3EPXA

Crystal structure of trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2r,3r,4s)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
326
structure length
322
Chain Sequence
AKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCEGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords IAG-nucleoside hydrolase
publication title Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
pubmed doi rcsb
source organism Trypanosoma vivax
total genus 119
structure length 322
sequence length 326
chains with identical sequence B
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 3epxA00
3T8IA 1KIEA 3FZ0A 1KICA 3EPWA 4KPNA 5TSQA 3B9GA 4KL0A 2FF2A 3MKMA 1HP0A 4I75A 3B9XA 4I73A 1HOZA 4I74A 2YHGA 4KPOA 1YOEA 4I70A 4P5FA 4I71A 2MASA 2FF1A 4I72A 3T8JA 3EPXA 3G5IA 4WR2A 1Q8FA 2C40A 3MKNA 1R4FA 1MASA 1EZRA
chains in the Genus database with same CATH superfamily
3T8IA 1KIEA 3FZ0A 1KICA 3EPWA 4KPNA 5TSQA 3B9GA 4KL0A 2FF2A 3MKMA 1HP0A 4I75A 3B9XA 4I73A 1HOZA 4I74A 2YHGA 4KPOA 1YOEA 4I70A 4P5FA 4I71A 2MASA 2FF1A 4I72A 3T8JA 3EPXA 3G5IA 4WR2A 1Q8FA 2C40A 3MKNA 1R4FA 1MASA 1EZRA
chains in the Genus database with same CATH topology
3T8IA 1KIEA 3FZ0A 1KICA 3EPWA 4KPNA 5TSQA 3B9GA 4KL0A 2FF2A 3MKMA 1HP0A 4I75A 3B9XA 4I73A 1HOZA 4I74A 2YHGA 4KPOA 1YOEA 4I70A 4P5FA 4I71A 2MASA 2FF1A 4I72A 3T8JA 3EPXA 3G5IA 4WR2A 1Q8FA 2C40A 3MKNA 1R4FA 1MASA 1EZRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T8I A;  1KIE A;  3FZ0 A;  1KIC A;  3EPW A;  4KPN A;  5TSQ A;  3B9G A;  4KL0 A;  2FF2 A;  3MKM A;  1HP0 A;  4I75 A;  3B9X A;  4I73 A;  1HOZ A;  4I74 A;  2YHG A;  4KPO A;  1YOE A;  4I70 A;  4P5F A;  4I71 A;  2MAS A;  2FF1 A;  4I72 A;  3T8J A;  3EPX A;  3G5I A;  4WR2 A;  1Q8F A;  2C40 A;  3MKN A;  1R4F A;  1MAS A;  1EZR A; 
#chains in the Genus database with same CATH topology
 3T8I A;  1KIE A;  3FZ0 A;  1KIC A;  3EPW A;  4KPN A;  5TSQ A;  3B9G A;  4KL0 A;  2FF2 A;  3MKM A;  1HP0 A;  4I75 A;  3B9X A;  4I73 A;  1HOZ A;  4I74 A;  2YHG A;  4KPO A;  1YOE A;  4I70 A;  4P5F A;  4I71 A;  2MAS A;  2FF1 A;  4I72 A;  3T8J A;  3EPX A;  3G5I A;  4WR2 A;  1Q8F A;  2C40 A;  3MKN A;  1R4F A;  1MAS A;  1EZR A; 
#chains in the Genus database with same CATH homology
 3T8I A;  1KIE A;  3FZ0 A;  1KIC A;  3EPW A;  4KPN A;  5TSQ A;  3B9G A;  4KL0 A;  2FF2 A;  3MKM A;  1HP0 A;  4I75 A;  3B9X A;  4I73 A;  1HOZ A;  4I74 A;  2YHG A;  4KPO A;  1YOE A;  4I70 A;  4P5F A;  4I71 A;  2MAS A;  2FF1 A;  4I72 A;  3T8J A;  3EPX A;  3G5I A;  4WR2 A;  1Q8F A;  2C40 A;  3MKN A;  1R4F A;  1MAS A;  1EZR A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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