2V8EA

Crystal structure of human complement factor h, scr domains 6-8 (h402 risk variant), in complex with ligand.
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
187
structure length
187
Chain Sequence
MGLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
molecule keywords COMPLEMENT FACTOR H
publication title Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
pubmed doi rcsb
source organism Homo sapiens
total genus 34
structure length 187
sequence length 187
ec nomenclature
pdb deposition date 2007-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA03
1C1ZA 2IZ4A 3IX0A 5HYTB 2RLPA 2KRIA 2W81A 1QO6A 1OK1A 3TVJA 2W80A 3NFPI 3O8EB 2WIIC 2CG6A 2JGWA 4CSYA 3EJHA 1QGBA 3OP8A 2IZ3A 3ERBA 3KXVA 4LOSA 1QUBA 2O39C 2QY0A 5JPMG 1O9AA 5HYUB 1H2QP 4AYIA 5HZPB 1OK9A 4K12A 1E88A 1TPNA 4JHSA 2RKZA 2A55A 1HCCA 3OXUD 1Z92B 2B5ID 3INBC 2RKYA 4AYEA 2XQWC 2YRAA 1MD7A 3SW0X 3IU3I 1E5GA 1ZJKA 4DJZA 1SS2A 3M7PA 1G4FA 1H2PP 2XRDA 1NWVA 2CKUA 4A5WB 2UWNA 1GHQB 2XWBF 5HYPA 1HFHA 4J38B 4AYDA 1OK2A 1VVCA 3CALA 3GOVA 2XRBA 4AYMA 1SRZA 2YBYA 2XWJI 1GPZA 1HFIA 1H04P 4IGDA 1U5MA 1GKGA 2ERJA 3RJ3D 2RL0A 1ELVA 4FXGG 1E8BA 1Q3XA 2LOJA 1UOTP 4YNXA 1OJWA 2JRAA 1H03P 4ONTD 1TPMA 2G7IA 3T5OA 4WJG2 2BZMA 1GKNA 2EC3A 2RLQA 4KKDA 2JGXA 3ZRZA 3KZJA 3ZD1A 4LOTA 4B2SA 5I0QB 1TPGA 3MQLA 2EHFA 4F4OC 2V8EA 1OK3A 1G4GA 3GXEA 1OJVA 4C16A 1PPQA 3OEDC 1LY2A 5FO8C 1CKLA 4B2RA 4ZH1D 3L89M 1FBRA 2CG7A 2MCYA 3ZD2A 1OJYA 1VVDA 2MCZA 2KMSA 3R62A 1MD8A 4PZ5A 4MUCA
chains in the Genus database with same CATH superfamily
1C1ZA 2IZ4A 3CI0J 3IX0A 5HYTB 2RLPA 2KRIA 2W81A 1QO6A 1OK1A 3TVJA 2W80A 3NFPI 3O8EB 2WIIC 2CG6A 4MSLA 2JGWA 4CSYA 3EJHA 1QGBA 3OP8A 2IZ3A 3ERBA 3KXVA 3K3TA 4LOSA 1QUBA 2O39C 2QY0A 5JPMG 1O9AA 5HYUB 1H2QP 4AYIA 3FGRA 5HZPB 1OK9A 4K12A 1E88A 1TPNA 2Y8SA 4JHSA 2RKZA 2A55A 1HCCA 3OXUD 3WSXA 1Z92B 2B5ID 3INBC 2RKYA 4AYEA 2XQWC 2YRAA 1MD7A 3SW0X 3IU3I 1E5GA 1ZJKA 5DN4A 4DJZA 1SS2A 3M7PA 1G4FA 1H2PP 2XRDA 1NWVA 2CKUA 4A5WB 2UWNA 1GHQB 2XWBF 5HYPA 1HFHA 4J38B 4AYDA 4PO7A 1OK2A 1VVCA 3CALA 3GOVA 2XRBA 1RLHA 1SRZA 2YBYA 4AYMA 2XWJI 1GPZA 1HFIA 1H04P 4IGDA 1U5MA 3ZLEA 1GKGA 2ERJA 2ZYCA 3F6KA 3RJ3D 2RL0A 1ELVA 2I2LA 2Y8RA 4FXGG 1E8BA 1Q3XA 2LOJA 1UOTP 4YNXA 4YIZA 1OJWA 2JRAA 1H03P 4ONTD 4BWCA 1TPMA 2G7IA 3T5OA 4WJG2 2BZMA 1GKNA 2EC3A 3ZLDA 2RLQA 4KKDA 5DN5A 2JGXA 4APLA 3ZRZA 3FGTA 3KZJA 3ZD1A 4LOTA 4N7EA 4B2SA 5I0QB 2X2ZA 1TPGA 3MQLA 2EHFA 4F4OC 2V8EA 3VWOA 1OK3A 1G4GA 3GXEA 1OJVA 4C16A 1PPQA 3OEDC 3WSYA 1LY2A 5FO8C 1CKLA 4B2RA 4ZH1D 3L89M 3NJAA 1FBRA 2CG7A 2MCYA 3ZD2A 1OJYA 2Y8TA 1VVDA 2MCZA 2KMSA 3R62A 1MD8A 4PZ5A 4MUCA
chains in the Genus database with same CATH topology
1C1ZA 2IZ4A 3IX0A 5HYTB 2RLPA 2KRIA 2W81A 1QO6A 1OK1A 3TVJA 2W80A 3NFPI 3O8EB 2WIIC 2CG6A 2JGWA 4CSYA 3EJHA 1QGBA 3OP8A 2IZ3A 3ERBA 3KXVA 4LOSA 1QUBA 2O39C 2QY0A 5JPMG 1O9AA 5HYUB 1H2QP 4AYIA 5HZPB 1OK9A 4K12A 1E88A 1TPNA 4JHSA 2RKZA 2A55A 1HCCA 3OXUD 1Z92B 2B5ID 3INBC 2RKYA 4AYEA 2XQWC 2YRAA 1MD7A 3SW0X 3IU3I 1E5GA 1ZJKA 4DJZA 1SS2A 3M7PA 1G4FA 1H2PP 2XRDA 1NWVA 2CKUA 4A5WB 2UWNA 1GHQB 2XWBF 5HYPA 1HFHA 4J38B 4AYDA 1OK2A 1VVCA 3CALA 3GOVA 2XRBA 4AYMA 1SRZA 2YBYA 2XWJI 1GPZA 1HFIA 1H04P 4IGDA 1U5MA 1GKGA 2ERJA 3RJ3D 2RL0A 1ELVA 4FXGG 1E8BA 1Q3XA 2LOJA 1UOTP 4YNXA 1OJWA 2JRAA 1H03P 4ONTD 1TPMA 2G7IA 3T5OA 4WJG2 2BZMA 1GKNA 2EC3A 2RLQA 4KKDA 2JGXA 3ZRZA 3KZJA 3ZD1A 4LOTA 4B2SA 5I0QB 1TPGA 3MQLA 2EHFA 4F4OC 2V8EA 1OK3A 1G4GA 3GXEA 1OJVA 4C16A 1PPQA 3OEDC 1LY2A 5FO8C 1CKLA 4B2RA 4ZH1D 3L89M 1FBRA 2CG7A 2MCYA 3ZD2A 1OJYA 1VVDA 2MCZA 2KMSA 3R62A 1MD8A 4PZ5A 4MUCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C1Z A;  2IZ4 A;  3IX0 A;  5HYT B;  2RLP A;  2KRI A;  2W81 A;  1QO6 A;  1OK1 A;  3TVJ A;  2W80 A;  3NFP I;  3O8E B;  2WII C;  2CG6 A;  2JGW A;  4CSY A;  3EJH A;  1QGB A;  3OP8 A;  2IZ3 A;  3ERB A;  3KXV A;  4LOS A;  1QUB A;  2O39 C;  2QY0 A;  5JPM G;  1O9A A;  5HYU B;  1H2Q P;  4AYI A;  5HZP B;  1OK9 A;  4K12 A;  1E88 A;  1TPN A;  4JHS A;  2RKZ A;  2A55 A;  1HCC A;  3OXU D;  1Z92 B;  2B5I D;  3INB C;  2RKY A;  4AYE A;  2XQW C;  2YRA A;  1MD7 A;  3SW0 X;  3IU3 I;  1E5G A;  1ZJK A;  4DJZ A;  1SS2 A;  3M7P A;  1G4F A;  1H2P P;  2XRD A;  1NWV A;  2CKU A;  4A5W B;  2UWN A;  1GHQ B;  2XWB F;  5HYP A;  1HFH A;  4J38 B;  4AYD A;  1OK2 A;  1VVC A;  3CAL A;  3GOV A;  2XRB A;  4AYM A;  1SRZ A;  2YBY A;  2XWJ I;  1GPZ A;  1HFI A;  1H04 P;  4IGD A;  1U5M A;  1GKG A;  2ERJ A;  3RJ3 D;  2RL0 A;  1ELV A;  4FXG G;  1E8B A;  1Q3X A;  2LOJ A;  1UOT P;  4YNX A;  1OJW A;  2JRA A;  1H03 P;  4ONT D;  1TPM A;  2G7I A;  3T5O A;  4WJG 2;  2BZM A;  1GKN A;  2EC3 A;  2RLQ A;  4KKD A;  2JGX A;  3ZRZ A;  3KZJ A;  3ZD1 A;  4LOT A;  4B2S A;  5I0Q B;  1TPG A;  3MQL A;  2EHF A;  4F4O C;  2V8E A;  1OK3 A;  1G4G A;  3GXE A;  1OJV A;  4C16 A;  1PPQ A;  3OED C;  1LY2 A;  5FO8 C;  1CKL A;  4B2R A;  4ZH1 D;  3L89 M;  1FBR A;  2CG7 A;  2MCY A;  3ZD2 A;  1OJY A;  1VVD A;  2MCZ A;  2KMS A;  3R62 A;  1MD8 A;  4PZ5 A;  4MUC A; 
#chains in the Genus database with same CATH topology
 1C1Z A;  2IZ4 A;  3CI0 J;  3IX0 A;  5HYT B;  2RLP A;  2KRI A;  2W81 A;  1QO6 A;  1OK1 A;  3TVJ A;  2W80 A;  3NFP I;  3O8E B;  2WII C;  2CG6 A;  4MSL A;  2JGW A;  4CSY A;  3EJH A;  1QGB A;  3OP8 A;  2IZ3 A;  3ERB A;  3KXV A;  3K3T A;  4LOS A;  1QUB A;  2O39 C;  2QY0 A;  5JPM G;  1O9A A;  5HYU B;  1H2Q P;  4AYI A;  3FGR A;  5HZP B;  1OK9 A;  4K12 A;  1E88 A;  1TPN A;  2Y8S A;  4JHS A;  2RKZ A;  2A55 A;  1HCC A;  3OXU D;  3WSX A;  1Z92 B;  2B5I D;  3INB C;  2RKY A;  4AYE A;  2XQW C;  2YRA A;  1MD7 A;  3SW0 X;  3IU3 I;  1E5G A;  1ZJK A;  5DN4 A;  4DJZ A;  1SS2 A;  3M7P A;  1G4F A;  1H2P P;  2XRD A;  1NWV A;  2CKU A;  4A5W B;  2UWN A;  1GHQ B;  2XWB F;  5HYP A;  1HFH A;  4J38 B;  4AYD A;  4PO7 A;  1OK2 A;  1VVC A;  3CAL A;  3GOV A;  2XRB A;  1RLH A;  1SRZ A;  2YBY A;  4AYM A;  2XWJ I;  1GPZ A;  1HFI A;  1H04 P;  4IGD A;  1U5M A;  3ZLE A;  1GKG A;  2ERJ A;  2ZYC A;  3F6K A;  3RJ3 D;  2RL0 A;  1ELV A;  2I2L A;  2Y8R A;  4FXG G;  1E8B A;  1Q3X A;  2LOJ A;  1UOT P;  4YNX A;  4YIZ A;  1OJW A;  2JRA A;  1H03 P;  4ONT D;  4BWC A;  1TPM A;  2G7I A;  3T5O A;  4WJG 2;  2BZM A;  1GKN A;  2EC3 A;  3ZLD A;  2RLQ A;  4KKD A;  5DN5 A;  2JGX A;  4APL A;  3ZRZ A;  3FGT A;  3KZJ A;  3ZD1 A;  4LOT A;  4N7E A;  4B2S A;  5I0Q B;  2X2Z A;  1TPG A;  3MQL A;  2EHF A;  4F4O C;  2V8E A;  3VWO A;  1OK3 A;  1G4G A;  3GXE A;  1OJV A;  4C16 A;  1PPQ A;  3OED C;  3WSY A;  1LY2 A;  5FO8 C;  1CKL A;  4B2R A;  4ZH1 D;  3L89 M;  3NJA A;  1FBR A;  2CG7 A;  2MCY A;  3ZD2 A;  1OJY A;  2Y8T A;  1VVD A;  2MCZ A;  2KMS A;  3R62 A;  1MD8 A;  4PZ5 A;  4MUC A; 
#chains in the Genus database with same CATH homology
 1C1Z A;  2IZ4 A;  3IX0 A;  5HYT B;  2RLP A;  2KRI A;  2W81 A;  1QO6 A;  1OK1 A;  3TVJ A;  2W80 A;  3NFP I;  3O8E B;  2WII C;  2CG6 A;  2JGW A;  4CSY A;  3EJH A;  1QGB A;  3OP8 A;  2IZ3 A;  3ERB A;  3KXV A;  4LOS A;  1QUB A;  2O39 C;  2QY0 A;  5JPM G;  1O9A A;  5HYU B;  1H2Q P;  4AYI A;  5HZP B;  1OK9 A;  4K12 A;  1E88 A;  1TPN A;  4JHS A;  2RKZ A;  2A55 A;  1HCC A;  3OXU D;  1Z92 B;  2B5I D;  3INB C;  2RKY A;  4AYE A;  2XQW C;  2YRA A;  1MD7 A;  3SW0 X;  3IU3 I;  1E5G A;  1ZJK A;  4DJZ A;  1SS2 A;  3M7P A;  1G4F A;  1H2P P;  2XRD A;  1NWV A;  2CKU A;  4A5W B;  2UWN A;  1GHQ B;  2XWB F;  5HYP A;  1HFH A;  4J38 B;  4AYD A;  1OK2 A;  1VVC A;  3CAL A;  3GOV A;  2XRB A;  4AYM A;  1SRZ A;  2YBY A;  2XWJ I;  1GPZ A;  1HFI A;  1H04 P;  4IGD A;  1U5M A;  1GKG A;  2ERJ A;  3RJ3 D;  2RL0 A;  1ELV A;  4FXG G;  1E8B A;  1Q3X A;  2LOJ A;  1UOT P;  4YNX A;  1OJW A;  2JRA A;  1H03 P;  4ONT D;  1TPM A;  2G7I A;  3T5O A;  4WJG 2;  2BZM A;  1GKN A;  2EC3 A;  2RLQ A;  4KKD A;  2JGX A;  3ZRZ A;  3KZJ A;  3ZD1 A;  4LOT A;  4B2S A;  5I0Q B;  1TPG A;  3MQL A;  2EHF A;  4F4O C;  2V8E A;  1OK3 A;  1G4G A;  3GXE A;  1OJV A;  4C16 A;  1PPQ A;  3OED C;  1LY2 A;  5FO8 C;  1CKL A;  4B2R A;  4ZH1 D;  3L89 M;  1FBR A;  2CG7 A;  2MCY A;  3ZD2 A;  1OJY A;  1VVD A;  2MCZ A;  2KMS A;  3R62 A;  1MD8 A;  4PZ5 A;  4MUC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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