1DENA 1SHPA 3CI7A 2ODYE 4NTXB 3OTJI 1ZJDB 1T7CB 1B0CA 1ADZA 2LFKA 5C67C 2FI4I 1TFXC 3GYMI 4U30W 3WNYA 4ISOB 1JC6A 1D0DA 2J6DA 1AAPA 2CA7A 1FY8I 1QLQA 1BUNB 1TAWB 3BTKI 4NTYB 1G6XA 1OA55 2LFLA 1JV9A 3BTEI 1P2KI 1UUAA 1BPTA 3BTWI 3UIRC 1KUNA 3BTFI 1FANA 1ZR0B 4ISLB 5JB7A 4Y11I 4Y0YI 1YLCB 4U32X 3BTDI 3T62D 5JB4A 4BNRI 4TPII 1EJMB 1YKTB 1P2QB 1CO7I 4PTIA 3AUBA 3OFWA 1LD6A 1KIGI 1KTHA 2UUXA 3BTQI 4BD9B 1UUBA 9PTIA 1TCPA 3LDIA 1MTND 1BPIA 3TGJI 1EAWB 2R9PE 3AUGA 3TGII 2KNTA 2FI5I 5JB6A 2M01A 2M99A 8PTIA 1F5RI 2KCRA 1TAPA 1NAGA 1TOCR 3AUEA 1FAKI 3AUCA 3FP7J 5JB5A 7PTIA 5PTIA 4DTGK 2FI3I 4NTWB 1T8NB 4WWYC 3UOUB 4DG4C 1YLDB 1JV8A 1KNTA 1YC0I 2RA3C 1OA65 3FP8I 3M7QB 2HEXA 1AALA 2W8XA 1IRHA 1F7ZI 2DDIA 1DEMA 2JOTA 2IJOI 1P2OB 2TPII 1DTXA 3BYBA 1BHCA 3LDMA 3AUDA 3BTHI 1DTKA 1BZXI 2PTCI 1BTIA 3AUHA 2UUYB 2FTMB 1CA0D 3FP6I 3BTMI 3LDJA
chains in the Genus database with same CATH topology
1TPAI 3D65I 1D0DB 1BRCI 2FTLI 1P2JI 1PITA 1BTHP 1BRBI 2ZVXA 4WXVC 4Y0ZI 1CBWD 1P2MB 1T8MB 1K6UA 3TPII 1BZ5A 3P95E 3P92E 3BTTI 3L3TE 2KAII 3U1JE 3L33E 1BF0A 4BQDA 1P2II 1BIKA 1P2NB 2DDJA 1LD5A 1T8LB 1T8OB 3AUIA 2ZJXA 4Y10I 3TGKI 4ISNB 1Y62A 2TGPI 3BTGI 6PTIA 1DENA 1SHPA 3CI7A 2ODYE 4NTXB 3OTJI 1ZJDB 1T7CB 1B0CA 1ADZA 2LFKA 5C67C 2FI4I 1TFXC 3GYMI 4U30W 3WNYA 4ISOB 1JC6A 1D0DA 2J6DA 1AAPA 2CA7A 1FY8I 1QLQA 1BUNB 1TAWB 3BTKI 4NTYB 1G6XA 1OA55 2LFLA 1JV9A 3BTEI 1P2KI 1UUAA 1BPTA 3BTWI 3UIRC 1KUNA 3BTFI 1FANA 1ZR0B 4ISLB 5JB7A 4Y11I 4Y0YI 1YLCB 4U32X 3BTDI 3T62D 5JB4A 4BNRI 4TPII 1EJMB 1YKTB 1P2QB 1CO7I 4PTIA 3AUBA 3OFWA 1LD6A 1KIGI 1KTHA 2UUXA 3BTQI 4BD9B 1UUBA 9PTIA 1TCPA 3LDIA 1MTND 1BPIA 3TGJI 1EAWB 2R9PE 3AUGA 3TGII 2KNTA 2FI5I 5JB6A 2M01A 2M99A 8PTIA 1F5RI 2KCRA 1TAPA 1NAGA 1TOCR 3AUEA 1FAKI 3AUCA 3FP7J 5JB5A 7PTIA 5PTIA 4DTGK 2FI3I 4NTWB 1T8NB 4WWYC 3UOUB 4DG4C 1YLDB 1JV8A 1KNTA 1YC0I 2RA3C 1OA65 3FP8I 3M7QB 2HEXA 1AALA 2W8XA 1IRHA 1F7ZI 2DDIA 1DEMA 2JOTA 2IJOI 1P2OB 2TPII 1DTXA 3BYBA 1BHCA 3LDMA 3AUDA 3BTHI 1DTKA 1BZXI 2PTCI 1BTIA 3AUHA 2UUYB 2FTMB 1CA0D 3FP6I 3BTMI 3LDJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TPA I;  3D65 I;  1D0D B;  1BRC I;  2FTL I;  1P2J I;  1PIT A;  1BTH P;  1BRB I;  2ZVX A;  4WXV C;  4Y0Z I;  1CBW D;  1P2M B;  1T8M B;  1K6U A;  3TPI I;  1BZ5 A;  3P95 E;  3P92 E;  3BTT I;  3L3T E;  2KAI I;  3U1J E;  3L33 E;  1BF0 A;  4BQD A;  1P2I I;  1BIK A;  1P2N B;  2DDJ A;  1LD5 A;  1T8L B;  1T8O B;  3AUI A;  2ZJX A;  4Y10 I;  3TGK I;  4ISN B;  1Y62 A;  2TGP I;  3BTG I;  6PTI A;  1DEN A;  1SHP A;  3CI7 A;  2ODY E;  4NTX B;  3OTJ I;  1ZJD B;  1T7C B;  1B0C A;  1ADZ A;  2LFK A;  5C67 C;  2FI4 I;  1TFX C;  3GYM I;  4U30 W;  3WNY A;  4ISO B;  1JC6 A;  1D0D A;  2J6D A;  1AAP A;  2CA7 A;  1FY8 I;  1QLQ A;  1BUN B;  1TAW B;  3BTK I;  4NTY B;  1G6X A;  1OA5 5;  2LFL A;  1JV9 A;  3BTE I;  1P2K I;  1UUA A;  1BPT A;  3BTW I;  3UIR C;  1KUN A;  3BTF I;  1FAN A;  1ZR0 B;  4ISL B;  5JB7 A;  4Y11 I;  4Y0Y I;  1YLC B;  4U32 X;  3BTD I;  3T62 D;  5JB4 A;  4BNR I;  4TPI I;  1EJM B;  1YKT B;  1P2Q B;  1CO7 I;  4PTI A;  3AUB A;  3OFW A;  1LD6 A;  1KIG I;  1KTH A;  2UUX A;  3BTQ I;  4BD9 B;  1UUB A;  9PTI A;  1TCP A;  3LDI A;  1MTN D;  1BPI A;  3TGJ I;  1EAW B;  2R9P E;  3AUG A;  3TGI I;  2KNT A;  2FI5 I;  5JB6 A;  2M01 A;  2M99 A;  8PTI A;  1F5R I;  2KCR A;  1TAP A;  1NAG A;  1TOC R;  3AUE A;  1FAK I;  3AUC A;  3FP7 J;  5JB5 A;  7PTI A;  5PTI A;  4DTG K;  2FI3 I;  4NTW B;  1T8N B;  4WWY C;  3UOU B;  4DG4 C;  1YLD B;  1JV8 A;  1KNT A;  1YC0 I;  2RA3 C;  1OA6 5;  3FP8 I;  3M7Q B;  2HEX A;  1AAL A;  2W8X A;  1IRH A;  1F7Z I;  2DDI A;  1DEM A;  2JOT A;  2IJO I;  1P2O B;  2TPI I;  1DTX A;  3BYB A;  1BHC A;  3LDM A;  3AUD A;  3BTH I;  1DTK A;  1BZX I;  2PTC I;  1BTI A;  3AUH A;  2UUY B;  2FTM B;  1CA0 D;  3FP6 I;  3BTM I;  3LDJ A; 
#chains in the Genus database with same CATH topology
 1TPA I;  3D65 I;  1D0D B;  1BRC I;  2FTL I;  1P2J I;  1PIT A;  1BTH P;  1BRB I;  2ZVX A;  4WXV C;  4Y0Z I;  1CBW D;  1P2M B;  1T8M B;  1K6U A;  3TPI I;  1BZ5 A;  3P95 E;  3P92 E;  3BTT I;  3L3T E;  2KAI I;  3U1J E;  3L33 E;  1BF0 A;  4BQD A;  1P2I I;  1BIK A;  1P2N B;  2DDJ A;  1LD5 A;  1T8L B;  1T8O B;  3AUI A;  2ZJX A;  4Y10 I;  3TGK I;  4ISN B;  1Y62 A;  2TGP I;  3BTG I;  6PTI A;  1DEN A;  1SHP A;  3CI7 A;  2ODY E;  4NTX B;  3OTJ I;  1ZJD B;  1T7C B;  1B0C A;  1ADZ A;  2LFK A;  5C67 C;  2FI4 I;  1TFX C;  3GYM I;  4U30 W;  3WNY A;  4ISO B;  1JC6 A;  1D0D A;  2J6D A;  1AAP A;  2CA7 A;  1FY8 I;  1QLQ A;  1BUN B;  1TAW B;  3BTK I;  4NTY B;  1G6X A;  1OA5 5;  2LFL A;  1JV9 A;  3BTE I;  1P2K I;  1UUA A;  1BPT A;  3BTW I;  3UIR C;  1KUN A;  3BTF I;  1FAN A;  1ZR0 B;  4ISL B;  5JB7 A;  4Y11 I;  4Y0Y I;  1YLC B;  4U32 X;  3BTD I;  3T62 D;  5JB4 A;  4BNR I;  4TPI I;  1EJM B;  1YKT B;  1P2Q B;  1CO7 I;  4PTI A;  3AUB A;  3OFW A;  1LD6 A;  1KIG I;  1KTH A;  2UUX A;  3BTQ I;  4BD9 B;  1UUB A;  9PTI A;  1TCP A;  3LDI A;  1MTN D;  1BPI A;  3TGJ I;  1EAW B;  2R9P E;  3AUG A;  3TGI I;  2KNT A;  2FI5 I;  5JB6 A;  2M01 A;  2M99 A;  8PTI A;  1F5R I;  2KCR A;  1TAP A;  1NAG A;  1TOC R;  3AUE A;  1FAK I;  3AUC A;  3FP7 J;  5JB5 A;  7PTI A;  5PTI A;  4DTG K;  2FI3 I;  4NTW B;  1T8N B;  4WWY C;  3UOU B;  4DG4 C;  1YLD B;  1JV8 A;  1KNT A;  1YC0 I;  2RA3 C;  1OA6 5;  3FP8 I;  3M7Q B;  2HEX A;  1AAL A;  2W8X A;  1IRH A;  1F7Z I;  2DDI A;  1DEM A;  2JOT A;  2IJO I;  1P2O B;  2TPI I;  1DTX A;  3BYB A;  1BHC A;  3LDM A;  3AUD A;  3BTH I;  1DTK A;  1BZX I;  2PTC I;  1BTI A;  3AUH A;  2UUY B;  2FTM B;  1CA0 D;  3FP6 I;  3BTM I;  3LDJ A; 
#chains in the Genus database with same CATH homology
 1TPA I;  3D65 I;  1D0D B;  1BRC I;  2FTL I;  1P2J I;  1PIT A;  1BTH P;  1BRB I;  2ZVX A;  4WXV C;  4Y0Z I;  1CBW D;  1P2M B;  1T8M B;  1K6U A;  3TPI I;  1BZ5 A;  3P95 E;  3P92 E;  3BTT I;  3L3T E;  2KAI I;  3U1J E;  3L33 E;  1BF0 A;  4BQD A;  1P2I I;  1BIK A;  1P2N B;  2DDJ A;  1LD5 A;  1T8L B;  1T8O B;  3AUI A;  2ZJX A;  4Y10 I;  3TGK I;  4ISN B;  1Y62 A;  2TGP I;  3BTG I;  6PTI A;  1DEN A;  1SHP A;  3CI7 A;  2ODY E;  4NTX B;  3OTJ I;  1ZJD B;  1T7C B;  1B0C A;  1ADZ A;  2LFK A;  5C67 C;  2FI4 I;  1TFX C;  3GYM I;  4U30 W;  3WNY A;  4ISO B;  1JC6 A;  1D0D A;  2J6D A;  1AAP A;  2CA7 A;  1FY8 I;  1QLQ A;  1BUN B;  1TAW B;  3BTK I;  4NTY B;  1G6X A;  1OA5 5;  2LFL A;  1JV9 A;  3BTE I;  1P2K I;  1UUA A;  1BPT A;  3BTW I;  3UIR C;  1KUN A;  3BTF I;  1FAN A;  1ZR0 B;  4ISL B;  5JB7 A;  4Y11 I;  4Y0Y I;  1YLC B;  4U32 X;  3BTD I;  3T62 D;  5JB4 A;  4BNR I;  4TPI I;  1EJM B;  1YKT B;  1P2Q B;  1CO7 I;  4PTI A;  3AUB A;  3OFW A;  1LD6 A;  1KIG I;  1KTH A;  2UUX A;  3BTQ I;  4BD9 B;  1UUB A;  9PTI A;  1TCP A;  3LDI A;  1MTN D;  1BPI A;  3TGJ I;  1EAW B;  2R9P E;  3AUG A;  3TGI I;  2KNT A;  2FI5 I;  5JB6 A;  2M01 A;  2M99 A;  8PTI A;  1F5R I;  2KCR A;  1TAP A;  1NAG A;  1TOC R;  3AUE A;  1FAK I;  3AUC A;  3FP7 J;  5JB5 A;  7PTI A;  5PTI A;  4DTG K;  2FI3 I;  4NTW B;  1T8N B;  4WWY C;  3UOU B;  4DG4 C;  1YLD B;  1JV8 A;  1KNT A;  1YC0 I;  2RA3 C;  1OA6 5;  3FP8 I;  3M7Q B;  2HEX A;  1AAL A;  2W8X A;  1IRH A;  1F7Z I;  2DDI A;  1DEM A;  2JOT A;  2IJO I;  1P2O B;  2TPI I;  1DTX A;  3BYB A;  1BHC A;  3LDM A;  3AUD A;  3BTH I;  1DTK A;  1BZX I;  2PTC I;  1BTI A;  3AUH A;  2UUY B;  2FTM B;  1CA0 D;  3FP6 I;  3BTM I;  3LDJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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