2UWNA

Crystal structure of human complement factor h, scr domains 6-8 (h402 risk variant), in complex with ligand.
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
187
structure length
187
Chain Sequence
MGLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
molecule keywords HUMAN COMPLEMENT FACTOR H
publication title Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
pubmed doi rcsb
source organism Homo sapiens
total genus 37
structure length 187
sequence length 187
ec nomenclature
pdb deposition date 2007-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2uwnA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2uwnA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2uwnA03
4IGDA 5HYTB 5HZPB 2V8EA 3R62A 3GXEA 2CG6A 1QO6A 2QY0A 1Q3XA 2RKZA 3IU3I 3KZJA 3ZD1A 1TPNA 1O9AA 1TPGA 2KRIA 2RLQA 2YRAA 1C1ZA 3MQLA 2RKYA 1ZJKA 1GPZA 3INBC 2XWBF 1TPMA 3CALA 1SS2A 1HFHA 1E8BA 2YBYA 1OK2A 1G4FA 1GKGA 1VVDA 4WJG2 1HFIA 2A55A 1OJVA 3T5OA 1H2PP 4ONTD 2RL0A 2BZMA 4B2RA 4DJZA 1SRZA 1E88A 3O8EB 3SW0X 1HCCA 1U5MA 4ZH1D 2W81A 5HYPA 2W80A 4F4OC 2JGXA 1FBRA 1H2QP 1Z92B 1OK1A 5I0QB 4C16A 1G4GA 2KMSA 1OK9A 2LOJA 4FXGG 4A5WB 4AYEA 3OEDC 3ZD2A 3OP8A 2CKUA 1QUBA 1NWVA 4MUCA 2EHFA 4AYDA 2MCYA 1OJYA 4PZ5A 2XRDA 2JRAA 3M7PA 4LOSA 2EC3A 4K12A 1QGBA 1PPQA 3OXUD 4JHSA 3ERBA 2IZ4A 4YNXA 2IZ3A 2UWNA 3RJ3D 4AYIA 1MD7A 5FO8C 1OJWA 1OK3A 2MCZA 1LY2A 1UOTP 2G7IA 2XRBA 4B2SA 1H04P 1H03P 5JPMG 4KKDA 2XWJI 2B5ID 3NFPI 4CSYA 3EJHA 1VVCA 3GOVA 1CKLA 1GHQB 2XQWC 3ZRZA 2WIIC 1E5GA 2O39C 3KXVA 4LOTA 1GKNA 2ERJA 4AYMA 4J38B 2CG7A 2RLPA 5HYUB 3L89M 1MD8A 2JGWA 1ELVA 3IX0A 3TVJA
chains in the Genus database with same CATH superfamily
4IGDA 5HYTB 5HZPB 2V8EA 3R62A 3GXEA 2CG6A 1QO6A 2QY0A 1Q3XA 2RKZA 3IU3I 3KZJA 3ZD1A 1TPNA 1O9AA 1TPGA 2KRIA 2RLQA 3VWOA 2YRAA 3WSYA 1C1ZA 3K3TA 3MQLA 2RKYA 1ZJKA 1GPZA 3INBC 3NJAA 2XWBF 3F6KA 1TPMA 3CALA 1SS2A 1HFHA 3ZLEA 1E8BA 2YBYA 1OK2A 4N7EA 1G4FA 1GKGA 1VVDA 1RLHA 4WJG2 1HFIA 4YIZA 2A55A 1OJVA 3FGTA 3T5OA 1H2PP 4ONTD 2RL0A 2BZMA 4B2RA 4DJZA 1SRZA 1E88A 3O8EB 3SW0X 2ZYCA 2Y8RA 1HCCA 1U5MA 4ZH1D 2W81A 5HYPA 2W80A 4F4OC 2JGXA 1FBRA 1H2QP 4MSLA 5DN5A 1Z92B 1OK1A 5I0QB 4C16A 1G4GA 2KMSA 1OK9A 2LOJA 4FXGG 3WSXA 4A5WB 4AYEA 3OEDC 3ZD2A 3OP8A 2CKUA 1QUBA 1NWVA 4MUCA 2EHFA 4AYDA 2MCYA 1OJYA 2Y8TA 4PZ5A 2XRDA 2JRAA 3M7PA 4LOSA 2EC3A 4PO7A 4K12A 1QGBA 1PPQA 3OXUD 3ZLDA 4APLA 4JHSA 3ERBA 2I2LA 2IZ4A 2IZ3A 4YNXA 2UWNA 2Y8SA 3RJ3D 4AYIA 5DN4A 1MD7A 5FO8C 1OJWA 1OK3A 2MCZA 1LY2A 1UOTP 2G7IA 2XRBA 4B2SA 1H04P 1H03P 5JPMG 4KKDA 3CI0J 2XWJI 2B5ID 3NFPI 4CSYA 3EJHA 1VVCA 3GOVA 1CKLA 1GHQB 4BWCA 2XQWC 3FGRA 3ZRZA 2WIIC 1E5GA 2O39C 3KXVA 4LOTA 1GKNA 2ERJA 4AYMA 4J38B 2CG7A 2X2ZA 2RLPA 5HYUB 3L89M 1MD8A 2JGWA 1ELVA 3IX0A 3TVJA
chains in the Genus database with same CATH topology
4IGDA 5HYTB 5HZPB 2V8EA 3R62A 3GXEA 2CG6A 1QO6A 2QY0A 1Q3XA 2RKZA 3IU3I 3KZJA 3ZD1A 1TPNA 1O9AA 1TPGA 2KRIA 2RLQA 2YRAA 1C1ZA 3MQLA 2RKYA 1ZJKA 1GPZA 3INBC 2XWBF 1TPMA 3CALA 1SS2A 1HFHA 1E8BA 2YBYA 1OK2A 1G4FA 1GKGA 1VVDA 4WJG2 1HFIA 2A55A 1OJVA 3T5OA 1H2PP 4ONTD 2RL0A 2BZMA 4B2RA 4DJZA 1SRZA 1E88A 3O8EB 3SW0X 1HCCA 1U5MA 4ZH1D 2W81A 5HYPA 2W80A 4F4OC 2JGXA 1FBRA 1H2QP 1Z92B 1OK1A 5I0QB 4C16A 1G4GA 2KMSA 1OK9A 2LOJA 4FXGG 4A5WB 4AYEA 3OEDC 3ZD2A 3OP8A 2CKUA 1QUBA 1NWVA 4MUCA 2EHFA 4AYDA 2MCYA 1OJYA 4PZ5A 2XRDA 2JRAA 3M7PA 4LOSA 2EC3A 4K12A 1QGBA 1PPQA 3OXUD 4JHSA 3ERBA 2IZ4A 4YNXA 2IZ3A 2UWNA 3RJ3D 4AYIA 1MD7A 5FO8C 1OJWA 1OK3A 2MCZA 1LY2A 1UOTP 2G7IA 2XRBA 4B2SA 1H04P 1H03P 5JPMG 4KKDA 2XWJI 2B5ID 3NFPI 4CSYA 3EJHA 1VVCA 3GOVA 1CKLA 1GHQB 2XQWC 3ZRZA 2WIIC 1E5GA 2O39C 3KXVA 4LOTA 1GKNA 2ERJA 4AYMA 4J38B 2CG7A 2RLPA 5HYUB 3L89M 1MD8A 2JGWA 1ELVA 3IX0A 3TVJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IGD A;  5HYT B;  5HZP B;  2V8E A;  3R62 A;  3GXE A;  2CG6 A;  1QO6 A;  2QY0 A;  1Q3X A;  2RKZ A;  3IU3 I;  3KZJ A;  3ZD1 A;  1TPN A;  1O9A A;  1TPG A;  2KRI A;  2RLQ A;  2YRA A;  1C1Z A;  3MQL A;  2RKY A;  1ZJK A;  1GPZ A;  3INB C;  2XWB F;  1TPM A;  3CAL A;  1SS2 A;  1HFH A;  1E8B A;  2YBY A;  1OK2 A;  1G4F A;  1GKG A;  1VVD A;  4WJG 2;  1HFI A;  2A55 A;  1OJV A;  3T5O A;  1H2P P;  4ONT D;  2RL0 A;  2BZM A;  4B2R A;  4DJZ A;  1SRZ A;  1E88 A;  3O8E B;  3SW0 X;  1HCC A;  1U5M A;  4ZH1 D;  2W81 A;  5HYP A;  2W80 A;  4F4O C;  2JGX A;  1FBR A;  1H2Q P;  1Z92 B;  1OK1 A;  5I0Q B;  4C16 A;  1G4G A;  2KMS A;  1OK9 A;  2LOJ A;  4FXG G;  4A5W B;  4AYE A;  3OED C;  3ZD2 A;  3OP8 A;  2CKU A;  1QUB A;  1NWV A;  4MUC A;  2EHF A;  4AYD A;  2MCY A;  1OJY A;  4PZ5 A;  2XRD A;  2JRA A;  3M7P A;  4LOS A;  2EC3 A;  4K12 A;  1QGB A;  1PPQ A;  3OXU D;  4JHS A;  3ERB A;  2IZ4 A;  4YNX A;  2IZ3 A;  2UWN A;  3RJ3 D;  4AYI A;  1MD7 A;  5FO8 C;  1OJW A;  1OK3 A;  2MCZ A;  1LY2 A;  1UOT P;  2G7I A;  2XRB A;  4B2S A;  1H04 P;  1H03 P;  5JPM G;  4KKD A;  2XWJ I;  2B5I D;  3NFP I;  4CSY A;  3EJH A;  1VVC A;  3GOV A;  1CKL A;  1GHQ B;  2XQW C;  3ZRZ A;  2WII C;  1E5G A;  2O39 C;  3KXV A;  4LOT A;  1GKN A;  2ERJ A;  4AYM A;  4J38 B;  2CG7 A;  2RLP A;  5HYU B;  3L89 M;  1MD8 A;  2JGW A;  1ELV A;  3IX0 A;  3TVJ A; 
#chains in the Genus database with same CATH topology
 4IGD A;  5HYT B;  5HZP B;  2V8E A;  3R62 A;  3GXE A;  2CG6 A;  1QO6 A;  2QY0 A;  1Q3X A;  2RKZ A;  3IU3 I;  3KZJ A;  3ZD1 A;  1TPN A;  1O9A A;  1TPG A;  2KRI A;  2RLQ A;  3VWO A;  2YRA A;  3WSY A;  1C1Z A;  3K3T A;  3MQL A;  2RKY A;  1ZJK A;  1GPZ A;  3INB C;  3NJA A;  2XWB F;  3F6K A;  1TPM A;  3CAL A;  1SS2 A;  1HFH A;  3ZLE A;  1E8B A;  2YBY A;  1OK2 A;  4N7E A;  1G4F A;  1GKG A;  1VVD A;  1RLH A;  4WJG 2;  1HFI A;  4YIZ A;  2A55 A;  1OJV A;  3FGT A;  3T5O A;  1H2P P;  4ONT D;  2RL0 A;  2BZM A;  4B2R A;  4DJZ A;  1SRZ A;  1E88 A;  3O8E B;  3SW0 X;  2ZYC A;  2Y8R A;  1HCC A;  1U5M A;  4ZH1 D;  2W81 A;  5HYP A;  2W80 A;  4F4O C;  2JGX A;  1FBR A;  1H2Q P;  4MSL A;  5DN5 A;  1Z92 B;  1OK1 A;  5I0Q B;  4C16 A;  1G4G A;  2KMS A;  1OK9 A;  2LOJ A;  4FXG G;  3WSX A;  4A5W B;  4AYE A;  3OED C;  3ZD2 A;  3OP8 A;  2CKU A;  1QUB A;  1NWV A;  4MUC A;  2EHF A;  4AYD A;  2MCY A;  1OJY A;  2Y8T A;  4PZ5 A;  2XRD A;  2JRA A;  3M7P A;  4LOS A;  2EC3 A;  4PO7 A;  4K12 A;  1QGB A;  1PPQ A;  3OXU D;  3ZLD A;  4APL A;  4JHS A;  3ERB A;  2I2L A;  2IZ4 A;  2IZ3 A;  4YNX A;  2UWN A;  2Y8S A;  3RJ3 D;  4AYI A;  5DN4 A;  1MD7 A;  5FO8 C;  1OJW A;  1OK3 A;  2MCZ A;  1LY2 A;  1UOT P;  2G7I A;  2XRB A;  4B2S A;  1H04 P;  1H03 P;  5JPM G;  4KKD A;  3CI0 J;  2XWJ I;  2B5I D;  3NFP I;  4CSY A;  3EJH A;  1VVC A;  3GOV A;  1CKL A;  1GHQ B;  4BWC A;  2XQW C;  3FGR A;  3ZRZ A;  2WII C;  1E5G A;  2O39 C;  3KXV A;  4LOT A;  1GKN A;  2ERJ A;  4AYM A;  4J38 B;  2CG7 A;  2X2Z A;  2RLP A;  5HYU B;  3L89 M;  1MD8 A;  2JGW A;  1ELV A;  3IX0 A;  3TVJ A; 
#chains in the Genus database with same CATH homology
 4IGD A;  5HYT B;  5HZP B;  2V8E A;  3R62 A;  3GXE A;  2CG6 A;  1QO6 A;  2QY0 A;  1Q3X A;  2RKZ A;  3IU3 I;  3KZJ A;  3ZD1 A;  1TPN A;  1O9A A;  1TPG A;  2KRI A;  2RLQ A;  2YRA A;  1C1Z A;  3MQL A;  2RKY A;  1ZJK A;  1GPZ A;  3INB C;  2XWB F;  1TPM A;  3CAL A;  1SS2 A;  1HFH A;  1E8B A;  2YBY A;  1OK2 A;  1G4F A;  1GKG A;  1VVD A;  4WJG 2;  1HFI A;  2A55 A;  1OJV A;  3T5O A;  1H2P P;  4ONT D;  2RL0 A;  2BZM A;  4B2R A;  4DJZ A;  1SRZ A;  1E88 A;  3O8E B;  3SW0 X;  1HCC A;  1U5M A;  4ZH1 D;  2W81 A;  5HYP A;  2W80 A;  4F4O C;  2JGX A;  1FBR A;  1H2Q P;  1Z92 B;  1OK1 A;  5I0Q B;  4C16 A;  1G4G A;  2KMS A;  1OK9 A;  2LOJ A;  4FXG G;  4A5W B;  4AYE A;  3OED C;  3ZD2 A;  3OP8 A;  2CKU A;  1QUB A;  1NWV A;  4MUC A;  2EHF A;  4AYD A;  2MCY A;  1OJY A;  4PZ5 A;  2XRD A;  2JRA A;  3M7P A;  4LOS A;  2EC3 A;  4K12 A;  1QGB A;  1PPQ A;  3OXU D;  4JHS A;  3ERB A;  2IZ4 A;  4YNX A;  2IZ3 A;  2UWN A;  3RJ3 D;  4AYI A;  1MD7 A;  5FO8 C;  1OJW A;  1OK3 A;  2MCZ A;  1LY2 A;  1UOT P;  2G7I A;  2XRB A;  4B2S A;  1H04 P;  1H03 P;  5JPM G;  4KKD A;  2XWJ I;  2B5I D;  3NFP I;  4CSY A;  3EJH A;  1VVC A;  3GOV A;  1CKL A;  1GHQ B;  2XQW C;  3ZRZ A;  2WII C;  1E5G A;  2O39 C;  3KXV A;  4LOT A;  1GKN A;  2ERJ A;  4AYM A;  4J38 B;  2CG7 A;  2RLP A;  5HYU B;  3L89 M;  1MD8 A;  2JGW A;  1ELV A;  3IX0 A;  3TVJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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